Guest guest Posted March 30, 2004 Report Share Posted March 30, 2004 Tue, 30 Mar 2004 08:18:02 -0500 HSI - Jenny Thompson No Bacteria Left Behind No Bacteria Left Behind Health Sciences Institute e-Alert March 30, 2004 ************************************************************** Dear Reader, Every day, school is in session inside our bodies. And the students and teachers are one and the same: bacteria. Bacteria are highly adaptive because they actually " teach " one another to resist antibiotics. When one bacterium develops resistance to an antibiotic, it can share that resistance with similar and even unrelated strains. They do this by passing DNA-containing organisms called plasmids, from one to another. The result: Due to the excessive use of antibiotics, virtually all of the bacterial infections known to scientists are becoming resistant to even the most powerful antibiotics. Fortunately, awareness of this overuse has led to a general rethinking about how best to utilize antibiotics. Now a new test has been developed that may provide doctors with the information they need to avoid prescribing antibiotics unnecessarily. ----------------------------- Sorting the Bs from the Vs ----------------------------- Antibiotics can only control bacteria - not viruses. But because many viral and bacterial infections have similar symptoms, doctors often prescribe antibiotics to treat viruses on the chance that they might be bacteria. So it's no mystery why many unneeded prescriptions are filled for respiratory infections and colds that are viral infections. Currently there are tests that can determine the exact nature of an infection, but they tend to either take too long to show results or are too expensive to be practical. But a new test may change all that. This test quickly measures levels of procalcitonin, a blood protein that rises sharply in the presence of a bacterial infection. Procalcitonin levels rise only slightly in response to viral infections. As reported in The Lancet medical journal last month, researchers at the University Hospital in Basel, Switzerland, devised a trial to examine the procalcitonin test. More than 240 subjects who were admitted to the hospital with lower respiratory tract infections were assigned either standard care, or care based on the results of a procalcitonin test. In the procalcitonin group, 43 percent showed levels high enough to prescribe antibiotics. In the standard care group, patients were diagnosed using x-rays and other tests to determine infection type. In this group, 83 percent received antibiotics. Favorable outcomes for patients in both groups were about equal, and none of the patients in the procalcitonin group experienced any adverse effects due to a lack of antibiotics. Follow-up tests to verify infection types confirmed that approximately 20 percent of the patients in both groups had bacterial infections. One of the authors of the study observed that while antibiotics were over-prescribed in the procalcitonin group, " The test halves antibiotic use, without altering the clinical outcome. " ----------------------------- No dipstick just yet ----------------------------- What the immediate future holds in store for the procalcitonin test remains to be seen. More research and development is required in order to transform it into what one antibiotic resistance expert calls a " quick and easy dipstick test " that could reveal bacterial infection right away. So it may be awhile yet before your doctor has a procalcitonin test ready to use in his office. In the meantime, doctors and patients alike need to be more careful about resorting to antibiotics to treat every sniffle, earache and cough. And the growing crisis of antibiotic resistance is only part of the reason to be wary. Just last month, in the e-Alert " Protection Jumps The Rails " (2/19/04), I told you about a large University of Washington study that revealed how excessive antibiotic use may be associated with an elevated risk of breast cancer. In that study, the women who had the highest rates of cumulative days of antibiotic use over 17 years had a sharply increased risk of death due to breast cancer. And in a recent " Baseline of Health " newsletter, HSI Panelist Jon Barron shared details about a 2003 study of the effects of antibiotic use in young children. The Henry Ford Hospital (Detroit) researchers followed 448 children from birth to seven years. Nearly half of the children received antibiotic treatments (mostly penicillin) within the first six months of life, and among these children the risk of developing asthma was two and a half times greater than the risk to children who received no antibiotics within the first six months. Risk of developing allergies was also significantly increased in the antibiotic group. ----------------------------- Good alternatives ----------------------------- Without question, antibiotics are important, life-saving tools. But the overuse of these drugs has to be curtailed or the antibiotic resistance crisis will turn into a disaster. So the next time your doctor suggests writing an antibiotic prescription, ask specific questions about why it's necessary and what other options might be workable. For instance, in many cases a natural antibiotic could be just as effective as a pharmaceutical variety. In the e- Alert I mentioned above I reviewed four natural antibiotics recommended by HSI Panelist Allan Spreen, M.D.: vitamin C, grapefruit seed extract, olive leaf extract and colloidal silver. (You can find that e-Alert on our web site at www.hsibaltimore.com with a search of the e-Alert archives.) And I've made a special note to follow the progress of the procalcitonin test, which could emerge as the most important means of cutting back antibiotic use. As that develops I'll keep you posted. ************************************************************** To start receiving your own copy of the HSI e-Alert, visit: http://www.hsibaltimore.com/freecopy.html Or forward this e-mail to a friend so they can sign-up to receive their own copy of the HSI e-Alert. ************************************************************** ... and another thing Crunching numbers can be frustrating when the numbers can't be entirely trusted. In the e-Alert " Postcard From Buenos Aires " (3/16/04), I told you how the prostate-specific antigen (PSA) test may be a useful tool for predicting the potential for prostate cancer, but only when combined with other types of screening for the disease. In response, an HSI member named Peg wrote with this question: " On the subject of PSA, what are the levels? What is a low number and high number to really be concerned with? I hear the numbers and I really don't know what they mean. " This is a good question, because any man who has a PSA test will be able to discuss the results better with his doctor if he knows the simple parameters. Here are the PSA ranges, as listed by the National Cancer Institute (NCI): * Normal - 0 to 4 nanograms per milliliter (ng/ml) * Slightly Elevated - 4 to 10 ng/ml * Moderately Elevated - 10 to 20 ng/ml * Highly Elevated - more than 20 ng/ml According to NCI guidelines, PSA false positive results occur mostly in men who are 50 or older. In this age group, about 15 of every 100 men tested will have PSA levels in the slightly elevated range or higher. Of those 15, only three will actually have cancer. Once again, it can't be stressed strongly enough that a single elevated PSA reading should not prompt a biopsy without confirmation of cancer possibility from other screening methods. To Your Good Health, Jenny Thompson Health Sciences Institute ************************************************************** Sources: " Effect of Procalcitonin-Guided Treatment on Antibiotic Use and Outcome in Lower Respiratory Tract Infections: Cluster- Randomised, Single-Blinded Intervention Trial " The Lancet, Vol. 363, 2004, thelancet.com " Test May Lower Antibiotic Use " Helen R. Pilcher, Nature Science Update, 2/20/04, nature.com " New Test May Determine Antibiotic Need " Associated Press, 2/18/04, msnbc.com " Antibiotic Use in Relation to the Risk of Breast Cancer " Journal of the American Medical Association, Vol. 291, 2004, ama-assn.org " Asthma and Antibiotics " Jon Barron, Baseline of Health, 10/13/04, jonbarron.org " Questions and Answers About the Prostate-Specific Antigen (PSA) Test " National Cancer Institute, cis.nci.nih.gov Copyright ©1997-2004 by www.hsibaltimore.com, L.L.C. 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