Biological Effects of Soy on Hormonal Status of Premenopausal Women: Its Prominent Role as Estrogen Antagonist

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Biological Effects of Soy

JoAnn Guest

Dec 04, 2004 16:16 PST

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Biological Effects of Soy on Hormonal Status of Premenopausal Women

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Medical Abstract Title:

 

Biological Effects of a Diet of Soy Protein

Rich in Isoflavones on the Menstrual Cycle

of " Premenopausal " Women

 

Author:

Cassidy A, Bingham S, Setchell KD

 

Source:

Am J Clin Nutr. 1994; 60:333-340.

 

Abstract:

 

The influence of a diet containing soy protein on the hormonal status

and regulation of the menstrual cycle was examined in six premenopausal

women with regular ovulatory cycles.

 

Soy protein (60 g containing 45 mg isoflavones) given daily for 1 mo

significantly (P < 0.01) increased follicular phase length and/or

delayed menstruation.

Midcycle surges of luteinizing hormone and follicle-stimulating hormone

were significantly suppressed during dietary intervention with soy

protein.

 

Plasma estradiol concentrations increased in the follicular phase and

cholesterol concentrations decreased 9.6%.

 

Similar responses occur with tamoxifen, an antiestrogen undergoing

clinical trial as a prophylactic agent in women at high risk for breast

cancer.

 

These effects are presumed to be due to nonsteroidal estrogens of the

isoflavone class, which behave as partial estrogen agonists/antagonists.

 

The responses to soy protein are potentially *beneficial *

 

with respect to

" risk factors " for breast cancer

 

and may in part explain the low incidence

of breast cancer and its correlation with a high soy intake in Japanese

and Chinese women.

www.enzy.com

 

______________

 

JoAnn Guest

mrsjo-

DietaryTi-

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AIM Barleygreen

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