Fwd: [SSRI-Research] Prenatal exposure to Prozac

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JustSayNo

Tue, 17 Feb 2004 11:15:09 -0500

[sSRI-Research] Prenatal exposure to Prozac

 

Prenatal exposure to Prozac:

http://www.health.gov.au/tga/docs/html/aadrbltn/aadr9711.htm#ssri

 

This one applies to Paxil, but all SSRIS work similarly:

 

Perinatal Outcome Following Third Trimester Exposure to Paroxetine

http://archpedi.ama-assn.org/issues/v156n11/abs/poa20091.html

 

Three more:

 

Prenatal exposure to fluoxetine (Prozac) produces site-specific &

age-dependent alterations in brain serotonin transporters in rat progeny

Evidence from autoradiographic studies.

 

Cabrera-Vera TM, Battaglia G.

 

J Pharmacol Exp Ther 1998 Sep;286(3):1474-81.

The results of this study show that prenatal exposure to the selective

serotonin reuptake inhibitor fluoxetine (Prozac) induces changes in the

density of brain serotonin transporters in rats, which are particularly

evident in regions of the limbic system, such as the hypothalamus,

hippocampus and amygdala. These data indicate that fluoxetine alters brain

function in rats exposed to the drug while in uterus.

 

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Pregnancy outcome following first-trimester exposure to fluoxetine.

Pastuszak A, Schick-Boschetto B, Zuber C, Feldkamp M, Pinelli M, Sihn S, et

al.

 

JAMA 1993 May 5;269(17):2246-8.

 

The results of this study show that women who use the antidepressant

fluoxetine (Prozac) in the first trimester of pregnancy have approximately a

2-fold increased risk of miscarriage, compared to nonusers.

 

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Birth outcomes in pregnant women taking fluoxetine.

Chambers CD, et al.

 

N Engl J Med, 335(14):1010-5 1996 Oct 3.

 

This study evaluated pregnancy outcome of women who took the antidepressant

fluoxetine (a serotonin uptake inhibitor) while expecting, and compared it

to that of women who did not take the drug. In infants exposed to the drug,

the incidence of three or more minor anomalies was 15.5% vs. 6.5% in

controls. Infants exposed to fluoxetine during the third trimester had,

compared to those exposed only during the first and second trimester,

reduced birth weight and length, an almost 5-fold increased risk of

premature delivery, a 2.6-fold increased risk of being admitted to

special-care nurseries, and an almost 9-fold increased risk of experiencing

respiratory difficulties, cyanosis on feeding, and jitteriness.

 

Here's another study, but you have to purchase it:

 

Sydney Morning Herald

Breastfeeding can pass on medication

 

WOMEN who use Prozac and similar antidepressants during pregnancy and

breastfeeding can expose their babies to withdrawal and toxic effects,

according to a Federal Government drug effects watchdog.

Illawarra Mercury 04/08/2003 Cost - $1.65 154 words