Arthritis and Frequent Megadoses of Niacinamide

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Arthritis and Frequent Megadoses of Niacinamide

(Vitamin B-3)

 

SOME NOTES ON NIACINAMIDE THERAPY FOR ARTHRITIS

by William Kaufman, M.D., Ph.D.

(Reprinted with the kind permission of Charlotte

Kaufman)

 

The (more frequent) 250 mg dose of niacinamide is 40

to 50 % more effective in the treatment of arthritis

than the (less frequent) 500 mg. dose. As an

illustration, see the reprint of my Tom Spies Memorial

Lecture: Niacinamide, a Most Neglected Vitamin. This

illustrative case history begins on page 17 column 2

and continues on page 18 column 2.

 

Do not use hard gelatin capsules containing 250 mg

niacinamide because they do not deliver niacinamide as

efficiently as 250mg niacinamide in thin gelatin

capsules in the treatment of joint dysfunction

(arthritis).

 

In my paper in J. Amer Geriat. Society, 1955 3:927-936

I noted that niacinamide (alone or combined with other

vitamins) in a thousand patient-years of use has

caused no adverse side effects.

 

Some brands of niacinamide on the market today

contains excipients that act as preservatives,

probably meant to prolong shelf life. Some patients

have severe adverse reactions to these preparations

while most do not experience any ill effects.

 

Niacinamide has un-gated entrance to the central

nervous system. It has a strong affinity for the

central nervous system's benzodiazepine receptors and

causes a pleasant calmative effect. In addition, it

improves central nervous system function in the kinds

of central nervous symptom impairments noted in my

1943 book, starting on page 3.

 

Please keep in mind niacinamide is a systemic

therapeutic agent. It measurably improves joint

mobility, muscle strength, decreases fatigability. It

increases maximal muscle working capacity, reduces or

completely eliminates arthritic joint pain.

Niacinamide heals broken strands of DNA and improves

many kinds of CNS functioning.

 

Some joints are so injured by the arthritic process

that no amount of niacinamide therapy will cause

improvement in joint mobility, but it takes three

months of niacinamide therapy before you can conclude

this, since some joints are slow to heal.

 

WILLIAM KAUFMAN, PhD, MD

January 13,1998