Cancer Reasearch

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laxseed links

 

http://www.thensome.com/flaxseedlinks.htm

 

 

 

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-Herbal

Medicine, Healing, and Cancer :..Herbal Medicine, Healing and

Cancer is for humans but the information within it is so awesome and it

contains preventative tips also. Donald Yance has reviewed the

literature and has treated human cancer victims for over twenty

years..amazon sells it for less than $16 dollars! For instance, I

almost bought Melatonin for Yuki who just had radical surgery in case

of mammary cancer(thank goodness it was a cyst) because of that book. I

wish I had known about two years ago when I started the search to keep

Morgan alive. He also explains why possibly flaxseed and cottage cheese

may work-He explains what butryic acid is..He mentions Spes as a great

pain killer for cancer..and on and on..

Here is his excerpt on flaxseed oil and sulphur rich protein

Herbal Medicine, Healing & Cancer" by Donald Yance

"Flaxseed oil is rich in essential fatty acids, particularly ALA,

which, when taken in combination with sulfur-rich proteins, actually

works to create a new food. This was first discovered and made famous

by Johanna Budwig, a West German physician who had done a great deal of

research on the oil-protein combination. She discovered that EFAs need

to bind to sulfur-rich proteins (she used low-fat cottage cheese)

before the body can properly assimilate them. Budwig found that by

feeding people with terminal cancer this oil-protein combination, the

yellowish-green substance in their blood was replaced by the healthy

red pigment, hemaglobin. The phosphatides returned and the lipoproteins

reappeared.

Of all the deficiencies that may exist in people with cancer, perhaps

those that are most important and totally ignored are EFAs, which, when

taken with protein, enhance our albumin levels. Albumin is a blood

protein of immense importance to good health. When flaxseed oil and

sulfur-rich protein are combined, the ALA and the EFAs in the flaxseed

oil become water-soluble and electron-rich; this causes the cell

membrane to become more stable by making it more flexible and

fluidlike. The electron-rich fatty acids now allow for efficient

transport of materials and energy between the inner and outer cell

membrane. This is important to the health of all cells and to the

entire immune system.

A simple recipe for achieving these cellular benefits is to add 1 to 2

teaspoons of flaxseed oil or ground flaxseeds to 1 cup of organic

yogurt (preferabley goat or soy yogurt).

Omega-3 fatty acids are extremely important because they modulate

prostaglandins, which are very active biological substances important

to nearly every bodily function. They suppress tumor-promoting

prostaglandin E2 by increasing prostiglandin E3 and suppressing AA.

They also inhibit cancer wasting. EPA and ALA, as well as other related

omega-3 fatty acids, plus GLA from evening primrose oil, have been

found to kill a number of tumor-cell lines and cause a significant

reduction in tumor growth in animal studies." (pp.219-220)

 

Biosynthetic pathway to the cancer chemopreventive

secoisolariciresinol diglucoside-hydroxymethyl glutaryl ester-linked

lignan oligomers in flax (Linum usitatissimum) seed.

Application of stable and radioisotope precursor/tracer experiments

resulted in the identification of various phenylpropanoid, monolignol,

and lignan metabolites involved in the biosynthesis of the cancer

chemopreventive secoisolariciresinol diglucoside (SDG; 1)-containing

ester-linked "polymer(s)" in flax (Linum usitatissimum) seed.

Results from this study will facilitate future isolation and

characterization of the proteins and enzymes involved in biosynthesis

of the SDG-HMG ester-linked oligomers in flax seed.

"1: Carcinogenesis 1996 Jun;17(6):1373-6

Flaxseed and its lignan and oil components reduce mammary tumor growth

at a late stage of carcinogenesis.

Thompson LU, Rickard SE, Orcheson LJ, Seidl MM.

Department of Nutritional Sciences, Faculty of Medicine, University of

Toronto, Ontario, Canada.

Flaxseed, a rich source of mammalian lignan precursor

secoisolariciresinol-diglycoside (S.D.) and alpha-linolenic acid (ALA),

has been shown to be protective at the early promotion stage of

carcinogenesis. The objective of this study was to determine whether

supplementation with flaxseed, its lignan or oil fractions, beginning

13 weeks after carcinogen administration, would reduce the size of

established mammary tumors (present at the start of treatment) and

appearance of new tumors in rats. Dietary groups consisted of the basal

diet (BD, 20% corn oil) alone or supplemented with a gavage of 2200

nmol/day S.D. [s.D., equal to level in 5% flaxseed (F)], 1.82% flaxseed

oil (OIL, equal to level in 5% F) or 2.5% or 5% flaxseed (2.5% F and 5%

F, respectively). After 7 weeks of treatment, established tumor volume

was over 50% smaller in all treatment groups (OIL, 2.5% F, 5% F, P <

0.04; S.D., P < 0.08) while there was no change in the BD group. New

tumor number and volume were lowest in the S.D. (P < 0.02) and 2.5%

F (P < 0.07) groups. The combined established and new tumor volumes

were smaller for the S.D., 2.5% F and 5% F groups (P < 0.02)

compared to the OIL and BD groups. The high negative correlation (r =

-0.997, P < 0.001) between established tumor volume and urinary

mammalian lignan excretion in the BD, S.D., 2.5% F and 5% F groups

indicates that the reduction in tumor size is due in part to the

lignans derived from the S.D. in flaxseed. However, there was no

relationship between new or total tumor development and urinary lignan

levels. The effect of flaxseed oil may be related to its high ALA

content. In conclusion, the S.D. in flaxseed appears to be beneficial

throughout the promotional phase of carcinogenesis whereas the oil

component is more effective at the stage when tumors have already been

established.

PMID: 8681458 [PubMed - indexed for MEDLINE]"medline

 

" 1: Cancer Lett 1999 Jul 19;142(1):91-6

Dietary supplementation with secoisolariciresinol diglycoside

(SDG) reduces experimental metastasis of melanoma cells in mice.

Li D, Yee JA, Thompson LU, Yan L.

Department of Biomedical Sciences, Creighton University School of

Medicine, Omaha, NE 68124-0405, USA.

We investigated the effect of dietary supplementation with

secoisolariciresinol diglycoside (SDG), a lignan precursor isolated

from flaxseed, on experimental metastasis of B16BL6 murine melanoma

cells in C57BL/6 mice. Four diets were compared: a basal diet (control

group) and the basal diet supplemented with SDG at 73, 147 or 293

micromol/kg (equivalent to SDG provided in the 2.5, 5 or 10% flaxseed

diet). Mice were fed the diet for 2 weeks before and after an

intravenous injection of 0.6 x 10(5) tumor cells. At necropsy, the

number and size of tumors that formed in the lungs were determined. The

median number of tumors in the control group was 62, and those in the

SDG-supplemented groups were 38, 36 and 29, respectively. The last was

significantly different from the control (P < 0.01). Dietary

supplementation with SDG at 73, 147 and 293 micromol/kg also decreased

tumor size (tumor cross-sectional area and volume) in a dose-dependent

manner compared with the control values. These results show that SDG

reduced pulmonary metastasis of melanoma cells and inhibited the growth

of metastatic tumors that formed in the lungs. It is concluded that

dietary supplementation with SDG reduces experimental metastasis of

melanoma cells in mice.

PMID: 10424786 [PubMed - indexed forflaxseed melanoma-medline MEDLINE] "

Protective effects of dietary phytoestrogens in

chronic renal disease.1: J Ren Nutr 2001 Oct;11(4):183-93

Protective effects of dietary phytoestrogens in chronic renal disease.

Ranich T, Bhathena SJ, Velasquez MT.

Division of Renal Diseases and Hypertension, Department of Medicine,

George Washington University Medical Center, Washington, DC 20037, USA.

Phytoestrogens are naturally occuring plant compounds that are present

primarily in soybeans as isoflavones and in flaxseed as lignans.

Because of their structural similarity to endogenous estrogens,

phytoestrogens bind to both estrogen receptors (ER)-alpha and beta (but

more strongly to ER-beta) and exert estrogen-like effects. There is

increasing evidence that dietary phytoestrogens have a beneficial role

in chronic renal disease. Nutritional intervention studies have shown

that consumption of soy-based protein and flaxseed reduces proteinuria

and attenuates renal functional or structural damage in animals and

humans with various forms of chronic renal disease. It is not clear

which component(s) of the soybean or flaxseed is (are) responsible for

the protective effects observed in experimental animals and in limited

studies in humans. Vegetable protein has been shown to have a

beneficial effect on renal disease in animals and humans. Thus, the

role of soy and flaxseed cannot be ruled out. Isoflavones and lignans

are readily absorbed from the gut and converted to active metabolites,

which may be partly responsible for the beneficial renal effects of soy

protein and flaxseed. In addition, an interaction between type of

protein and phytoestrogens is also possible. The biological actions of

isoflavones and lignans have been well defined in different cell types

in vitro and also in vivo, but how these compounds might reduce renal

injury remains to be elucidated. Possible mechanisms include inhibition

of cell growth and proliferation via ER-mediated mechanisms or

non-ER-mediated pathways through inhibition of tyrosine protein

kinases, modulation of growth factors involved in extracellular matrix

synthesis and fibrogenesis, inhibition of cytokine-induced activation

of transcription factors, inhibition of angiogenesis, antioxidative

action, suppression of platelet activating factor and platelet

aggregation, and immunomodulatory activity. To date, clinical trials in

humans are few, of relatively short duration, and involve a small

number of patients. Prospective randomized trials are needed to

evaluate the long-term safety and effectiveness of dietary

phytoestrogens on renal disease progression in patients with chronic

renal failure. Copyright 2001 by the National Kidney Foundation, Inc.

 

 

if you don't like cottage cheese here are supplement

that substitutes-by Biosan-companion nutrients lots

of flaxseed information by naturesdistributors

flax

seed

COTTAGE CHEESE CALCIUM

INTRODUCTION

FATTy ACIDS FLAXSEED

all about flaxseed

flaxseed-cancer

DESIGNING HEALTH-FLAX SEED

more on

flaxseed oil

FLAXSEED

OIL LABRADORS

bht

LIVER CANCER in hills

herbal parasite cleanser

cancer-parasite theory

diets for dogs-ie liver problems,kidney problems etc

 

Holistic links

cancer-diets etc and experienceMORE DIET

INFORMATION

IMMUNE ENHANCING STUDY

DOG

IMMUNE DISEASE

Dodds on Immune system

AIHA-AUTOIMMUNE

 

immunostimulants-Dr Schoen-

Hydrazine Sulfate

Hydrazine sulfate

 

 

Coenzyme-10, Co Q10

FLAXSEED

LIGNANS & THE IMMUNE SYSTEM -a great review

" Flaxseed contains Secoisolariciresinol diglucoside (SDG), a potent

antioxidant and a known precursor of the mammalian lignans,

enterolactone and enterodiol. These compounds have other

pharmacological properties including phytoestrogen properties similar

to isoflavones. Studies performed in the Department of Physiology,

College of Medicine, University of Saskatchewan, have shown that SDG

prevents the development of hypercholesterolemic atherosclerosis,

reduces total cholesterol and LDL-cholesterol, and has a tendency to

raise HDL-cholesterol in animal models. In addition, SDG has shown the

ability to lower blood pressure, and has demonstrated that it is

effective in preventing diabetes mellitus (Type I and Type II) and

endotoxic shock. "

"The rapid rate of postmenopausal bone loss is mediated by the

inflammatory cytokines interleukin-1, interleukin-6, and tumor necrosis

factor alpha. Dietary supplementation with flaxseeds and flaxseed oil

in animals and healthy humans significantly reduces cytokine production

while concomitantly increasing calcium absorption, bone calcium, and

bone density. Possibilities may exist for the therapeutic use of the

omega-3 fatty acids, as supplements or in the diet, to blunt the

increase of the inflammatory bone resorbing cytokines produced in the

early postmenopausal years, in order to slow the rapid rate of

postmenopausal bone loss. Evidence also points to the possible benefit

of gamma-linolenic acid in preserving bone density. (Kettler D, Altern

Med Rev, 6(1): 61, 2001) "

"Results of many studies indicate that consumption of n-3 fatty acids

can benefit persons with cardiovascular disease and rheumatoid

arthritis. However, encapsulated fish oil is unlikely to be suited to

lifetime daily use and recommendations to increase fish intake have not

been effective. Foods naturally rich in n-3 fatty acids, such as

flaxseed meal can be used to achieve desired biochemical effects

without the ingestion of supplements or a change in dietary habits. A

wide range of n-3-enriched foods could be developed on the basis of the

therapeutic and disease-preventive effects of n-3 fatty acids.

(Mantzioris E, et al, Am J Clin Nutr, 72(1): 42, 2000)

TARGET="_blank" >Fat soluable vitamins A,D,E,K

antioxidant group

VITAMINS AND COFACTORS

fundamentals

of nutrition

Jean C. Hofve, DVM-nutrition

canine building blocks

Colorado State nutrition

Enzymatic

studies-do a search ie:IP6

Altvetmed

cancer diet

MORE DESCRIPTION ON HERBS ETC COMMERCIAL SITE

melatonin cancer treatment-some research

homepathy Christina Chambreau, DVM

WELLPET Cancer diets

lymphoma comparison protocols

 

Friday April 13 06:39 PM EDT Study: Common Seed Fights Cancer A

recent Canadian study shows that a common seed may be a promising new

cancer fighter, researchers say. Dr. Paul Gross of Princess Margaret

Hospital and a team of researchers from the University of Toronto asked

a group of newly diagnosed breast cancer patients to eat two

tablespoons of ground flaxseed in a muffin each day. Then, Gross'

research team analyzed samples of their tumors. The study found that

flax actually slowed the growth of breast cancer. "The scientific

community is very interested in this study," Gross said. "We've been

bombarded by other investigators from around the world." Researchers

found that in less than a month, the women taking flaxseed slowed their

rate of tumor growth by up to 33 percent. There also was nearly a

60-percent drop in the spread of the most aggressive cancer cells.

"Flaxseed is the first nutritional product that has been studied, and

that has produced hard scientific evidence," Gross said. According to

the study, researchers believe that a fiber in the seed helps to sweep

the hormone estrogen out of the body, which blocks its ability to make

tumors grow. Flax would be the first cancer treatment that isn't a

chemical, researchers said. However, since flax is a food, it doesn't

have the backing of a drug company. Researchers said that they don't

know how much longer they would be able to continue their work. Some

cancer support groups believe that the data shouldn't be ignored.

"There is a community out there who are hungry for this kind of

information, and it won't bother them that it's not a pharmaceutical,"

Sue Wright of the Willow Breast Cancer Support Center. "In fact, it

might even encourage them."