Guest guest Posted March 24, 2004 Report Share Posted March 24, 2004 Healthy Skin, Hair, & Nails This page is being developed because we have received many queries regarding the use of certain drugs (SSRIs) and peeling skin on the hands and fingers. A simple answer to the question is yes, these drugs do cause skin on the palms to crack and peel. Compounds containing fluoride do interfere with thyroid function, and skin function as a secondary symptom. Nutrient deficiencies caused by Anti-Thyroid Drugs are thought to be responsible for most of the skin rashes. Thiouracil compounds impede conversion of dietary carotene into vitamin A and exacerbate the vitamin A deficiencies seen in Grave's Dis-ease. Frequently, vitamin A supplements are needed to correct skin problems. In the block and replace protocol, thyroid hormone overcomes the vitamin antagonists, allowing proper dietary conversion of carotene. Exfoliative dermatitis with symptoms of cracking and peeling skin should be reported to your health care provider immediately, if you are taking any Rx for hyperthyroid, depression, or cancer, etc. Russian research shows an association to thyroid hormones very clearly. The skin is the largest endocrine organ of the body, as they are finally figuring out. By applying toxic substances one can actually cause systemic thyroid hormone alterations - see fluorinated steroids or the fluoride baths to treat hyperthyroidism. Likewise, low systemic thyroid hormones influence the skin and the activity of the skin cells - it's all a feedback mechanism. PFPC newsletter #9 talks about that quite a bit, as it applies to topical " benefits " of fluoride. What happens is the same as with many other fluoride in pharmaceutical compounds, be it Prozac, Paxil, fluoroquinolones, Baycol, etc - UV radiation changes the nature of the fluoride compounds in circulation which then act on the thyroid hormone receptors in the skin. J Invest Dermatol. 1986 Mar;86(3):244-8. Abnormal lipogenesis in thyroid hormone-deficient epidermis. Rosenberg RM, Isseroff RR, Ziboh VA, Huntley AC. Striking skin changes can accompany hypothyroidism, among them a scaly ichthyosis. The pathogenesis of these disorders is unknown. Since altered sterol metabolism has been associated with other scaling dermatoses, we tested the hypothesis that altered epidermal lipogenesis may accompany hypothyroidism and induce the observed scaling. Thyroidectomized (TX) rats were sacrificed 53 days postthyroidectomy, and the rate of incorporation of the radiolabeled precursor, [14C]acetate, into epidermal lipids was determined. Approximately 2- fold decreases in incorporation of precursor into both polar and neutral lipids were observed in the TX epidermis; the most significant decreases, however, were in the neutral lipids, particularly the sterol and sterol-ester moieties. Total cholesterol pool size was also reduced in the TX epidermis. Similar decreases in sterol biosynthesis were noted in human keratinocytes cultivated in medium devoid of thyroid hormone. These findings demonstrate that lipid metabolism, and notably sterol synthesis, is altered in epidermal keratinocytes deprived of thyroid hormone, and suggest that, as in other scaling disorders, this abnormal sterologenesis may lead to the clinically observed ichthyosis that can accompany hypothyroidism. " In 1953 Leo Spira, MD, Ph.D. published his book " The Drama of Fluorine - Arch Enemy of Mankind " . Drawing upon his many articles which had been published in the Lancet, the British Dental Journal, and other recognized medical journals, the great British physician summarized his findings of over 30 years of pioneering research into various disease states he ultimately found to be related to fluoride intake. One of the most frequent symptoms of early fluorosis observed by Spira were " mottled " and deformed nails, which would often split or chip. " The commonest feature, however, was the occurrence of raised longitudinal ridges on the surface of the finger and toe-nails...In addition, dull, opaque, chalky-white specks, patches or transverse bands, such as are familiar to everybody, appeared frequently on several nails... " Further Spira wrote, " There was a frequent complaint that the hair was falling out prematurely. " In addition Spira reported of several skin diseases and wrote, " Patients felt apprehensive and irritable and were subject to frequent attacks of depression and even melancholia with loss of energy and general lassitude " . The symptoms Spira was describing were later referred to in other European literature as the " Spira-Syndrome " (Schoehl,1985). It must be clear to any endocrinologist that the conditions Spira was describing in the early part of the past century are identical to those now commonly ascribed to zinc deficiency and/or hypothyroidism. On a courtesy visit to the US, Spira had asked the PHS if they also had observed such symptoms, and was told that this was not quite the case. However, recent documents obtained show that the opposite was true. Even Dean himself had noticed such symptoms and wrote about them already in 1932: " The hair of some of these mottled enamel cases is unusually coarse, almost like horse hair. Finger nails are apparently not normal. Two of the three local physicians state that there is apparently an unusually large account of skin disorders among those using the city water supply. Future surveys will attempt to obtain this additional dermatological data in order to determine whether it correlates with the mottled enamel. " [from: T. Dean's monthly report to Surgeon General Hugh S. Cumming, March 4, 1932, part of the H. Trendley Dean collection, History of Medicine Section, National Library of Medicine).] Future surveys were never done. Discussing a study at 8 ppm, we find even more " white blotches " - 3 to 5 per nail: " Another change noted was in the nails. From 10-20 percent of the younger individuals examined has a rather unusual type of nail structure, the most characteristic aspect being transverse white blotches often completely across the nail, usually symmetrical and on all the nails, there very frequently being from three to five of these per nail. The incidence of these finally decreased with age, the oldest patient being 57. In the control area with 139 high school students examined, none showed transverse striations. " [Abstracts of the proceedings of the meetings of the Technical Advisory Committee on the fluoridation of water supplies with the Departmental Working Committee for the Newburgh-Kingston Demonstration; Harold C. Hodge, chairman; April 24, 1944; part of the H.Trendley Dean collection, History of Medicine Section, National Library of Medicine).] " look for new information on SPF and fluoride in sunscreen coming soon... Common Ingredients in health & beauty products Disorders that could show in your nail bed, and some problems below that may be indicated by your nails if they are: Blue - problems with asthma, emphysema, or cadiovascular difficulties. Brittle - iron, calcium or vitamin A deficiency or problem with kidney function or circulation or thyroid. Breaking, Chipping, Cracking, or Peeling - general nutritional deficiency. Dark, Flat - anemia or B12 deficiency. Dry - vitamin A deficiency Hanging - protein deficiency, low in vitamin C and folic acid No moon - nervous system stress or overactive thyroid Soft - overactive thyroid Splitting - shortage of hydrochloric acid in your system Spoon - iron deficiency Thick - circulatory or thyroid problem Vertical ridges - iron deficiency White bands - protein deficiency White lines - heart disease, high fever, and liver problems White spots - often zinc deficiency, but the infamous White Spots on someone's nails are not caused by zinc deficiency, as they are just as common in people with excessively high zinc levels. Please note: the problems and manifestations listed above are only supplied for interest and general information, as nails could have markings with totally different medical reasons, and diseases do not always show in this manner. Please see your medical practitioner if you have a medical query and do not use the information above for use as diagnosis of any medical condition. It is meant as information only. Supplements for nails Unflavored gelatin can improve the quality of your nails, if taken regularly over an extended period of time (6 weeks minimum). Dissolve 1 oz (25 g) of unflavored gelatin in some juice and take daily. B Complex, and especially Nutritional Yeast, B12, B6, Folic Acid. Vitamin A, also increase Beta Carotene for 2 weeks. Too little or too much Cod liver oil may interfere with thyroid function. Vitamin C. Vitamin E or wheat germ oil (EFAs and for some GLAs as from Evening Primrose oil). Probiotics. Protein must be available in sufficient quantities. Zinc when in short supply would also be required by the body either in diet or a supplement. Avoid taking more than 50 mg. daily from all sources. Horsetail herb. Liver supporting herbs if a rash is present. 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