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Doc,

 

Dr. Mercola (http://www.mercola.com/2002/jul/6/biotin.htm) just came

out with a reference about raw eggs. In light of your recommendation

to eat raw eggs, can you comment on this?

 

--------------

By Hamid M. Said

 

Biotin is an essential micronutrient for all mammals and is a member

of the B complex group of vitamins. Biotin was discovered in

nutritional experiments that revealed a factor in many foodstuffs

that was capable of curing the scaly dermatitis, hair loss, and

neurologic signs induced in rats fed dried egg whites.

 

Avidin is a glycoprotein found in egg whites and binds biotin very

specifically and tightly. From an evolutionary standpoint, avidin

probably serves as a antibacterial in egg whites because it is

resistant to a broad range of bacterial proteases in both the free

and biotin-bound forms.

 

Because it is resistant to digestive enzymes from the pancreas

dietary avidin binds to dietary biotin and prevents its absorption.

The normal bacteria of the large intestine synthesize biotin. Cooking

changes avidin and makes it susceptible to digestion and unable to

interfere with the intestinal absorption of biotin.

 

The fact that we have a requirement for biotin has been most clearly

shown in 2 situations that result in biotin deficiency:

 

1) Prolonged consumption of raw egg whites and

 

2) IV nutrition without biotin supplementation in patients with

short- gut syndrome

 

 

Interestingly, the biotin requirements for normal persons and for

persons in special clinical circumstances are not known. Safe and

adequate doses have been suggested.

 

American Journal Clinical Nutrition February 2002;75(2):179-80

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