Nicotinamide Riboside: New Vitamin Linked to Longevity Gene

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> Tue, 7 Sep 2004 16:22:39 +0200

 

> " Sepp (Josef) Hasslberger " <sepp

> New Vitamin Linked to Longevity Gene

>

 

> <http://www.betterhumans.com/index.aspx>

>

<http://www.betterhumans.com/About_Us/Press/Press_Releases/release.aspx?articleI\

D=2004-05-08-1>Welcome

>

>

>

<http://www.betterhumans.com/News/news.aspx?articleID=2004-05-14-2>New

>

> Vitamin Linked to Longevity Gene

>

>

<http://www.betterhumans.com/News/index.aspx>http://www.betterhumans.com/News/ne\

ws.aspx?articleID=2004-05-14-2

>

>

>

<http://media.fastclick.net/w/click.here?sid=9487 & m=3 & c=1>

>

> New Vitamin Linked to Longevity Gene

>

> Has role in gene regulation, metabolism and aging

>

> By Gabe Romain

> Betterhumans Staff

> 5/14/2004

>

>

> A new vitamin has been discovered that plays an

> important role in

> such processes as gene regulation, metabolism and

> aging.

>

> The finding, by researcher

> <http://www.dartmouth.edu/~brenner/cv.html>Charles

> Brenner and

> colleagues at

> <http://www.dartmouth.edu/dms/>Dartmouth Medical

> School

> in Hanover, New Hampshire, establishes a new

> mechanism for the

> creation of an important small

> <http://www.wikipedia.org/wiki/Molecule>molecule in

> <http://www.wikipedia.org/wiki/Cell_(biology)>cells.

>

> The molecule, nicotinamide adenine dinucleotide

> (NAD), is a

> <http://www.wikipedia.org/wiki/Coenzyme>coenzyme

> that works both as a

> partner that helps

> <http://www.wikipedia.org/wiki/Enzyme>enzymes and

> as an ingredient that other enzymes consume.

>

> NAD controls

>

<http://www.wikipedia.org/wiki/Cholesterol>cholesterol

>

> levels and prevents

> <http://www.wikipedia.org/wiki/Pellagra>pellagra-a

> disease

> characterized by red skin lesions,

> <http://www.wikipedia.org/wiki/Dermatitis>dermatitis

> and mental

> confusion leading to

> <http://www.wikipedia.org/wiki/Dementia>dementia.

>

> Studies have also shown that a coenzyme related to

> NAD, called NADH,

> activates a

>

<http://www.betterhumans.com/Resources/Encyclopedia/article.aspx?articleID=2004-\

01-13-5>gene

>

> called Sir2 that has been shown to

>

<http://www.betterhumans.com/News/news.aspx?articleID=2003-12-31-4>extend

>

> lifespan in yeast and roundworms.

>

> Making NAD

>

> Brenner and colleagues made their discovery while

> studying an enzyme

> involved in NAD synthesis that was similar to an

> enzyme implicated in

> cancer development.

>

> The researchers found that in

> <http://www.wikipedia.org/wiki/Yeast>yeast without

> the enzyme, every

> known NAD pathway shut down.

>

> This should have killed the cells, since no vitamins

> or supplements

> were thought available to keep them alive.

>

> But it didn't.

>

> Instead, the researchers discovered, another NAD

> precursor called

> nicotinamide riboside kinase served as a vitamin

> that prevented cell

> death.

>

> Their findings overturn some assumptions about NAD

> synthesis that

> have been in textbooks for decades.

>

> Useful nutrient

>

> To reinforce the vitamin hypothesis, the researchers

> looked for the

> compound in a food and found it in

> <http://www.wikipedia.org/wiki/Whey>whey.

>

> Brenner thinks that the new vitamin may be a useful

> nutrient for

> treating some disorders.

>

> <http://www.wikipedia.org/wiki/Niacin>Niacin, for

> example, can help

> lower cholesterol, but it has uncomfortable flushing

> effects in

> patients, so nicotinamide riboside supplementation

> may offer an

> alternative.

>

> The finding could also improve the use of some

> cancer drugs, such as

> tiazofurin and benzamide riboside.

>

> " Cancer drugs that look like nicotinamide riboside

> are converted to

> toxic NAD analogs through a pathway that is likely

> to be the same as

> our vitamin activation pathway, " says Brenner.

>

> " Certain tumors respond, while others don't, so if

> we can select the

> right patients we will have a more effective

> treatment strategy, " he

> says. " In the future, testing for nicotinamide

> riboside kinase

> expression might be used to identify the patients

> that are likely to

> respond to this class of drugs. "

>

> The research is reported in the journal

> <http://www.cell.com/>Cell

>

(<http://www.cell.com/content/article/abstract?uid=PIIS0092867404004167>read

>

> abstract).

>

(http://www.cell.com/content/article/abstract?uid=PIIS0092867404004167)

>

>

> --

>

> The individual is supreme and finds its way through

> intuition.

> Sepp (Josef) Hasslberger

>

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