Effects of Fluoride

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                      Scientific Facts on the

                       Biological Effects of

                              Fluorides

    1. Fluoride exposure disrupts the synthesis of

    collagen and leads to the breakdown of

    collagen in bone, tendon, muscle, skin,

    cartilage, lungs, kidney and trachea.

   

A.K. Susheela and Mohan Jha, " Effects of Fluoride on

    Cortical and Cancellous Bone Composition, " IRCS

    Medical Sciences: Library Compendium, Vol. 9, No.11,

    pp. 1021-1022 (1981); Y. D. Sharma, " Effect of

    Sodium Fluoride on Collagen Cross-Link Precursors, "

    Toxicological Letters, Vol. 10, pp. 97-100 (1982); A.

    K. Susheela and D. Mukerjee, " Fluoride poisoning and

    the Effect of Collagen Biosynthesis of Osseous and

    Nonosseous Tissue, " Toxicological European Research,

    Vol. 3, No.2, pp. 99-104 (1981); Y.D. Sharma,

    " Variations in the Metabolism and Maturation of

    Collagen after Fluoride Ingestion, " Biochemica et

    Biophysica Acta, Vol. 715, pp. 137-141 (1982); Marian

    Drozdz et al., " Studies on the Influence of Fluoride

    Compounds upon Connective Tissue Metabolism in

    Growing Rats " and " Effect of Sodium Fluoride With

    and Without Simultaneous Exposure to Hydrogen

    Fluoride on Collagen Metabolism, " Journal of

    Toxicological Medicine, Vol. 4, pp. 151-157 (1984).

   

2. Fluoride stimulates granule formation and

    oxygen consumption in white blood cells, but

    inhibits these processes when the white blood

    cell is challenged by a foreign agent in the

    blood.

   

Robert A. Clark, " Neutrophil Iodintion Reaction

    Induced by Fluoride: Implications for Degranulation

    and Metabolic Activation, " Blood, Vol. 57, pp. 913-

    921 (1981).

   

 

3. Fluoride depletes the energy reserves and

    the ability of white blood cells to properly

    destroy foreign agents by the process of

    phagocytosis. As little as 0.2 ppm fluoride

    stimulates superoxide production in resting

    white blood cells, virtually abolishing

    phagocytosis. Even micro-molar amounts of

    fluoride, below 1 ppm, may seriously depress

    the ability of white blood cells to destroy

    pathogenic agents.

   

John Curnette, et al, " Fluoride-mediated Activation of

    the Respiratory Burst in Human Neutrophils, " Journal

    of Clinical Investigation, Vol. 63, pp. 637-647 (1979);

    W. L. Gabler and P. A. Leong, ., " Fluoride Inhibition

    of Polymorphonumclear Leukocytes, " Journal of Dental

    Research, Vol. 48, No. 9, pp. 1933-1939 (1979); W. L.

    Gabler, et al., " Effect of Fluoride on the Kinetics of

    Superoxide Generation by Fluoride, " Journal of Dental

    Research, Vol. 64, p. 281 (1985); A. S. Kozlyuk, et al.,

    " Immune Status of Children in Chemically

    Contaminated Environments, " Zdravookhranenie, Issue

    3, pp. 6-9 (1987)

   

4. Fluoride confuses the immune system and

    causes it to attack the body's own tissues,

    and increases the tumor growth rate in

    cancer prone individuals.

   

Alfred Taylor and Nell C. Taylor, " Effect of Sodium

    Fluoride on Tumor Growth, " Proceedings of the

    Society for Experimental Biology and Medicine, Vol.

    119, p. 252 (1965); Shiela Gibson, " Effects of Fluoride

    on Immune System Function, " Complementary Medical

    Research, Vol. 6, pp. 111-113 (1992); Peter Wilkinson,

    " Inhibition of the Immune System With Low Levels of

    Fluorides, " Testimony before the Scottish High Court

    in Edinburgh in the Case of McColl vs. Strathclyde

    Regional Council, pp. 17723-18150, 19328-19492, and

    Exhibit 636, (1982); D. W. Allman and M. Benac,

    " Effect of Inorganic Fluoride Salts on Urine and

    Cyclic AMP Concentration in Vivo, " Journal of Dental

    Research, Vol. 55 (Supplement B), p. 523 (1976); S.

    Jaouni and D. W. Allman, " Effect of Sodium Fluoride

    and Aluminum on Adenylate Cyclase and

    Phosphodiesterase Activity, " Journal of Dental

    Research, Vol. 64, p. 201 (1985)

   

5. Fluoride inhibits antibody formation in the

    blood.

    S. K. Jain and A. K. Susheela, " Effect of Sodium

    Fluoride on Antibody Formation in Rabbits, "

    Environmental Research, Vol. 44, pp. 117-125 (1987)

   

6. Fluoride depresses thyroid activity.

    Viktor Gorlitzer Von Mundy, " Influence of Fluorine

    and Iodine on the Metabolism, Particularly on the

    Thyroid Gland, " Muenchener Medicische

    Wochenschrift, Vol. 105, pp. 182-186 (1963); A.

    Benagiano, " The Effect of Sodium Fluoride on Thyroid

    Enzymes and Basal Metabolism in the Rat, " Annali Di

    Stomatologia, Vol. 14, pp. 601-619 (1965); Donald

    Hillman, et al., " Hypothyroidism and Anemia Related

    to Fluoride in Dairy Cattle, " Journal of Dairy Science,

    Vol. 62, No.3, pp. .416-423 (1979); V. Stole and J.

    Podoba, " Effect of Fluoride on the Biogenesis of

    Thyroid Hormones, " Nature, Vol. 188, No. 4753, pp.

    855-856 (1960); Pierre Galleti and Gustave Joyet,

    " Effect of Fluorine on Thyroid Iodine Metabolism and

    Hyperthyroidism, " Journal of Clinical Endocrinology

    and Metabolism, Vol. 18, pp. 1102-1110 (1958)

   

 

7. Fluorides have a disruptive effect on

    various tissues in the body.

    T. Takamorim " The Heart Changes in Growing Albino

    Rats Fed on Varied Contents of Fluorine, " The

    Toxicology of Fluorine Symposium, Bern, Switzerland,

    Oct 1962, pp. 125-129; Vilber A. O. Bello and Hillel J.

    Gitelman, " High Fluoride Exposure in Hemodialysis

    Patients, " American Journal of Kidney Diseases, Vol.

    15, pp. 320-324 (1990); Y. Yoshisa, " Experimental

    Studies on Chronic Fluorine Poisoning, " Japanese

    Journal of Industrial Health, Vol. 1, pp. 683-690 (1959)

   

 

8. Fluoride promotes development of bone

    cancer.

    J.K. Mauer, et al., " Two-Year Cacinogenicity Study Of

    Sodium Fluoride In Rats, " Journal of the National

    Cancer Institute, Vol. 82, pp. 1118-1126 (1990);

    Proctor and Gamble " Carcinogenicity Studies with

    Sodium Fluoride in Rats " National Institute of

    Environmenrtal Health Sciences Presentation, July 27,

    1985; S. E. Hrudley et al., " Drinking Water

    Fluoridation and Osteosarcoma, " Canadian Journal of

    Public Health, Vol. 81, pp. 415-416 (1990); P. D.

    Cohn, " A Brief Report on the Association of Drinking

    Water Fluoridation and Incidence of Osteosarcoma in

    Young Males, " New Jersey Department of Health,

    Trenton, New Jersey, Nov. 1992; M. C. Mahoney et al.,

    " Bone Cancer Incidence Rates in New York, " American

    Journal of Public Health, Vol. 81, pp. 81, 475 (1991);

    Irwin Herskowitz and Isabel Norton, " Increased

    Incidence of Melanotic Tumors Following Treatment

    with Sodium Fluoride, " Genetics Vol. 48, pp. 307-310

    (1963); J. A. Disney, et al., " A Case Study in Testing

    the Conventional Wisdom: School Based Fluoride

    Mouth Rinse Programs in the USA, " Community

    Dentistry and Oral Epidemiology, Vol. 18, pp. 46-56

    (1990); D. J. Newell, " Fluoridation of Water Supplies

    and Cancer - An Association?, " Applied Statistics, Vol.

    26, No. 2, pp. 125-135 (1977)

   

9. Fluorides cause premature aging of the

    human body.

   

Nicholas Leone, et al., " Medical Aspects of Excessive

    Fluoride in a Water Supply, " Public Health Reports,

    Vol. 69, pp. 925-936 (1954); J. David Erikson,

    " Mortality of Selected Cities with Fluoridated and

    Non-Fluoridated Water Supplies, " New England

    Journal of Medicine, Vol. 298, pp. 1112-1116 (1978);

    " The Village Where People Are Old Before Their

    Time, " Stern Magazine, Vol. 30, pp. 107-108, 111-112

    (1978)

    10. Fluoride ingestion from mouth rinses and

    dentifrices in children is extremely

    hazardous to biological development, life

    span and general health.

    Yngve Ericsson and Britta Forsman, " Fluoride

    Retained From Mouth Rinses and Dentifrices In

    Preschool Children, " Caries Research, Vol. 3, pp. 290-

    299 (1969); W. L. Augenstein, et al., " Fluoride

    Ingestion In Children: A Review Of 87 Cases, "

    Pediatrics, Vol. 88, pp. 907-912, (1991); Charles Wax,

    " Field Investigation Report, " State of Maryland

    Department of Health and Mental Hygiene, March 19,

    1980, 67 pages; George Waldbott, " Mass Intoxication

    from Over-Fluoridation in Drinking Water, " Clinical

    Toxicology, Vol. 18, No.5, pp. 531-541 (1981)

    Other Facts

    The contents of a family size tube of

    fluoridated toothpaste is enough to kill a 25

    pound child.

    In 1991, the Akron (Ohio) Regional Poison Center

    reported that " death has been reported following

    ingestion of 16mg/kg of fluoride. Only 1/10 of an ounce

    of fluoride could kill a 100 pound adult. According to

    the Center, " fluoride toothpaste contains up to

    1mg/gram of fluoride. " Even Proctor and Gamble, the

    makers of Crest, acknowledge that a family-sized tube

    " theoretically contains enough fluoride to kill a small

    child. "

    Fluorides have been used to modify behavior

    and mood of human beings.

    It is a little known fact that fluoride compounds were

    added to the drinking water of prisoners to keep them

    docile and inhibit questioning of authority, both in Nazi

    prison camps in World War II and in the Soviet gulags

    in Siberia.

    Fluorides are medically categorized as

    protoplasmic poisons, which is why they are

    used to kill rodents.

    The September 18, 1943 issue of the Journal of the

    American Medical Association, states, " fluorides are

    general protoplasmic poisons, changing the permeability

    of the cell membrane by inhibiting certain enzymes. The

    exact mechanisms of such actions are obscure. "

    Fluoride consumption by human beings

    increases the general cancer death rate.

    In 1975 Dr. John Yiamouyiannis published a

    preliminary survey which showed that people in

    fluoridated areas have a higher cancer death rate than

    those in non-fluoridated areas. The National Cancer

    Institute attempted to refute the studies. Later in 1975

    Yiamouyiannis joined with Dr. Dean Burk, chief

    chemist of the National Cancer Institute (1939-1974) in

    performing other studies which were then included in

    the Congressional Record by Congressman Delaney,

    who was the original author of the Delaney

    Amendment, which prohibited the addition of cancer-

    causing substances to food used for human

    consumption. Both reports confirmed the existence

    of a link between fluoridation and cancer. (Note:

    Obviously Dr. Burk felt free to agree with scientific

    truth only after his tenure at National Cancer Institute

    ended, since his job depended on towing the party line).

    Fluorides have little or no effect on decay

    prevention in humans.

    In 1990 Dr. John Colquhoun was forced into early

    retirement in New Zealand after he conducted a study

    on 60,000 school children and found no difference in

    tooth decay between fluoridated and unfluoridated

    areas. He additionally found that a substantial number

    of children in fluoridated areas suffered from dental

    fluorosis. He made the study public.

    There is no scientific data that shows that

    fluoride mouth rinses and tablets are safe for

    human use.

    In 1989 a study by Hildebolt, et al. on 6,000 school

    children contradicted any alleged benefit from the use of

    sodium fluorides. A 1990 study by Dr. John

    Yiamouyiannis on 39,000 school children contradicted

    any alleged benefits from the use of sodium fluorides. In

    1992 Michael Perrone, a legislative assistant in New

    Jersey, contacted the FDA requesting all information

    regarding the safety and effectiveness of fluoride tablets

    and drops. After 6 months of stalling, the FDA admitted

    they had no data to show that fluoride tablets or drops

    were either safe or effective. They informed Perrone

    that they will " probably have to pull the tablets and

    drops off the market. "

    The fact that fluoride toothpastes and school

    based mouth rinses are packaged in

    aluminum accentuates the effect on the body.

    In 1976, Dr. D. Allman and coworkers from Indiana

    University School of Medicine fed animals 1 part-per-

    million (ppm) fluoride and found that in the presence

    of aluminum, in a concentration as small as 20 parts

    per billion, fluoride is able to cause an even larger

    increase in cyclic AMP levels. Cyclic AMP inhibits

    the migration rate of white blood cells, as well as the

    ability of the white blood cell to destroy pathogenic

    (disease-causing) organisms. Reference: Journal of

    Dental Research, Vol. 55, Sup B, p. 523, 1976, " Effect

    of Inorganic Fluoride Salts on Urine and Tissue Cyclic

    AMP Concentration in Vivo " . (Note: It is no small

    accident that toothpaste tubes containing fluoride are

    often made of aluminum)

    " Fluoridation is the greatest case of scientific

    fraud of this century "

    Robert Carlton, Ph. D., former U. S. EPA scientist on

    " Marketplace " Canadian Broadcast Company, Nov. 24,

    1992

    " Regarding fluoridation, the EPA should act

    immediately to protect the public, not just on

    the cancer data, but on the evidence of bone

    fractures, arthritis, mutagenicity and other

    effects "

    William Marcus, Ph. D., senior EPA toxicologist,

    Covert Action, Fall 1992, p. 66

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