Guest guest Posted March 15, 2004 Report Share Posted March 15, 2004 http://coldcure.com/html/dep.html Do you have a yeast infection? Do you have: athlete's foot? jock itch, thrush, recurrent cystitis or other vaginal infections, endometriosis, fungal infections of the nails or skin, problems from exposure to chemical fumes, perfumes, tobacco smoke etc., food allergies, abdominal bloating, diarrhoea or constipation, pre-menstrual syndrome. depression, fatigue, lethargy, poor memory, food cravings, muscular aches, tingling, numbness, burning, unaccountable aches, swelling in joints, erratic vision, spots before the eyes, floaters?, tachycardia, impotence or lack of sexual desire, symptoms usually worse on damp days, persistent drowsiness / tired all the time, lack of co-ordination, headaches / migraines, Mood swings, loss of balance, rashes, mucus in stools, belching and /or flatulence, bad breath, dry mouth or throat, nasal itch and/or congestion, nervous irritability, prostatitis, tightness in chest, ear sensitivity or fluid in ears, heartburn and indigestion, cardiac arrhythmias, HIV/AIDS. I ask again, do you have a yeast problem? I have read that over eighty percent of us do, primarily because we have taken antibiotics and consume a high carbohydrate and sugar diet.. Find out using this questionnaire from the Yeast Connection site. Learn more about the benefits of coconut oil and why it is good for you here. Is it possible that the majority of diseases that we think of as being magnesium deficiency diseases are really manifestations of Candida suprainfections? If yes, could coconut oil be the preventative or cure for a very large number of divergent chronic diseases? I think so. Walter Last also seems to think so in his new on-line book, 66 Natural Ways to Cure Diseases. See his section on Candida yeast as the cause of many widely different diseases and conditions including lack of energy, digestive disturbances, arthritic joint pains, skin diseases, menstrual problems, emotional instability, cancer and depression. Walter Last explains that killing the Candida yeast is not enough, one must also replace the intestinal microflora with acidophilus bacteria, the good guys as discussed here. I think that principal biological pathways in which Candida causes many diseases is through impaired magnesium metabolism and by diets that promote Candida yeast growth. More on the fungusamongus problem at the FungusFocus web site. Look at the prostatitis page and you will notice that fungus-induced prostatitis has many coterminous symptoms identical to magnesium deficiency. On the other hand, go to your physician and ask him if you have a Candida infection and unless you have a mushroom growing out of your nose, he/she is very likely to tell you that yeast infections nearly always occur in immunosuppressant people, and they do not occur in you. Ask him if you might be magnesium deficient, and he will likely tell you that no one is magnesium deficient except for drunks. Why the adverse opinions? Well, if your doctor prescribed magnesium or coconut oil every time you visited, why go? I think that it makes vastly more financial sense to dissuade us from looking for root causes of illnesses than to treat simple underlying problems with natural products. Does the idea that " Candida infection " is bogus have support on the Internet? Yes, some. There are a few sites that proclaim " Candidiasis hypersensitivity " to be bogus, but the main antagonist seems to be the QuackWatch site. The QuackWatch site is pretty clear that systemic yeast infection is bogus. Is it? I don't know, but if you find benefit from large doses of coconut oil in treating the bewildering variety of Candida-related illnesses, I imagine that you will suspect that the QuackWatch guy, Stephen Barrett, M.D., needs watching! I do know this much. Five years ago, I complained of a severe yeast infection, and after seeing many physicians, and after being treated with many antifungals and antibiotics in the intervening years, I continued to have the problem until I used coconut oil. Steven Barrett is entitled to his opinion, but this is free country and we can disagree in good faith. Who is Steven Barrett? He is reported to be a non-practicing psychiatrist in Allentown, Pennsylvania, working out of his basement, who is laughed at in this page. Why wouldn't he be practicing? Did he get busted by the state, like my previous psychiatrist (who is now taking magnesium) for self-prescribing psychiatric drugs? What does George think about the disease causing potential of Candida yeast? I think Barrett is correct. Candida can not reach all these places to cause these other diseases, but its breakdown product, acetaldehyde, can and does. Acetaldehyde is an irritant, a toxin, a reproductive toxin, a mutagen and a carcinogen. It is a dangerous industrial chemical. It is also flammable, and five times more dangerous than the well known embalming fluid formaldehyde, of which it is a chemical relative. How do people detoxify this harmful chemical? Molybdenum is said to be vital in detoxifying acetaldehyde. In The Candida/Aldehyde detox pathway and the Molybdenum Connection, about 300 micrograms of the dietary supplement molybdenum, along with the B-vitamin pantethine (the active part of pantothenic acid), taken three times a day has been recommended to help people detoxify this truly harmful chemical. Alternatively, molybdenum is found in foods, with potatoes having about 600 micrograms per 100 grams. If potatoes are no longer eaten due to their high glycemic index, one might need a supplemental source for this vital nutrient. On the other hand, the Linus Pauling Institute reports that no healthy person has ever been reported to be deficient of this nutrient, although excesses are toxic . How about HIV/AIDS? Candida yeast is found in nearly all of these patients. Would coconut oil help treat HIV/AIDS? Dr Mercola thinks so because these oils are also antiviral to a number of viruses including HIV, measles, herpes simplex (HSV-1), vesicular stomatitis virus, visna virus and cytomegalovirus (CMV). Dr. Mercola points out that lauric acid is a medium chain fatty acid, which has the additional beneficial function of being formed into monolaurin in the human or animal body. Monolaurin is the antiviral, antibacterial, and antiprotozoal monoglyceride used by the human or animal to destroy lipid-coated viruses such as HIV, herpes, cytomegalovirus, influenza, and various pathogenic bacteria, including listeria monocytogenes and helicobacter pylori, and protozoa such as giardia lamblia. Some studies are being conducted to see if lowering the yeast load in HIV can prevent the disease from becoming AIDS, with some success. Some studies have also shown some antimicrobial effects of the free lauric acid. Do you feel like we have been deprived of the truth for long enough? Do you think implementation of Codex will prohibit the sale of coconut oil too? Seems like it should if the main purpose of Codex is to protect pharmaceutical company income. Want to know what that white stuff in your mouth is? Could it be candida? Dentists often find candida yeast infections in peoples' mouths. Here is a slide show about oral candida, which is likely to present more than you want to know. When your dentist chides you about not taking care of your gums by brushing better, he should be recommending antifungal treatments. One of these days, I will add a section here about the benefits of garlic. Briefly, the medical literature supports the fact that garlic has important anticancer, antibacterial, antiviral and antifungal effects. I am experimenting with a teaspoon of minced garlic 4 times a day to add a second potent antifungal agent to my program to kill intestinal candida yeast. So far it is helping quite a bit (allowed me to reduce my magnesium intake by more than 50%), but I am not ready to discuss this matter in the detail that it deserves. Killer Sugars Excessive amounts of carbohydrates, sugar, specifically dextrose (glucose) interfere with magnesium metabolism to a grave extent. Abnormally high urinary losses of magnesium can also be caused by a number of kidney conditions discussed here. Perhaps the easiest and most important to deal with is excessive glucose sugar, which flushes magnesium from cells and into the urine. High glucose sugars also promote yeast infections of the intestines (and the vagina in women), death of beneficial intestinal bacteria and malabsorption of nutrients (such as magnesium). There may be no greater health problem facing the West than improper magnesium / glucose ratios. We love candy, sugar, sweet drinks and rich carbohydrate products. They are the same heavily commercialized products that make us fat, cause heart attacks, hypertension, strokes, diabetes, impair our immunity and cause many other diseases, all treatable by expensive medicines and medical specialists to the delight of the pharmaceutical drug pushers. We can now add depression, and mood disorders to the list. High carbohydrate consumption causes intracellular magnesium deficiency and high intracellular calcium, the exact intracellular conditions causing depression. High carbohydrate consumption (doesn't matter if it's starches or sugars) results in high insulin levels throughout the day, and interferes with sleep at night. This report [barbagallo, Renick 1994] shows that high blood glucose levels cause the flushing of different minerals from cells, among which is magnesium. Calcium, on the other hand, is not affected. These effects have also been seen by Delva et al. in 2002. Delva showed that only the man made dextrose molecule, the D-dextrose caused problems, while the natural form L-Dextrose, did not cause the problem. This is reminiscent of the problem with man-made D-glutamates. Guerrero-Romero and Rodriguez-Moran reported low serum magnesium in diabetes in 2002. Barbagallo reported altered cellular magnesium responsiveness to hyperglycemia in hypertensive subjects in 2001, finding: For all subjects, ionized magnesium responses to hyperglycemia were closely related to basal ionized magnesium levels with the higher the ionized magnesium, the greater the response (n=26, r=0.620, P<0.001). Thus, (1) erythrocytes from hypertensive vis-a-vis normotensive subjects are resistant to the ionic effects of extracellular hyperglycemia on ionized magnesium levels, and (2) cellular ionic responses to glucose depend on the basal ionized magnesium environment. Altogether, these data support a role for altered extracellular glucose levels in regulating cellular magnesium metabolism and also suggest the importance of ionic factors in determining cellular responsiveness to nonhormonal as well as hormonal signals. These problems may result from inadequate insulin, and resultant loss of magnesium though kidneys. This paper shows that insulin is required inside the kidneys to prevent magnesium wasting. If nearly all of your insulin is being used to handle glucose in your blood, and there is little left over for use by the kidneys, frank magnesium wasting occurs, followed shortly by depression, anxiety and various states of hyperemotionality discussed here. Consequently, conserving insulin by dietary means (low glucose consumption) can prevent depression. There are many other causes of renal magnesium wasting, mostly drug and disease related. Increasing levels of magnesium were found to cause a marked depression of glucose-stimulated insulin secretion at fixed calcium levels, particularly at levels which bracketed the concentration of ultrafiltrable magnesium found in normal rat plasma (1.3 meq/l), i.e., increasing magnesium from 0.6 to 1.2 meq/l depressed insulin secretion, and increasing magnesium from 1.2 to 2.4 meq/l resulted in a further depression. Glucose lowering of magnesium (but not calcium) poses problems because calcium is the antagonist of magnesium. This means that resultant higher calcium levels will further lower magnesium levels throughout the body. After eating a high-carbohydrate diet for years, magnesium deficiency and high calcium is often inevitable, perhaps from inadequate insulin. This relationship will not show up in blood magnesium tests, because 99% of magnesium is stored inside the cells, intracellularly, while much calcium is found external to cells. Only the Exatest or red blood cell magnesium (not whole blood or serum) tests will tell you the truth about your intracellular magnesium / calcium ratios. If intracellular magnesium is low and calcium is high, there is little doubt that high glucose / high calcium / low magnesium is the main cause of depression. The reduced intracellular magnesium alters the way cells open the door for glucose. The low-magnesium and high-calcium ratio causes the insulin-key to not fit in cellular-locks. Also, the intracellular magnesium and calcium content of the pancreas cells change. This makes the pancreas overshoot insulin. The next time you eat carbohydrates, the same events occur and it gets worse and worse. Eventually the pancreatic cells stop making insulin and frank diabetes results, requiring insulin shots. Consequently, the high incidence of diabetes occurring in depression and vise versa is explained. Further, type-2 diabetes is caused by magnesium deficiency, and can be cured even in the very elderly with magnesium in dosages like are used to treat depression. See this case report of an 86-year old woman, deeply depressed, cured of her diabetes using magnesium. See this Google.com search for " magnesium " and " diabetes " for the latest news. A diabetic's diet (avoiding foods with a high glycemic index) may be recommended for most people, but the main dietary culprit for those of us with borderline diabetes is simply to eliminate all candy, sugar, wheat breads, potatoes, beans and especially high dextrose content sweet products from our diets, getting us back to a diet more suitable to our paleolithic digestive system. Very briefly, we really, really need to get back to a paleolithic diet. Here is a google.com search for " diet " AND " diabetics " . Here are some recommended books concerning getting back to natural diets. Here is some on hypoglycemia and magnesium relationships. Here are over 200 links on google.com, wherein Dr. Mildred Seelig MD (a world-class magnesium expert) warns of the Western catastrophe of too much sugar and too little magnesium. In Dr. Seelig's new book (The Magnesium Factor), there is a 3 page list of alternate names for " sugar " , requiring careful reading of labels on processed foods. I prefer to avoid all processed foods, simply because sugar is in nearly everything processed by man. Diabetes increases myocardial (heart) calcium 400 times normal causing severe problems including many heart attacks through calcification of heart tissues. Eating regularly when not hungry can create a state of hyperinsulin secretion. Insulin increases appetite because it signals the need to transport sugar from the blood into the cells. The only known " remedy " for hyperinsulin secreters is hard exercise (60 minutes at 65% maximum heart rate capacity at least 4 times weekly). Seems like snacking on comfort foods would be helpful in depression and who of us can resist a chocolate bar when we feel bad. But snacking, particularly on high glycemic index foods like chocolate and other candies will always cause insulin to elevate, which will lower intracellular magnesium levels and worsen depression. Remember chocolate and candies are not natural foods but are processed foods. On the other hand, there are some instances wherein a food has a low GI value but a high " insulin index " value. This applies to dairy foods and to some highly palatable energy-dense " indulgence foods " such as jelly beans, Mars bars and yogurt. Some foods (such as meat, fish, and eggs) that contain no carbohydrate, just protein and fat (and essentially have a GI value of zero), still stimulate significant rises in blood insulin. At the present time, scientists don't know how to interpret this type of response (low glycemia, high insulinemia) for long-term health. It may be a good outcome because the rise in insulin has contributed to the low level of glycemia. On the other hand, I think it may be not-so-good, because the increased demand for insulin contributes to beta-cell " exhaustion " and the development of type 2 diabetes. Until studies are carried out to answer these types of questions, the glycemic index remains a proven tool for predicting the effects of food on health. Perhaps all that is needed to " safety " foods like these is additive magnesium. Clearly, carbohydrates require much more magnesium for their proper utilization than other foods. Here is a list of common foods by glycemic index thanks to the Integrative Healthcare website. The index implies an equal weight of foods. A much larger file (1 MB) of 1200 foods is available. This file is taken from the University of Sydney Glycemic Index website, which seems to be the most authoritative source available. GLYCEMIC INDEXES OF COMMON FOODSBreads & Grains waffle - 76 doughnut - 76 bagel - 72 wheat bread, white - 70 bread, whole wheat - 69 cornmeal - 68 bran muffin - 60 rice, white - 56 rice, instant - 91 rice, brown - 55 bulgur - 48 spaghetti, white - 41 whole wheat - 37 wheat kernels - 41 barley - 25 Cereals Rice Krispies - 82 Grape Nuts Flakes - 80 corn Flakes - 77 Cheerios - 74 shredded wheat - 69 Grape Nuts 67 Life - 66 oatmeal - 61 All Bran - 42 Fruits watermelon - 72 pineapple - 66 raisins - 64 banana - 53 grapes - 52 orange - 43 pear - 36 apple - 36 Starchy Vegetables potatoes, baked - 83 potatoes, instant - 83 potatoes, mashed - 73 sweet potatoes - 54 green peas - 48 Legumes baked beans - 48 chick peas - 33 butter beans - 31 lentils - 29 kidney beans - 27 soy beans - 18 Dairy ice cream - 61 yogurt, sweetened - 33 milk, full fat - 27 milk, skim - 32 Snacks rice cakes - 82 jelly beans - 80 graham crackers - 74 corn chips - 73 life savers - 70 angel food cake - 67 wheat crackers - 67 popcorn - 55 oatmeal cookies - 55 potato chips - 54 chocolate - 49 banana cake - 47 peanuts - 14 Sugars glucose - 100 corn syrup - 100 honey - 73 sucrose - 65 lactose - 46 fructose - 23 Beverages soft drinks - 68 orange juice - 57 apple juice - 41 Foods listed from highest to lowest glycemic index within category. Glycemic index was calculated using glucose as the reference with GI of 100. Modified from Foster-Powell and Brand Miller (1995). Concerning me, I used to get cardiac palpitations (up to one each 10 beats) from certain " high glycemic index " foods. I found that eating chocolate, candy, eggs or potatoes in large amounts started palpations within an hour, and avoiding these foods prevented them or lessened them. Meat, peanuts and fish had no effect. As an experiment, I used a few " pinches " of magnesium sulfate crystals (with an equal amount of fructose for flavor) dissolved and held in the mouth over a half-hour to stop these palpitations very rapidly, but they continued unabated if not treated with magnesium. Palpitations in me seemed to be a sensitive indicator of my immediate magnesium status. Magnesium ingested in this manner may be picked up by the lymphatic and venous systems surrounding the oral cavity area and appears transported directly to the heart — much like nitroglycerin. Magnesium supplementation is well known to terminate palpitations which are accompanied by mitral valve prolapse. In this same article, they showed that 54% of patients with emotional symptoms (anxiety and depression) had these symptoms resolve using magnesium. The literature does support the concept of imbalances between calcium and magnesium as causal for many episodes of cardiac palpitations and most more serious and deadly heart conditions. Perhaps Majid Ali, MD in his wonderful article entitled " Lions, Hypoglycemia, Insulin Roller Coasters, Heart Attacks " from his book What Do Lions Know about Stress says it best in his 5 faces of sugar-insulin dysregulation thesis. He writes of his conversation with his God-like-in-wisdom friend Choura, " Sugar is the primary villain in human metabolism. Excess sugar in food stresses human energy systems in many ways and causes the dysregulation of carbohydrate metabolism. Sugar-insulin dysregulation has five faces, " says Choura. " What are those faces? " Ali asked. Choura replies, " First, sugar creates sudden surges in blood glucose levels — a condition called hyperglycemia. Second, sudden hyperglycemia triggers the rapid release of large amounts of insulin from the pancreas—a condition called hyperinsulinemia. Third, the insulin response to high blood sugar overshoots its mark and drives the blood sugar level below the normal range—a state of low blood sugar called hypoglycemia. The fourth face of glucose-insulin dysregulation is the insensitivity of insulin receptors at cell membranes (peripheral insulin resistance). The fifth face of glucose-insulin dysregulation is too much adrenaline—a state you may call adrenergic hypervigilance. When an insulin surge drives sugar below the desirable range, the adrenal glands kick in and dispense blasts of adrenaline to counter the insulin. Adrenaline is one of the most—if not the most—potent oxidant in the human body. The oxidative fires lit by adrenaline overdrive the heart causing arrhythmias, tighten arteries producing high blood pressure, rev up nerve-muscle conduction sites causing stiff muscles, jitters and sweating. And that sugar-insulin-adrenergic dysregulation is what the stress specialists call the 'STRESS RESPONSE'. " I am breathless in the face of this wisdom-of-the-ages. I can't help but realize, here we are again; right back at the stress response that we know drives down magnesium levels and causes our depression. We now also see that sugar drives intracellular levels of magnesium down, which independently causes depression — counter to what we intuitively believe. What are we to do about our love affair with sweets? Are we doomed to a life without sweets to avoid depression, heart attacks and most of the other illnesses that plague Western society? Many people have a sweet tooth, brought on by the opiate-like activity of sweet carbohydrates. Yes we are talking about addiction. Complete elimination of sweetness from our diet is not desirable or practical. Fortunately there is a very sweet food, fructose, that is extremely low on the glycemic index. Fructose (GI 20) is a natural sugar, a monosaccharide and the mirror image of glucose. Fructose has exactly the same amount of energy, 4 kcal/gram as sugar or dextrose but it is up to twice as sweet as sugar therefore much less is required for sweetness. Fructose, fruit sugar, is the natural sweetener found in all fruits. Orally ingested fructose travels to the liver and can be used there without the need for much insulin. Fructose is converted to glucose in the liver and contributes to an increase in blood glucose, rather than being stored as glycogen. Unlike sucrose and glucose which cause quick changes to the blood glucose levels and disrupt the metabolic control of a person with diabetes, fructose is absorbed more slowly and causes fewer changes in blood glucose levels. Fructose does not interfere as much with the magnesium / glucose ratio, perhaps because only one-half of the amount of fructose produces the same sweetness as sugar. Fructose is available at health food stores, but its table use may not be totally satisfactory because it is hygroscopic, meaning it will become wet from moisture that it picks up from the air. Its primary use in foods is in cooking and preparation of sweet drinks. Alternatively, to satisfy a sweet tooth, and totally avoid aggravating depression, use Stevia, the ultra safe, herbal, top secret, super-sweetener that the FDA doesn't want you to know about. Avoid potatoes and eggs (the Classic Mexican-American breakfast-taco which causes diabetes in astonishing numbers) with their complex carbohydrates, which can have a greater impact on insulin than pure sugar. Regardless of your dietary interests, try for a maximum of 30 grams of carbohydrates a day. Keep your intake of high glycemic index foods to a minimum. Eat your steaks and balanced Omega-3, -6 and 9 fats, because cholesterol has nothing to do with heart attacks, but a too low cholesterol has much to do with involuntary suicide, as you will be reminded here. On the other hand, there is also reason to be cautious about fructose, a very sweet carbohydrate. Ledochowski et al. at the Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria found in 2000 that elimination of fructose and high fructose content fruits from the diet has great benefit in treating depression in people that do not metabolize fructose or sorbitol correctly. They found that when fructose is not well absorbed, when it reaches the colon it is broken down by bacteria to short fatty acids, CO2 and hydrogen gas resulting in bloating, cramps, osmotic diarrhea and other symptoms of irritable bowel syndrome. They showed that fructose malabsorption is associated with early signs of mental depression and low serum tryptophan concentrations. They found that a fructose-reduced diet could not only improve gastrointestinal complaints but also reduced depression scores by 65 percent after 4 weeks of diet (P < 0.0001), and there was a significant reduction of abdominal distension (P < 0.0001) and stool frequency (P < 0.01). Improvement of signs of depression and of abdominal distension was more pronounced in females than in males. They concluded that fructose- and sorbitol-reduced diet in subjects with fructose malabsorption does not only reduce gastrointestinal symptoms but also improves mood and early signs of depression. Consequently, if you have bloating, cramps, diarrhea or other bowel symptoms, you should eliminate all fruits from your diet and not use fructose or sorbitol as a sweetener. You know that alcohol is a carbohydrate. But did you know that alcohol is a very large contributor to low magnesium and depression, as well as dehydration, anxiety, osteoporosis, heart problems and diabetes? Study " alcohol " and " magnesium deficiency " on google. Got a hang-over headache? Try magnesium. Think about it. Back in the early '60s when I was in the old Strategic Air Command (SAC), when we got drunk and the APs rounded us up and escorted us back to the barracks, they gave us really large doses of vitamin B-6 (which is vital for magnesium metabolism), and we were usually sufficiently sober the next day to pass for being " present for duty " . Magnesium would have been better. Dr. Ricardo Brown at Wayne State University found that acetaldehyde (the extremely toxic breakdown product of alcohol) reduced calcium entry into heart cells, which reduced inter-cellular exchanges that allow the heart to pump. The exposure to alcohol also caused cardiomyopathy, a condition in which the chambers of the heart are dilated more than normal. From there, Dr. Brown looked into whether those who suffered from diabetic cardiomyopathy or hypertension were worse off than those with normal hearts in response to alcohol consumption. Again, using diabetic or hypertensive rats as models, he found that the ability of the heart to contract in the presence of alcohol was even more depressed. His findings, published in the European Journal of Pharmacology for reduced heart damage from acetaldehyde toxicity was to supplement with magnesium, thus helping to restore proper calcium levels. He showed that in rats the cardiac damage from alcohol was much lower when large amounts of magnesium was added to the diet. Drunks urinate (waste) very large amounts of magnesium. I can hear it now, one drunk says to another, " Hey, Billy-Bob, pass me the magnesium. " The other drunk says, " No way Jose, get your own. " Remember that being stupid is a right, but being too stupid is a wrong. Although some alcohol-industry funded research suggests that small amounts of alcohol daily are healthful, perhaps by releasing magnesium from bone storage depots, I will not waste the non-alcoholic's time in discussing this totally preventable health risk (alcoholism) any further. For me, any alcohol is too much. Wanna hear a really good military story? While I was in SAC, I had a 1951 Buick with a bad transmission. One day I found that some stranger was removing the motor from my car with a portable hoist. Actually, he was stealing it. I called the California Highway Patrol and they arrested him and hauled him off to jail. The following Monday, I was recounting this story to my Captain, when the Mather AFB commander called. The General was in a rage, and he wanted me and my Captain front-and-center in his office in an hour. Why me? I was just a lowly airman. When we got there, we saluted and stood tall, not having the slightest idea of why we were there, and we were a bit scared. The General accused me of having his top B-52 crew chief locked up on a trumped-up charge of stealing my motor. Well, George was not going to have anything to do with that, so I explained the facts to him. He really didn't like it and was fuming mad, certainly he was having palpitations. He told me that my actions effectively grounded one of his B-52 bombers that was needed for his Crome Dome missions. Crome Dome was an Air force program that used B-52s loaded with hydrogen bombs to cruise off the northern coast of the old Soviet block, an action which threatened life on this planet in a program eventually called Mutually Assured Destruction (MAD). Well, the discussion and debate got really heated, but when it was all over the general told me that he would trade my motor for his B-52! Hummm. Sounded good to me, but I drove a hard bargain and got the general to fix my Buick's transmission too. I am probably the only person on Earth to have ever held a B-52 hostage for a Buick motor! There are a number of minerals such as zinc, vanadium and chromium that are vital to carbohydrate metabolism. Without adequate intake of these minerals, life is not possible, and premature death, cancer, cardiovascular disease, and diseases of aging (including depression and insomnia) occur. Insulin is often called " insulin zinc " because of the essential role played by zinc. A dietary intake of more than 15 mg zinc per day is required for good health, and intake of 100 mg per day has been shown to improve cellular immunity in old people and younger people, while 300 mg per day for 6 weeks impairs cellular immunity. The best source of supplemental zinc is zinc gluconate. GTF chromium is an essential insulin cofactor too. GTF stands for Glucose Tolerance Factor. Although 65% of the public has glucose intolerance, 90% of the public is low in chromium, thus our ability to regulate sugar is seen as a chromium deficiency - but there is more because high glucose diets flush out chromium 3 times faster than low glucose diets. Chromium picolinate has long been recommended to enhance glucose handling, but " picolinate " is a pancreatic excretory product and is no longer recommended for use in dietary supplements. A B-vitamin complex of chromium called chromium nicotinate is found to be three-times more readily absorbed than other forms of chromium and is now recommended. The National Academy of Sciences recommends 50 to 200 mcg of chromium daily, but less than 10% of the public gets 50 mcg per day from their diet. Supplements of chromium in 200 mcg daily doses (1 or more daily) are needed by 90% of the public and all people having problems with high glycemic index foods. Me? I use 400 mcg chromium with each meal and bedtime to support my magnesium taurate dosages. WARNING: This much chromium as " chromium picolinate (GTF chromium) " would be highly toxic. Picolinate is the toxic ingredient. This toxicity is particularly embarrassing to the U.S. Department of Agriculture since they developed it, patented it and continue to support it. Vanadium can mimic the role of insulin, reducing the need for insulin. See this google.com search for " vanadium " and " glucose " . Dietary supplements of vanadium [as vanadyl sulfate 5000 micrograms (equivalent to 975 micrograms vanadium)] several times a day may be very beneficial in lowering the need for insulin, and is a hot topic of current interest amongst researchers and body builders. I am experimenting with vanadium and I take two tablets of 975 mcg vanadium with each meal and bedtime. I am finding that these minerals appear to greatly stabilize magnesium balance and seem to prevent its urinary loss. What is interesting here is the absence or deficiency of these minerals can reduce the effectiveness of insulin on sugars thus leading to " magnesium wasting disease " which leads to depression. Redistribution of magnesium by insulin shots into cells may cause lower magnesium serum levels, which should be interpreted as beneficial not detrimental. Throughout this section on " Killer Sugars " , I have acted as if we all knew what our blood sugar was supposed to be. You have been told by your doctor that the range was " 65 to 109 mg/dL " . Life Extension magazine editor William Faloon presents a powerful case that such reference numbers are pure garbage. He presents his point with the observation that the pancreas, the body's main blood glucose level regulator, stops secreting insulin when glucose levels drop below 83 mg/dL, this data having been published in HARRISON'S PRINCIPLES OF INTERNAL MEDICINE, Thirteenth Edition, McGraw Hill, 1994, pages 2001 - 2004. Faloon's point is that " the pancreas thinks glucose levels should be no higher than 83 mg/dL and certainly not as high as physicians say to be " normal " , which is a reference range of " what is observed " in our sick population, and not what it would be in a healthy population. Following the diet I present below for five months lowered my blood sugar level one hour after lunch to 84 mg/dL. In a study of 2000 men over a 22 year period, the research showed that men with fasting blood glucose values over 85 mg/dL had a 40% increased risk of death from cardiovascular disease than those with lower blood glucose in otherwise healthy men. Getting sugar out of our diets will not only keep depression away but will keep us living longer. Succeed! Depression is not a psychosis! Milk & Calcium Toxicity The third dietary cause of inadequate intracellular magnesium is competition by calcium. This is one very obvious cause, particularly to people who have gone off their ridiculous calcium supplements and dairy products diet and gotten much better in just a day or two. To those people that refuse to eliminate calcium supplementation (perhaps due to previous advice from a physician), I offer my condolences and hope that you have a good long-term health care insurance policy. People ask me if I worry about not getting enough calcium by " over " emphasizing magnesium. People seem to want to supplement their already calcium-rich, dairy product laden diets with calcium too, not magnesium. Some people are actually afraid to stop drinking milk, even though they are toxic from drinking too much of it and supplementing with calcium to theoretically " prevent osteoporosis " . Why? The dairy industry has used " osteoporosis prevention " as a marketing tool for calcium. However, milk and calcium supplements do not seem to be the correct answer. In countries where dairy products are commonly consumed, there are actually more hip fractures than in other countries. When put to the test, most studies show that dairy products and calcium supplements have little effect on osteoporosis. As surprising as that may be, when researchers have measured bone loss in postmenopausal women, most have found that calcium intake has little effect on the bone density of the spine. There is also little or no effect on bone at the hip, where serious breaks can occur. Some studies have found a small effect from calcium intake on bone density in the forearm. The overall message seems to be that, as long as one is not grossly deficient in calcium, calcium supplements and dairy products do not have much beneficial effect. Science magazine (August 1, 1996) noted: " ...the large body of evidence indicating no relationship between calcium intake and bone density. " Why not? For one thing, hormones very carefully regulate the amount of calcium in bones. Other studies have shown that increasing magnesium intake increases bone absorption of calcium. Why? The balance of calcium and magnesium must be maintained, and since there is plenty of calcium in our diets, bone density increases from extra magnesium is an automatic reaction. On the other hand, simply increasing calcium intake does not fool these hormones into building more bone, any more than delivering an extra load of bricks will convince a construction crew to build a larger building. Psychiatrists have known for many years that loss of hormonal control of calcium causes severe mental illnesses (dementias) including depression. Apparently, long term, stress with excessive calcium intake and limited magnesium intake can cause loss of hormonal control of calcium. What happens to people that go cold-turkey on dairy and calcium supplements? In the spring of 1998, I had a heel bone density test done using the new FDA approved Sahara ultrasound test for osteoporosis, which is made by the Hologic Company. The test cost me $20 and was totally painless, as are all ultrasounds. It was conducted by a respected local clinic, so what did I have to loose? My 1998 test result was taken when I was 58. I had a new test done in Spring of 2003. These are my test results for 1998 and 2003. My wife said I was (and still am) very hard headed, and these tests confirm her observations. Until I became depressed in 1999, I had been practicing the high-calcium-is-good-for-you-concept too. My bone density has fallen a bit, but my bone density is still 1 standard deviation higher than average. My heel bone density remains high, and T-Scores changed from +0.6 to +0.1 over the five years. These T-Scores are indicative of very low risk of bone breakage from osteoporosis. Obviously my bone density was not damaged by no-more-calcium-than-I-can-obtain from vegetables. Also, I drink de-ionized (essentially distilled) water without any mineral content, so that is not a source of hidden calcium. My mental health is much better with low calcium and I very much believe in very low calcium as a healthy way of living, but only if there is adequate magnesium. Please contact Hologic and find a local clinic that can do this test for you before you terminate calcium. Recheck each year. Calcium toxicity is something that even the National Dairy Council has a great concern, saying near the bottom of their page: " However, overuse of calcium-fortified foods, calcium supplements, or antacids containing calcium may increase risk of calcium toxicity, characterized by high blood levels of calcium, kidney damage, and calcification of soft tissues. " High blood levels of calcium are called hypercalcemia, which can cause: nausea, vomiting, alterations of mental status, abdominal or flank (kidney) pain, constipation, lethargy, depression, weakness and vague muscle/joint aches, polyuria, headache, coma (severe elevation) and death (particularly in the elderly who are more sensitive to excess calcium). Kidney damage includes kidney stones. Do you really want to have " calcified soft tissues " ? They include calcified arteries (hardening of the arteries), calcified heart valves (mitral valve prolapse), and calcified tendons. As we age, calcium also accumulates in the soft tissues of the body. When calcium deposits in dead tissue, it is called dystrophic calcium (like atherosclerotic plaques). When excess calcium becomes deposited in living tissue, it is called metastatic calcium (like arteriosclerosis). Heart attacks and death often result from excess accumulations of calcium in these conditions but do not occur from excess magnesium, which appears highly protective. When calcium gets into cells, the cells turn on, whatever " on " is for those cells. In the case of stress-induced depression and related mental disorders, the cells are the neurosynaptic cells of the brain discussed in depth here. When calcium enters a muscle cell, the muscle contracts. If excessive calcium stays there, the muscle stays contracted and results in severe pain. The familiar knots in our upper backs and necks are just such calcified muscles that are stuck in the " on " or contracted position. The pathological version of this condition is called fibromyalgia where there are many such knotted muscles. The extreme example of this is rigor mortis (as in death), in which all the muscles of the body are flooded with calcium and contract - permanently. As we age, we accumulate more and more dystrophic and metastatic calcium, and become stiffer and stiffer. The solution, balance excess calcium with excess magnesium, or simply don't indulge in the Calcium-At-Any-Cost campaign! Feel like you have been lied to? Yes? You are right. Interestingly, physicians now, (finally) report that low blood calcium can be caused by underactive parathyroid glands, low calcium in the diet, severe burns or infections, pancreatitis, kidney failure, or low blood magnesium. Which of these six possible ways to develop low blood calcium is most likely to be cause of low calcium in the Western diet? Anybody remember magnesium fortification or magnesium promotions by any company? Any danger here? No. How about calcium promotions and advertisements? Aren't they everywhere? Yes! Given this apparent intent to poison Americans with calcium, why would anyone be concerned at this juncture about overdoing magnesium? Is this Al Qaeda's secret weapon for killing Americans? NO! We invented this one all by ourselves, probably thanks to the NIH's unbalanced consensus statement on calcium (a monograph absent balance with magnesium). Nothing that I am saying should be construed to mean anything more than we must feed ourselves in a way that keeps our magnesium and calcium balance correct, or, in many of our cases, reestablish a proper, healthy calcium magnesium balance, nearly always by reducing calcium overloads and increasing magnesium. If we don't want to balance our calcium and magnesium ratios using supplemental magnesium and a low calcium diet, we can always allow psychiatrists to do it with electroconvulsive therapy (ECT). All of these effects are exaggerated in space flight, and pose serious problems of heart attacks during flight and post flight. In addition to the previously described ischemic mechanisms which may lead to calcium overload of the myocardium and the arterial wall, and potentially leading to a myocardial infarction, other conditions complicating space flights, can precipitate calcium overload with cell necrosis, i.e. catecholamine elevations, insulin resistance and magnesium ion loss and deficiency. A major effort is in place to maintain magnesium serum levels during space flight, because loss of magnesium during space flight is found to be a limiting factor on space flight duration. The loss of magnesium is much greater in men and current interest in women in space flight is stimulated by their lower losses of magnesium. Candida albicans yeast is a serious problem in space flight because it depletes acidophilus bacteria and would greatly reduce magnesium absorption. One might hypothesize that female astronauts are strongly interested in preventing vaginal yeast infections in space flights and that they use acidophilus, a major promoter of magnesium absorption prophylactically, thus explaining these differences. Scientists and physicians will want to read this ten-page report titled " Calcium and Magnesium Deposits in Disease " , by Mildred S. Seelig, MD, MPH of the American College of Nutrition, a world-class expert on magnesium. This article points out that most abnormal mineral deposits are calcareous, occurring in areas of tissue damage that can be caused by magnesium deficiency. Topics covered: Mineralization of arteries and heart by calcium excess, magnesium deficiency. Atherogenic and/or calcemic diets. Low magnesium and spontaneous myocardial infarction. High vitamin-D and/or phosphate diet intensifies magnesium deficiency. Stress and catecholamines. Mitochondrial lesions of ischemic hearts resemble those of magnesium deficiency. Diabetes increases myocardial calcium (Ca) 400 times normal. Mineralization by calcium of human arteriosclerotic arteries with aging due to lifelong magnesium deficiency. Infantile and juvenile cardiovascular calcification resemble experimental magnesium deficiency. Cardiovascular calcification in diabetes mellitus and renal failure, kidneys, urolithiasis, effect of magnesium in preventing. Soft tissue calcification inhibition by magnesium. Chrondrocalcinosis, enlarged joints, pseudogout Ca-PP-dihydrate. Apatite formation. Inhibit subcutaneous calcification by injection of CaATP with magnesium. Articular calcification of uremia. Interstitial and periarticular calcinosis. Myositis ossifacans. Tendons. Fluoride toxicity. Vitamin-D toxicity. Placenta calcification. Pancreatic calcification. Ocular calcification. Cardiovascular damage prevented by magnesium. These and other similar conditions, even in absence of magnesium deficiency, may be responsive to magnesium treatment over a one year period. The " Calcium-At-Any-Cost " campaign currently underway in the United states appears identical to the " Vitamin D-At-Any-Cost " campaign of the early part of the twentieth century. After many years of campaigning for a diet richer in vitamin-D, people began to get far too much with serious consequences. Normal exposure to sunlight provides enough vitamin-D to satisfy healthy bodily processes for most of us (exceptions including clinical cases of Season Affective disorder (SAD), and possibly dark-skinned people living in low-sunlight conditions). Supplementing with vitamin-D, pills, enriched breakfast foods, milk, and other sources of vitamin D led to an epidemic of calcification of soft tissues, such as the kidney, heart, aorta, muscle, hypercalcemia, decalcification of bone, muscular weakness, joint pains, and various other symptoms, all being symptoms of excess calcium. The " Vitamin D-At-Any-Cost " campaign was replaced by the " Calcium-At-Any-Cost " campaign, which has failed us too. It is time to get serious and address the real problem, magnesium deficiency. EDITORIAL OPINION: If a health consciousness revolution occurs and magnesium gets the attention currently afforded calcium, great displacement is likely in medicine, because much of modern clinical practice appears built on the foundation of faulty calcium-magnesium balances. For those of us that have consumed too much calcium relative to magnesium, excess calcium has become a neurotoxin. For example, I used to be so sensitive to calcium, that a single 500 mg calcium dietary supplement induced in me a strong feeling of depression within 1 hour (relievable with 400 mg magnesium). To me, this is clear evidence that either treatment-resistant or stress-induced depression are not necessarily psychological or psychiatric disorders (although depression certainly can be). Rather, these forms of depression are a disorder of calcium / magnesium balance. Many people, women usually, e-mail me saying that magnesium did not terminate their depression. I always respond with a request for them to review their dietary supplements and dairy intake for calcium. Invariably, they report between 1000 and 2000 mg daily intake of calcium, as dietary supplements plus dairy, or that they used a non-ionizable compound of magnesium, such as magnesium carbonate, magneisum oxide or magnesium hydroxide. People have also used magnesium chelates of undescribed nature, magnesium aspartate or magnesium glutamate with greatly worsened symptoms. I report back to them that in my opinion their calcium intake is preventing their recovery and their choice of magnesium compounds is wrong. Those that make the suggested changes usually report back to me with really nice words of praise and thanks you notes for their very speedy recovery. From these results and others, we can infer that large doses of ionic magnesium in the treatment of depression and other disorders either: (a) restore hormonal control of calcium or (b) rebalence the calcium / magnesium serum ratio. In my opinion, re-balancing the calcium / magnesium ratio is more likely. Why? The effects of magnesium, although extremely strong, are short-lived; and continued magnesium supplementation is usually required to maintain well being. If hormonal control were re-established, it seems to me that we would not need continued large doses of magnesium daily. This is not to say that over a long time, hormonal control may eventually result, particularly if we eliminate sugar and other high glycemic index foods from our diets and supplement with chromium and possibly vanadium. Viewed under a dark field microscope, these red blood cells taken from a Gulf War medical reporter show many small spikes sticking out from their surfaces. These cell-surface spikes are produced by severe intracellular magnesium depletion and excess calcium resulting in echinocytes. I wonder if presence of echinocytes is predictive of who will benefit from magnesium therapy in treatment of depression and other disorders. I suspect magnesium treatment eventually eliminates echinocytes, restoring the picture of normal red blood cells. From this microphotograph, overdoing calcium supplements and foods rich in calcium (especially dairy products) and ignoring magnesium dietary intake appears to result in visible cellular " calcium toxicity " . This photograph is amazing; and should illustrate a new way of determining severe, potentially life-threatening calcium/magnesium imbalance. The presence of spikes would prevent spiked blood cells from flowing smoothly through arteries and veins. It seems to me that spiked red blood cells (echinocytes) passing through the arteries and arterioles of the heart and brain could trigger strokes and heart attacks and all precursor symptoms associated with these disorders. Remember magnesium is used to regulate receptor sites for neurotransmitters, and is active in the hippocampus (the emotional center of the body). Our children may be at great risk because they think they need to remain thin to be accepted. Those foods that are high in magnesium that would help them cope with the stresses of growing up (school yard bullies, PMSing teen girls, and teen life in general) are not on their plates. However, milk and cheese products are on their plates, and calcium/magnesium imbalances may contribute to school violence in manic or manic depressive (bi-polar) students. Without enough magnesium, these young people can loose control over their moods, sometimes with devastating results. Violence or meanness to others has not been reported in the medical literature to be caused by insufficient magnesium except in some ADHD, mania or manic-depressive patients. Consequently, I am not worried about ADHD, manic, manic depressive, or depressive patients getting too much magnesium, rather I am concerned that our calcium / magnesium balance be corrected. My worries about milk are additive to what some scientists worry about concerning homogenized milk. " Homogenizing cow's milk transforms healthy butterfat into microscopic spheres of fat containing xanthine oxidase (XO) which is one of the most powerful digestive enzymes there is. The spheres are small enough to pass intact right through the stomach and intestines walls without first being digested. Thus this extremely powerful protein knife, XO, floats throughout the body in the blood and lymph systems. When the XO breaks free from its fat envelope, it attacks the inner wall of whatever vessel it is in. This creates a wound. The wound triggers the arrival of patching plaster to seal off that wound. The patching plaster is cholesterol. Hardening of the arteries, heart disease, chest pain, heart attack is the result. " Atherosclerosis,1989;77:251-6. If you really want the scoop, and don't mind reading about the " pus " in milk, enjoy this site. Milk gives people gas too. Some depressed people appear to need more calcium because laboratory tests show that they are in a negative calcium balance. That means they leak not just magnesium (hypomagnesemia), but calcium too. They may have accelerated bone loss perhaps from post menopausal osteoporosis or other diseases or disorders. They are in a bad predicament. If they increase calcium they often become more depressed. If they decrease calcium they believe that they risk breaking bones from osteoporosis or osteomalacia. Magnesium deficiency is usually associated with hypocalcemia (low blood calcium), hypophosphatemia (low phosphate), and/or hypokalemia (low potassium). Hypokalemia or hypocalcemia are important clinical complications of hypomagnesemia. When a person is unresponsive to treatment for hypokalemia or hypocalcemia, magnesium may have been depleted. What to do? The medical literature clearly supports taking more magnesium and taking boron supplements or eating foods high in boron to help prevent the loss of these critical minerals. Hypokalemia can also be treated by switching from plain table salt (sodium chloride) to Morton's Lite Salt (50/50 sodium/potassium chloride), or preferably by switching to Morton's Salt Substitute (nearly pure potassium chloride). Hypocalcemia has been treated with calcium supplements, but in depression and hyperemotionality, the doses needed are much lower and can be easily be obtained from lower calcium content food (non dairy). How about CalMax, the heavily TV promoted calcium supplement with magnesium? NOT FOR US! NO! Why not? First, CalMax is very expensive, and second it has a highly absorbable compound of calcium (calcium gluconate) and a poorly absorbed magnesium compound (magnesium carbonate). Although CalMax is on the right track, the ratios of calcium (400 mg per dose) versus magnesium (200 mg) are biologically misleading because the calcium is so much better absorbed than magnesium. I estimate that CalMax is the biologically functional equivalent of 400 mg calcium and about 75 mg of magnesium. Consequently, to get 1000 mg (for example) of biologically available magnesium from CalMax daily, one would also get over 5000 mg of calcium, which is decidedly unhealthy. How about Coral Calcium? HA! How about Caltrate? HA! You figure these out for yourself! Calcium has been hyped as an anti-cancer agent recently on TV. However, these scientists reported in 1986 that large amounts of calcium supplements are promoters of cancer relative to the clear anti-cancer action of both zinc and magnesium supplements. These scientists reported in 2003 that large supplements of calcium increase the rate of prostate cancer. This is not to say that normal intake of calcium found in foods causes cancer, rather large amounts of supplemental calcium does nothing to help prevent it and appears to promote prostate cancer. Cadmium is a well-known cancer causative agent, which is inactivated in the body by both zinc and magnesium supplements but not by calcium supplements according to these scientists. Consequently protection against cancer is afforded by zinc and magnesium supplementation, but not large doses of calcium supplements; and very large intake of calcium supplements should be considered to be promotive of cancer. In fact, a comprehensive review of the evidence links the consumption of milk from cows treated with bovine growth hormone (IGF-1 or insulin-like growth factor 1) with an increased risk of breast, prostate and colon cancer. IGF-1 is known to stimulate the growth of both normal and cancerous cells I had an Exatest intracellular mineral test done in March of 2003, 3 years after starting and very carefully maintaining a low calcium diet (zero calcium supplements, and nearly zero dairy products). I was concerned that after 3 years of extremely low calcium intake that perhaps I had " over done it " . I was very surprised to find that my intracellular calcium was out-of-range-HIGH. The high intracellular calcium made my intracellular phosphorous/calcium ratio extremely low and my intracellular magnesium/calcium too low. I had tried to limit my sodium intake (like our doctors tell us to do), and was amazed to find that both my intracellular potassium and sodium levels were also out-of-range-LOW. See my full report from IntraCellular Diagnostics here for overall results and here for individual element concentrations and ratios. I strongly urge all to take this test before starting a magnesium repletion program and monitor progress after first month of treatment, and again on a regular monthly or bi-monthly basis. You may be surprised to find very low intracellular magnesium and very high intracellular calcium are seriously affecting your health. To avoid possible circadian rhythm errors, test at the same time each day, preferably between 9 and 10 AM. Why do you think we have been lied to about the extreme importance to supplement our diets with calcium? Why do you think that billions of people throughout the non-Western world have never supplemented their diets with calcium and never drink milk and have no osteoporosis? This figure from Dr. Seelig's new book (The Magnesium Factor) shows that in 1977 Western countries having the highest dietary calcium to magnesium ratios (Finland, United States and Netherlands) had rampant ischemic heart disease. More data here. On the other hand, Japan with a one to one ratio of calcium to magnesium had about 1/10 the incidence of ischemic heart disease. Why do we keep pushing the idea that more and more calcium is healthy; when in fact, it is a principal cause, perhaps the main cause, of heart disease and deaths in the United States? Are there some vested commercial interest at work here? Why doesn't the National Institute of Health speak to this horrifying issue? Why doesn't the Food and Drug Administration act? Why do doctors, nutritionists and dietitians push this toxic drug? Are they stupid? If there is any good to come from taking away our rights to free choice of vitamins, minerals, herbs and amino acids through implementation of the treaty provisions of CODEX, one would hope that calcium supplements would be prohibited. Not likely! I suspect that vested interests will prevail and magnesium supplements will be restricted, but not harmful calcium, sodium or sugar. Dr. Seelig points out that immediately after this data was released in 1978, Finland took action and people started consuming much more magnesium and potassium and much less calcium and sodium, and that now Finland has a ischemic heart disease rate lower than Japan. Did the U.S. take similar action? Ha! You gotta be kidding! Like calcium and magnesium, phosphate is essential to every cell in humans, plants, animals – every living thing. It is necessary for many of the biochemical molecules and processes that define life itself. Phosphate is a charged group of atoms, or ion. It is made up of a phosphorus atom and four oxygen atoms (PO4) and carries three negative charges. The phosphate ion combines with various atoms and molecules within living organisms to form many different compounds essential to life. Some examples of phosphate’s role in living matter include: (1) Giving shape to DNA (Deoxyribonucleic Acid), which is a blueprint of genetic contained in every living cell. A sugar-phosphate backbone forms the helical structure of every DNA molecule, playing a vital role in the way living matter provides energy for biochemical reactions in cells. The compound adenosine triphosphate (ATP), which is extremely dependent upon adequate magnesium for its function) stores energy living matter gets from food (and sunlight in plants) and releases it when it is required for cellular activity. After the energy, in the form of a high-energy phosphate bond, is released the ATP becomes a lower-energy adenosine diphosphate (ADP)or a still lower-energy adenosine monophosphate (AMP) molecule. These will be replenished to the higher-energy ATP (or ADP) state with the addition of phosphate by various mechanisms in living cells. The forming and strengthening of bones and teeth. We get phosphate from the foods we eat. These examples show the phosphorus content of some foods (mg/100 grams of various foods). Milk 93 Lean Beef 204 Potatoes 56 Broccoli 72 Wheat Flour 101 Cheddar Cheese 524 Do we get too much phosphate? For some people eating too much cheese, yes, they are getting too much calcium and phosphate, contributing significantly to magnesium deficiency. High phosphate (phosphoric acid) content soda (Coca Colas and Pepsi Colas) probably should be avoided, if for no other reason they are also high in glucose. Am I greatly worried about too much phosphate in our diets? Not yet, but only if we avoid cheese and its dual phosphate and calcium load. In summary, we can do much with our diet. We can ingest enormous amounts of magnesium (and fight off diarrhea), or we can save money by using less magnesium, ingest few or no high carbohydrate foods (especially sugar, corn syrup, soft drinks, alcoholic beverages, bread, rice, cakes, pancakes, waffles and potatoes), terminate our fascination with dairy and calcium (along with cheese's excessive phosphate), and supplement with probiotics to regain our mental health and defeat depression. Also, we will not need those nasty antidepressants! What's Left To Eat? After reading what not to eat (mainly calcium and sugar), you are probably wondering what is left to eat. The natural food pyramid on the right shows what I eat every day. It is different from the USDA fodder pyramid in that no man-made refined carbohydrates are eaten, as per the strickest version of the Atkins diet. I hardly ever (about once or twice a year - when trapped at someone's party) eat refined wheat products, breakfast cereals, waffles, pancakes, bread, cake, candy, french fries, pasta, rice or other starchy foods of any kind. These highly refined carbohydrate foods are the entire bottom row of the USDA fodder pyramid and are the main cause of obesity and ill health in America. Even though fats have twice the calories of carbohydrates, fat people have eaten vastly more carbohydrates than fats, often in an ill advised attempt to prevent or control depression. The entire bottom row of the antiquated USDA fodder pyramid is essentially " processed (man-made) foods " , and many are also high in neurotoxic glutamates and very low in magnesium, manganese, potassium and vitamins found in the raw grains from which they were made. I avoided them entirely for a few months and lost ten pounds per month during the first 5 months. I now feel much better about my weight. Then, my weight stabilized at a very fit 165 pounds for my 5 foot 10 inch frame. The benefits of the natural food pyramid include weight loss, high vitamin and mineral content, lower food cost, low insulin requirements and absolutely no food craving. Better yet, my blood pressure fell to 100/60 and my blood sugar fell to 84 mg/dL. Why no craving? Because the carbohydrate foods that I no longer eat have an addictive property due to insulin production. Once a person stops eating them, the cravings disappear. Popcorn? Tacos? Yes! Anytime! Cheese? Not for me, except for cottage cheese, which is low in calcium and wonderfully high in taurine (1700 mg per cup). Meat? Yes, bring it on buddy! Fish? Of course! Fresh beans, tomatoes, pears, apples, dates, raisins, grapefruit, eggs, nuts, peanuts, cashews, vegetables of all kinds (except potatoes), yes! WARNING: An alternate sources of potassium, which is high in potatoes, is needed if potatoes are eliminated from the diet to avoid serious health problems. Foods high in potassium include fresh tomatoes, bananas, beet greens, dates, raisins, grapefruit, soybeans, lima beans and other foods shown on this USDA list of foods (by their potassium content), or on this easy to read table. When you think " bananas are high in potassium " , remember that it would take about ten of them a day to give the RDA for potassium. Processed foods like cakes, Twinkies, doughnuts, puddings, Jell-O, beer, chocolate or candy? No. Once my carbohydrate intake dropped, my craving for them disappeared too, and I now look at them like other people look at globs of fat! Yuck! Vitamins, minerals and balanced sodium and potassium (Morton's Lite-Salt) salt? Yes, of course! One would need be an idiot not to consume an adequate supply of repair parts for one's mind and body! We are what we eat, and I am built mainly of protein, not carbohydrate. Why would anyone build their body with excess carbohydrates to be fat? Sure, we need some carbohydrate for fuel and amino acid production, but an excess will always be stored as fat. If you want carbohydrates as well as wonderfully balanced minerals, try cashew nuts. Interestingly, significant avoidance of dangerous trans fatty acids (trans fats) occurs on this diet. These are the man-made fats (shortening, partially hydrogenated vegetable oils and hydrogenated vegetable oils). Eat butter and use olive oil and coconut instead! They won't hurt you! Remember that the USDA's main role is to promote agriculture, not necessarily human health. Read Marion Nestle's eye-opener book Food Politics. Did Atkins discover something new? No. Apparently, the high carbohydrate diet was first found to cause obesity in 1863 by William Banting, and a diet very similar to this diet was found effective in weight loss and appetite suppression. According to Carol Hoernlein of the msgtruth.org site, we all must be very careful when restricting carbohydrates, because an imbalance of certain amino acids is possible with unintended, adverse consequences. Tyramine is an amino acid that can be deadly to some taking certain medications like MAOI inhibitors. The blood pressure can raise dangerously high. It is usually a medicine - food interaction when it is deadly. In cases of folks who are sensitive to MSG, tyramine usually just gives them a headache, but it is quite upsetting. The other problem with tyramine is that amino acids like it and tyrosine compete for uptake into the brain with tryptophane. Foods that were found to have high (possibly dangerous) concentrations of tyramine included chicken liver, air-dried sausage, soy sauce, draft beer, aged-cheese, tofu, sauerkraut and others. When you don't eat enough carbohydrates (complex carbs are best) - and eat just protein (a perversion of the Atkins diet), tyrosine wins the battle and gets to the brain first where it acts as an " upper " . Tryptophane is the loser in the race, but the brain needs tryptophane to make serotonin - the feel good calming stuff the brain needs to keep us from getting depressed. Too much protein and tyramine and not enough carbs = depression and agitation. Also, too much protein depletes magnesium. These reasons are probably why famed psychiatrists Judith Wurtman and her husband Richard Wurtman of MIT recommend carbohydrates for depression, and in particular, PMS related depression. Unfortunately, abuse of this technique causes enormous illness in the U.S. and Western culture. Please do not accept what I have written above to mean " no carbohydrates " ; rather, please accept it as meaning one should eat foods that are not refined. Body fat develops because the body does not have sufficient minerals to burn the carbohydrates. That is why, IMHO, people can best loose weight consuming diets low in refined carbohydrates, supplemented with large amounts of magnesium and other minerals like manganese and zinc. Tyrosine imbalance is the reason people - who have misinterpreted Atkins to mean " eat all the steaks you want, but cut out all carbohydrates " - become acutely ill. After preparing the above natural food pyramid, I realized that the bottom level foods (vegetables, meats and fruits) were the first foods eaten by primitive humans millions of years ago, at the time our digestive systems were designed. Only recently (relatively) were dairy products added to the human diet. Even more recently people learned how to bake bread, prepare high carbohydrate fancy-foods, and separate out fats and oils from foods. Clearly vitamins and mineral supplements are a twentieth century invention. Consequently, this is a reasonably " natural " food pyramid. What can be learned here? Warning! Following the dietary and supplement recommendations outlined here will have the effect of preventing or correcting hyperinsulinemia, which will result in life extension of between 30 and 50 years, and much better health. These effects may ruin your personal relationship with your physicians and nurses, reduce profits of major drug companies, reduce the profits of processed food manufacturers, reduce hospital admissions, reduce employment opportunities in those industries and otherwise adversely affect our national Economy. Prevention of hyperinsulinemia by following these dietary suggestions will consequently prevent most cases of atherosclerosis, vascular disease, diabetes type 2, impotence, kidney failure, heart failure, liver damage, stroke, obesity, neuropathy, retinopathy, gangrene and other illnesses. Proceed with these dietary recommendations only if you agree that these " economic " side effects are irrelevant to you and that you accept the risk of longevity attendant with eating right. Read more about these horrific economic side effects and prospects for longevity at the Healing Matters site. Exercise Perhaps every person that has seen a psychiatrist for depression is told to exercise. I wonder how many follow the doctor's advice. Exercise is good for you, but not too much or it will stimulate appetite. Why? The fact is that exercise changes the way our cells react with insulin. Exercise makes our cells less resistant to insulin, and therefore more able to hold magnesium. Exercise is mandatory for diabetics for the same reason. How much exercise? Well, the doctors suggest brisk walking, and we all know that we feel better after a walk. But the good feeling doesn't last. Why? Quite a number of papers show that resistance training for insulin resistance is better than aerobic training. Resistance training is referring to muscular exercises, body building and heavy, but not exhausting exercise. If you just do a bicep curl, you immediately increase the insulin sensitivity of your bicep. Walk briskly, and you immediately increase the sensitivity of your legs to insulin. Just by exercising you are increasing the blood flow to that muscle and decreasing insulin resistance, and improving retention of intracellular magnesium. It has been shown conclusively that resistance training, I.E. muscle building, will increase insulin sensitivity. If we are so depressed that we can't exercise, then we need to have someone exercise us, perhaps with an electric cattle prod to get us up off our butts! Get a menial job stacking boxes in a hardware store, stack lumber in a lumberyard, walk goats up a mountain, walk to the top of every hill and mountain in your state, one per day. Go to the gym and lift weights all day. Swim upstream in a fast moving creek. Think about the astronauts with their enormous loss of muscle mass (30% per flight) and vicious loss of magnesium. What do they do? They body-build with a vengeance, and so must we. They will sometimes exercise while on TV being interviewed. What kind of exercise? Depends on the person. Exercise enough that you sleep well at night. Exercise enough so that you are truly tired at the end of a day. Do fifteen minutes of exercise? OK, but do it each 30 minutes that you are awake! See what I mean? EXERCISE as if your life depended on it! I recently hired a laborer that very much impressed me. I had a large gully on a terrace behind my house and I needed to have the gully up that terrace slope filled in with soil. I hired a Mexican laborer, and with a shovel and wheelbarrow, that middle-aged man filled in that gully with an entire 12-ton dump truck of soil in 8 hours. How did he do it? One wheel barrow at a time walking up the hill. Can you imagine being nearly fifty years old and pushing a wheel barrow full of dirt up a hill all day long and then saying, " Para nada. Ése no es ningún problema. Gracias por el trabajo. " He went home to a beer. Me? I was exhausted from watching him work! Remember what you are trying to do, which is restore your body's cells sensitivity to insulin, which restores their ability to absorb and retain magnesium. How long will it take? Maybe six months, but such is a short time for such an enormous benefit. Dr. Mildred S. Seelig, the magnesium guru, points out the too much exercise will cause a loss of magnesium, but I think the benefits of exercise outweigh this problem because we can simply take more magnesium to compensate. Salt is a subject of some controversy right now, particularly as it applies to exercise. There is one vocal school that says too much salt (sodium chloride) causes hypertension, and another that disagrees. Some say that our high ratio of sodium relative to potassium intake is causing hypertension, a point of view which has support at the NIH, and is my opinion too. The NIH's point being that increasing fresh vegetable intake (naturally high in potassium) and lowering salt (sodium chloride) ingestion reduces hypertension. For data comparing the sodium and other electolyte ratio changes from the year 1900 and 2000 see this link in this page. Others say that our potassium to sodium relative intake is dangerously low, and suggest increasing our intake of potassium chloride. I prefer to leave this debate in the hands of your physician, who after examining you can make an intelligent recommendation. Why? Too little dietary sodium intake will cause death in climates where the temperature is very high due to loss of salt in the sweat from excessive exercise or hard labor. Anyone that has tasted sweat will notice that it has a salty taste, clear evidence that one is loosing sodium and, to a lesser extent, potassium through the sweat. On the other hand, people with kidney disease may not be able to excrete sufficient sodium to clear excess dietary sodium, and will need a low sodium diet (a natural food diet and not a processed foods diet). The RDA for sodium is 2,400 mg per day (approximately 6,000 mg salt or 1 teaspoon of salt), while the estimated RDA for potassium is believed to be about 4,000 mg. In 1900 it was 6,000 mg, a time of very low incidence of heart problems. Nutritionists and physicians that proclaim a ZERO additive salt intake to be generally good advise actually provide deadly advise for people who sweat excessively due to exercise or labor in high heat conditions. Also, the main cause of death from protracted diarrhea is loss of salt (sodium chloride). On the other, other hand, injected potassium chloride instantly kills by stopping the heart; and in fact, IV potassium chloride is used to execute criminals. A friend of mine on Martha's Vineyard felt that if a little bit of potassium chloride was good, then a bunch would be better. She took an entire teaspoon of pure potassium chloride salt and it " melted a hole through her stomach " . She immediately caused herself to throw up and probably saved her life in the process, at least she saved herself a trip to the emergency room. Enough said? I repeat! Potassium chloride must never be consumed straight! It must always be dilluted in water or used as a seasoning in food and judiciously used. I have experimented with judicious amounts of potassium chloride (1/4 teaspoon) dissolved in an 8-oz glass of water to lower my pulse rate. Good idea? Actually, yes, it is a very good idea! If our pulse rates can easily be lowered by reasonable intake of potassium chloride (in a glass of water or by simply substituting it for regular table salt), then such seems to indicate a deficiency situation that has been corrected. However, remember that metabolic shock is hyperkalemia! Morton's Salt Company makes a mixture of sodium and potassium chloride salt that is increasingly popular. Is it safe? Yes, I think so because it is an equal 50/50 mixture of sodium and potassium salts. However, many people eat processed foods which are already high in sodium chloride salt, and their intake may be so high that use of Morton's Salt Substitute (nearly pure potassium chloride) is absolutely necessary. The heathiest ratio of sodium to potassium is about 1:30 (the ratio found in Americans in 1900), not the 2.5:1 ratio of today. Notice that Morton's Salt Substitute label asks the user to consult with a physician before using. I think that is some weird government regulatory scare tactic to keep us consuming toxic amounts of sodium chloride. Why? I don't know, but refuse to believe in paranoid conspiracy theories, and would rather write it off to stupidity. Limiting salt intake is only one of several steps necessary to reduce total sodium intake. Nearly all processed foods contain additive sodium, either as sodium chloride, or as some other food additive such as monosodium glutamate (MGS), or drugs such as OTC antacids and headache remedies. More on reducing hidden sources of dietary sodium here. I think the best idea for most of us is to consider additive dietary potassium chloride to be necesary, with preference given to eating high potassium content natural foods, not processed foods (very high in sodium chloride). Also, anyone that has developed muscle cramps from working in high temperatures and sought medical advise is certain to have been told that increasing potassium intake will help prevent muscle cramps. Consequently, both sodium and potassium are needed in extra amounts in high heat, sweat conditions. However, potassium chloride must never be consumed straight! it must always be dilluted in water or used as a seasoning in food. In your decision making on potassium and sodium intake, remember that sodium drives down magnesium and potassium drives it up. Succeed! Depression is not a psychosis! Diagnosis Of Magnesium Deficiency Serum or blood levels of magnesium (typically found in clinical laboratories) are a total waste of blood, money and time except in acute alcoholism, starvation or diabetic acidosis. These tests have perpetuated the myth that magnesium deficiency does not exist, and should be made illegal due to the grave, national-health damage caused by them. There are only three tests worthwhile: oral dosing, magnesium loading and intracellular spectroscopy, although some still like the red blood cell test. " Oral Dosing " is nothing more than giving magnesium at proper dosages and observing improvement as described in my section on Dosage " . Never give toxic forms of magnesium. This test does not require a physician or laboratory tests and is considered definitive. " Magnesium Loading " is considered the standard by the few physicians who at least recognize the possibility of magnesium deficiency. The test is somewhat tedious and frustrating to patients. First one has to collect every drop of urine for exactly 24 hours. The urine is then analyzed for total magnesium and creatinine output in a clinical laboratory. Then the patient is given intravenously a specific " load " of magnesium and a second 24 hour urine is collected and tested for magnesium and creatinine. If less than 50% of the administered magnesium is excreted, this is " proof " of magnesium deficiency. In fact, if less than 20% is excreted, " borderline " magnesium deficiency is suspected. " Intracellular spectroscopy " , the Intracellular Diagnostic's " EXAtest involves a simple, painless scraping of the soft tissues, (epithelial cells) from the floor of the mouth right under the tongue. This is an easy, non-invasive, risk-free test. The oral epithelial (surface) cells from the mouth scraping are placed on a slide and sent to a laboratory for x-ray analysis using an electron microscope. At about the same cost as the magnesium load test and much better patient compliance, this test also gives intracellular levels of magnesium, calcium, potassium, sodium, chloride, and phosphorus, as well as equally important ratios between these minerals. If your physician will or can not order this important and accurate test for you, find another physician. If you have any of the symptoms or illnesses that are being discussed on this page, it is extremely wise to have this test done. The lab is: Intracellular Diagnostics, 553 Pilgrim Drive, Suite B, Commerce Park, Foster City, CA 94404, 800-874-4804. Their price, which was quoted February of 2003, was $175.00, which they say is usually covered by insurance and Medicare. They will refer you to the closest physician capable of doing the collection. Red blood cell testing (not whole blood or serum tests) can be performed in most medical laboratories and is reasonably accurate. More on magnesium testing at the HeadachePainFree site. Succeed! Depression is not a psychosis! The Essentiality of Boron Boron is well known for its role in preventing urinary losses of both calcium and magnesium. Apparently, it can raise both calcium and magneisum by about 1/3. Consequently, boron is important in recovery from depression; and it has the potential to reduce the amount of magnesium required to alleviate depression, and increases resistance to diarrhea. Boron has recently been found to be important in brain and psychological function. Published studies consistently show that the administration of small amounts of boron (2-3 mg/day) reduce the amount of calcium and magnesium urinary excretion. The effect of boron in preserving critical minerals is more apparent when dietary intake of magnesium is low. In response to boron supplementation, estrogen and testosterone levels increase in postmenopausal women, which may restart menses. Boron's function in bone formation appears to be related to magnesium metabolism. Boron also appears helpful in treating and preventing autoimmune diseases, such as rheumatoid arthritis. In human deficiency studies, supplementation with boron improved several parameters including mental alertness, memory, mineral metabolism, and blood hemoglobin. Recently, the National Academy of Science's Institute of Medicine has set the tolerable upper intake levels for boron at 20 milligrams per day, but did not establish a RDA. Along with a diet high in boron, I also took 6 to 12 milligrams of boron (Twin Labs Tri-Boron) in the morning. Many years ago, when boric acid was used as a food preservative, 500 mg were found to have adverse effects in humans causing severe gastrointestinal distress and problems with appetite. Some important food sources of boron are shown in the following table. Concentrations of Boron in Selected Foods (from: Futureceuticals) FoodBoronFoodBoron(mg/100g)(mg/100g)Almond2.82Hazel Nuts2.77Apple (red)0.32Honey0.50Apricots (dried) 2.11Lentils0.74Avocado2.06Olive0.35Banana0.16Onion0.20Beans (Kidney)1.40Orange0.25Bran (wheat)0.32Peach0.52Brazil Nuts1.72Peanut Butter1.92Broccoli0.31Pear0.32Carrot0.30Potato0.18Cashew Nuts1.15Prunes1.18Celery0.50Raisins4.51Chick Peas0.71Walnut1.63Dates1.08Wine (Shiraz Cabaret)0.86Grapes (red)0.50 I am also worried about toxic overloads of heavy minerals (lead, cadmium, mercury, etc.), and the critical role of other nutrients in mental health, which have only recently become of interest to physicians. The brain is a chemical factory that produces serotonin, dopamine, norepinephrine, and other organic brain chemicals 24 hours a day. The only raw materials for their syntheses are nutrients, namely, amino acids, cholesterol, essential fatty acids, vitamins and minerals. If the brain receives improper amounts of these nutrient building blocks or receives toxic heavy metals, which take the place of essential nutrients (particularly minerals) in the brain, we must expect serious problems with our organic neurotransmitters. For example, some depression patients have a genetic pyrrole disorder which renders them grossly depleted in vitamin B-6. A pyrrole is a basic chemical structure that is used in the formation of heme, which makes blood red. Pyrroles bind with B6 and then with zinc, thus depleting these nutrients. These individuals cannot efficiently create serotonin (a neurotransmitter) since B-6 is an important factor in the last step of its synthesis. Some people report 500 mg B6 to be needed daily to stabilize their mood. Many of these persons appear to benefit from prescription drugs like Prozac, Paxil, Zoloft, or other serotonin-enhancing medications. However, as with all non-nutritive mind-altering drugs, side effects occur and the true cause of the mental difficulties remains uncorrected. Similar – and more healthful – benefits can be achieved by simply taking sufficient amounts of B-6 along with supporting nutrients such as magnesium, boron, taurine and essential fatty acids. Succeed! Depression is not a psychosis! Foods That Contain 100 mg or More of Either Calcium or Magnesium per 100 Grams (3-1/2 oz) The following figure shows the amount of magnesium and calcium in foods wherein the amount of either magnesium or calcium exceeds 100 milligrams (1/4 the RDA for magnesium) per one hundred grams of that same food. A complete list of hundreds of foods (fresh foods and processed foods by brand name) arranged by their magnesium content is in this USDA report, which is a document that you should print out and tape to your refrigerator. Here is the USDA index for all nutrients alphabetically and by weight. The following foods shown in bold and brown have more magnesium than calcium, while all other foods shown have more calcium than magnesium. milligrams Magnesium per 100 grams food milligrams Calcium per 100 grams food Beverages & Mixes Cocoa powder 520130 Chocolate drink15030 Milo210465 Ovaltine0270Biscuits, Cakes, Cereals, Desserts Biscuit, chocolate40110 Biscuit, crispbread, rye10050 Biscuit, gingernut25130 Biscuit, semi-sweet20120 Bran, wheat520110 Buckwheat230114 Cake, sponge10140 Carob flour10350 Custard10140 Custard tart20110 Flour, soy (full fat)240210 Flour, soy (low fat)290240 Flour, wholemeal14040 Milk pudding (e.g.. sago)10130 Millet16210 Pancake10120 Pizza, cheese & tomato20240 Rye11538 Scone20620 Sponge pudding, steamed10210 Wheat bran490120 Wheat germ33672 Wheat grain16046 Yeast, brewer's231210 Yeast, dried bakers23080Egg & Cheese Dishes Cauliflower cheese20160 Cheese soufflé20230 Macaroni cheese20180 Quiche Lorraine20260Fats & Oils None Fish & Other Seafood Crab, canned30120 Haddock, fried30110 Mussels, boiled30200 Oysters, raw40190 Prawns, boiled40150 Sardines, canned40460 Scallops, steamed 40120Fruits Avocado1065 Figs, dried90280 Lemon slices10110Meat & Meat Products Tripe, stewed20150Milk & Milk Products Buttermilk10120 Cheese, Camembert20380 Cheese, Cheddar30800 Cheese spread30510 Cream cheese10100 Cheese, Danish blue 20580 Cheese, edam30740 Cheese, parmesan501220 Cheese, processed20700 Cheese, Stilton30360 Cheese, Swiss0950 Ice cream10140 Ice cream, non-dairy10120 Milk, cow's, condensed skim40380 Milk, cow's condensed whole10280 Milk, cow's dried skimmed1201020 Milk, cow's dried whole801020 Milk, cow's evaporated, whole30280 Milk, cow's flavored0110 Milk, cow's fresh skimmed10130 Milk, cow's fresh whole10120 Milk, goat's20130 Milk shake, flavored0110 Yogurt, flavored0130 Yogurt, fruit low-fat20160 Yogurt, natural low-fat20180 Yogurt, plain0145Nuts Almonds260250 Brazil410180 Cashews26738 Filberts18410 Pecans14273 Peanuts, raw in shells13040 Peanuts, roasted salted18060 Pistachio, shelled0130 Sesame seeds - hulled0110 Sunflower seeds38120 Walnuts13060Sauces & Condiments Curry powder0645 Dulse (red seaweed)220300 Mustard powder0335 Olives, ripe0106 Oxo Cubes60180 Pepper 50130 Worcestershire sauce0100Soups NoneSugars, Jams & Spreads Fish paste30280 Peanut butter18040 Treacle, black140500Sweets Caramel0140 Carob bar30160 Chocolate square, milk60220 Fruit and honey bar20070 Molasses258684 Sesame bar14090 Toffee, mixed30100Vegetables Alfalfa230900 Broccoli24103 Collard greens57250 Dandelion greens36190 Kale10250 Kelp (Warning! very high in glutamate)7601110 Onions, spring10140 Parsley, sprigs50330 Tofu111128 Turnip greens10250 Watercrest10150 No wonder we have trouble getting enough magnesium from our food! Calcium is found in most of these foods in great excess over magnesium thus preventing magnesium from being fully absorbed into the body. To us, calcium has become a neurotoxin. Have we lost some degree of control over the normally exquisitely regulated calcium ion concentration in our brains? Can we recover if we continue to eat neurotoxins? I don't think so. Remember, the amount of magnesium and calcium is shown for 100 grams of the food. Some of these foods we eat in small amounts, so the data is not particularly meaningful. However, milk and cheese products, which we eat in great amounts, are loaded with calcium and harmful fats. We are not likely to gain significant advantage from eating or drinking them in order to gain magnesium. Want a pizza? How about a hamburger? I remember that my mother fed me a lot of peanut butter sandwiches when I was young. I grew to dislike those sandwiches there were so many. But it looks like mom knew best after all. She also fed me lots of cocoa powder in water drinks. I hated them and demanded that the cocoa powder be in milk (I thought she was being cheap). I still love chocolate bars and drinks and I guess that is good. Chocolate contains many drug-like compounds, some of which are very similar to anandamide, a substance in the brain whose name literally means " internal bliss. " Anandamide binds to and activates the cannabinoid receptors in the brain, mimicking the effects of drugs such as marijuana. Almonds and peanuts I love, but I don't like walnuts. Guess I need to develop a taste for them after all. I am surprised at how little magnesium and calcium there are in foods that I thought were good for us, like eggs, soups, fish, fruit, meat and vegetables. Although meats and vegetables generally have more magnesium than calcium, one would need to eat a lot of them to add up to a useful amount. I am surprised that pizzas (gobs of calcium) and hamburgers (not much of anything) are still legal. I am not surprised at the absence of magnesium and calcium in fats, beverages (alcoholic beverages were zero), sugars, sweets, sauces and condiments. What do your eat? Does this table suggest your choice of foods needs to change to maintain a good mood? The official USDA Nutrient Database for Magnesium content of selected foods (30 pages) is here. The USDA nutrient database for all foods and nutrients can be accessed here. Guess what characteristic the following foods have in common according to the USDA: Margarine, M & M MARS candy, STARBURST Fruit Chews, honey, radishes, corn syrup, frosting, whipped cream, salad dressings, butter, cornstarch, beef broth soup, chicken with rice soup, pepper sauce, candy, gumdrops, salt, alcoholic beverages, Honey Nut CHEX cereals, carbonated beverages, and peanut, olive, sesame, sunflower, safflower vegetable oils. ANSWER: Zero mg magnesium per 100 grams of the food. ZERO! Succeed! Depression is not a psychosis! Non-Dietary and Non-Stress Causes of Hypomagnesemia From the Hypomagnesemia web site, causes of low blood magnesium (hypomagnesemia) other than inadequate magnesium and boron intake and stress are related to primarily to renal and gastrointestinal losses: Renal and gastrointestinal (GI) losses: Malabsorption of magnesium in the ileum results in hypomagnesemia. Situations of decreased absorption include malabsorption syndromes (e.g., celiac disease, sprue), radiation injury to the bowel, bowel resection, or small bowel bypass. Significant losses of magnesium resulting in hypomagnesemia may result from chronic diarrhea, laxative abuse, inflammatory bowel disease, or neoplasm. Renal losses from primary renal disorders or secondary causes (e.g., drugs, toxins such as mercury, hormones, osmotic load) may result in magnesium wasting and subsequent hypomagnesemia. Primary renal disorders cause hypomagnesemia by decreased tubular reabsorption of magnesium by the damaged kidneys. This condition occurs in the diuretic phase of acute tubular necrosis, post obstructive diuresis, and renal tubular acidosis. Drugs: Diuretics (e.g., thiazide, loop diuretics), cisplatin (causes dose-dependent kidney damage in 100% of patients receiving this drug), pentamidine, some antibiotics, fluoride poisoning, oral contraceptives. See larger list in this page here. Endocrine disorders: Primary aldosteronism decreases magnesium levels by increasing renal flow. Hypoparathyroidism and hyperthyroidism may cause renal wasting. Osmotic diuresis results in magnesium loss in the kidney: Diabetic patients, especially those with poor glucose control, develop hypomagnesemia from a glucose-induced osmotic diuresis. Alcoholics become hypomagnesemic partially by an osmotic diuresis from alcohol. Urinary losses have been reported to be 2-3 times control values. Miscellaneous: Extracellular volume expansion, as in cirrhosis or intravenous (IV) fluid administration, may decrease magnesium levels. Redistribution of magnesium into cells may cause lower magnesium levels. Insulin causes this effect. Excessive lactation may create a significant amount of magnesium loss. Hungry bone syndrome may lead to lower serum magnesium concentrations. Pregnant women have been found to be magnesium depleted, especially those women who experience pre term labor. Leaky Gut Syndrome. Always treat with probiotics. Antibiotics because they lead to the overgrowth of abnormal flora in the gastrointestinal tract (bacteria, parasites, candida, fungi) causing " Leaky Gut Syndrome " . Treatment with probiotics and/or CoQ10 is often curative. Caffeine and other strong gut irritants. Foods and beverages contaminated by parasites like Giardia Lamblia, Cryptosporidium, Blastocystis hominis and others. Always treat with probiotics and/or CoQ10. Foods and beverages contaminated by bacteria like Helicobacter pylori, Klebsiella, citrobacter, Pseudomonas and others. Always treat with probiotics. Chemicals in fermented and processed food (dyes, preservatives, peroxidized fats). Enzyme deficiencies (e.g. celiac disease, lactase deficiency causing lactose intolerance.) NOTE: Scientists believe that lactose malabsorption may interfere with the availability of L-tryptophan and the synthesis of the neurotransmitter serotonin. NSAIDS (non-steroidal anti-inflammatory drugs) like ASA, ibuprofen, indomethacin, etc. Prescription corticosteroids (e.g. prednisone) and methotrexate. High refined carbohydrate diet (e.g. candy bars, cookies, cake, soft drinks, white bread). Mold and fungal mycotoxins in stored grains, fruit and refined carbohydrates. Toxic mold in the walls of buildings. Inadequate bile production. More medical important information on hypomagnesia symptoms and causes are here, and here on the Family Practice Notebook site. This google.com search for " magnesium wasting may provide additional important information. Succeed! Depression is not a psychosis! Magnesium and Calcium Ions in Synaptic Function in Brain This figure from LTP Lecture Notes from the University of California, San Diego - Department of Cognitive Science, one can clearly see that magnesium ions and calcium ions are involved in nerve cell electrical conduction activity across brain cell synapses. Too much calcium ion and glutamate and not enough magnesium ion, particularly in the hippocampus, play a vital role in brain cell synaptic dysfunction leading to depression and other mood and behavioral disorders. The earliest indication that glutamate and many synthetic glutamate receptor agonists are toxic was obtained in the 1970's (Olney and Ho, 1970). However, most surprising was the finding that even endogenous glutamate may cause neurotoxicity via over-excitation under certain conditions - a situation called " excitotoxicity " . Processes that increase the sensitivity of glutamate receptors or affect glutamate homeostasis often induce cell death usually connected with Calcium2+ ion overload. Most of the better known neurotransmitter systems - dopamine, noradrenalin, serotonin (5HT), and acetylcholine in particular - have modulatory roles; and when defective require specific drugs, preferably supplemental natural hormones, to restore their balance. They are produced by a few neurons located in specific clusters, and drugs affecting them often have specific effects. Receptors for these neurotransmitters tend to operate fairly slowly, taking milliseconds or longer to communicate. Rather than directly changing the potential of the neuron, they often trigger second-messenger responses. On the other hand, most of the brain's regular function operates quickly, and involves the excitatory and inhibitory amino acids. The excitatory amino acid neurotransmitters include glutamate (between 70 and 85 percent) and aspartate. The receptors for amino acids are generally calcium and magnesium ion channels and to a lesser extent zinc. When the receptor is activated, these ions enter or exit the cell, which change its potential. Taurine, Gamma-aminobutyric (GABA) acid and glycine are major inhibitory neurotransmitters in the central nervous system (CNS), predominantly active in the spinal cord and brain stem. Taurine and glycine also acts as a modulator of excitatory amino acid transmission mediated by N-methyl-D-asparate (NMDA) receptors. NMDA receptors are unique for several reasons. Unlike most neuronal receptors, they require two agonists (glutamate or aspartate, plus glycine) before the channel opens. These two agonists bind to two different locations on the NMDA receptor. After both agonists have bound to the channel, it opens enough for potassium to enter. Normally, a magnesium ion is bound to a specific location at the opening of the channel. The magnesium ion allows potassium to pass through but prevents calcium. NMDA receptors are only activated following depolarization of the postsynaptic membrane, which relieves their voltage-dependent blockade by Mg2+ ions. Once the cell becomes activated enough, the cell potential rises enough that the magnesium ion is no longer stuck to the cell. Calcium can enter the cell through the fully open NMDA channel. Once inside, calcium sets into motion a series of responses, which enhance the strength of the synapse. Calcium helps cells do many things, including carry nerve signals. Neurons normally are very careful about the amount of calcium they allow in because they use minute changes in levels of internal calcium to interpret messages from other neurons. Too much calcium inside cells leads to cell death. Over-stimulation of both non-NMDA and NMDA receptors with glutamate results in a large influx of calcium into the cell interior, particularly the neuronal mitochondria. Although normal levels are necessary for many cellular processes, if the intra neuronal mitochondrial concentration of calcium is excessive, such can result in a series of calcium-depended enzymes that are normally suppressed, becoming activated. When these enzymes, like lipid peroxidase, nitric oxide synthetase, and xanthine oxidase, are activated, they cause the production of free radicals and nitric oxide, cytoskeletal breakdown, failure to generate ATP (the cells' energy source), lipid peroxidation, and nucleic acid fragmentation, which leads to neuronal death. Similarly, in Wilson's disease (a serious copper accumulation disease), zinc given to eliminate copper accumulation (in the brain) results in elimination of depression found in Wilson's disease patients. NMDA receptors are involved in excitotoxicity (nerve cell death via over-stimulation). The chemicals that agonize (activate) NMDA receptors can also kill the very same nerve cells they are activating. Glutamic and aspartic acid, are capable of doing damage if present in sufficient amounts. This excitotoxicity is directly responsible for much of the damage attributed to various types of trauma and insult to the CNS from many diseases, and helps explain why magnesium glutamate and magnesium aspartate worsen depression (These compounds contain about 9 times the amount of these ligands than magnesium). Note " PRECAUTIONS " concerning using magnesium glutamate and aspartate to treat depression. If you want to dig into neurotransmitter biochemicals further, see " Neurotransmitters " , but you will not find mention of magnesium ions. Harold Murck writing in Nutritional-Neuroscience in 2002 pointed out that there are several findings on the action of magnesium ions which support their therapeutic potential in affective disorders. Examinations of the sleep-electroencephalogram (EEG) and of endocrine systems point to the involvement of the limbic-hypothalamus-pituitary-adrenocortical axis as magnesium affects all elements of this system. Magnesium has the property to suppress hippocampal kindling, to reduce the release of adrenocorticotrophic hormone (ACTH) and to affect adrenocortical sensitivity to ACTH. The role of magnesium in the central nervous system could be mediated via the N-methyl-D-aspartate-antagonistic, gamma-aminobutyric acidA-agonistic or a angiotensin II-antagonistic property of this ion. A direct impact of magnesium on the function of the transport protein p-glycoprotein at the level of the blood-brain barrier has also been demonstrated, possibly influencing the access of corticosteroids to the brain. Furthermore, magnesium dampens the calciumion-proteinkinase C related neurotransmission and stimulates the Na-K-ATPase. All these systems have been reported to be involved in the pathophysiology of depression. Despite the antagonism of lithium to magnesium in some cell-based experimental systems, similarities exist on the functional level, i.e. with respect to kindling, sleep-EEG and endocrine effects. Carman and Wyatt, writing in Biological Psychiatry as early as 1979 showed that decreases in cerebrospinal fluid (CSF) calcium accompany mood elevation and motor activation in depressed patients undergoing treatment with ECT, lithium, and total sleep deprivation. Similarly, decreases in CSF calcium occur during acute psychotic agitation or mania. On the other hand, periodic recurrences of such agitated states are accompanied at their onset by transient increases in serum calcium and phosphorus. Several observations suggest that such serum ion shifts may trigger the more enduring and opposite shifts in CSF calcium and, in turn, the manic behavior. Progressive restriction of dietary calcium was earlier reported to mitigate and finally abolish both rhythmic rises in serum calcium and periodic agitated episodes in one psychotic patient. Lithium, which decreases the efficiency of alimentary calcium absorption, may function similarly. Conversely, a modest oral calcium lactate supplement (approximately one additional Recommended Daily Allowance of dietary calcium) seemed to slightly intensify agitation in six patients. Dihydrotachysterol (DHT), an analog of vitamin D, which more exactly mimics the increase in both serum calcium and phosphorus, appeared in at least one periodically psychotic patient to trigger and opposite shift in CSF calcium. Moreover, in eight patients, manic symptomatology appeared de novo or grew significantly and substantially worse during 2 to 6 weeks of oral DHT administration. On the other hand, in 12 patients, subcutaneous injections of synthetic salmon calcitonin (SCT) decreased serum calcium and phosphorus, increased CSF calcium, and decreased agitation while augmenting depressive symptomatology. SCT also decreased quantified motor activity, frequency and severity of periodic agitated episodes, serum CPK and prolactin, and nocturnal sleep, while DHT or calcium lactate had opposite effects on the same parameters. Succeed! Depression is not a psychosis! Calcium Channel Blockers Calcium channel blockers, especially magnesium ions, alter influx of calcium from the extracellular fluid to the cytosol of cells through calcium channels, which is important for the release of neurotransmitters from presynaptic neurons. Thus magnesium ions act presynaptically rather than by blocking receptors postsynaptically to prevent over stimulation by calcium, and are therefore nature's true calcium-channel blockers. In health, exquisite homeostatic regulation of serum calcium levels exists, and alterations from the norm in calcium serum levels are well known to cause serious mental illness. Free intracellular calcium-ion concentrations are elevated in platelets and lymphocytes of manic and bipolar depressed patients but not in control or unipolar depressed patients or in patients made euthymic (normal, neither elated nor depressed) by various medications or electroconvulsive therapy (ECT). Some element of hyperexcitable as shown by Weston in 1921, or an imbalance in calcium/magnesium ratio (either induced by stress, improper diet, or calcium toxicity) in tissues are most likely necessary for magnesium supplementation to provide benefits observed in the treatment of the general class of symptoms called " depression " . I find interesting that beneficial mechanisms of action of many dangerous, prescription psychiatric drugs and ECT on manic and bipolar illness is restoration of proper calcium serum/magnesium balance, a property easily restored with over-the-counter magnesium taurate. Prescription calcium channel-blockers often produce mental depression as a side effect in cardiac therapy, while magnesium used as a calcium channel blocker in cardiology does not. I find it interesting that cardiology has embraced magnesium to rescue patients, while psychiatry has not. The earliest substance to be reported having calcium-channel blocking effects was magnesium ion. These findings were reported by Weston 80 years ago to ameliorate excited psychotic states. See journal pages at: Weston, PG. Magnesium as a sedative. American Journal of Psychiatry, 1921–22;1:637–8. Weston showed that 220 doses out of 250 doses of magnesium sulfate given to 50 patients having various types of agitation, with half being patients having agitated depression, caused patients to relax and sleep from four to six hours. This is about a 90% success rate. He noted that side effects from giving too much magnesium were quickly and easily reversed by giving calcium chloride. With such vital effects known for 80 years, it seems unlikely that psychiatry will, without political force, in this century embrace magnesium in the treatment of depression. Due to the strong pharmaceutical company lobby, deference will be given to the known SSRIs and other patentable and highly profitable anti-depressant drugs, even though magnesium plays a much wider role in mental health, particularly depression and other hyperexcitability states. The pharmaceutical drug lobby is simply too strong. Perhaps the only person in the United States government sufficiently interested in improving health capable of bringing magnesium to the attention of the public in a meaningful way is U.S. Senator from Utah, Orrin G. Hatch. Wouldn't federal and state laws reading in part, " Treatment by physicians of disease with drugs having any significant side effect without treating underlying malnutrition attributed to causing such disease, shall be considered malpractice " really change medicine for the better? Succeed! Depression is not a psychosis! Mail - More reliable, more storage, less spam Quote Link to comment Share on other sites More sharing options...
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