Boron as an antidote in acute fluoride intoxication

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Fluoride 1980; 13(1):30-38 Boron as an antidote in acute fluoride intoxication in rabbits: its action on the fluoride and calcium-phosphorous metabolism

Elsair J, Merad R, Denine R, Reggabi M, Benali S, Azzouz M, Khelfat K, and M Tabet Aoul

Laboratories of Physiology, Toxicology, and Galenic Pharmacy, Medical Institue, Algiers, Algeria

Summary: The kinetics of calcium, phosphorous and fluoride were studied after daily adminisration of 60 mg/kg fluoride to rabbits in drinking water for two months and subsequent addition of boron following a lapse of 11 and 45 days during which fluoride was discontinued.

Boron tends to increase the elmination of fluoride from the body. Fluoremia returned to normal levels in all groups on day 11. At that time, the fluoride balance was negative compared with normal levels. When boron was added the negative balance was more pronounced because of relative hyperfluoria and because of a decrease in the digestive utilization coefficient. In bones the fluoride content decreased more slowly. It remained very high on day 45 in the fluoride group, but returned to normal when boron was given.

Calcium and phosphorous balances were normal in all cases on days 11 and 45. This was due to normalization of calcium and phosphorous digestive utilization coefficient, in the 45-day fluoride group after addition of boron.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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