Tocotrienols

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Tocotrienols lower cholesterol Mohammad Minhajuddin, PhD, of the University of Rochester, and colleagues reported in the May 2005 issue of Food and Chemical Toxicology that tocotrienols from rice brain oil significantly lower total and low-density lipoprotein cholesterol (LDL). Tocotrienols are four of the eight members of the vitamin E family, whose benefits have only recently been explored. Dr Minhajuddin's team fed rats a diet designed to induce atherosclerosis which more than doubled their cholesterol levels, tripled their triglyceride levels, and increased their LDL cholesterol by a factor of five after three weeks. Markers of oxidative damage were also increased. The animals were then given varying doses of tocotrienol rich fraction from rice bran oil for one week. It was found that administration of tocotrienols lowered cholesterol dose-dependently, with the greatest benefit observed at a daily dose of 8 international units (IU) per kilogram, which is equivalent to a dose of 560 IU for a 154 pound human. Total cholesterol levels were lowered by 42 percent, and LDL cholesterol by 62 percent. HMG-CoA reductase, an enzyme that is used by the liver to make cholesterol, was reduced during treatment with tocotrienols, as well as two of the markers of oxidative damage. –Life Extension

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