Guest guest Posted September 28, 2004 Report Share Posted September 28, 2004 " HSI - Jenny Thompson " <HSIResearch Sugar Shock Tue, 28 Sep 2004 08:56:21 -0400 Sugar Shock Health Sciences Institute e-Alert September 28, 2004 ************************************************************** Dear Reader, Chicken or egg – which came first? Even though it's an intriguing question, whatever the answer may be, it doesn't really matter. I don't expect that even chickens spend much time mulling it over. But a similar sort of question – one that matters considerably – is posed by type 2 diabetes: Is heart health compromised by the high blood sugar levels of diabetes, or by other conditions such as hypertension that can be triggered by diabetes? In short: Which comes first and which matters most? Two studies published this month in the Annals of Internal Medicine indicate that hyperglycemia (high blood sugar) may be more of a culprit in the development of heart disease than previously expected. And more importantly, the findings send a strong warning to those who are not considered diabetic. --------------------------- Getting a little hyper --------------------------- In the e-Alert " Waking Up is Hard to Do " (9/20/04), I told you about the groundbreaking INTERHEART study that revealed a list of health factors that put the heart at greatest risk. I'm sure that most HSI members were not surprised to see diabetes high on that list. For many years now, researchers have been examining the ways diabetes is associated with heart disease. One of the most recent of those studies comes from Johns Hopkins University here in Baltimore. The Hopkins researchers reviewed the results of 13 studies to analyze the association between heart disease in diabetic subjects and the severity of hyperglycemia (which is measured by the percentage of glycosylated hemoglobin (HbA1c) in blood). Daily fluctuations of blood glucose do not affect HbA1c, so this marker provides a more accurate overall indicator of hyperglycemia. In a nutshell: An HbA1c level of five percent is considered quite safe, and seven percent or less is considered normal. A level higher than seven is a red flag, signaling the possibility of type 2 diabetes. After reviewing the 13 studies, the Hopkins team concluded that hyperglycemia may be directly associated with an increased risk of heart disease in people with diabetes. And more specifically, every time HbA1c increases by one percentage point, the risk of heart disease or stroke raises by nearly 20 percent. Likewise, when HbA1c percentage drops, heart disease risk drops as well. --------------------------- The danger zone --------------------------- In the e-Alert " Sugar in the Morning, Sugar in the Evening... " (9/4/02), I told you about the A1c test, which gives an average measurement of HbA1c percentage in the blood over the 60 to 90 days prior to the test date. And it was this test that was used by a UK research team to monitor hyperglycemia in more than 10,200 subjects (both diabetic and non-diabetic) over a three-year period, with an additional three-year follow-up period. The UK researchers found that for every HbA1c percentage point that rose above five percent, risk of problems associated with heart disease rose more than 20 percent. And this elevated risk remained consistent, even when other factors such as smoking, high blood pressure and a previous history of heart problems were taken into account. This study produced two striking results: 1) Moderate-to-high blood sugar levels were apparently directly responsible for heart disease risk, and 2) Subjects whose HbA1c percentages were well below the conventional danger level were still at risk. One of the authors of the study told the New York Times that the commonly accepted " average " blood sugar readings may need to be reassessed. --------------------------- Way to go --------------------------- The next time you have a blood test, talk to your doctor about these two studies and ask him to make a point of including an A1c test to determine your HbA1c level. If your HbA1c reading is in the pre-diabetic or diabetic range, your doctor may suggest taking a drug to manage blood sugar levels. The most common drug for type 2 diabetes is Glucophage, the brand name for metformin. But most people will probably find the tried and true method of diet modification and daily exercise to be more effective. In the e-Alert " Common Sense Approach To Treating Type II Diabetes " (2/13/02), I told you about a New England Journal of Medicine study that enlisted more than 3,200 adults (the average age was 51) who were diagnosed with pre-diabetic elevated glucose levels. Subjects were divided into three groups: one group received a daily dose of Glucophage; one group received a daily placebo; and one group participated in an intensive program with a goal of at least 7 percent weight loss through diet adjustment, two and a half hours of moderate exercise each week, and educational sessions to reinforce behavior modification. After following these subjects for an average of almost 3 years, the researchers found that Glucophage reduced the incidence of diabetes by about 30 percent versus placebo, but lifestyle changes slashed the incidence rate by more than HALF - a full 58 percent. Plus, patients in the Glucophage group had six times more gastrointestinal side effects than those in the exercise and diet group. Changing key lifestyle factors such as diet and physical activity is easier said than done. But in the case of controlling blood sugar, a little effort goes a long way. ************************************************************** ....and another thing Sometimes I wonder how experts in any given field attain that exalted level of " Expert " . I've come to believe that the number one requirement is to simply sound like an expert. Never mind the actual content of what's being said, as long as you give it the ring of expertise. Here's a good example... A couple of weeks ago, members of the Royal College of General Practitioners gathered for a conference in London. One of the items on their agenda: How to address the growing obesity epidemic. The solution: Make exercise more accessible and affordable. Of course, this bright idea overlooks the glaringly obvious fact that exercise is already free and accessible to all. It's called Get Off Your Duff And Walk, Jog, Do Pushups, Situps, Whatever, Just Get Moving! But the Royal College's idea is to make workout and sports equipment more accessible. And how do you do that? According to an Associated Press report, one of the College's experts has the answer: Tax breaks for exercisers! Under this plan, if you purchase sports or exercise equipment, you'll be allowed a deduction at tax time. Okay... is this REALLY the motivation that obese people have been waiting for? Imagine someone who's overweight, sitting down to watch a couple hours of television after finishing off a large meal. I'm pretty sure they're NOT thinking, " I'd be exercising right now if I could just get a tax break. " It's logic only a bureaucrat could love: Motivate good health with tax breaks. The best part is a quote from one of the College's experts. (I won't mention his name. No reason to rub it in.) This expert – a doctor – told the AP, " After all, obese people are likely to use more National Health Service resources than fit and healthy people. " Uh... how's that again? I wonder if this expert ever saw the inside of a health club? Because if he had, he would have seen lots of fit and healthy people working out. That's how they GET fit and healthy: They use the resources. If obese people were in the least bit inclined to do any type of exercise (which doesn't really require any NHS resources), then they would be fit and healthy instead of obese. Maybe it's time to give experts a tax break every time they keep a crackpot idea where it belongs: back on the drawing board. To Your Good Health, Jenny Thompson Health Sciences Institute ************************************************************** Sources: " Meta-Analysis: Glycosylated Hemoglobin and Cardiovascular Disease in Diabetes Mellitus " Annals of Internal Medicine, Vol. 141, No. 6, 9/21/04, annals.org " Association of Hemoglobin A1c with Cardiovascular Disease and Mortality in Adults: The European Prospective Investigation into Cancer in Norfolk " Annals of Internal Medicine, Vol. 141, No. 6, 9/21/04, annals.org " High Blood Sugar Also Poses Risk to Heart " Denise Grady, The New York Times, 9/21/04, nytimes.com " Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin " The New England Journal of Medicine, Vol. 346, No. 6, 2/7/02, content.nejm.org " U.K. Docs Suggest Tax Breaks for Exercise " The Associated Press, 9/16/04, usatoday.com Copyright ©1997-2004 by www.hsibaltimore.com, L.L.C. The e-Alert may not be posted on commercial sites without written permission. 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