Guest guest Posted October 2, 2003 Report Share Posted October 2, 2003 I found interesting article regarding CoQ10. Any comments on this? I don't like this word synthetic. The whole article is here:http://www.smartnutrition.info/JamesSouth-idebenone.htm Idebenone by James South MA Idebenone is a synthetic analog (variant) of one of life's most essential biochemicals, coenzyme Q10 (Co Q10). Co Q10 is an important antioxidant component of the lipid (fatty) membranes that surround all cells, as well as the lipid membranes surrounding the various organelles ("little organs"), such as mitochondria and microsomes, inside cells. Co Q10 is also an important member of the "Electron Transport Chain" (ETC) within mitochondria, which are the "power plants" of the cell. Most of the oxygen we breathe is used inside the electron transport chain to produce much of the ATP bioenergy that powers virtually every activity of our cells and bodies. Without CoQ10, or a good substitute, human life quickly ends, and Idebenone is a "better Co Q10" that has been extensively researched the past 15 years. Co Q10’s pro-oxidant action to order When blood flow is seriously reduced to any part of the body, as in a heart attack, stroke, trauma, shock, or chronic poor blood circulation- cellular/ mitochondrial oxygen (O2) levels quickly drop in the affected region. Yet because oxygen is seven to eight times more soluble in the lipid zones of cell membrane, compared to the watery compartments of the cell, there is still sufficient oxygen remaining in the membranes of cells and organelles, as well as in the electron transport chain, to auto-oxidize Co Q10. As the Co Q10 auto-oxidizes, hydrogen peroxide, superoxide and hydroxl free radicals are rapidly formed in massive numbers. These free radicals quickly damage cell/ organelle structure and function, as well as rapidly halt ATP energy generation by the electron transport chain. Brain and spinal cord cells are especially prone to such damage, and may be irreparably damaged or even destroyed within minutes. Why Idebenone is superior to Co Q10 Enter Idebenone to the rescue! Studies have shown that under the same cellular low oxygen conditions that cause Co Q10 to act as a pro-oxidant producer of damaging free radicals, Idebenone prevents the free radical dam-age and maintains relatively normal cell ATP levels. In short, while Idebenone can effectively substitute for Co Q10's positive and life essential functions, it doesn't have Co Q10's free radical producing and energy crashing "dark side" which occurs under hypoxic (low oxygen) conditions. Idebenone's potential benefits fall into five categories; antiaging, energy enhancement, cognition enhancement, organ protector and protector against excitatory amino acid neurotoxicity. Jasmina Quote Link to comment Share on other sites More sharing options...
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