body's more powerful detox enzymes - cytochromep450

August 23, 2004

Cytochromep450

Cytochrome P450 is a family of the body's

more powerful detox enzymes. Over 60 key forms are known, with

hundreds of genetic variations possible, producing a wide variety of susceptibility

to specific toxins. As the saying goes, "One man's meat is

another man's poison".

Problems with P450 are often involved in porphyria type

disorders (HMMMM...what do 99 per cent of autistic children have?).

P450 production may be inhibited or substantially used up by H2

blockers, some antacids, SSRI's (Prozac, Paxil, Zoloft, etc.,)

and perhaps one fifth of all medications. In this

manner, these drugs have the potential to worsen, or

even create, a susceptibility to many common chemicals, and

thus may trigger Multiple Chemical Sensitivities / Environmental

Illness and related syndromes. The oddness of some of these

symptoms may prompt some doctors to prescribe SSRI's, thus making the

situation worse.

Long term inhibition of heme synthesis

due to P450 insufficiency may cause anemia. This, and the

resulting metabolic reductions, may cause reductions in the body's

ability to maintain itself, showing up as a wide variety of health

problems similar to those of Wilson's Syndrome,

as well as behavioral and cognitive problems similar

to those described in The Cold Body

Page. A related detoxification pathway involves Paraoxonase

and related oxonases.

Mechanism

of Interaction

Hyperactive

Bioinorganic Proteins (Looks like party pictures)

A general detox enzyme.

Homo

sapiens - Oxidative phosphorylation

P450

Inhibited by SSRI's, can cause porphyria type problems.

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