Xanthine Oxidase and Its Role in Heart Disease

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This is a 1983 Pub Med abstract

 

Homogenized bovine milk xanthine oxidase: a critique of the hypothesis

relating to plasmalogen depletion and cardiovascular disease.

 

Clifford AJ, Ho CY, Swenerton H.

 

A hypothesis has repeatedly been promoted that xanthine oxidase from

homogenized bovine milk is absorbed intact, damaging cardiovascular tissue

by depleting plasmalogens and initiating atherosclerotic changes that

culminate in heart disease. In the light of recent experimental evidence,

the present paper examines the validity of this hypothesis and associated

claims. The evidence leads to the conclusion that 1) absorption of dietary

xanthine oxidase has not been demonstrated; 2) a relationship between

intakes of homogenized milk and levels of serum xanthine oxidase activity

have not been established; 3) a direct role for xanthine oxidase in

plasmalogen depletion has not been established; 4) neither liposome

formation during homogenization of milk nor absorption of intact liposomes

from the gastrointestinal tract has been demonstrated; and 5) data are

lacking to support the claim that large doses of folic acid inhibit

xanthine oxidase in vivo and/or are therapeutic in heart disease.

Experimental evidence has failed to substantiate, and in many cases has

refuted, the xanthine oxidase/plasmalogen depletion hypothesis.

 

PMID: 6349321 [PubMed - indexed for MEDLINE]

 

Best wishes from Robin

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Best wishes,

Robin