Guest guest Posted May 25, 2008 Report Share Posted May 25, 2008 Sent to me by one of our members: The Budwig Diet Revision Germany's Dr. Joanna Budwig is widely credited for discovering that 2 simple food items, cold-pressed flax seed oil and low-fat cottage cheese, will cure or prevent many forms of cancer and a long list of other degenerative diseases including cardiovascular diseases and skin diseases. But the 50-year old "Budwig Diet" is long in the tooth and newer data has emerged that shows where we can improve on it. essential fatty acids referencesSulfur-rich protein and calcium in the "Budwig protocol" is provided by cottage cheese. Because many people can not take "dairy", lets look more closely at the cottage cheese. Human milk is higher in whey and much lower in casein than cow milk or goat milk; casein is the main protein in cheese and cottage cheese. Caseins differ somewhat; cow milk contains a lot of alpha-casein, which because of its different properties is the main cause of milk and "dairy" indigestion in humans. Beta lactoglobulins in cow milk can also be problematic as allergens, and cow milk also contains more alpha s1-casein than goat milk. All of this explains why many people find goat milk less problematic than cow milk. The problematic milk components can be removed leaving low-fat whey, most of which is an exact match across the whole mammalian order. The common ingredients are more easily assimilated than any other protein and do not produce sensitivity or allergy issues. The Physicians Desktop Reference for Prescription Drugs lists one pure whey isolate as "well-tolerated by even severely milk-sensitive individuals", and practice corroborates that. Bottom line - although biological incompatibilities exist in foreign milk, comments that lump 'dairy' products together as problematic are sloppy; the statement does not apply to high-quality whey, and it is widely acknowledged to be the most healthy fraction of milk. The Budwig Diet revision uses undenatured whey instead of cottage cheese. Undenatured whey contains the sulfur-containing amino acids methionine and cysteine compounds including cystine. Methionine is transformed into cysteine by the liver. Cellular cysteine is the rate-limiting factor in production of glutathione, the body's master antioxidant and detoxifier. Glutathione is crucial to life; it's involved in ATP energy generation, immune system support, liver and other organ support, reducing toxin load and oxidative stress, and importantly, it shrinks tumors when levels are maintained. More glutathione information including the role whey can play in cancer therapy is available here with glutathione references. Cottage cheese doesn't boast those benefits; in fact it's only a sulfur amino acid source. The Budwig Diet revision's replacement of the bio-incompatible cottage cheese with compatible cold-processed whey adheres to the principles of the "Budwig Diet", and will provide huge additional benefit. Unlike cottage cheese, cold-processed whey is mildly alkalizing to the body, and several cold-processed wheys are listed in the US PDR as a specific anti-cachexia (anti-wasting) formula. The flaxseed oil in the original plan provides the essential fatty acid alpha-linolenic acid (ALA), which is thought to be a 'good' omega-3 oil; however, more recent science has revealed that it's a common but faulty assumption that ALA is physiologically equivalent to omega-3 essential fatty acids EPA and DHA, and that there is no known need for alpha-linolenic acid (ALA) independent of its conversion to EPA/DHA. And in adults the conversion rate is tiny; the US Environmental Protection Agency has posted this powerpoint presentation (slide 5) that explains less than 1% conversion of ALA to EPA (some sources say somewhat higher), and <0.01% to DHA. Though these details have traditionally escaped the followers of Joanna Budwig and Udo Erasmus, fatty acids expert Dr. Floyd Chilton fully explains them in his book Inflammation Nation. Chilton says (page 97), "I wish I could tell you that the (ALA) in flaxseed oil could replace wild fish as a rich source of EPA and DHA but the scientific literature simply does not support this contention. ...We do the conversion but very slowly, and we also eat a lot of fatty acids such as LA that 'compete' for enzymes that convert ALA to EPA and DHA, further limiting its conversion." This competition is most pronounced in the common condition of low EPA/DHA and higher omega-6 fatty acid intake seen in the modern diet. Thus the omega-6 content of the flax oil, (25% of the amount of ALA) seen in the table below, also inhibits the conversion. Composition of flax seed oil: Fatty acid Percent Alpha linolenic (omega-3) 55 Linoleic (omega-6) 13.8 Oleic 21.5 Stearic 2.2 Palmitic (saturated) 7.1 Budwig and her followers including Udo Erasmus also purport to supply the needed fatty acids to rebuild cell walls so they can carry more oxygen and etc., by supplying ALA; however, cell walls actually contain negligible ALA and are high EPA and DHA. This explains why for more than maintenance you may need vastly more EPA and DHA than an ALA supplement can provide, and why fish oil supplements are more popular for inflammation. For these reasons flax oil seems a less brilliant choice for biological support in humans than it did 50 years ago. Unlike ALA, EPA and DHA are essential to health and can reverse illness, including the coronary heart disease, skin disorders and cancer claimed by proponents of the Budwig Diet. The Budwig Diet revision ensures adequate EPA and DHA are supplied. Wild salmon oil, wild fish oil, and cod liver oil provide lots of EPA and DHA. Wild salmon oil, even minimally refined oil, has almost no impurities. Inflammation can be further reduced by adding GLA or Borage oil. Some people may feel safer by staying closer to the original diet by adding these EFAs rather than replacing the flax oil of the original Budwig diet, but it is unwise to not include them at all, thus this Budwig Diet revision was probably inevitable. Essential Fatty Acids References:"Specific inhibitory effect of dietary eicosapentaenoic acid on N-nitroso-N-methylurea-induced mammary carcinogenesis in female Sprague-Dawley rats" (Carcinogenesis; 11(11): 2015-9, Nov 1990) found that EPA significantly reduced (60% versus 93.3%) mammary tumour incidence and number in rats and significantly reduced prostaglandin levels, suggesting that the breast cancer inhibition by EPA may be mediated via lipid metabolism and associated reduction in prostaglandin synthesis. Omega-3 fatty acids from fish oil significantly reduced weight loss and tumour growth rate in an experimental colon cancer cachexia system in this study: (Tisdale MJ and Dhesi JK. Inhibition of weight loss by omega-3 fatty acids in an experimental cachexia model. Cancer Res; 50(16): 5022-6. Aug 15 1990) "Anticachectic and antitumor effect of eicosapentaenoic acid and its effect on protein turnover" (Cancer Res; 51(22): 6089-93. Nov 15 1991) studied the effect of eicosapentaenoic acid (EPA) and gamma-linolenic acid (GLA) on weight loss and tumour growth in mice with cachexia-inducing colon cancer. EPA inhibited both weight loss and tumour growth rate in a dose-related manner; body weight was effectively maintained (weight loss did not occur even when tumour growth resumed), there was delay in tumour progression of growth, and overall survival was approximately doubled in EPA-treated animals. EPA significantly reduced protein degradation without affecting protein synthesis. The effect of GLA on both host body weight loss and tumour growth was much less pronounced than that of EPA. "Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines" (Prostate; 18(3): 243-54. 1991) showed that while linoleic acid and omega-6 fatty acid stimulated the grown of (androgen-unresponsive) human prostate cancer cells, EPA and DHA, two omega-3 fatty acids, were equally efffective in inhibiting growth of these same prostate cancer cells in a dose-dependent manner, with a 65% reduction in growth. In the small double-blind, placebo-controlled study, "Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer", (Gastroenterology; 103(3): 1096-8. Sep 1992) 20 patients with sporadic adenomatous colorectal polyps were given omega-3 fatty acid supplementation for 12 weeks. While there was no change in the controls, the group of 10 that received fish oil containing EPA and DHA the "S"-phase cells (a reliable marker of colon cancer risk) significantly dropped in 2 weeks and stayed lower throughout the trial. Arachidonic acid (inflammatory) levels also decreased. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 26, 2008 Report Share Posted May 26, 2008 I have seen the “Budwig Revision” before. Undenatured whey is a good if it is the right kind or it is made fresh (actually fresh is always better). We sometimes use it for those who need to put on weight or have concerns with anemia. However, we do not advise mixing it with the FO/CC mixture. Many ingredient combinations look good on paper and even in a petri dish (especially when they attack cancer cells) and therefore “should” work in “theory”. But once they get into the human body, things may not happen the way that was “predicted”. Why should we change something that has worked for so many people? I see this all the time with cancer patients or natural cancer sites in that they want to make a proven protocol fit into what is more convenient for the patient or they just totally throw caution to the wind and post the protocol using incorrect directions. Dr. Budwig knew what she was doing and the results speak for themselves. Many don’t understand all the how’s and why’s because they either don’t understand Quantum Physics or they make it a point to try to disprove Quantum Physics because they think it is pseudo-science. Many do not understand the importance of the emulsification process between the cottage cheese (quark) and the Flax seed oil and how this really works in the body. I notice that the person who wrote the Budwig Revision is also selling Borage Oil and Omega 3 Fish Oil (both of which he recommends in the article) underneath the Budwig article. How many have been cured using the Budwig Diet Revision? Truly, if people are getting results then Iet’s see some testimonies. Certainly I have no problem with finding additional products that would work in the same way that the cottage cheese does as I am not “married” to cottage cheese, but in order to do that it means that there would have to be diagnosed cancer patients (not people who “think” they have cancer) who are willing to step out and try something that Dr. B did not recommend. Again, if this has already happened, I would love to read some testimonies. The CO/FO is only PART of the Budwig protocol. There is so much more to the protocol, for instance daily sunshine without sunglasses or sunscreen. Because so many are looking for a one-ingredient or one-product cure-all (even among the natural health community) we try to focus on just one part or aspect. This is the thinking of conventional medicine. However, the body will always heal in a synergistic way which means no one product, food, modality will heal completely. It is always about bringing the whole body into health in a synergistic manner. Many refuse this concept, do their own thing and then wonder why they do not get results. I did a seminar several years back with a person who I respect and who has a very good book on healing cancer. We were doing a question and answer session at the end and I was shocked when this person said that using non-organic cottage cheese with the flaxseed oil was acceptable. I tried to disagree in as nice of manner as possible. There are many versions of the Budwig Protocol directions on the Internet and probably 90% of them are incorrect. People think that it will not hurt to change this or that or to add this or that. Again, they do not understand synergy. Possibly the “Budwig Revision” came about out of the concern for those who are supposedly lactose intolerance? Dr. Budwig said that she never once had a problem with her patients being lactose intolerant on her program. So why do we see this now? The main reason is because she had easy access to raw, un-adulterated dairy. Raw, organic cottage cheese would be the BEST to use with the FO for those who are lactose intolerant. Another reason would be that some have been warned that they are allergic to dairy and thus refuse to even try raw, organic cottage cheese. The emulsification process between the oil and the cottage cheese allows many, many “lactose intolerant” people to do just fine on the protocol. However, the must be willing to give it a try. Below is information from www.healingcancernaturally.com which contains a lot of good information about the Budwig Protocol: Suggested & Possible Reasons for Dairy/Lactose Intolerance and Sensitivity Pasteurization: generally speaking, all commercial milk seems to be pasteurized, even organic milk. Pasteurization destroys beneficial bacteria (probiotics) and enzymes naturally occurring in milk products, both of which help in digestion. Homogenization: various research points to homogenization of milk being a culprit in consumers experiencing lactose intolerance symptoms and “milk allergy”. Non-organic milk (see below) Why use Organic Dairy 1. Antibiotics - Conventional milk (and meat) products are very likely to contain antibiotics which harm and destroy the good (beneficial) intestinal flora. This apparently both impedes proper digestion/optimal mineral nutrient assimilation and immune system performance and contributes to the currently observed Candidiasis epidemic (Candidiasis being defined as “overgrowth in the gastrointestinal tract of the usually benign yeast [or fungus] Candida albicans”). Candida fungus overgrowth has become widespread apparently due to indiscriminate antibiotics use in the food chain. 2. Genetically engineered bovine growth hormone (Posilac) - Conventional dairy products in the US may or do contain bovine growth hormone. See for instance rense.com/general48/milk.htm (“cows treated with Posilac have been developing bone cancers”). Tips and Suggestions For Dairy/Cottage Cheese/Lactose Intolerance/Sensitivity on the Budwig diet: How To Tolerate Dairy Products Use organic milk only. Use organic raw dairy products wherever obtainable. It is easier to find raw products than most of us think. Yes, you might have to be a little inconvenienced to find it. J Re-introduce beneficial gut bacteria into pasteurized milk products by culturing your own yoghurt and making yoghurt quark from it by straining. Buy products with live cultures (such as Nancy's Cottage Cheese, see www.nancysyogurt.com which also provides a store locator). Use goat’s milk products/goat yoghurt (best to drain it to obtain yoghurt quark). Goat milk is more expensive than cow’s milk. Use kefir. Use EFT (Emotional Freedom Technique): EFT is also reported to have healed lactose intolerance. (“EFT is a meridian-based DIY technique helping many to overcome compulsions and addictions [and numerous other issues and complaints], of which an aversion to cottage cheese could be considered. EFT may warrant investigation by those who really want to carry out Dr. Budwig's protocol as she intended and overcome their aversion to cottage cheese.”) Take the enzyme lactase when consuming dairy (lactase pills etc.). Try probiotics and systemic enzymes. Try organic low lactose milk (if available) and make yogurt and/or yoghurt quark with it. Below are several posts from the FO/CC group who have a lot of experience using the Budwig Protocol: Wilhelm – Budwig Scholar from the Flax Seed Oil Group: " Yes, whey helps to raise the glutathione level as does Quark and CC, and any cystine, cysteine and even methionine foods. Be sure not to overdo it with supplements because it can also raise the homocysteine level which is not desirable. " I don't know what you gain by using a whey supplement. There are many brands and qualities of whey powder available. One thing that I don't like about whey powders is that you don't know the origin of the milk from which they were made. As I understand it, whey powders come from almost any place. At least with milk, CC, etc. you either know where these products come from or you have a fair idea from what area they are coming and what the farming practices are in those places are. " Sulphurated proteins (SPs) are the sulphur containing proteins cystine, cystein and methionine. Many foods contain them but only in very small amounts. Dairy products are high in SPs, especially quark and cottage cheese because the whey has been removed, leaving mainly the milk solids where the proteins are. " Sandra: “The reason for draining off the whey is to have a denser amount of sulphur proteins that will bond with the oil to make it more water soluble and readily metabolized. Quark and CC have a denser amount.” -- Wilhelm explains reasons not to add whey powder to the BP. These are some of the same reasons why Dr. Budwig did not care for supplements in general – 1) it's difficult to know what is really in them and – 2) an excess of one isolated nutrient can cause an imbalance in your system, as with homocyteine, that can interfere with the BP working as well and as easily as it could otherwise. Dr. Budwig created a protocol that is ideal for healing the cancer patient as well as those with other diseases. Practically every part of it has been questioned over the years and the FO/CC is fortunate to have Michael B. who lives in Germany and is a Budwig scholar himself, with his own Budwig website in German, as well as Wilhelm, who grew up in Germany, adding insight to these questions. Both can read Dr. Budwig's German books as well as those in English. Robyn writes: (PhD in Biochemistry in the area of milk protein, was asked to explain how quark or cottage cheese makes flaxseed oil water soluble.) The statements below apply equally to quark, organic low-fat cottage cheese, drained yoghurt cheese and kefir cheese of which all can be used with the flaxseed oil. Quark or cottage cheese is mostly casein that has been precipitated from milk. When casein is held in solution ie before milk is coagulated to make cheese, it is rolled up, a bit like a long length of string might be rolled into a ball. It does not unravel because small sections of the string are attracted to other sections of the string. The points of attraction are sulphur atoms. So a sulphur on one section of the string sticks to a sulphur somewhere else along the string and a " disulphide bridge " is formed. Disulphide bridges are strong in chemical terms. They hold everything in place. The sulphur needed to form the disulphide bridges comes from the amino acid, cysteine. All proteins are made up of long strings of amino acids and cysteine is just one of them, but it is one that contains sulphur and very few amino acids contain sulphur. That makes it special. When the milk is subjected to heat and acid (vinegar), or a culture, the casein is affected. Its disulphide bridges are broken. It unravels and exposes other types of chemical forces (previously hidden and shielded inside the rolled up ball) and now lots of caseins stick together in a big mess. That is, it coagulates and precipitates to give us curds(cottage cheese) and whey. At this point the sulphurs that previously teamed up with another sulphur to form a disulpide bridge or link are still sticking out of the precipitated casein, but now they are just single unattached sulphurs. They are desperate to attach to something else. Flax seed oil is a great candidate. Oils are not generally water soluble. They repel water. However when the flax seed oil is grabbed by the sulpur in casein, its water repellant properties are modified and it is no longer so water repelling. So as long as the flax seed oil is stuck on to a sulphur in the casein it can be thought of as " water soluble " . In reality it is not so much water soluble as less water repellant. In any event it can now go places it would not otherwise be able to go, so long as it is attached to cysteine. Cottage cheese is therefore a " carrier " of flax seed oil. The flax seed oil is bonded to the casein through the sulphur in cysteine. The sulphur has only become available because the casein has been unraveled. I don't know of another source of readily available sulphur which is available for bonding. ______________________________ Certainly if people want to substitute ingredients, that is their choice. All fish oil is contaminated to an extent, even though the extent may be very small, it is still contaminated. There have been people on the BP that have used Fish Oil supplements and again, their choice, but it is not part of Dr. Budwig’s Protocol. There have been just as many NOT use it and got excellent results. For these reasons flax oil seems a less brilliant choice for biological support in humans than it did 50 years ago. Dr. Budwig did not pass away until 2003 (she was 95 and still very active) and did not see fit to change her protocol. This was only five years ago. Dr. Budwig was able to cure countless cases of cancers by combining flaxseed oil with a sulfur rich protein food source such as low fat cottage cheese. Just two simple food ingredients, flaxseed oil and low fat cottage cheese, easily obtainable from any health food store and supermarket, could save millions of cancer victims. There was nothing suggestive in her years of experimentation and proven clinical trials using flaxseed oil to defeat cancer; she PROVED it beyond all reasonable doubt and published her results I know, from experience, that there is great necessity in correctly following a protocol, if you want results. I am NOT saying that using whey protein will not give results, because I don’t know. What I am saying is that IF this “revised program” works, where are the results? If I had cancer and was going to use the BP, I would want to use the exact same protocol that Dr. B promoted and has worked for many, many people. Conventional medicine does enough of the guinea-pig game. I actually participated in it for one month and quickly decided not to play. One year later I found out that one of the chemicals in my chemo cocktail (“double whammy” is what my onco called it) had been stopped because the “clinical trials” (no one told me I was in a clinical trial) showed that it was being given in dosages that were KILLING people! For even more information, a very good article summarizing the correct BP along with many testimonies can be found at: http://www.cancertutor.com/Cancer/Budwig.html Be Well Loretta Sent to me by one of our members: The Budwig Diet Revision Germany's Dr. Joanna Budwig is widely credited for discovering that 2 simple food items, cold-pressed flax seed oil and low-fat cottage cheese, will cure or prevent many forms of cancer and a long list of other degenerative diseases including cardiovascular diseases and skin diseases. But the 50-year old " Budwig Diet " is long in the tooth and newer data has emerged that shows where we can improve on it. essential fatty acids references Sulfur-rich protein and calcium in the " Budwig protocol " is provided by cottage cheese. Because many people can not take " dairy " , lets look more closely at the cottage cheese. Human milk is higher in whey and much lower in casein than cow milk or goat milk; casein is the main protein in cheese and cottage cheese. Caseins differ somewhat; cow milk contains a lot of alpha-casein, which because of its different properties is the main cause of milk and " dairy " indigestion in humans. Beta lactoglobulins in cow milk can also be problematic as allergens, and cow milk also contains more alpha s1-casein than goat milk. All of this explains why many people find goat milk less problematic than cow milk. The problematic milk components can be removed leaving low-fat whey, most of which is an exact match across the whole mammalian order. The common ingredients are more easily assimilated than any other protein and do not produce sensitivity or allergy issues. The Physicians Desktop Reference for Prescription Drugs lists one pure whey isolate as " well-tolerated by even severely milk-sensitive individuals " , and practice corroborates that. Bottom line - although biological incompatibilities exist in foreign milk, comments that lump 'dairy' products together as problematic are sloppy; the statement does not apply to high-quality whey, and it is widely acknowledged to be the most healthy fraction of milk. The Budwig Diet revision uses undenatured whey instead of cottage cheese. Undenatured whey contains the sulfur-containing amino acids methionine and cysteine compounds including cystine. Methionine is transformed into cysteine by the liver. Cellular cysteine is the rate-limiting factor in production of glutathione, the body's master antioxidant and detoxifier. Glutathione is crucial to life; it's involved in ATP energy generation, immune system support, liver and other organ support, reducing toxin load and oxidative stress, and importantly, it shrinks tumors when levels are maintained. More glutathione information including the role whey can play in cancer therapy is available here with glutathione references. Cottage cheese doesn't boast those benefits; in fact it's only a sulfur amino acid source. The Budwig Diet revision's replacement of the bio-incompatible cottage cheese with compatible cold-processed whey adheres to the principles of the " Budwig Diet " , and will provide huge additional benefit. Unlike cottage cheese, cold-processed whey is mildly alkalizing to the body, and several cold-processed wheys are listed in the US PDR as a specific anti-cachexia (anti-wasting) formula. The flaxseed oil in the original plan provides the essential fatty acid alpha-linolenic acid (ALA), which is thought to be a 'good' omega-3 oil; however, more recent science has revealed that it's a common but faulty assumption that ALA is physiologically equivalent to omega-3 essential fatty acids EPA and DHA, and that there is no known need for alpha-linolenic acid (ALA) independent of its conversion to EPA/DHA. And in adults the conversion rate is tiny; the US Environmental Protection Agency has posted this powerpoint presentation (slide 5) that explains less than 1% conversion of ALA to EPA (some sources say somewhat higher), and <0.01% to DHA. Though these details have traditionally escaped the followers of Joanna Budwig and Udo Erasmus, fatty acids expert Dr. Floyd Chilton fully explains them in his book Inflammation Nation. Chilton says (page 97), " I wish I could tell you that the (ALA) in flaxseed oil could replace wild fish as a rich source of EPA and DHA but the scientific literature simply does not support this contention. ...We do the conversion but very slowly, and we also eat a lot of fatty acids such as LA that 'compete' for enzymes that convert ALA to EPA and DHA, further limiting its conversion. " This competition is most pronounced in the common condition of low EPA/DHA and higher omega-6 fatty acid intake seen in the modern diet. Thus the omega-6 content of the flax oil, (25% of the amount of ALA) seen in the table below, also inhibits the conversion. Composition of flax seed oil: Fatty acid Percent Alpha linolenic (omega-3) 55 Linoleic (omega-6) 13.8 Oleic 21.5 Stearic 2.2 Palmitic (saturated) 7.1 Budwig and her followers including Udo Erasmus also purport to supply the needed fatty acids to rebuild cell walls so they can carry more oxygen and etc., by supplying ALA; however, cell walls actually contain negligible ALA and are high EPA and DHA. This explains why for more than maintenance you may need vastly more EPA and DHA than an ALA supplement can provide, and why fish oil supplements are more popular for inflammation. For these reasons flax oil seems a less brilliant choice for biological support in humans than it did 50 years ago. Unlike ALA, EPA and DHA are essential to health and can reverse illness, including the coronary heart disease, skin disorders and cancer claimed by proponents of the Budwig Diet. The Budwig Diet revision ensures adequate EPA and DHA are supplied. Wild salmon oil, wild fish oil, and cod liver oil provide lots of EPA and DHA. Wild salmon oil, even minimally refined oil, has almost no impurities. Inflammation can be further reduced by adding GLA or Borage oil. Some people may feel safer by staying closer to the original diet by adding these EFAs rather than replacing the flax oil of the original Budwig diet, but it is unwise to not include them at all, thus this Budwig Diet revision was probably inevitable. Essential Fatty Acids References: " Specific inhibitory effect of dietary eicosapentaenoic acid on N-nitroso-N-methylurea-induced mammary carcinogenesis in female Sprague-Dawley rats " (Carcinogenesis; 11(11): 2015-9, Nov 1990) found that EPA significantly reduced (60% versus 93.3%) mammary tumour incidence and number in rats and significantly reduced prostaglandin levels, suggesting that the breast cancer inhibition by EPA may be mediated via lipid metabolism and associated reduction in prostaglandin synthesis. Omega-3 fatty acids from fish oil significantly reduced weight loss and tumour growth rate in an experimental colon cancer cachexia system in this study: (Tisdale MJ and Dhesi JK. Inhibition of weight loss by omega-3 fatty acids in an experimental cachexia model. Cancer Res; 50(16): 5022-6. Aug 15 1990) " Anticachectic and antitumor effect of eicosapentaenoic acid and its effect on protein turnover " (Cancer Res; 51(22): 6089-93. Nov 15 1991) studied the effect of eicosapentaenoic acid (EPA) and gamma-linolenic acid (GLA) on weight loss and tumour growth in mice with cachexia-inducing colon cancer. EPA inhibited both weight loss and tumour growth rate in a dose-related manner; body weight was effectively maintained (weight loss did not occur even when tumour growth resumed), there was delay in tumour progression of growth, and overall survival was approximately doubled in EPA-treated animals. EPA significantly reduced protein degradation without affecting protein synthesis. The effect of GLA on both host body weight loss and tumour growth was much less pronounced than that of EPA. " Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines " (Prostate; 18(3): 243-54. 1991) showed that while linoleic acid and omega-6 fatty acid stimulated the grown of (androgen-unresponsive) human prostate cancer cells, EPA and DHA, two omega-3 fatty acids, were equally efffective in inhibiting growth of these same prostate cancer cells in a dose-dependent manner, with a 65% reduction in growth. In the small double-blind, placebo-controlled study, " Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer " , (Gastroenterology; 103(3): 1096-8. Sep 1992) 20 patients with sporadic adenomatous colorectal polyps were given omega-3 fatty acid supplementation for 12 weeks. While there was no change in the controls, the group of 10 that received fish oil containing EPA and DHA the " S " -phase cells (a reliable marker of colon cancer risk) significantly dropped in 2 weeks and stayed lower throughout the trial. Arachidonic acid (inflammatory) levels also decreased. Quote Link to comment Share on other sites More sharing options...
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