physohex or physoderm

[Guest guest]

I was chatting with friends last week and something triggered my memory about a product that was used on infants as an antibacterial scrub. I know it was taken off the market. Now with so many staph infections and all the ill health you bring home from the hospitals these days, what do you all remember about this??

Judy

[Guest guest]

I think Physohex was pulled. I am not sure about

Physderm. It may have been put out as a replacement

without the offending ingredient, hexachlorophene.

 

http://www.rxlist.com/cgi/generic2/hexchlorph_wcp.htm

 

 

WARNINGS

 

RINSE THOROUGHLY AFTER EACH USE. Patients should be

closely monitored and use should be immediately

discontinued at the first sign of any of the symptoms

described below.

 

Rapid absorption of hexachlorophene may occur with

resultant toxic blood levels when preparations

containing hexachlorophene are applied to skin lesions

such as ichthyosis congenita, the dermatitis of

Letterer-Siwe's syndrome, or other generalized

dermatological conditions. Application to burns has

also produced neurotoxicity and death.

 

pHisoHex SHOULD BE DISCONTINUED PROMPTLY IF SIGNS OR

SYMPTOMS OF CEREBRAL IRRITABILITY OCCUR.

 

Infants, especially premature infants or those with

dermatoses, are particularly susceptible to

hexachlorophene absorption. Systemic toxicity may be

manifested by signs of stimulation (irritation) of the

central nervous system, sometimes with convulsions.

 

nfants have developed dermatitis, irritability,

generalized clonic muscular contractions and

decerebrate rigidity following application of a 6

percent hexachlorophene powder. Examination of

brainstems of those infants revealed vacuolization

like that which can be produced in newborn

experimental animals following repeated topical

application of 3 percent hexachlorophene. Moreover, a

study of histologic sections of premature infants who

died of unrelated causes has shown a positive

correlation between hexachlorophene baths and lesions

in white matter of brains.

 

http://www.cdc.gov/niosh/topics/skin/conference/s1t2.html

h. Hexachlorophene can be lethal from percutaneous

absorption. Children may be specifically susceptible.

 

 

i. Hexachlorophene (6.3%) was added to “baby

powder†in France due to a manufacturing error. It

caused encephalopathy and ulcerative skin lesions. 36

of 204 exposed children died within a few days of

exposure (Martin-Bouyer et al., 1982).

 

ii. pHisoHex® soap contains 3% hexachlorophene.

Repeated bathing of premature children in undiluted

pHisoHex has been associated with a vacuolar

encephalopathy and lower survival rates. A study of

248 children autopsied over a 7.5 year period showed

encephalopathy in 17 infants (Shuman et al., 1974).

PHisoHex has been restricted to prescription use or as

a surgical scrub for health care personnel since 1972

(Freeman and Maibach, 1991).

 

http://www.squidly.com/archives/000254.php

 

kadee

 

 

--- bobjudy wrote:

 

> I was chatting with friends last week and something

> triggered my memory about a product that was used on

> infants as an antibacterial scrub. I know it was

> taken off the market. Now with so many staph

> infections and all the ill health you bring home

> from the hospitals these days, what do you all

> remember about this??

> Judy

 

 

 

 

 

 

[Guest guest]

Its not used in hospitals here now .... they acknowledge that tap water is best - soap and water actually - even for wounds tap water is on a par with sterile normal saline - officially accepted - so if there is no saline for a patient I use tap water!

 

-

Kadee Did

Tuesday, March 28, 2006 8:19 AM

Re: physohex or physoderm

I think Physohex was pulled. I am not sure aboutPhysderm. It may have been put out as a replacementwithout the offending ingredient, hexachlorophene.http://www.rxlist.com/cgi/generic2/hexchlorph_wcp.htmWARNINGSRINSE THOROUGHLY AFTER EACH USE. Patients should beclosely monitored and use should be immediatelydiscontinued at the first sign of any of the symptomsdescribed below.Rapid absorption of hexachlorophene may occur withresultant toxic blood levels when preparationscontaining hexachlorophene are applied to skin lesionssuch as ichthyosis congenita, the dermatitis ofLetterer-Siwe's syndrome, or other generalizeddermatological conditions. Application to burns hasalso produced neurotoxicity and death.pHisoHex SHOULD BE DISCONTINUED PROMPTLY IF SIGNS ORSYMPTOMS OF CEREBRAL IRRITABILITY OCCUR.Infants, especially premature infants or those withdermatoses, are particularly susceptible tohexachlorophene absorption. Systemic toxicity may bemanifested by signs of stimulation (irritation) of thecentral nervous system, sometimes with convulsions. nfants have developed dermatitis, irritability,generalized clonic muscular contractions anddecerebrate rigidity following application of a 6percent hexachlorophene powder. Examination ofbrainstems of those infants revealed vacuolization like that which can be produced in newbornexperimental animals following repeated topical application of 3 percent hexachlorophene. Moreover, astudy of histologic sections of premature infants whodied of unrelated causes has shown a positivecorrelation between hexachlorophene baths and lesionsin white matter of brains.http://www.cdc.gov/niosh/topics/skin/conference/s1t2.htmlh. Hexachlorophene can be lethal from percutaneousabsorption. Children may be specifically susceptible.i. Hexachlorophene (6.3%) was added to “babypowder†in France due to a manufacturing error. Itcaused encephalopathy and ulcerative skin lesions. 36of 204 exposed children died within a few days ofexposure (Martin-Bouyer et al., 1982). ii. pHisoHex® soap contains 3% hexachlorophene. Repeated bathing of premature children in undilutedpHisoHex has been associated with a vacuolarencephalopathy and lower survival rates. A study of248 children autopsied over a 7.5 year period showedencephalopathy in 17 infants (Shuman et al., 1974). PHisoHex has been restricted to prescription use or asa surgical scrub for health care personnel since 1972(Freeman and Maibach, 1991).http://www.squidly.com/archives/000254.phpkadee--- bobjudy wrote:> I was chatting with friends last week and something> triggered my memory about a product that was used on> infants as an antibacterial scrub. I know it was> taken off the market. Now with so many staph> infections and all the ill health you bring home> from the hospitals these days, what do you all> remember about this??> Judy