Cancer Cachexia and Tumor Growth Reduction in Rats supplemented with N-3 (Fish o

[Guest guest]

Cancer Cachexia and Tumor Growth Reduction

in Rats supplemented with N-3 (Fish oil)

JoAnn Guest

Nov 12, 2004 16:31 PST

 

Cancer Cachexia and Tumor Growth Reduction

 

---

 

http://www.annieappleseedproject.org/cancactumgro.html

 

Cancer Cachexia and Tumor Growth Reduction

in Walker Tumor-Bearing Rats Supplemented

With N-3 (fish oil) Fatty Acids for One Generation

 

Valeria Togni ; Claudia C. C. Ota ; Alessandra Folador ; O.

Tchaikovski Junior ; Julia Aikawa ; Ricardo K. Yamazaki ; Fabio A. Freitas ;

Rita Longo ; Edgair F. Martins ; Philip C. Calder ; Rui Curi ; Luiz C.

Fernandes

 

Abstract: In this study we investigated the effect of lifelong

supplementation of the diet with coconut oil (CO, rich in saturated

fatty acids)

or fish oil (FO, rich in n-3

polyunsaturated fatty acids, PUFAs) on tumor growth,

animal survival, and metabolic indicators of cachexia in adult rats.

 

Female Wistar rats were supplemented with CO or FO prior to mating

and

then throughout pregnancy and gestation, and then the male offspring

were supplemented from weaning until 90 days of age.

 

Then they were inoculated subcutaneously with Walker 256 tumor

cells. Tumor weight at 14 days in control rats (those fed standard chow)

was approximately 20 g.

 

These animals displayed cancer " cachexia " , which was characterized by

loss of weight,

hypoglycemia, hyperlacticidemia,

hypertriacylglycerolemia, and depletion of glycogen stores.

 

Supplementation of the diet with CO did not change these parameters,

except that there was a smaller decrease in serum triacylglycerol

concentration.

 

Supplementation of the diet with FO significantly

decreased tumor growth (by approximately 60%), increased survival

(50% at 30 days postinoculation vs. 30% in the controls and 13.5% in the

CO group), and prevented the fall in body weight.

 

Furthermore, FO supplementation partly abolished the fall in serum

glucose, totally prevented the elevation in serum lactate

concentrations, partly prevented the hypertriacylgylcerolemia, and

preserved tissue glycogen stores.

 

Lifelong consumption of FO, rich in n-3 PUFAs, protects against tumor growth and

cancer cachexia and

improves survival.

 

Nutrition and Cancer Volume: 46 Number: 1 Page: 52 -- 58

_________________

 

JoAnn Guest

mrsjo-

DietaryTi-

www.geocities.com/mrsjoguest/Genes