progesterone

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Dr. HingHau Tsang's Crusade on Nutrition

 

 

 

Newsletter #75 --- Estrogen Dominance, Natural Progesterone and Men

 

 

 

Just as in women, men suffer the effects of " estrogen dominance " .

 

Many researchers including John R. Lee, M.D (Leading pioneer in natural

progesterone therapy), Dr. Jesse Hanley and Dr. Peter Eckhart are coming to

the conclusion that the over abundance of estrogen and estrogen like

substances (xenoestrogens or foreign estrogens) are responsible for a vast

number of today's health problems. This over abundance of estrogen is

referred to as estrogen dominance which is an increasingly serious problem

for both women and men. Dr. Lee believes that it is excessive exposure to

estrogen that is the primary cause of prostate enlargement and prostate

cancer. Xenoestrogens in the environment are among the culprits. Sources of

xenoestrogens includes commercially raised beef, chicken and pork, birth

control pills, spermacide, detergent, plastics, plastic drinking bottles,

pesticides, herbicides, personal care products, canned foods and lacquers.

 

Men produce estrogen (Estradiol) but in much lower amount than women. Men

also produce progesterone, but about half the amount from that of females.

Progesterone is made in men by the adrenal glands and testes. Progesterone

is vital to good health in both women and men. It is the primary precursor

of our adrenal cortical hormones and testosterone. The male hormone,

testosterone, is an antagonist to estradiol (E2). It is made from

progesterone. Men normally continue to produce relatively normal level of

testosterone for their age and well into the seventies. Contrary to common

perception, testosterone does not cause prostate cancer. Young men have high

levels of testosterone and old men low levels. If testosterone were the

cause of prostate cancer, young men would be dying of prostate cancer.

Studies had shown that men with the highest level of testosterone have the

least prostate enlargement. Conversely, men with the highest level of

estrogen have enlarged prostates. Declining testosterone from aging,

together with increasing level of estrogen, is the most likely reason for

prostate enlargement and cancer in men.

 

The prostate is embryologically the same as the uterus in the female.

Research Studies (Listed at the end of this newsletter) have shown that when

prostate cells are exposed to estrogen, the cells proliferate and become

cancerous. When progesterone or testosterone was added, cancer cell dies.

During the aging process, progesterone level falls in men, especially after

age 60. Progesterone is the chief inhibitor of an enzyme called 5-alpha

reductase that is responsible for converting testosterone to

dihydrotestosterone (DHT), a much more potent derivative that is linked to

prostate cancer. When the level of progesterone falls in men, the amount of

conversion from testosterone to DHT increases. Unfortunately, DHT is not as

powerful an inhibitor of cancer cell compared to testosterone. When the

level of testosterone decreases, the relative level of estradiol in men

increases. Estradiol, turns on BCL2 oncogene (Onco means cancer) and

increases the risk of prostate cancer if adequate amount of progesterone is

not there to counteract its effect by stimulating the P53 cancer protection

gene.

 

Benign prostatic hyperplasia (BPH), a prostate enlargement condition, is a

common condition affecting the majority of male above age 50. Prostate

cancer is a leading cause of cancer in men. It is slow growing, with a

doubling time of 5 years. Numerous anecdotal reports of reduction of BPH and

reversal of prostate cancer through the use of natural progesterone

supplementation have been reported.

 

Clinical Evidence

 

Dr. John Lee's women patients used natural progesterone for osteoporosis.

Some of their spouses also used it for their bones and their prostate cancer

went into remission. Dr. John Lee has had about 10 out of 10 men in

remission from prostate cancer using Natural Progesterone cream. One man was

being treated at Mayo Clinic for prostate cancer and it had spread to the

bone. He began to use his wife's progesterone cream for his bones. After 6

months of progesterone cream applied to his skin, Mayo Clinic could find no

evidence of any prostate cancer. Several men with prostate cancer have told

Dr. Lee that their PSA (Prostate Specific Antigen) level-decreased when they

started using a daily dab of progesteorne cream, and that they have had no

progression of their prostate lesions. Dr. Peter Eckhart also had patients

in remission from prostate cancer. Studies had shown that PSA level returns

to normal upon application of natural progesterone cream before or after

prostate surgery.

 

Dr. Lee reported twelve men who applied natural progesterone cream for their

osteoporosis. All of them began to experience relief from their condition,

after three months of daily massage, they were also experiencing an improved

urine flow, with less pressure on their prostate glands and a noticeable

decrease in nightly urination. Each patient was also suffering from enlarged

prostates.

 

2 Ways to combat " Estrogen Dominance " in Men

 

1. Cut out the estrogen mimicking chemicals in our life

 

Use glass or ceramics whenever possible to store food

 

If you must use plastics, do not heat them up in the microwave oven or leave

them in the sun.

 

Use a simple detergent with less chemicals (e.g. Nature Clean)

 

Use a simple soap

 

Use natural pest control not pesticides.

 

Avoid Synthetic Chemicals.

 

Don't use herbicides.

 

Buy hormone free meats to eat.

 

Buy " Organic " produce, produce grown without pesticides, herbicides or

synthetic fertilizer

 

Use Condoms without spermicide for Birth control.

 

2. Apply Natural Progesterone cream

 

Progesterone cream can help to reduce the prostate size. Progesterone's

inhibitory effect on 5 alpha reductase is far more effective than Proscar

which is standard agents used in traditional medicine to cure BPH. All men

over age 40 should consider natural progesterone replacement therapy, or

even earlier if there is a history of prostate caner or BPH. The amount

needed is 8 - 12 mg a day (1/8 tsp -1/4 tsp twice daily). Men should apply

directly to their scrotum (testical sac) twice daily. This allows it to get

into the prostate receptors.

 

Symptoms of prostatism such as urinary urgency and frequency decreased

considerably after application of Natural Progesterone cream. Physiological

doses of progesterone also appear to enhance sexual drive. Natural

progesterone cream prevents osteoporosis in men. Natural progesterone cream

might decrease male balding due to the corresponding rise in testosterone.

Progesterone cream might provide relief from pain and swelling of rheumatoid

arthritis when rubbed into the joints.

 

Side Effects of Natural progesterone cream

 

Side Effects for Natural Progesterone taken in physiologic doses are

minimal.

 

In a study in the Medical Tribune fifteen years ago, progesterone was given

to college age men. Sperm maturation was observed to be inhibited. In other

words, it appears that progesterone taken by men in physiologic doses may

act only as a contraceptive. In women, progesterone increases sex drive.

 

Progesterone has no feminizing characteristics.

 

Research Studies

 

In 1988 a very important study was done at Nanjing Medical College in China

where progesterone reduced the prostate weights of test animals.

 

Six different studies at the University of Milan in Italy, the University of

Turku in Finland, Montreal General Hospital in Quebec, St. George's Hospital

in London, the University of Mainz in Germany and the Roswell Park Memorial

Institute in New York all independently had results that suggest that

progesterone is a powerful 5-alpha reductase inhibitor that stops the

conversion of testosterone into DHT in test animals.

 

At Staten Island College in New York and Mt. Sinai Medical School (also in

New York ) progesterone was shown to raise the level of androstenedione in

the prostate gland itself. Remember that a healthy prostate needs an

abundance of androgens such as testosterone and androstenedione and DHEA to

function well as it does in your youth.

 

At the University of Maryland in Baltimore human prostate cells were shown

to have progesterone receptor sites. This was also demonstrated at the

Institute of Clinical Medicine in Rome.

 

The Center for Drug Research in India did four different studies suggesting

that progesterone shrank enlarged rat prostates, progesterone antagonized

the stimulating effects of estrogen, that progesterone stimulates alkaline

phosphatase and depressed acid phosphatase in the prostate and generally is

supportive of proper prostate function.

 

At the University of Laval in Quebec progesterone inhibited estrogen from

binding to the prostate and progesterone receptors were clearly

demonstrated.