Hypothesis: Iodine, Selenium and Breast Cancer Regression

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Mon Nov 17, 2003 1:07 pm

Subject:

Hypothesis: Iodine, Selenium and Breast Cancer Regression

 

 

Medical Abstract Title:

Hypothesis: Iodine, Selenium and Breast Cancer Regression

 

Author:

Cann SA, van Netten JP, van Netten C.

 

Source:

Cancer Causes Control. 2000;11(2):121-12.7

 

Abstract:

 

BACKGROUND: In this paper we examine some of the evidence regarding

the use of selenium and iodine in breast cancer remission.

 

Seaweed is a popular dietary component in Japan and a rich source

of both of these essential elements.

 

We hypothesize that this dietary preference may be associated with

the low incidence of benign and malignant breast disease in Japanese

women.

 

In animal and human studies, iodine administration has been shown to

cause regression of both iodine-deficient goiter and benign

pathological breast tissue.

 

Iodine, in addition to its incorporation into thyroid hormones, is

organified into anti-proliferative iodolipids in the thyroid; such

compounds may also play a role in the proliferative control of

extrathyroidal tissues. Selenium acts synergistically with iodine.

 

All three mono-deiodinase enzymes are selenium-dependent and are

involved in thyroid hormone regulation. In this way selenium status

may affect both thyroid hormone homeostasis and iodine availability.

 

CONCLUSION: Although there is suggestive evidence for a preventive

role for iodine and selenium in breast cancer, rigorous

retrospective and prospective studies are needed to confirm this

hypothesis.

 

http://www.enzy.com/abstracts/display.asp?id=3570

 

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