Guest guest Posted October 11, 2004 Report Share Posted October 11, 2004 Milk and the Cancer Connection JoAnn Guest Oct 10, 2004 17:48 PDT Milk and the Cancer Connection With complete references for researchers by Hans R. Larsen, MSc ChE On January 23, 1998 researchers at the Harvard Medical School released a major study providing conclusive evidence that IGF-1 is a potent risk factor for prostate cancer. Should you be concerned? Yes, you certainly should, particularly if you drink milk produced in the United States. IGF-1 or insulin-like growth factor 1 is an important hormone which is produced in the liver and body tissues. It is a polypeptide and consists of 70 amino acids linked together. All mammals produce IGF-1 molecules very similar in structure and human and bovine IGF-1 are completely identical. IGF-1 acquired its name because it has insulin-like activity in fat (adipose) tissue and has a structure which is very similar to that of proinsulin. The body's production of IGF-1 is regulated by the human growth hormone and peaks at puberty. IGF-1 production declines with age and is only about half the adult value at the age of 70 years. IGF-1 is a very powerful hormone which has profound effects even though its concentration in the blood serum is only about 200 ng/mL or 0.2 millionth of a gram per milliliter(1-4). IGF-1 and cancer IGF-1 is known to stimulate the growth of both normal and cancerous cells(2,5). In 1990 researchers at Stanford University reported that IGF-1 promotes the growth of prostate cells(2). This was followed by the discovery that IGF-1 accelerates the growth of breast cancer cells(6-. In 1995 researchers at the National Institutes of Health reported that IGF-1 plays a central role in the progression of many childhood cancers and in the growth of tumours in breast cancer, small cell lung cancer, melanoma, and cancers of the pancreas and prostate(9). In September 1997 an international team of researchers reported the first epidemiological evidence that high IGF-1 concentrations are closely linked to an increased risk of prostate cancer(10). Other researchers provided evidence of IGF-1's link to breast and colon cancers(10,11). The January 1998 report by the Harvard researchers confirmed the link between IGF-1 levels in the blood and the risk of prostate cancer. The effects of IGF-1 concentrations on prostate cancer risk were found to be astoundingly large - much higher than for any other known risk factor. Men having an IGF-1 level between approximately 300 and 500 ng/mL were found to have more than four times the risk of developing prostate cancer than did men with a level between 100 and 185 ng/mL. The detrimental effect of high IGF-1 levels was particularly pronounced in men over 60 years of age. In this age group men with the highest levels of IGF-1 were eight times more likely to develop prostate cancer than men with low levels. The elevated IGF-1 levels were found to be present several years before an actual diagnosis of prostate cancer was made(12). The evidence of a strong link between cancer risk and a high level of IGF-1 is now indisputable. The question is why do some people have high levels while others do not? Is it all genetically ordained or could it be that diet or some other outside factor influences IGF-1 levels? Dr. Samuel Epstein of the University of Illinois is one scientist who strongly believes so. His 1996 article in the International Journal of Health Sciences clearly warned of the danger of high levels of IGF-1 contained in milk from cows injected with synthetic bovine growth hormone (rBGH). He postulated that IGF-1 in rBGH-milk could be a potential risk factor for breast and gastrointestinal cancers(13). The milk connection Bovine growth hormone was first synthesized in the early 1980s using genetic engineering techniques (recombinant DNA biotechnology). Small scale industry-sponsored trials showed that it was effective in increasing milk yields by an average of 14 per cent if injected into cows every two weeks. In 1985 the Food and Drug Administration (FDA) in the United States approved the sale of milk from cows treated with rBGH (also known as BST) in large scale veterinary trials and in 1993 approved commercial sale of milk from rBGH-injected cows(13-16). At the same time the FDA prohibited the special labelling of the milk so as to make it impossible for the consumer to decide whether or not to purchase it(13). Concerns about the safety of milk from BST-treated cows were raised as early as 1988 by scientists in both England and the United States(14,15,17-22). One of the main concerns is the high levels of IGF-1 found in milk from treated cows; estimates vary from twice as high to 10 times higher than in normal cow's milk(13,14,23). There is also concern that the IGF-1 found in treated milk is much more potent than that found in regular milk because it seems to be bound less firmly to its accompanying proteins(13). The concerns were vigorously attacked by consultants paid by Monsanto, the major manufacturer of rBGH. In an article published in the Journal of the American Medical Association in August 1990 the consultants claimed that BST-milk was entirely safe for human consumption(16,24).They pointed out that BST-milk contains no more IGF-1 than does human breast milk - a somewhat curious argument as very few grown-ups continue to drink mother's milk throughout their adult life. They also claimed that IGF-1 would be completely broken down by digestive enzymes and therefore would have no biological activity in humans(16). Other researchers disagree with this claim and have warned that IGF- 1 may not be totally digested and that some of it could indeed make its way into the colon and cross the intestinal wall into the bloodstream. This is of special concern in the case of very young infants and people who lack digestive enzymes or suffer from protein-related allergies(13,14,20,22,25). Researchers at the FDA reported in 1990 that IGF-1 is not destroyed by pasteurization and that pasteurization actually increases its concentration in BST-milk. They also confirmed that undigested protein could indeed cross the intestinal wall in humans and cited tests which showed that oral ingestion of IGF-1 produced a significant increase in the growth of a group of male rats -a finding dismissed earlier by the Monsanto scientists(25). The most important aspect of these experiments is that they show that IGF-1 can indeed enter the blood stream from the intestines - at least in rats. Unfortunately, essentially all the scientific data used by the FDA in the approval process was provided by the manufacturers of rBGH and much of it has since been questioned by independent scientists. The effect of IGF-1 in rBGH-milk on human health has never actually been tested and in March 1991 researchers at the National Institutes of Health admitted that it was not known whether IGF-1 in milk from treated cows could have a local effect on the esophagus, stomach or intestines(26,27). Whether IGF-1 in milk is digested and broken down into its constituent amino acids or whether it enters the intestine intact is a crucial factor. No human studies have been done on this, but recent research has shown that a very similar hormone, Epidermal Growth Factor, is protected against digestion when ingested in the presence of casein, a main component of milk(13,23,2. Thus there is a distinct possibility that IGF-1 in milk could also avoid digestion and make its way into the intestine where it could promote colon cancer(13,22). It is also conceivable that it could cross the intestinal wall in sufficient amounts to increase the blood level of IGF-1 significantly and thereby increase the risk of breast and prostate cancers(13,14). The bottom line Despite assurances from the FDA and industry-paid consultants there are now just too many serious questions surrounding the use of milk from cows treated with synthetic growth hormone to allow its continued sale. Bovine growth hormone is banned in Australia, New Zealand and Japan. The European Union has maintained its moratorium on the use of rBGH and milk products from BST-treated cows are not sold in countries within the Union. Canada has also so far resisted pressure from the United States and the biotechnology lobby to approve the use of rBGH commercially. In light of the serious concerns about the safety of human consumption of milk from BST-treated cows consumers must maintain their vigilance to ensure that European and Canadian governments continue to resist the pressure to approve rBGH and that the FDA in the United States moves immediately to ban rBGH-milk or at least allow its labelling so that consumers can protect themselves against the very real cancer risks posed by IGF-1. References Wilson, Jean D. and Foster, Daniel W., eds. Williams Textbook of Endocrinology, 8th edition, London, W.B. Saunders Company, 1992, pp. 1096-1106 Cohen, Pinchas, et al. Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells. Journal of Clinical Endocrinology and Metabolism, Vol. 73, No. 2, 1991, pp. 401-07 Rudman, Daniel, et al. Effects of human growth hormone in men over 60 years old. New England Journal of Medicine, Vol. 323, July 5, 1990, pp. 1-6 LeRoith, Derek, moderator. Insulin-like growth factors in health and disease. Annals of Internal Medicine, Vol. 116, May 15, 1992, pp. 854-62 Rosenfeld, R.G., et al. Insulin-like growth factor binding proteins in neoplasia (meeting abstract). Hormones and Growth Factors in Development and Neoplasia, Fogarty International Conference, June 26-28, 1995, Bethesda, MD, 1995, p. 24 Lippman, Marc E. The development of biological therapies for breast cancer. Science, Vol. 259, January 29, 1993, pp. 631-32 Papa, Vincenzo, et al. Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer. Cancer Research, Vol. 53, 1993, pp. 3736-40 Stoll, B.A. Breast cancer: further metabolic-endocrine risk markers? British Journal of Cancer, Vol. 76, No. 12, 1997, pp. 1652-54 LeRoith, Derek, et al. The role of the insulin-like growth factor-I receptor in cancer. Annals New York Academy of Sciences, Vol. 766, September 7, 1995, pp. 402-08 Mantzoros, C.S., et al. Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. British Journal of Cancer, Vol. 76, No. 9, 1997, pp. 1115-18 Cascinu, S., et al. Inhibition of tumor cell kinetics and serum insulin growth factor I levels by octreotide in colorectal cancer patients. Gastroenterology, Vol. 113, September 1997, pp. 767-72 Chan, June M., et al. Plasma insulin-like growth factor I and prostate cancer risk: a prospective study. Science, Vol. 279, January 23, 1998, pp. 563-66 Epstein, Samuel S. Unlabeled milk from cows treated with biosynthetic growth hormones: a case of regulatory abdication. International Journal of Health Services, Vol. 26, No. 1, 1996, pp. 173-85 Epstein, Samuel S. Potential public health hazards of biosynthetic milk hormones. International Journal of Health Services, Vol. 20, No. 1, 1990, pp. 73-84 Epstein, Samuel S. Questions and answers on synthetic bovine growth hormones. International Journal of Health Services, Vol. 20, No. 4, 1990, pp. 573-82 Daughaday, William H. and Barbano, David M. Bovine somatotropin supplementation of dairy cows - Is the milk safe? Journal of the American Medical Association, Vol. 264, August 22/29, 1990, pp. 1003- 05 Brunner, Eric. Safety of bovine somatotropin. The Lancet, September 10, 1988, p. 629 (letter to the editor) Kronfeld, D.S., et al. Bovine somatotropin. Journal of the American Medical Association, Vol. 265, March 20, 1991, pp. 1389-91 (letters to the editor) Rubin, Andrew L. and Goodman, Mark. Milk safety. Science, Vol. 264, May 13, 1993, pp. 889-90 (letters to the editor) Challacombe, D.N., et al. Safety of milk from cows treated with bovine somatotrophin. The Lancet, Vol. 344, September 17, 1994, pp. 815-17 (letters to the editor) Coghlan, Andy. Milk hormone data bottled up for years. New Scientist, October 22, 1994, p. 4 Coghlan, Andy. Arguing till the cows come home. New Scientist, October 29, 1994, pp. 14-15 Mepham, T.B., et al. Safety of milk from cows treated with bovine somatotrophin. The Lancet, Vol. 344, July 16, 1994, pp. 197-98 (letter to the editor) Grossman, Charles J. Genetic engineering and the use of bovine somatotropin. Journal of the American Medical Association, Vol. 264, August 22/29, 1990, p. 1028 (editorial) Juskevich, Judith C. and Guyer, C. Greg. Bovine growth hormone: human food safety evaluation. Science, Vol. 249, August 24, 1990, pp. 875- 84 Mepham, T.B. Bovine somatotrophin and public health. British Medical Journal, Vol. 302, March 2, 1991, pp. 483-84 NIH technology assessment conference statement on bovine somatotropin. Journal of the American Medical Association, Vol. 265, March 20, 1991, pp. 1423-25 Playford, R.J., et al. Effect of luminal growth factor preservation on intestinal growth. The Lancet, Vol. 341, April 3, 1993, pp. 843-48 ------End of References------ --- Her last meal: PIZZA --- DAIRY EDUCATION BOARD NEWSLETTER Adding Insult to personal loss! THE FUGITIVE, THE " CRIME " AND THE ONE ARMED MAN... As a grand jury convenes in Orange County, California, balancing the scales of justice and wisdom to decide whether to charge Al Joyner with the death of his wife, Flo Jo, the true CEREAL killer stalks other victims having committed and gotten away with similar crimes against humanity. Harrison Ford wore a bloodstained shirt and was unfairly accused of murdering his wife in the blockbuster 1997 move, THE FUGITIVE, after a series of events incorrectly pointed the finger at Dr. Richard Kimball. Florence Joyner's husband might soon be the victim of a similar miscarriage of justice. Flo Jo's body revealed petechial marks, often a sign of a violent struggle or beating. These blacks and blues were on her chest and neck and eyelids. Who would even imagine that they might have been self-induced? Certainly not the medical examiner, nor the Sheriff's Department who oversaw the official coroner's inquiry. The identity of Flo Jo's killer is contained in the actual autopsy but the coroner had not the vision to identify the evildoer. Rumors had the autopsy team first investigate the possible use of hormones. When no steroids were found the conclusion was made that her death was due to heart disease. Eleven days after the initial autopsy was completed, histological examination of brain tissues resulted in the final explanation: " POSITIONAL ASPHYXIA due to EPILEPTIFORM SEIZURE. " In plain English, the coroner believes that Flo Jo had an epileptic seizure and smothered in her pillow. The FUGITIVE'S movie wife called his name over the telephone, to be recorded by the 911 operator. In the movie, the prosecutor and jury assumed that she was naming her killer. Flo Jo named her killer but the medical examiner did not examine his medical records closely enough. Through Flo Jo's death a lesson should have been learned so that future lives be saved. Flo Jo knew that her body was filled with mucus. She was producing histamines, the body's natural anti-body defense to an invading antigen. Her solution was to take an anti-histamine, BENADRYL. Flo Jo's lungs were filled with frothy fluid. Her tracheobronchial tree contained mucus and frothy fluid. mucus and congestion filled her adrenals and spleen, pancreas and kidneys. The coroner, aware that her last meal was PIZZA, eaten 15 hours earlier, called the brick-sized lump of undigested food with flecks appearing to be cheese in her stomach: " digested food. " One wonders whether the gooddoctor ever took a class in nutrition. After 15 hours, food still in the stomach creates duress and can no way be called digested. Flo Jo's body pumped enormous amounts of histamines which in turn created enormous amounts of mucus, filling her lungs, body organs and cavities with a tenacious glue. Flo Jo's autopsy is consistent with that of slow heart response type changes, usually noted with respiratory failure or obstruction. She slowly suffocated, gasping for breath while the bronchioles of her lungs filled with mucus, and not the life sustaining oxygen required by every cell in her body. This is the time for an INQUEST. This is the time for OUTRAGE. This is the time for JUSTICE. The autopsy reveals TRUTH. Epileptic seizures often result in damage to the lips or tongue or cheeks. Flo Jo had no such damage. Strangulation usually breaks the tiny hyoid bone in the neck. Flo Jo's bone was intact. The black and blues, petechial marks were not delivered by Al Joyner, Flo Jo's grieving husband. These marks could very well have been caused by Flo Jo herself, struggling violently to breathe, gasping for breath which was impossible to take in. As her body died, asphyxiating, the brain triggered an emergency wake-up call, an electrical and biochemical jolt and seizure that could not clear Flo Jo's lungs. This failed jump- start later appeared as an epileptiform seizure on the coroner's report. One-half million children in New York, thousands of Native-American children on reservations, millions of children across America live below the poverty level and have asthma. These kids are the beneficiaries of free breakfast, lunch and snack, all dairy-based. Eighty percent of milk and cheese protein is CASEIN, a tenacious glue and allergenic substance causing histamines which result in mucus. The one-armed killer has killed before. This demon is a CEREAL killer and remains free to kill over and over again. His name is the DAIRY INDUSTRY and his murder weapon is the MILK MUSTACHE AD. He has gotten away with his crimes and must not be permitted to kill again. In posing for her ad, FLO JO was BETRAYED by her killer. Her ad might have betrayed others for whom she was a role model. For the sake of the TWENTY CHILDREN who will die today and tomorrow, and every day until he is identified, for the sake of this innocent man, Al, father of Mo Jo, husband to Flo Jo, we MUST examine the evidence and LET FLO JO'S DEATH BECOME HER HEALING LEGACY. Should you desire additional information or a means of expressing your opinion... please contact: Robert Cohen Executive Director Dairy Education Board 201-967-7001 http://www.notmilk.com -- COLOSSAL COLOSTRUM FRAUD -- WHAT IS COLOSTRUM? When a mother gives birth to her infant, her mammary glands produce a pre-milk formula called colostrum. Cows, dogs, sheep, humans... all mammals produce their own " perfect formula " which provides disease- preventing immunological factors and hormones which promote growth. Colostrum is super-saturated with hormones. WHAT SHOULD NURSING MAMMALS CONSUME? Puppies should not drink human breast milk and calves should not drink pig's milk. Neither should dolphins drink cat's milk, nor squirrels drink camel milk. That is not nature's plan. Instinctively, we know that dog's milk and pig's milk contain substances best suited for those specific species. Most human adults would be disgusted at the thought of consuming canine or porcine hormones, lactoferrins or immunoglobulins. WHAT DO HORMONES DO? All hormones regulate one or more of the thousands of metabolic processes occurring every second inside of the human body. Some hormones regulate cellular metabolism. Vitamin D, the sunshine vitamin, is actually a steroid hormone. In the 1850's, scientists first recognized that the thyroid gland produced a substance which regulated metabolism. A decade later, it was noted that the pancreas acted as a gland, secreting a substance that would later be identified as insulin. Hormones are chemical messengers. Adrenalin is a hormone. When danger occurs (the fight or flight response) the adrenal glands (located atop the kidneys) secrete small amounts of epinephrine/adrenalin into the bloodstream. We have all experienced the " adrenalin surge " in which the heartbeat increases. Superhuman feats often occur while under the influence of such hormonal action (lifting a car off of an accident victim or fighting off a gang of attackers). Estrogen and progesterone are hormones; the magic of female behavior is influenced by internal secretions of these steroids. The male equivalent is testosterone. Various hormones have various roles. Prolactin is responsible for regulating milk production while insulin regulates blood sugar levels. GROWTH HORMONES There exists a separate group of hormones that regulate growth. These protein hormones (made up of amino acids) instruct cells to grow. The first one of these to be discovered was appropriately named 'Human Growth Hormone' (hGH) or human somatotropin (hST). Dogs have canine somatotropin CST/CGH, pigs have porcine somatotropin (pST/pGH) and cows have bovine somatotropin (bST/bGH). Human Growth hormone was discovered just before World War II. It was so named because of what it did: promoted cellular proliferation and growth. Two decades after GH was discovered, an even more powerful growth factor was found. IGF-I Insulin-like growth factor (IGF-I) received its name because its structure resembled insulin. However, its function is nothing like insulin. Had IGF-I been discovered before GH, it would have received that name. IGF-I is much more powerful than GH. IGF-I is the most powerful growth hormone known to science. Protein hormones are made up of amino acids. GH has 191 different amino acids IGF-I has 70 amino acids. Maps of these hormones can be made so that each amino acid is identified as a specific position on the chain. For example, amino acid #10 in BST is leucine and amino acid #12 is alanine. In IGF-I, amino acid #10 is cysteine while #12 is methionine. Every amino acid structure of every hormone is now known to science. HORMONAL DIFFERENCES BETWEEN SPECIES Human growth hormone differs from chimpanzee growth hormone, dog growth hormone, pig growth hormone and cow growth hormone. VARIATION Human and cow growth hormones both have 191 amino acids, but the sequence of amino acids on that chain differs by about 35%. A MIRACLE OF SCIENCE IGF-I in humans and cows has no differences. IGF-I, the most POWERFUL growth hormone in the human body, is identical between humans and cows. DOES COLOSTRUM WORK? Manufacturers and multi-level marketing sales persons call colostrum the ultimate anti-aging formula. They claim that their formula removes wrinkles and promotes athletic endurance. It repairs muscle tears and promotes nerve growth. ARE THE CLAIMS ACCURATE? YES! Colostrum works. IGF-I works! Hormones work. WHAT ELSE CAN COLOSTRUM DO FOR YOU? Colostrum does not discriminate. Its major component is IGF-I, the most powerful growth hormone and cellular proliferator. When IGF-I is produced naturally, it loses its potency (by attaching to receptor proteins or by being broken down into its basic components) in less than 30 seconds. In colostrum, IGF-I can " survive " for 30 minutes. WHAT HAPPENS WHEN IGF-I IN COLOSTRUM FINDS AN EXISTING CANCER? Infants are not usually born with cancers. Cancers are quite common in adults, but normally controlled by our immune systems. THE MISSING LINK - CANCER IS COMMON, WAITING TO GROW On November 8, 1994 the New York Times reported the results of an autopsy study on pre-mature deaths (page C-1, Gina Kolata). The study revealed that nearly 40% of women between the ages of 40 and 50 have breast cancer and virtually all adults over the age of 50 have some form of cancer. HOW LONG DOES IT TAKE FOR A CANCER TO GROW? Every cancer begins with one cell. That cell doubles, on average, every ninety days. After three months, it is two cells. After six months, four. After one year, the cancer is 16 cells in size. After twenty cycles, or doublings, that cancer will grow to one million cells, which is the tiniest lump a woman can feel in her breast. It can take five years for a cancer to be clinically diagnosed. Somewhere along that timeline, the cancer stops growing, usually suppressed by the immune system's tight genetic control. SOMETHING MAKES CANCER GROW IGF-I has been called the key factor in the growth and proliferation of breast and prostate cancers. WOULD YOU TAKE A SUBSTANCE CONTAINING THE KEY FACTOR TO CANCER'S GROWTH? Remove wrinkles from your face or get an extra burst of energy and you might very well be lighting the fuse for your future cancer diagnosis. Colostrum works. There is no debate. It might very well work too well. Take colostrum today and in five years you might not make the connection between today's phenomenal growth product and tomorrow's not- so phenomenal cancer. Robert Cohen Executive Director Dairy Education Board 201-967-7001 http://www.notmilk.com _________________ JoAnn Guest mrsjo- DietaryTi- www.geocities.com/mrsjoguest/Genes Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.