OLIVE LEAF EXTRACT:Edited From The HIV ReSource Review

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Alternative Therapy Articles

Edited From The HIV ReSource Review

 

 

OLIVE LEAF EXTRACT

 

http://www.gate.net/~sameyer/Alternatives.htm

 

 

Financially stressed clients are often unable to buy food,

micronutrient supplements or enteral products.

Yet, many of these individuals are advocates and users of

alternative treatments. One alternative product

that is currently in use in Fort Lauderdale is olive leaf extract

(OLE). The extract was featured in a newsletter that many HIV-

challenged individuals read. (1)

 

This holistic treatment newsletter reports OLE is in use throughout

the United States. Considering the

author's report, people living with AIDS, across the US, are

satisfied users of OLE.

 

Users note an improvement in immune system parameters. People

supposedly experience a variety of other benefits

as well.

 

It's surprising that a comprehensive search of the world wide web

(WWW), MEDLINE and AIDSLINE reveal only two additional sources

concerning information on OLE.

 

One WWW article written by an anonymous author states the report is

similar to information

supplied by a major supplier of OLE capsules. (2) According to the

author, olive oil has been used for burns, inflammation of the

mucous membranes, malaria, the discomfort of teething, fevers,

venereal disease, ear aches, and heart disease.

 

Proponents insist OLE has powerful antiviral, antifungal,

antibacteria and antioxidant properties. The discovery of OLE was

said to begin with knowledge of a bitter compound from the olive

tree leaf called oleuropein. Another substance derived from

oleuropein (referred to as elenolic acid) supposedly also has

beneficial properties.

 

Sources report that protocols including OLE will benefit not only

persons with AIDS but those who are immune compromised and

chemically impaired, persons with systemic yeast infections and

cancer patients.

Unfortunately, as this OLE proponent notes some

end stage cases may not benefit because the information

may not be known in time!!

 

The minimum protocol includes the use of OLE, a prescription

medicine, and a lemon and olive oil drink. A number of other

supplements are also encouraged.

 

The olive leaf extracts in this product purportedly include a strong

complement of flavonoids.

Research suggests isoflavones and other phytochemicals reduce the

risk for heart disease, osteoporosis and certain cancers. (3)

Limonene, contained in the peel of citrus fruits, is one of the best

known phytochemicals. (4)

 

Users report that monotherapy with the OLE product is not as

effective as the combination protocol. It's notable that,

individual names, addresses and telephone numbers are given as

testimonials.

 

Besides these testimonials a physician is reported as

saying that if the product were effective he could not discuss it

because the FDA would classify the product as an unapproved new drug

and it would be removed from the market.

 

Based on the report of an interview with someone who is said to be

the first `test case' another compound is recommended as an addition

to the original protocol. (5, 6) Eden is sometimes taken with Cat's

Claw, vitamin C, 3TC, DDI, and protease inhibitors. Distributors

note OLE is not taken before bedtime because it may provide the user

with excess energy.

_________________

Anti-HIV activity of olive leaf extract (OLE) and modulation of host

cell gene expression by HIV-1 infection and OLE treatment.

 

Lee-Huang S, Zhang L, Huang PL, Chang YT, Huang PL.

 

Department of Biochemistry, New York University School of Medicine,

New York, NY 10016, USA. Sylvia.lee-huang

 

We investigated the antiviral activity of olive leaf extract (OLE)

preparations standardized by liquid chromatography-coupled mass

spectrometry (LC-MS) against HIV-1 infection and replication.

 

We find that OLE inhibits acute infection and cell-to-cell transmission

of HIV-1 as assayed by syncytia formation using uninfected MT2 cells

co-cultured with HIV-1-infected H9 T lymphocytes. OLE also inhibits

HIV-1 replication as assayed by p24 expression in infected H9 cells.

 

 

These anti-HIV effects of OLE are dose dependent, with EC(50)s of

around 0.2 microg/ml. In the effective dose range, no cytotoxicity

on uninfected target cells was detected. The therapeutic index of

OLE is above 5000.

 

To identify viral and host targets for OLE, we

characterized gene expression profiles associated with HIV-1

infection and OLE treatment using cDNA microarrays. HIV-1 infection

modulates the expression patterns of cellular genes involved in

apoptosis, stress, cytokine, protein kinase C, and hedgehog

signaling.

 

HIV-1 infection up-regulates the expression of the heat-

shock proteins hsp27 and hsp90, the DNA damage inducible transcript

1 gadd45, the p53-binding protein mdm2, and the hedgehog signal

protein patched 1, while it down-regulates the expression of the

anti-apoptotic BCL2-associated X protein Bax.

 

Treatment with OLE

reverses many of these HIV-1 infection-associated changes. Treatment

of HIV-1-infected cells with OLE also up-regulates the expression of

the apoptosis inhibitor proteins IAP1 and 2, as well as the calcium

and protein kinase C pathway signaling molecules IL-2, IL-2Ralpha,

and ornithine decarboxylase ODC1.

 

PMID: 12878215 [PubMed - indexed for MEDLINE]

 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=PubMed & list_uids=12878215 & dopt=Abstract

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