Guest guest Posted May 18, 2004 Report Share Posted May 18, 2004 Bitter Melon Fruits Include Components Resembling Insulin BITTER MELON (MOMORDICA CHARANTIA) Other botanical names include: Bitter Melon is a common vegetable. Eaten by many throughout the world. Bitter Melon grows on a vine and is cousin of the squash. The bitter melon has green cucumber shaped fruit. Bitter melon isn't its only name. Botanists and scientists call it-- Momordica charantia (botanical name). There are many nick-names, including bitter gourd, carilla plant,wild cucumber,Kuguazi, African cucumber, karela, and its medicinal herb name in china, Kuguazi. Bitter melon is science-friendly. For example, you can find it in the " MERCK INDEX " , the chemist's and physician's encyclopedia of chemicals,drugs and biologicals. WHERE DOES IT COME FROM? Bitter melon is native to almost all tropical climates. It is common inAfrica, China, the Far East, India, Brazil, the Caribbean, etc. HERE IN PART IS WHAT THE U.S. DEPARTMENT OF AGRICULTURE SAYS ABOUT BITTER MELON: " Bitter melon is used for tumors in Brazil, for malignant ulcers in Guam. Arubans take the decoction for hypertension, Puerto Ricans for diabetes; Hondurans as a depurative; Peruvians for colic and worms. Jamaicans for colds, constipation, fever and stomachache; Congolese use the leaf for colic, the seed for roundworm. Japanese use the plant for constipation, headache, and skin ailments.... " *James A. Duke, PhD., Chief, Germplasm Resources Laboratory, United States Dept. of Agriculture, Washington, D.C., quoted from HANDBOOK OF MEDICINAL HERBS (1985;pp315-316) WHAT IS THE SCIENTIFIC RESEARCH DATA ABOUT BITTER MELON? Some research scientists are concerned with leukemia or lymphoma. Others with the immune system. Some research AIDS and HIV-1. Others seek proteins that have immunosuppressive effect. Still otherslook for hypoglycemic peptides. Some look for extracts that kill human leukemic lymphocytes. Some are interested in the highest neutral detergent fiber or monoclonal antibodies or the lowering of glucose concentrations or stimulators of insulin release. We think you will agree, that there is some- thing unique about this plant. Re: Its lowering of glucose concentrations, improving glucose tolerance, and promoting glucose disposal: " The mineral and amino acid analysis showed that the bitter gourd contained nutritionally useful quantities of the most essential mineral and amino acids. The blood sugar once lowered after 30 days did not increase even after 15 days of discontinuation of the treatment. " * *Journal of Ethnopharmacology 15(1):107-17 1986 Jan. " Investigations were carried out to evaluate the effect of Momordica charantia on the glucose tolerance of maturity onset diabetic patients. The juice of Momordia charantia was found to significantly improve the glucose tolerance of 73% of the patients investigated. " * *Journal of Ethnopharmacology 17(3):277-82 1986 Sept. " Cerrasee-A wild variety of Momordica charantia is traditionally prepared as a tea for the treatment of diabetes mellitus in the West Indies and Central America. *Diabetes Research Clinical & Experimental 2(2):81-4 1985 Mar. " The hypoglycaemic effect of orally administered extracts of fruits of cultivated Momordica charantia (Karela) was examined. The results suggest that orally administered karela extracts lower glucose concentrations independently of intestinal glucose absorption and involve an extra pancreatic effect. " * *Planta Medica 56(5); 426-9 1990 Oct. " The effect of Karela (Momordica charantia), a fruit indigenous to South America and Asia, on glucose and insulin concentrations was studied in nine non-insulin-dependent diabetics and six non-diabetic rats. These results show that karela improves glucose tolerance in diabetes. Doctors supervising *Asian* diabetics are aware of the fruit's hypoglycemic properties. " **British Medical Journal-Clinical Research 282(6279); 1823-4 1981June 6. " An aqueous extract from the unripe fruits of the tropical plant Momordica charantia was found to be potent stimulator of insulin release from beta cell rich pancreatic islets isolated from obese-hyperglycemic mice. Studies of 45 Ca fluxes suggest that the insulin releasing action is aresult of perturbations of membrane functions. In support for the idea of direct effects on membrane lipids, the action of the extract was found to mimic that of saponin. " * *Acta Biologica et Medica Germanica 41(12):1229-40 1982. " A hypoglycemic peptide, Polypeptide-p has been isolated from the fruit seeds and tissue of Momordica charantia. Polypeptide-p is a very effective hypoglycemic agent when administered subcutaneously to gerbils, langurs and humans. " * *Journal of Natural Products 44(6):648-55 1981 Nov.-Dec. " Extracts of Momordica charantia fruit pulp, seed, and whole plant were tested for their hypoglycemic effects on normal and diabetic rat models. The results indicate the presence of non-sapogenin hypoglycemic compound(s) in Momordica charantia fruit pulp and the activity is probably mediated either by improving the insulin secretory capacity of the B cells or by improving the action of the insulin. " * *Planta Medica 59(5):408-412 1993 " The Bitter Melon or Balsam Pear-- is cultivated as a tropical vegetable in South America, Asia, and Africa where it has been used as a traditional therapy for diabetes in a variety of cultures of these countries. One isolate of Momorica, Charantin is a mixture of steroidal glycosides and compares favorably to " tolbutamide " , an allopathic drug commonly used as a oral hypoglycemic agent. Another isolate, polypeptide-P has been shown to lower blood glucose when administered via subcutaneous injections. A variety of oral extracts have been shown to lower blood sugar and improve glucose tolerance in both human and animal studies. *Chakravarthy BK, Gupa S, and Gode KD: Functional beta cell regeneration in the islets of Pancreas in alloxan induced dibetic rats by epicatechin. Life Sc 31:2693-7, 1982 " ....The results indicated that M. charantia fruits and seeds contained components that resembled insulin in inhibiting hormone-induced lipolysis... " * *Wong CM, Yeung HW, Ng TB: Screening of (family Cucurbitaceae) for compounds with antilipolytic activity. *Journal of Ethnopharmacology 13(3):313-21, July 1985. http://home.istar.ca/~hlth2000/bittermelon.html *CLICK HERE to view Published Clinical Articles on MOMORDICA CHARANTIA --- BITTER MELON AS AN ALTERNATIVE TREATMENT FOR DIABETES Momordica charantia In Myanmar (Burma), China and India, it is highly prized for its anti-diabetic activity. Myanmar traditional physicians prescribe bittermelon to diabetic patients. Doctors in India are so confident of bitter melon's positive effect on diabetes, they dispense bitter melon in some of the most modern hospitals. According to James Duke of U.S Department of Agriculture, bitter melon has attained favor in China as a monoherbal medicine for diabetes mellitus. Bitter melon has twice the potassium of bananas, and it has been shown to increase the number of beta cells, those which produce insulin, in the pancreas. PREPARATION- Bitter melon is available through most Filipino and/or Asian grocery stores, and some farmers markets. The appropriate method of administering bitter melon is to make the extract from the fruit, vines, and leaves of the plant and either drink it as a juice, tea or administer it as a retention enema. Some say that drinking the juice or tea will result in the breakdown of the active components by stomach acids, therefore a retention enema would be a more efficient route. Momordica charantia (Bitter melon): Therapeutic Actions, Clinical Indications, and more Diabetic and Other Metabolic Neuropathies Abstracts THE INFLUENCE OF MOMORDICA CHARANTIA FRUIT JUICE ON PERIPHERAL NERVE STRUCTURE IN EXPERIMENTAL DIABETES Serasee is believed to work in a holistic manner. It is believed to work best if your food and water are clean and natural, and your heart and mind are pure. If you eat foods with a lot of chemicals it won't work so well. If you are full of toxins, use sparingly at first, as purification reactions may be strong Mormodica works from the subtlest levels to adjust you toward health, and works best with your total cooperation in the way of diet, attitude, etc. --- ---GLA in Borage Oil Useful in Diabetic Neuropathy Results of GLA (gamma linolenic acid) as found in evening primrose oil and Borage oil supplementation in diabetics truly astounding. Stein et al, in their research at the Department of Internal Medicine, Center for Diabetes Research at the University of Texas Southwestern Medical Center Dallas Texas have conclusively demonstrated the vital importance of oils that contain the essential Omega three fatty acids. These Omega three's as well as an important Omega six are the EFA's LNA and LA. When we lack them in our diet, we suffer degenerative disease Research shows the role certain beneficial fatty acids may play in preventing or improving cardiovascular complications attributed to diabetes. " Perhaps of equal or greater importance is the role certain beneficial fatty acids may play in preventing or improving cardiovascular complications attributed to diabetes. Buried in the annals of medicine are extremely optimistic studies attesting to these facts. This information has not been widely publicized in the past because fatty acids are naturally occurring nutrients and can not be patented by pharmaceutical companies and sold at exorbitant prices. One such fatty acid, gamma linolenic acid (GLA), is found in nature's most concentrated form as Borage seed oil (24% GLA). The results of GLA supplementation in diabetics are truly astounding, as outlined below. Diabetic neuropathy (a painful nerve disorder resulting from reduced blood flow and subsequent oxygen depravation of the limbs or organs) was reversed in studies conducted by seven medical centers. In a separate, but similar study, 12 patients afflicted with diabetic neuropathy were given 360 mg of GLA daily (the equivalent of two, 1000 mg. Borage oil capsules), while 10 others were given a placebo (inactive substance). After 6 months the GLA group showed statistically significant improvement as compared to the placebo group. In addition, GLA supplementation has been reported to normalize the faulty fatty acid metabolism attributed to diabetes by bypassing the enzyme system responsible for this disorder By doing so the body's response to inflammation, pain and swelling is stabilized. Arterial muscle tone, responsible for blood pressure and optimal circulation, is also regulated by this system. Animal studies conducted with GLA have revealed the normalization of intercellular sorbitol levels. Another study of Type 1 diabetics cited favorable changes in HDL ( " good " cholesterol) and blood platelet adhesiveness with GLA supplementation. Research shows the role certain beneficial fatty acids may play in preventing or improving cardiovascular complications attributed to diabetes. " Perhaps of equal or greater importance is the role certain beneficial fatty acids may play in preventing or improving cardiovascular complications attributed to diabetes. Buried in the annals of medicine are extremely optimistic studies attesting to these facts. This information has not been widely publicized in the past because fatty acids are naturally occurring nutrients and can not be patented by pharmaceutical companies and sold at exorbitant prices. One such fatty acid, gamma linolenic acid (GLA), is found in nature's most concentrated form as Borage seed oil (24% GLA). The results of GLA supplementation in diabetics are truly astounding, as outlined below. In a separate, but similar study, 12 patients afflicted with diabetic neuropathy were given 360 mg of GLA daily (the equivalent of two, 1000 mg. Borage oil capsules), while 10 others were given a placebo (inactive substance). After 6 months the GLA group showed statistically significant improvement as compared to the placebo group. In addition, GLA supplementation has been reported to normalize the faulty fatty acid metabolism attributed to diabetes by bypassing the enzyme system responsible for this disorder By doing so the body's response to inflammation, pain and swelling is stabilized. Arterial muscle tone, responsible for blood pressure and optimal circulation, is also regulated by this system. Animal studies conducted with GLA have revealed the normalization of intercellular sorbitol levels. Another study of Type 1 diabetics cited favorable changes in HDL ( " good " cholesterol) and blood platelet adhesiveness In summary, diabetics have been found to possess faulty fatty acid metabolism which may contribute to the cardiovascular complications associated with the disease. Scientific research has established the reduction of certain harmful fats, with the addition of beneficial fatty acids, may offer a significant breakthrough in combating diabetic cardiovascular complications with the potential of significantly lowering health care costs. " The study concluded that all diabetics should be considered for a dietary protocol of GLA. The good news is that although this disease accounts for almost half of the annual death toll from all causes, it is, in most cases, curable- permanently, quickly, economically, completely and often easily and by natural means. Let's not sugarcoat it: Glucose-lowering drugs can do more harm than good. The natural therapies used at the Whitaker Wellness Institute for diabetes help keep blood sugar levels in check without the side effects of drugs. These drugs usually succeed in lowering blood sugar levels, but may increase the *death* rate from heart attacks. (this is listed as a common side effect!) These drugs also are associated with weight gain, elevated cholesterol and triglyceride levels, nausea, diarrhea, constipation, stomach pain, drowsiness, and headache. The Natural Pharmacist: Natural Treatments for Diabetes includes up-to-date information on diabetes and chromium,alphalipoic acid, evening primrose oil, fenugreek, Gymnema sylvestre, magnesium, Momordica charantia, Coccinia indica, Pterocarpus marssupium, niacinamide, bilberry treatments. -- - Choose Your Fats: Diabetes & Weight Gain JoAnn Guest Apr 04, 2003 11:21 PST Diabetes In this discussion, diabetes refers to diabetes mellitus. Other forms of diabetes (such as diabetes insipidus)are not included. People with diabetes cannot properly process glucose, a sugar the body uses for energy. As a result, glucose stays in the blood, causing blood glucose to rise. At the same time, however, the cells of the body can be starved for glucose. Diabetes can lead to poor wound healing, higher risk of infections, and many other problems involving the eyes, kidneys, nerves,and heart. In type 1 diabetes, the pancreas cannot make the insulin needed to process glucose. Adult-onset diabetes is also called type 2, or non-insulin- dependent, diabetes. With type 2 diabetes, the pancreas often makes enough insulin, but the body has trouble using the insulin. Type 2 diabetes responds well to natural therapies. People with diabetes have a high risk for heart disease and atherosclerosis. In addition, those with diabetes have a higher mortality rate if they also have high homocysteine levels. Checklist for Diabetes- Rating Nutritional Supplements- Herbs Alpha lipoic acid Brewer's yeast (providing approximately 60 mcg of chromium per tablespoon) Chromium Evening primrose oil, Borage Oil Magnesium Cayenne (topical for neuropathy) Fenugreek (seeds) Psyllium Biotin Coenzyme Q10 L-carnitine Vitamin B1 (Thiamine) Vitamin B6 (gestational diabetes only) Vitamin C Vitamin E (for prevention of retrolental fibroplasia in premature infants, and for prevention of diabetic retinopathy) Zinc (preferably for those with a documented deficiency) Aloe vera Bilberry Bitter melon Gymnema Hairy Basil (seed) Holy Basil (leaf) Onion Fish oil (EPA/ DHA) The following are associated with diabetic retinopathy: Selenium, vitamin A, vitamin C, and vitamin E (combined) Fructo-oligosaccharides (FOS) Inositol Manganese Medium chain triglycerides Quercetin Taurine Vanadium (for type 2 diabetes) Vitamin B12 Vitamin B3 (niacinamide) Vitamin D Vitamin E (associated with abetalipoproteinemia) Eleuthero Ginkgo biloba Olive leaf Reishi Dietary changes that may be helpful: The relationship between eating carbohydrates and type 2 diabetes is a complex issue. While eating carbohydrates increases the need for insulin to keep blood sugar normal, diets high in total complex carbohydrates do not necessarily increase the risk of type 2 diabetes. Years ago, one researcher reported an increase in diabetes among Yemenite Jews who had migrated from a region where no sugar was eaten to one in which they ate a diet including sugar. However, other factors, such as " weight gain " , may explain the increased risk of diabetes that occurred in this group. Eating carbohydrate-containing foods, whether high in sugar or high in starch (i.e. breads with hydrogenated fats,refined processed breakfast cereals high in sugar), temporarily raise blood sugar and insulin levels. The blood sugar-raising effect of a food, called its " glycemic index, " depends on how rapidly its carbohydrate is absorbed. Many starchy foods have a glycemic index similar to sucrose (table sugar). People eating large amounts of foods with high glycemic indices (such as those mentioned above), have been reported to be at increased risk of type 2 diabetes. On the other hand, eating a diet high in carbohydrate-rich foods with low glycemic indices is associated with a low risk of type 2 diabetes. Beans, peas, fruit, and oats, have low glycemic indices, despite theirhigh carbohydrate content, due mostly to the health-promoting effects of " soluble " fiber. Diabetes disrupts the mechanisms by which the body controls blood sugar. Most doctors recommend that people with diabetes eliminate intake of sugar from refined snacks and processed foods, and replace these foods with high-fiber, whole foods. This tends to lower the glycemic index of the overall diet and has the additional benefit of increasing vitamin and mineral intake. A high-fiber diet has been shown to work better in controlling diabetes than the diet recommended by the ADA, and may control blood sugar levels as well as oral diabetes drugs. In the study, the increase in dietary fiber was accomplished exclusively through the consumption of foods naturally high in fiber—such as organic leafy green vegetables and fresh wholefruit—to a level beyond that recommended by the ADA. No fiber supplements were given. All participants received both the ADA diet (providing 24 grams of fiber per day) and the high- fiber diet (providing 50 grams of fiber per day), for a period of six weeks. After six weeks of following each diet, tests were performed to determine blood glucose, insulin, cholesterol, triglyceride, and other values. When glucose levels were monitored over a 24-hour period, participants eating the high-fiber diet had an average glucose level that was 10% lower than participants eating the ADA diet. Insulin levels were 12% lower in the group eating the high-fiber diet compared to the group eating the ADA diet, indicating a beneficial increase in the body's sensitivity to insulin. Moreover, people eating the high-fiber diet experienced significant reductions in total cholesterol, triglycerides, and LDL ( " bad " ) cholesterol compared to those eating the ADA diet. They also had slight decreases in glycosylated hemoglobin, a measure of chronically high blood glucose levels. High-fiber supplements, such as psyllium, guar gum (found in beans),24 pectin (from fruit) oat bran, and psyllium have improved glucose tolerance in some studies.Positive results have also been reported with the consumption of 1–3 ounces of powdered fenugreek seeds per day. Many doctors advise people with diabetes to eat a diet high in fiber.Focus should be placed on vegetables, seeds, oats, and organic whole-grain products. The fatty acids (omega-3s) in cold water fish also may afford some protection from diabetes. Incorporating a fish meal (alaskan salmon for example) into a weight-loss regimen was more effective than either measure alone at improving glucose and insulin metabolism and high cholesterol. Vegetarians have been reported to have a low risk of type 2 diabetes.When people with diabetic nerve damage switch to a vegan diet (no meat or dairy), improvements have been reported after several days.In one trial, pain completely disappeared in 17 of 21 people. Fats from meat and dairy also contribute to abnormally high triglyceride and homocysteine levels leading to heart disease, the leading killer of people with diabetes. Vegetarians also eat less protein than do meat eaters. The reduction of protein intake has lowered kidney damage caused by diabetes and may also improve glucose tolerance. Diets high in fat, especially saturated fat, worsen glucose tolerance and increase the risk of type 2 diabetes, an effect that is simply the result of weight gain caused by eating high-fat foods.Saturated fat is found primarily in meat, dairy fat, and the dark meat and skins of poultry. In contrast, glucose intolerance has been improved by diets high in " monounsaturated " oils,which may be good for people with diabetes. There is often difficulty in changing the overall percentage of calories from fat and carbohydrates in the diets of people with type 1 diabetes. However, modifying the quality of the dietary fat is achievable. In adolescents with type 1 diabetes, increasing " monounsaturated " fats (fat in almonds,macademia nuts, extra-virgin olive oils and avocadoes) relative to other fats in the diet is associated with better control over blood sugar and cholesterol levels. The easiest way to incorporate monounsaturates into the diet is to use extra-virgin olive oil. Should children avoid milk to prevent type 1 diabetes? Worldwide, children whose dietary energy comes primarily from dairy (or meat) products have a significantly higher chance of developing type 1 diabetes than do children whose dietary energy comes primarily from vegetable sources. Countries with high milk consumption have a high risk of diabetes. Animal research also indicates that *avoiding* milk affords protection from type 1 diabetes. Milk contains a protein related to a protein in the pancreas, the organ where insulin is made. Some researchers believe that children who are allergic to milk may develop antibodies that attack the pancreas, causing type 1 diabetes. Several studies have linked cows' milk consumption to the occurrence of diabetes in children. Some children who drink cows'milk produce antibodies to the milk, and it has been hypothesized that these antibodies can cross-react with and *damage* the insulin-producing cells of the pancreas. Lifestyle changes that may be helpful: Most people with type 2 diabetes are overweight. Excess abdominal weight does not stop insulin formation, but it does make the body less sensitive to insulin. Excess weight can even make healthy people pre-diabetic. Weight loss reverses this problem. In most studies, type 2 diabetes has improved with weight loss. Being overweight also increases the need for insulin. Therefore, people with diabetes should achieve and maintain appropriate body weight. Exercise helps decrease body fat and improve insulin sensitivity. People who exercise are less likely to develop type 2 diabetes than those who do not.However, exercise can induce low blood sugar or even occasionally increased blood sugar. Moreover, a preliminary study has shown that long-term physical activity was not associated with control of blood glucose in people with type 1 diabetes. Therefore, people with diabetes should never begin an intensive exercise program without consulting a healthcare professional. -- -------------------------------- Dietary Fiber for Diabetics- Effects of dietary fiber on glucose and lipoprotein metabolism in diabetic patients G Riccardi and AA Rivellese Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Naples, Italy. -------------------------------- Dietary recommendations for the treatment of diabetic patients issued by national and international diabetes associations consistently emphasize the need to increase *complex* carbohydrate consumption. However, these recommendations have been questioned on the basis of growing evidence that, in both insulin-dependent and non-insulin-dependent diabetic patients, a high-carbohydrate diet does not offer any advantage in terms of blood glucose and plasma lipid concentrations compared with a high-fat (mainly unsaturated) diet. However, much of the controversy between advocates and detractors of dietary carbohydrate can be settled by taking into account dietary *fiber*. Several studies have shown that the adverse metabolic effects of high-carbohydrate diets are neutralized when *fiber* and carbohydrate are *increased* " simultaneously " in the diet for diabetic patients. In particular, these studies demonstrated that a high-carbohydrate/high-fiber diet significantly improves blood glucose control and reduces plasma cholesterol levels in diabetic patients compared with a low-carbohydrate/low-fiber diet. In addition, a high-carbohydrate/high-fiber diet does not increase plasma insulin and triglyceride concentrations, despite the higher consumption of carbohydrates. Unfortunately, dietary fiber represents a heterogenous category, and there is still much to understand as to which foods should be preferred to maximize the metabolic effects of fiber. There are indications that only " water-soluble " fiber is active on plasma glucose and lipoprotein metabolism in humans. Therefore, in practice, the consumption of dried cooked beans,legumes and lentils, organic vegetables and fruits--rich in water-soluble fiber--should be particularly encouraged. The mechanisms by which dietary fiber exerts its hypoglycemic and hypolipidemic activities are unknown. However, the ability of dietary fiber to retard food digestion and nutrient absorption certainly has an important " influence " on lipid and carbohydrate metabolism. The beneficial effects of high-fiber foods are also exerted by some foods not particularly rich in fiber. The fiber content and physical form of the food can influence the accessibility of nutrients by digestive enzymes, thus delaying digestion and absorption. The identification of these foods with a low-glycemic response would help enlarge the list of foods particularly suitable for diabetic patients. In conclusion, a diet low in cholesterol and saturated fat should be recommended to all diabetic patients to prevent cardiovascular disease. A balanced increase in consumption of organic fiber-rich foods and unsaturated fat is the most rational way to replace foods rich in saturated fat and cholesterol in the diabetic diet. http://care.diabetesjournals.org/cgi/content/abstract/14/12/1115? maxtoshow= & HITS\ =100 & hits=100 & RESULTFORMAT= & titleabstract=soluble+fiber & searchid=1019 506413568_1\ 065 & stored_search= & FIRSTINDEX=0 JoAnn Guest mrs- Dieta- http://www.geocities.com/mrsjoguest/Magnesium.html Renal Failure & Lactic Acidosis in Diabetic Woman Receiving *Metformin*(a Diabetic Drug) ,Rofecoxib Acute Renal Failure and Lactic Acidosis Reported in Diabetic Woman Receiving Metformin and Rofecoxib-British Journal of Anaesthesia 12/09/2003 By Keely S. Solomon, PhD Doctors report that rofecoxib, a COX 2 inhibitor, may have contributed to a case of acute renal failure and metformin-related lactic acidosis. COX 2 inhibitors are becoming increasingly popular for treatment of inflammatory conditions due to a reduced incidence of gastrointestinal side effects compared with traditional non- steroidal anti-inflammatory drugs (NSAIDS). " What is less well appreciated is the role that the COX 2 inhibitors may play in the development of renal failure, " writes Grant Price, of Victoria Hospital, Kirkcaldy, Fife, Scotland. In the case report, Dr. Price describes a 58-year-old woman diagnosed with acute renal failure and lactic acidosis. The patient had a medical history that included 10 years of type 2 diabetes mellitus treated with diet modification and metformin. According to Dr. Price, metformin therapy leads to an increase in lactic acid production, and type B lactic acidosis has been documented as a rare complication of this treatment. Moreover, any renal impairment results in a reduced clearance of lactic acid, which can increase the risk for lactic acidosis in patients receiving metformin. " The COX 2 inhibitors may have an improved side-effect profile with regard to gastric side effects, but their renal safety profile has not been established, " cautions Dr. Price. Based on the evidence from this case, he suggests that COX 2 inhibitors " can lead to a potentially disastrous outcome " in patients receiving metformin. Br J Anaesth 2003 Dec;91:6:909-10. http://www.docguide.com/news/content.nsf/news/ 645F9985BE5980A485256DF700508846 _________________ JoAnn Guest mrsjoguest DietaryTipsForHBP http://www.geocities.com/mrsjoguest The complete " Whole Body " Health line consists of the " AIM GARDEN TRIO " Ask About Health Professional Support Series: AIM Barleygreen " Wisdom of the Past, Food of the Future " http://www.geocities.com/mrsjoguest/AIM.html PLEASE READ THIS IMPORTANT DISCLAIMER We have made every effort to ensure that the information included in these pages is accurate. However, we make no guarantees nor can we assume any responsibility for the accuracy, completeness, or usefulness of any information, product, or process discussed. SBC - Internet access at a great low price. Quote Link to comment Share on other sites More sharing options...
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