Supplement of Six selective amino acids arrest Progressive Renal Failure in Uremic Patients

April 6, 2005

Int Urol Nephrol. 2004;36(4):591-8. Related Articles, Links

Oral supplement of six selective amino acids arrest progression renal failure in

uremic patients.

Yatzidis H.

Laboratory for Experimental Surgery and Surgical Research, School of Medicine,

University of Athens, Greece. iyatzidi

Certain amino acids such as glycine, L-aspartic acid, L-glutamic acid,

L-glutamine, L-histidine and L-arginine taken orally by normal adults or

patients with renal failure increase glomerular filtration rate (GFR). Twelve

nondiabetic patients suffering from glomerulonephritis confirmed by renal biopsy

previously, with creatinine clearances ranging from 15 to 24 ml minute/1.73, and

on low protein diet 0.6 g/ kg/day, received an amino acid supplement daily in 2

or 3 doses for 1 year. At 4, 8 and 12 months creatinine clearance increased

slightly (NS, NS, NS), 24 hour urine volume increased (P < or = 0.001, 001,

0.001), 24 hour albuminuria decreased (P < 0.001, 0.001, 0.001), serum urea

increased (NS, NS, NS) serum albumin increased (NS, 0.05, 0.05), total

cholesterol decreased slightly (NS, NS, 0.01), HDL increased slightly (0.05,

0.05, 0.05), LDL decreased (NS, 0.001, 0.001) triglycerides decreased (0.001,

0.001, 0.001), Apo B remained unchanged (NS, NS, NS), ROS/H2O2 decreased (0.001,

0,001, 0.001), Hct increased (NS, 0.01, 0.01) Hb increased (0.05, 0.05, 0.05),

and serum phosphate decreased (0.01, 0.01, 0.01). After removal of supplements

at the end of the year all parameters remained unchanged. We believe that a

large controlled study should be undertaken to confirm these most encouraging

findings.

PMID: 15787344 [PubMed - in process]

ct & list_uids=

_________________

JoAnn Guest

mrsjoguest

DietaryTipsForHBP

AIM Barleygreen

" Wisdom of the Past, Food of the Future "

Recommended Posts