JAMA published results on Cancer in regards to Statins

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JAMA published results on Cancer in regards to Statins

JoAnn Guest

May 09, 2003 16:13 PDT

 

JAMA publish results of Statins cause cancer.

JAMA 1996 Jan 3;275(1):55-60Related Articles, Links

 

Comment in:

JAMA. 1996 Jan 3;275(1):67-9.

JAMA. 1996 May 15;275(19):1479-80; discussion 1481-2.

JAMA. 1996 May 15;275(19):1479; discussion 1481-2.

JAMA. 1996 May 15;275(19):1480-1; discussion 1481-2

JAMA. 1996 May 15;275(19):1480; discussion 1481-2.

JAMA. 1996 May 15;275(19):1480; discussion 1481-2.

JAMA. 1996 May 15;275(19):1481-2.

 

Carcinogenicity of lipid-lowering drugs.

 

Newman TB, Hulley SB.

 

Department of Laboratory Medicine, School of Medicine, University of

California, San Francisco, USA.

 

OBJECTIVE--To review the findings and implications of studies of

rodentcarcinogenicity of lipid-lowering drugs. DATA SOURCES--

 

Summaries of

carcinogenicity studies published in the 1992 and 1994 Physicians'

DeskReference (PDR), additional information obtained from the US

Food

and Drug

Administration, and published articles identified by computer

searching,bibliographies, and consultation with experts. STUDY

SAMPLE--We tabulated rodent carcinogenicity data from the 1994 PDR

for

all drugs listed as " hypolipidemics. "

 

For comparison, we selected a stratified random

sample of antihypertensive drugs. We also reviewed methods and

interpretation of carcinogenicity studies in rodents and results of

clinical trials in humans.

 

DATA SYNTHESIS--All members of the two most popular classes of lipid-

lowering drugs (the fibrates and the statins) cause cancer in

rodents,

in some cases at levels of animal exposure close to those prescribed

to

humans.

 

 

Evidence of carcinogenicity of lipid-lowering drugs from clinical

trials in humans is inconclusive because of inconsistent results and

insufficient durationof follow-up.

 

CONCLUSIONS--Extrapolation of this evidence of

carcinogenesis from rodents to humans is an uncertain process.

Longer-term

clinical trials and careful postmarketing surveillance during the

next severaldecades are needed to determine whether cholesterol-

lowering

drugs cause cancer inhumans.

 

In the meantime, the results of experiments in animals

and humans suggestthat lipid-lowering drug treatment, especially

with

the fibrates and

statins, should be avoided except in patients at high short-term

risk of coronary heart disease.

 

 

 

 

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