Fwd: [S-A] [HealthPillarWell] Aspartame & Cancers

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" Misty L. Trepke "

Sun, 28 Dec 2003 20:43:14 -0000

[s-A] [HealthPillarWell] Aspartame & Cancers

 

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Misty L. Trepke

http://www..com

 

ASPARTAME & CANCERS

Thu, 25 Mar 1999 22:20:40 EST

George R. Schwartz, M.D.

www.healthpress.com/cancer.htm

 

Summary

 

There is a startling epidemiologic connection between NutraSweet

(aspartame)and breast cancer. The biochemical mechanism which can

explain the correlation offers additional weight to the

epidemiologic research finding. This extraordinary correlation

points to millions of breast cancer cases possibly induced by

NutraSweet (aspartame). This alarming association mandates an

emergency need for close scientific scrutiny.

 

Mechanism of Action

 

NutraSweet (aspartame) is composed of linkages of aspartic acid,

phenylalanine and methanol. The aspartic acid acts as a

neuroexcitatory agent. (1) When NutraSweet is digested, it yields

10% methanol (wood alcohol).(2) The wood alcohol (methanol) is

widely distributed throughout the body including brain, muscle, fat

and nervous tissue. (3) It is then metabolized to formaldehyde which

enters the cells and binds to the proteins and DNA (the genetic

material). (4) Cytogenetic effects (changes in DNA) have been shown

to result from formaldehyde exposure (5) and DNA damage occurs from

formaldehyde.(6) The nature of the injury generally involves

breaking and then creation of cross linking within the genetic

material which alters the cells.

 

This finding has been confirmed numerous times and the

DNA-protein-cross-links are believed to cause cancers in experimental

animals.(7) Changes in the genetic material is associated with cancer

production in humans.(8) The ability of Aspartame to cause cellular

mutations has been shown through studies by Shephard, et al.(9)

There are increases in malignant brain tumors suggested to be

associated with aspartame use.(10) Formaldehyde is a known stimulant

for cancer and genetic damage in the cell . .(11, 12)

 

Epidemiology Research

 

Our epidemiologic research demonstrates the following:

 

**Rising incidence of breast cancer in the United States (more than

180,000 new cases yearly and now the single leading cause of death

in woman age 35-54) (13) over 25 years tracking increased aspartame

use. (In 1974 NutraSweet was approved for limited use, in 1983 it

was approved for use in diet sodas.) Note chart.

 

**We are now studying the rising incidence of prostate cancer, with

more than 132,000 new cases yearly and the second most common cancer

in men.(14) This cancer also appears to epidemiologically be

associated with a rise in aspartame use.

 

**Rising incidence of brain cancers.(15)

 

Cancer statistics also note that rates of breast and prostate cancer

are 5 to 6 times higher in North American and Europe than in Asia

and Africa, places where NutraSweet market penetration has so far

been less.(16, 17)

 

Chart of Pivotal Dates

 

 

The chart of breast cancer increases demonstrates these pivotal

times. Testing involving NutraSweet occurred in the l972-l973

period. Limited approval as a sweetener was granted (in the USA) in

l974 and full unlimited approval was granted in l983. Arrows on the

chart demonstrate the extraordinary concordance with increasing

breast cancer rates. The likelihood of this being a rare coincidence

is offset by the biochemical evidence supporting a likely mechanism

for cancer induction. Early animal experiments involving mice did

demonstrate mammary tumors and urogenital changes in males which

were found in initial testing prior to NutraSweet approval.

 

 

Hypothesis

 

The epidemiologic correlation's are striking and raise the

hypothesis of cancer induction. While there are many potential

pathways, we are postulating the most direct. NutraSweet converts to

methanol, which goes to intracellular formaldehyde. The latter

affects DNA causing cell toxicity and chromosome abnormalities which

precipitate cancers in susceptible people. NutraSweet has already

been shown to induce mammary tumors and testicular changes in

experimental animals.(18) Based on the epidemiologic associations,

and biochemical effects at the cellular-DNA level, NutraSweet

and aspartame should be carefully studied as a potential

environmental cause of well over one million cases of cancer.

 

Endnotes

 

1.. Blaylock, Russell L.: Excitotoxins: The Taste that Kills,

1997, Health Press.

2. Team NutraSweet, Monsanto Response, 1999.

3. Osborn H. Alcohol Substitutes. Treatment of Poisonings by

Methanol, Ethlyene Glycol and Isopropyl Alcohol p. 741-5 in Schwartz

GR, et al. Eds, Principles and Practice of Emergency Medicine,

Lippincott/Williams & Wilkins, 1999.

4. Trocho, et al. Formaldehyde Derived From Dietary " Aspartame

Binds to Tissue Components In Vivo. Life Sciences 63(5):337-349,

1998.

5. Shaham D, et al. DNA-Protein Crosslinks: A Biomarker of

Exposure to Formaldehyde. Carcinogenesis, Jan. 1996.

6. Ross WE, McMillan DR, Ross CF: Comparison of DNA Damage by

Methylmelamines and Formaldehyde, Journal National Cancer Institute

67:217-21, 1981.

7. Cassanova, et al.: DNA-Protein Cross-links and Cell Replication

at Specific Sites in the Nose of F344 Rats Exposed Subchronically to

Formaldehyde, Fundamental and Applied Toxicology 223, 535-536, 1994.

8. Olopade OI, Rowley JD: Recurring Chromosome Re-arrangements in

Human Cancer. P. 99-120, in Holland JF et al Eds., Cancer Medicine.

3rd edition, Lea & Febiger, 1993.

9. Shephard, et al., Mutagenics Activity of Peptides and the

Artificial Sweetener Aspartame after Nitrosation. Fd Chem Toxic

1993:31:323-29.

10. Olney JW, et al.: Increasing brain tumor rates: is there a

link to aspartame?. J Neuropath Exp Neurol 1996 Nov, 55:11, 1115-23.

11. Cassanova, et al.

12. Crosby RM, et al: Molecular analysis of formaldehyde-induced

mutations in human lymphoblasts and E.Coli. Environ Mol Mutagen. 12,

155-166, 1988.

13. Fisher B, et al.: Neoplasms of the Breast. P. 1706-1774, Cancer

Medicine, 3rd Ed. Lea & Febiger, 1993.

14. Trump DL, Neoplasms of the Prostate. p. 1562-1580, Cancer

Medicine, 3rd Ed. Lea & Febiger, 1993.

15. Olney, see 10.

16. Fisher, see 13.

17. Trump, see 14.

18. GP Searle research reported to FDA 1971-74, released under

Freedom of Information Act.

 

For more information:

Dr. George R. Schwartz, M.D.

(505) 982-9373

 

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