Magnesium & Carbohydrate Metabolism

[Guest guest]

Fri Mar 26, 2004 11:19 am

Post subject: Magnesium and Carbohydrate Metabolism

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Carbohydrate Metabolism

Magnesium and potassium in diabetes and carbohydrate metabolism.

Review of the present status and recent results.

 

Magnesium (SWITZERLAND) 1984, 3 (4-6) p315-23

http://www.mgwater.com/abstract.shtml#diabetes2

 

Diabetes mellitus is the most common pathological state in which secondary

magnesium deficiency occurs. Magnesium metabolism abnormalities vary according

to the multiple clinical forms of diabetes: plasma magnesium is more often

decreased than red blood cell magnesium.

 

Plasma Mg levels are correlated mainly with the severity of the diabetic state,

glucose disposal and endogenous insulin secretion.

 

Various mechanisms are involved in the induction of Mg depletion in diabetes

mellitus, i.e. insulin and epinephrine secretion, modifications of the vitamin D

metabolism, decrease of blood P, vitamin B6 and taurine levels, increase of

vitamin B5, C and glutathione turnover, treatment with high levels of insulin

and biguanides. K depletion in diabetes mellitus is well known.

 

Some of its mechanisms are concomitant to those of Mg depletion. But their

hierarchic importance is not the same: i.e., insulin hyposecretion is more

important versus K+ than versus Mg2+. Insulin increases the cellular inflow of

K+ more than that of Mg2+ because there is more free K+ (87%) than Mg2+ (30%) in

the cell.

 

The consequences of the double Mg-K depletion are either antagonistic: i.e.

versus insulin secretion (increased by K+, decreased by Mg2+) or agonistic i.e.

on the membrane: (i.e. Na+K+ATPase), tolerance of glucose oral load, renal

disturbances. The real importance of these disorders in the diabetic condition

is still poorly understood. Retinopathy and microangiopathy are correlated with

the drop of plasma and red blood cell Mg. K deficiency increases the noxious

cardiorenal effects of Mg deficiency. The treatment should primarily insure

diabetic control.

 

Magnesium and carbohydrate metabolism

 

THERAPIE (France), 1994, 49/1 (1-7)

 

The interrelationships between magnesium and carbohydrate metabolism have

regained considerable interest over the last few years. Insulin secretion

requires magnesium:

 

magnesium deficiency results in impaired insulin secretion while magnesium

replacement restores insulin secretion. Furthermore, experimental magnesium

deficiency reduces the tissues sensitivity to insulin.

 

Subclinical magnesium deficiency is common in diabetes. It results from both

insufficient magnesium intakes and increase magnesium losses, particularly in

the urine.

 

In type 2, or non-insulin-dependent, diabetes mellitus, magnesium deficiency

seems to be associated with insulin resistance. Furthermore, it may participate

in the pathogenesis of diabetes complications and may contribute to the

increased risk of sudden death associated with diabetes.

 

Some studies suggest that magnesium deficiency may play a role in spontaneous

abortion of diabetic women, in fetal malformations and in the pathogenesis of

neonatal hypocalcemia of the infants of diabetic mothers.

 

Administration of magnesium salts to patients with type 2 diabetes tend to

reduce insulin resistance. Long-term studies are needed before recommending

systematic magnesium supplementation to type 2 diabetic patients with

subclinical magnesium deficiency.

_________________

 

 

JoAnn Guest

mrsjoguest

DietaryTipsForHBP

http://www.geocities.com/mrsjoguest

 

 

 

 

 

 

 

 

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