Anti-Colitis Medications Cause Pancreatitis, Nephritis

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Anti-Colitis Medications Cause Pancreatitis, Nephritis

STRAFFORD [drugINTEL] - 3 Apr 2003 - Drugs used to treat Colitis containing or

giving rise to mesalamine (e.g., Dipentum (olsalazine); Azulfidine

(sulfasalazine); Asacol, Pentasa, Rowasa (all three trade names for mesalamine))

are identified with increased risk for Pancreatitis and Nephritis.

Traditionally these extremely hazardous health effects have been shrugged off as

occurring commonly together with Irritable Bowel Syndrome (IBS) / Inflammatory

Bowel Disease (IBD) / Crohn's Disease / Colitis, and called 'Idiopathic' (an

erudite-sounding term for 'unknown'). Perhaps for this reason, labels have

generally failed to warn strongly against these side effects. Repeated

epidemiological examination does ultimately support the conclusion that these

severe adverse events are caused by this class of drugs. In our experience, this

class of drugs produces significant adverse reactions, with cautions inadequate

or absent.

 

Ransford RA, Langman MJ.

Sulphasalazine and Mesalazine: Serious Adverse Reactions re-evaluated on the

basis of suspected Adverse Reaction reports to the Committee on Safety of

Medicines.

Gut 2002 Oct;51(4):536-9.

 

 

 

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