Allicin Effective Against MRSA Superbugs

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Allicin Effective Against MRSA Superbugs

Powerful New Evidence

 

A compound extracted from garlic is effective against even the most

antibiotic-resistant strains of MRSA, the killer hospital superbug,

and can cure patients with MRSA-infected wounds within days, according

to new research by microbiologist Dr Ron Cutler of the University of

East London (UEL).

 

In a paper to be published in the New Year, Dr Cutler, an expert in

the antimicrobial properties of plant extracts, claims that allicin -

a compound that occurs naturally in garlic kills not only established

varieties of MRSA, but also destroys the new generation of

super-superbugs that have evolved resistance to Vancomycin and

Glycopeptides, the powerful antibiotics widely considered to be the

last line of defence against MRSA.

 

MRSA (Methicillin-resistant Staphylococcus aureus) now causes an

estimated 5,000 deaths in UK hospitals each year mainly through

secondary infection of surgical wounds. Though MRSA organisms can live

harmlessly in humans and are carried in the nasal passages and on the

skin, they can cause fatal infection in immune-suppressed patients,

the elderly, the young and those with surgical implants.

 

Doctors have become increasingly alarmed over the past few months by

the emergence in UK hospitals of new generations of resistant strains

of MRSA known as VISAs, and GISAs (Vancomycin or Glycopeptide

resistant Staphylococcus aureus). MRSA has also become endemic in many

hospitals, especially in London and the South-East, prompting the NHS

to review its hygiene procedures.

 

Dr Cutler, who recently proved that allicin destroys the MRSA microbe

in laboratory trials, has now teamed up with a new company, Allicin

International, to develop topical treatments to prevent MRSA

infection. The group have developed a nasal cream, oral capsules and

soaps that have proved effective against both MRSA and GISA.

 

In partnership with colleagues in the NHS, Dr Cutler is now embarking

on a major clinical trial involving around two hundred volunteers,

including patients at several hospitals in London and the South East.

 

Dr Cutler said: " The trials we have conducted so far show that this

formulation is highly effective against MRSA and it could save many

lives. This finding is backed up by initial findings from a number of

recent case studies. We have been trying to set up a clinical trial

for many months now and, at last, we have secured funding from sources

including Allicin International.

 

MRSA is causing a genuine crisis in our hospital system in Britain and

worldwide. Antibiotics are increasingly ineffective, but we do have a

powerful natural ally. Plant compounds have evolved over millions of

years as chemical defence agents against infection. Garlic has been

used in medicine for centuries and it should be no surprise that it is

effective against this very modern infection. "

 

The research on the laboratory effects of allicin on GISA was

presented in part at the Institute of Biomedical Scientists congress

in Birmingham, October 2003, and is being prepared for publication in

the Journal of Biomedical Science to appear in the New Year. A full

clinical study involving the use of allicin to reduce nasal carriage

in healthy volunteers, involving hospitals from London and the South

East, is underway. Initial results are due to be published in summer 2004.

 

Case Study: Deborah's Story

Deborah Brown (34), a probation service officer who lives in Rainham,

Kent, contracted MRSA after a major spinal operation in November 2000.

The painful wounds on her spine failed to heal despite constant

applications of both oral antibiotics and creams, which also failed to

reduce the levels of MRSA in her tissue.

 

In December 2002, Deborahs mother Pauline contacted Dr Cutler after

seeing an item on TV about MRSA and received a course of Allimax cream

and capsules by post. Within two months, the MRSA had mostly cleared

from Deborah's tissues and the wounds had begun to heal, allowing an

operation to remove her spinal supports to be carried out in June 2003.

 

Deborah said: " The effect of the treatment was dramatic - I am making

a good recovery now but it was really awful at the time. Having

weeping wounds on my back that never healed for two years was

incredibly painful and I became increasingly depressed as the MRSA

didn't respond to repeated courses of antibiotics. If my case helps to

show that allicin works against MRSA then I am glad that something

good might come of it. "

 

Further Resources

Allicin - The Heart of Garlic by Peter Josling