Guest guest Posted March 16, 2005 Report Share Posted March 16, 2005 " HSI - Jenny Thompson " <HSIResearch HSI e-Alert - Wonder Goes Under Wed, 16 Mar 2005 08:36:28 -0500 HSI e-Alert - Wonder Goes Under Health Sciences Institute e-Alert **************************************************** March 16, 2005 **************************************************** Dear Reader, The Wonder Drug of the 20th Century will probably not finish out the 21st Century with its " wonder-ful " reputation intact. You may have heard about a recent New England Journal of Medicine study concluding that aspirin " therapy " may prompt serious digestive problems but very little cardiovascular protection for middle-aged women. This study is worth a closer look - especially for those who have been sold on the idea of aspirin as the silver bullet of heart health - because as other studies have revealed, there are a number of potential pitfalls for those who sign on for the Wonder Drug treatment. ----------- Risks revised ----------- The scope of his newest aspirin study is impressive. Researchers at the Brigham and Women's Hospital recruited well over 39,000 healthy women over the age of 45 who had experienced no cardiovascular events (such as heart attack or stroke). For a period of 10 years, half the group took 100 mg of aspirin every other day and half the group took a placebo. Now, if we're to believe the ads we see on television, the result of this study is a no-brainer, right? Aspirin surely proved to be protective. Right? Well...not exactly. Several hundred major cardiovascular events were reported in both groups - not surprising in a cohort of nearly 40,000 over a decade. But the placebo group reported only 45 more cardio events than the aspirin group - a statistically insignificant difference. Aspirin provided virtually no protection from heart attack, although those in the aspirin group had a 24 percent reduced risk of ischemic stroke. In a study of this size, those are significant results. But here's the troubling part: Women in the aspirin group were found to have a 40 percent increased risk of gastrointestinal bleeding. But this was not just any bleeding: it was bleeding severe enough to require transfusions. This sharply increased risk of internal bleeding sort of takes the edge off the good news: Women over the age of 65 who took aspirin were found to have a 30 percent reduced risk of ischemic stroke and a 34 percent reduced risk of heart attack. ----------- Benefits outweighed ----------- The Brigham and Women's research is by no means the first to find aspirin on wobbly footing. This past July the American Heart Journal published a UK study in which nearly 280 subjects who had suffered a first heart attack were given 300 mg aspirin daily, warfarin (a blood thinner) or a placebo. After two years, researchers reported that neither the aspirin nor the warfarin therapies provided any greater protection against death, nonfatal stroke, or nonfatal heart attacks than the placebo. Subjects that received aspirin therapy, however, were nearly twice as likely to suffer a heart attack or stroke as were those who took warfarin or placebo. Gastrointestinal problems were also elevated in the aspirin group. In an interview with Reuters Health, the lead researcher of the study, Dr. John G.F. Cleland, stated that any theoretical benefit of using aspirin after a heart attack " is outweighed by real evidence of harm. " ----------- Cold turkey ----------- But the problems linked with aspirin don't stop there. In the e-Alert " Under the Gun " (11/10/03), I told you about a French study that showed how severe angina and fatal heart attacks might be prompted by the sudden halt of regular aspirin intake. In reviewing more than 1,200 cases of coronary episodes, researchers found 51 patients who suffered heart attacks or other severe coronary problems less than one week after they stopped using aspirin. Subjects with a history of heart disease were at particularly high risk. One of the troubling concerns of this outcome is the fact that patients preparing for surgery are regularly advised to discontinue aspirin therapy to avoid excess bleeding during their operations. The French team told Reuters news service that doctors should not advise their coronary patients to stop using aspirin, and even stated that aspirin therapy " cannot be safely stopped in any case. " Aspirin is generally regarded as so benign that most people would find it hard to imagine that you could actually experience withdrawal symptoms by quitting an aspirin regimen. ----------- Side note ----------- The lead author of the Brigham and Women's research, Paul M. Ridker, M.D., told Reuters Health that the study clearly illustrates, " the importance of studying women as well as men in major cardiovascular clinical trials. " I'm trying to suppress the urge to say something like, " Well DUH! " And I shouldn't take Dr. Ridker to task; after all, he's the one who headed up this revealing study. But it's been clear for many years now that cardiovascular fitness is not exclusively a male health issue. Studies that specifically examine cardiovascular issues among women are long overdue. **************************************************** ....and another thing If you're trying to lose weight, here's something you might add to your diet: 20 minutes of extra sleep each night. In a study reported in a recent issue of Archives of Internal Medicine, researchers compared body mass index (BMI) to sleep habits in about 1,000 subjects. After taking medical problems and sleep disorders into account, the researchers found that overweight and obese subjects slept less than those with a normal BMI. So what's going on in the body that might cause sleep time to affect weight? The most likely suspects are a couple of hormones called ghrelin and leptin. Rising leptin levels trigger a feeling of being " full. " Rising ghrelin levels trigger feelings of hunger. Previous research has shown that among people who average only five hours of sleep each night, ghrelin tends to go up while leptin goes down. The opposite is generally true for people who average eight hours per night. The good news is that it may not take several hours of additional sleep for overweight people to bring their ghrelin and leptin levels in line. In this most recent study, the results suggest that many overweight people may experience benefits by adding just an additional 20 minutes of sleep each night. These results confirm a study reported last year that demonstrated how obesity risk may increase by as much as 50 percent among subjects who average five hours of sleep each night. Among subjects who averaged only six hours per night, obesity risk was increased by about 25 percent. To Your Good Health, Jenny Thompson Health Sciences Institute **************************************************** Sources: " A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women " The New England Journal of Medicine, published online 3/7/05, content.nejm.org " Aspirin Therapy Affects Men, Women Differently " Gene Emery, Reuters Health, 3/7/05, reutershealth.com " The Warfarin/Aspirin Study in Heart Failure (WASH): a Randomized Trial Comparing Antithrombotic Strategies for Patients with Heart Failure " American Heart Journal, Vol. 148, No. 1, July 2004, ncbi.nlm.nih.gov " Aspirin Not Good for People with Heart Failure " Will Boggs, M.D., Reuters Health, 7/7/04, reutershealth.com " Halting Aspirin Suddenly can Cause Heart Attack " Reuters, 10/29/03, reuters.com " Overweight and Obese Patients in a Primary Care Population Report Less Sleep Than Patients With a Normal Body Mass Index " Archives of Internal Medicine, Vol. 165, No. 1, 1/10/05, archinte.ama-assn.org " Sleep Deprivation Becomes New Factor in Obesity Debate " NutraIngredients.com, 1/11/05, nutraingredients.com " Lack of Sleep Raises Obesity Risk " The Associated Press, 11/16/04, wjz.com ************* Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.