#1 Biochemical disorders

[Guest guest]

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www.digitalnaturopath.com/cond/C371961.html

 

This is an EXCELLENT web link, in that it not only describes pyroluria

and how Omega-3's can be harmful supplements for pyroluria (but not

others) ..... but also refers to other biochemical disorders and

appropriate treatments for:

- schizophrenia,

- bipolar depression,

- manic depressives,

- alcoholics,

- anxiety,

- paranoia/paranoid personality disorder,

- panic attacks,

- depressions, etc.

 

It also offers symptoms and MINERAL-VITAMIN REQUIREMENTS.

 

For me, it is obvious why powerful " mind-altering " " legal drugs " such as

SSRI anti-depressants, SNRI's, atypical depressants and any other

psychotropic " legal drugs " do NOT CURE what we are told are " mental

illnesses/diseases/disorders/impairments " .... when in fact it appears

they are biochemical deficiencies!!!!

 

Under the heading: " Pyroluria suggest the following may be present " , the

1st explanation is " counter-indicators: EFA Type 3 Requirement " . This

states how Omega 3 fatty acids are potentially harmful supplements in

someone with " pyroluria " . It also explains WHY.

 

Pfeiffer Institute is referenced in the beginning definition and

treatment.

 

Yes it is difficult to realize we have been " duped " by a system we were

taught to trust in ... the triangulation of the " Pharma co's - FDA -

medical community " . The outcome of the 2nd round of FDA investigations

on Sept. 12 and 13th just proved this " financially-bottom line oriented "

triangulation.

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En-JOY.....

Encourage One Another

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PyroluriaLast updated: Sep 02, 2004

 

THE ANALYSTTM

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Pyroluria

 

 

 

Signs, symptoms and indicators | Conditions that suggest it |

Contributing risk factors | Other conditions that may be present | It can

lead to... | Recommendations

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Pyroluria is a familial disorder which occurs with stress, where an

above-average amount of a substance consisting of " kryptopyrroles "

circulate in the body. The substance is harmless in itself, but high

levels of these pyrrolles systemically bind with B6 and zinc, preventing

the use of these essential nutrients in the brain and body. The result is

a myriad of symptoms, including severe inner tension, ongoing anxiety,

poor stress control, fearfulness, and sometimes episodic anger.

 

Often such people have pale skin that easily burns, eyes that are

sensitive to light, white flecks/marks on their nails, and stretch marks

on their skin. They tire easily, are anemic, have poor dream recall,

prefer not to eat breakfast, notice upper abdominal pain when stressed,

and experience a " stitch " in their side if they run. They have a tendency

to become loners as they age. Mental symptoms are aggravated when

undergoing stress. In fact, pyroluria flares up when the individual is

undergoing prolonged stress, such as during a chronic and debilitating

illness.

 

Pyroluria may occur along with other imbalances as seen in some subtypes

of schizophrenia such as histapenia (low histamine), histadelia (high

histamine), high copper levels or cerebral allergies. It is the primary

imbalance for 20% of schizophrenics.

 

Alcohol use is one way for pyrolurics to shut off their anxiety, feel

more sociable, de-stress, and experience a short time when they feel more

normal. Without a knowledge of this chemical imbalance, those who try to

quit alcohol use must face coexisting with their symptoms. If additional

antianxiety support is needed, GABA, tryptophan, chromium and inositol

should be considered.

 

There is a urine lab test available which measures levels of

kryptopyrroles. Any alcoholic, or anyone with symptoms indicating the

possibility of this condition should have the lab test done.

 

Pyroluria is treated by restoring levels of vitamin B6 and zinc so that

this double deficiency is corrected. Supplementation with vitamin B6

until daily dream recall returns (a normal phenomenon) as well as with

zinc and manganese needs to be continued daily. With zinc, manganese and

vitamin B6 therapy the pyroluric patient may start to respond in 24 hours

and certainly some progress is noted within one week. However, total

recovery may take three to four months. The biochemical imbalance and

symptoms will usually recur within one to two weeks if the nutritional

program is stopped. [Pfeiffer, 1974]

 

 

Signs, symptoms & indicators of Pyroluria:

Lifestyle Being prone to 'stitches'

 

Symptoms - Environment

Rapid sunburning tendency

 

Symptoms - Food - General

Weak appetite

 

Symptoms - Food - Preferences

Rarely/never eating breakfast or regular avoidance of breakfast

 

Symptoms - Gas-Int - General

Unexplained nausea

 

Symptoms - General

Fatigue on light exertion

 

Symptoms - Head - Eyes/Ocular

(High) sensitivity to bright light

 

Symptoms - Mind - Emotional

Adverse reaction to stress Pyrolurics are devastated by stresses

including physical injury, emotional trauma, illness, sleep deprivation,

etc.

 

Emotional instability

 

Symptoms - Mind - General

Being an antisocial person

 

Symptoms - Nails

White spots on fingernails Leukonychia punctata (white spots) are a

sign of pyroluria.

 

 

Symptoms - Skeletal

Joint pain/swelling/stiffness

 

Symptoms - Skin - General

Lighter/paler skin color

 

Symptoms - Sleep

Forgetting dreams

 

 

 

Conditions that suggest Pyroluria:

Addictions Alcohol-related Problems As many as one-third to one-half

of alcoholics have the genetic, chemical imbalance called pyroluria.

 

 

Allergy

Allergies Indoor

Allergic Rhinitis / Hay Fever

 

Circulation

Anemia (Uncommon Nutritional) Pyrolurics are generally anemic.

 

 

Mental

Schizophrenia Approximately 20% of all schizophrenics have pyroluria

as their primary imbalance. Symptoms are many including a sweet, fruity

breath and body odor. The affected person has a tendency to have insight

(understand they have mental problems).

 

Bipolar Disorder, Manic-Depressive About 18% of those with bipolar

disorder are also pyroluric.

 

Anxiety Pyroluria is a known biochemical marker for life long anxiety

symptoms. According to one alcoholism treatment center, one-third to

one-half of alcoholics treated have this marker. High levels of pyrrolles

systematically bind to B6 and zinc, preventing the use of these nutrients

in the body and brain. The result is a myriad of symptoms, including

severe inner tension, ongoing anxiety, poor stress control, fearfulness,

and sometimes episodic anger.

 

Paranoia/Paranoid Personality Disorder Pyroluria can cause

hallucinations, delusions and paranoia.

 

Panic Attacks

Depression

 

Metabolic

Hypoglycemia

 

Nervous System

Motion Sickness

 

Nutrients

Zinc Requirement Pyroluria is caused by an overproduction of

kryptopyrrole during hemoglobin synthesis, which chemically combines with

vitamin B6 and zinc, resulting in their excretion and a deficiency of

both of these essential nutrients.

 

Vitamin B6 Requirement A functional pyridoxine deficiency is common in

pyroluria (often seen in alcoholics), due not so much to inadequate

intake as impaired conversion to its active form, pyridoxal-5-phosphate,

and enhanced degradation.

 

 

 

 

Risk factors for Pyroluria:

Symptoms - Food - Beverages Being a recovered alcoholic

Moderate/low/high alcohol consumption A higher than normal anxiety

level leads many with pyroluria to drink alcohol. As many as one-third to

one-half of alcoholics have this genetic chemical imbalance.

 

 

Symptoms - Gas-Int - General

History of unexplained nausea

 

Symptoms - Mind - Emotional

Small social support group size or no social support group

 

 

 

Pyroluria suggests the following may be present:

NutrientsCounter-indicators:

EFA (Essential Fatty Acid) Type 3 Requirement Omega 3 fatty acids are

potentially harmful supplements in someone with pyroluria. Omega 3s can

worsen mental symptoms in bipolar or schizophrenic patients, if they have

a pyrrole disorder.

 

Normally the desaturase enzymes which metabolize EFAs have a higher

affinity for the n3 (Omega3) series. It has been proposed that in

schizophrenia mutant desaturases are present which prefer the n6 series.

This change would account for the low levels of linoleic acid,

dihomogammalinolenic acid and 1 series prostaglandins which have been

reported in schizophrenia. It would also explain the high levels of

arachidonic and alpha-linolenic acids and the recently described

therapeutic response to alpha-linolenic acid. The abnormal pattern in n6

series EFAs in schizophrenics can almost exactly be imitated in rats by

depriving them of n3 EFAs. This is the nearest experimental equivalent to

an inability to metabolize EFAs because of an enzyme defect.

Heterozygotes carrying such a mutant gene would have an advantage over

either form of homozygote since they would be better able to cope with

variations in dietary intake of n3 and n6 EFAs. [schizophrenia: the role

of abnormal essential fatty acid and prostaglandin metabolism. Horrobin

DF, Huang YS. Med Hypotheses. 1983 Mar;10(3): pp329-36]

 

Pyroluric mental patients will usually get worse if given fish oils, DHA,

EPA, etc (alpha-linolenic acid metabolites). They thrive on Primrose Oil,

a good source of AA and other omega 6s.

 

 

 

 

Pyroluria can lead to:

Circulation Anemia (Uncommon Nutritional) Pyrolurics are generally

anemic.

 

 

Mental

Depression

 

Nutrients

Zinc Requirement Pyroluria is caused by an overproduction of

kryptopyrrole during hemoglobin synthesis, which chemically combines with

vitamin B6 and zinc, resulting in their excretion and a deficiency of

both of these essential nutrients.

 

Vitamin B6 Requirement A functional pyridoxine deficiency is common in

pyroluria (often seen in alcoholics), due not so much to inadequate

intake as impaired conversion to its active form, pyridoxal-5-phosphate,

and enhanced degradation.

 

 

 

 

Recommendations for Pyroluria:

Amino Acid / ProteinNot recommended:

Histidine

 

Lab Tests/Rule-Outs

Test for Urine Kryptopyrroles People with pyroluria produce excess

amounts of a byproduct from hemoglobin synthesis, called kryptopyrrole

(2,4-dimethyl-3-ethylpyrrole) or hemepyrrole. In these people an excess

amount of kryptopyrrole is found in the urine. The most accurate test for

pyroluria directly measures urine kryptopyrrole’s.

 

Test for Manganese Levels

Test Essential Fatty Acid Profile

 

Mineral

Zinc Kryptopyrrole is a reacting agent which combines irreversibly

with active vitamin B6. The resulting molecule then chelates zinc, the

combined product appearing in the urine. The whole syndrome is

stress-induced so the susceptible patient, when stressed, quickly becomes

vitamin B6 and zinc deficient.

 

Manganese Manganese is poorly absorbed, so the oral administration of

large doses of manganese gluconate daily for a long period of time may be

required. Manganese levels can be tested for in red blood cells. Daily

doses of 50mg or more may be required over a long period to bring these

levels to within the normal range.

 

 

Not recommended:

Copper

 

Vitamins

Vitamin B6 (Pyridoxine) Pyrolurics commonly respond within a few

months to B6, zinc and manganese. The nutrient dosage usually must be

increased when the pyroluric patient is under increased stress.

 

 

 

 

 

KEY Weak or unproven link

Strong or generally accepted link

Strongly counter-indicative

Likely to help

Highly recommended

May have adverse consequences

 

 

 

GLOSSARY

 

Allergy: Hypersensitivity caused by exposure to a particular antigen

(allergen), resulting in an increased reactivity to that antigen on

subsequent exposure, sometimes with harmful immunologic consequences.

 

Anxiety: Apprehension of danger, or dread, accompanied by nervous

restlessness, tension, increased heart rate, and shortness of breath

unrelated to a clearly identifiable stimulus.

 

Bipolar Disorder: Also known as manic-depression, this disorder is

characterized by alternating periods of extreme moods, usually swinging

from being overly elated or irritable (mania) to sad and hopeless

(depression) and then back again, with periods of normal mood in between.

The frequency of the swings between these two states, and the duration of

the mood, varies from person to person.

 

Chromium: Chromium is a mineral that becomes a part of the glucose

tolerance factor (GTF). Chromium aids in insulin utilization and blood

sugar control. By controlling blood sugar, chromium helps prevent the

damage caused by glucose, which is called glycation. Chromium helps

maintain normal cholesterol levels and improves high-density lipoprotein

levels. Chromium is also important in building muscle and reducing

obesity.

 

Chronic: Usually Chronic illness: Illness extending over a long period

of time.

 

Copper: An essential mineral that is a component of several important

enzymes in the body and is essential to good health. Copper is found in

all body tissues. Copper deficiency leads to a variety of abnormalities,

including anemia, skeletal defects, degeneration of the nervous system,

reproductive failure, pronounced cardiovascular lesions, elevated blood

cholesterol, impaired immunity and defects in the pigmentation and

structure of hair. Copper is involved in iron incorporation into

hemoglobin. It is also involved with vitamin C in the formation of

collagen and the proper functioning in central nervous system. More than

a dozen enzymes have been found to contain copper. The best studied are

superoxide dismutase (SOD), cytochrome C oxidase, catalase, dopamine

hydroxylase, uricase, tryptophan dioxygenase, lecithinase and other

monoamine and diamine oxidases.

 

DHA: Docosahexanoic Acid. A metabolite of the omega-3 fatty acid

alpha-linolenic acid.

 

Enzymes: Specific protein catalysts produced by the cells that are

crucial in chemical reactions and in building up or synthesizing most

compounds in the body. Each enzyme performs a specific function without

itself being consumed. For example, the digestive enzyme amylase acts on

carbohydrates in foods to break them down.

 

EPA: Environmental Protection Agency. Also: Eicosapentanoic Acid. A

metabolite of the omega-3 fatty acid alpha-linolenic acid.

 

Essential Fatty Acid: (EFA): A substance that the human body cannot

manufacture and therefore must be supplied in the diet.

 

Fatty Acids: Chemical chains of carbon, hydrogen, and oxygen atoms that

are part of a fat (lipid) and are the major component of triglycerides.

Depending on the number and arrangement of these atoms, fatty acids are

classified as either saturated, polyunsaturated, or monounsaturated. They

are nutritional substances found in nature which include cholesterol,

prostaglandins, and stearic, palmitic, linoleic, linolenic,

eicosapentanoic (EPA), and decohexanoic acids. Important nutritional

lipids include lecithin, choline, gamma-linoleic acid, and inositol.

 

GABA: The amino-acid derivative GABA (Gamma-Aminobutyric Acid) is a

calming substance. Tranquilizers like Valium and Librium owe their

soothing effects to the fact that they stimulate GABA receptors in the

brain.

 

Hallucination: A false or distorted perception of objects or events,

including sensations of sight, sound, taste, smell or touch, typically

accompanied by a powerful belief in their reality.

 

Hemoglobin: The oxygen-carrying protein of the blood found in red blood

cells.

 

Histamine: A chemical in the body tissues, produced by the breakdown of

histidine. It is released in allergic reactions and causes widening of

capillaries, decreased blood pressure, increased release of gastric

juice, fluid leakage forming itchy skin and hives, and tightening of

smooth muscles of the bronchial tube and uterus.

 

Inositol: Usually considered part of the vitamin B complex. It is

thought that along with choline, inositol is necessary for the formation

of lecithin within the body. Involved in calcium mobilization.

 

Manganese: An essential mineral found in trace amounts in tissues of the

body. Adults normally contain an average of 10 to 20mg of manganese in

their bodies, most of which is contained in bone, the liver and the

kidneys. Manganese is essential to several critical enzymes necessary for

energy production, bone and blood formation, nerve function and protein

metabolism. It is involved in the metabolism of fats and glucose, the

production of cholesterol and it allows the body to use thiamine and

Vitamin E. It is also involved in the building and degrading of proteins

and nucleic acid, biogenic amine metabolism, which involves the

transmitting of nerve impulses.

 

Metabolism: The chemical processes of living cells in which energy is

produced in order to replace and repair tissues and maintain a healthy

body. Responsible for the production of energy, biosynthesis of important

substances, and degradation of various compounds.

 

Metabolite: Any product (foodstuff, intermediate, waste product) of

metabolism.

 

Prostaglandin: Any of a class of physiologically active substances

present in many tissues, with effects such as vasodilation,

vasoconstriction, stimulation of the smooth muscles of the bronchus or

intestine, uterine stimulation; also involved in pain, inflammation,

fever, allergic diarrhea, and dysmenorrhea. A potent hormone -- similar

in structure to an unsaturated fatty acid -- that acts in extremely low

concentrations on local target organs; first isolated from the prostate.

 

Pyridoxine: (Vitamin B-6): A B-complex vitamin that plays a role as a

coenzyme in the breakdown and utilization of carbohydrates, fats and

proteins. It facilitates the release of glycogen for energy from the

liver and muscles. It also participates in the utilization of energy in

the brain and nervous tissue and is essential for the regulation of the

central nervous system.

 

Pyroluria: This condition is caused by an overproduction during

hemoglobin synthesis of kryptopyrrole, which chemically combines with

vitamin B6 and zinc, resulting in their excretion and a severe deficiency

of both of these essential nutrients. Most pyroluric individuals never

develop schizophrenia symptoms.

 

Schizophrenia: Any of a group of psychotic disorders usually

characterized by withdrawal from reality, illogical patterns of thinking,

delusions, and hallucinations, and accompanied in varying degrees by

other emotional, behavioral, or intellectual disturbances. Schizophrenia

is associated with dopamine imbalances in the brain and defects of the

frontal lobe and is caused by genetic, other biological, and psychosocial

factors.

 

Stitch: A sudden sharp pain, usually in the side, that can occur during

exercise such as running.

 

Tryptophan: Essential amino acid. Natural relaxant and sleep aid due to

its precursor role in serotonin (a neurotransmitter) synthesis. Along

with tyrosine, it is used in the treatment of addictions.

 

Vitamin B6: Influences many body functions including regulating blood

glucose levels, manufacturing hemoglobin and aiding the utilization of

protein, carbohydrates and fats. It also aids in the function of the

nervous system.

 

Zinc: An essential trace mineral. The functions of zinc are enzymatic.

There are over 70 metalloenzymes known to require zinc for their

functions. The main biochemicals in which zinc has been found to be

necessary include: enzymes and enzymatic function, protein synthesis and

carbohydrate metabolism. Zinc is a constituent of insulin and male

reproductive fluid. Zinc is necessary for the proper metabolism of

alcohol, to get rid of the lactic acid that builds up in working muscles

and to transfer it to the lungs. Zinc is involved in the health of the

immune system, assists vitamin A utilization and is involved in the

formation of bone and teeth.

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