Transfats Play a Role in Cancer, Diabetes, & Cardiovascular Disease

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Transfats Play a Role in Cancer, Diabetes & Cardiovascular disease JoAnn Guest

Aug 07, 2003 09:22 PDT

Hydrogenation Ruins the " Nutritional " Value of Vegetable Oils

 

Trans fats play a role in Cancer,

Diabetes, and Cardiovascular Disease!

 

Hydrogenation ruins the nutritional value of vegetable oils!

 

Fatty Acids are the building blocks of *fats*.

 

Amino Acids are the building blocks of *proteins*.

 

More than a decade of research at the University of Maryland has shown

that consumption of *trans-fatty* acids commonly called hydrogenated

vegetable oil has *adverse* effects in health areas such as heart

disease, cancer, diabetes, immunity, reproduction,lactation and

*obesity*!

 

These and earlier reports had shown that consumption of trans-fatty

acids lower the " good " HDL cholesterol-- in a dose response manner

 

and raise the atherogenic *lipoprotein*(a)in humans

 

-- as well as raising the " bad " LDL cholesterol and total blood

cholesterol levels by 20-30 milligram- percent.

 

Perhaps the most significant event was the report from researchers at

Harvard University, who evaluated more than 85,000 women in a long-term

prospective study and found that there was a significantly higher

*intake* of *trans-fatty* acids in those individuals who developed

--heart disease!

 

As regards to the question of cancer, trans-fatty acids induce adverse

*alterations* in the *activities* of the important

*enzyme* system that *metabolizes* " chemical carcinogens " and " drugs "

(medications),

i.e. the mixed-function oxidase cytochromes.

 

The initial research in this area was done by the Maryland group in

collaboration with the U.S. Food and Drug Administration.

 

Several groups around the world reported a higher intake of partially

*hydrogenated* fats in those individuals who have developed *cancer*.

 

Both primate and human studies have shown inappropriate handling of

blood sugar;

trans fatty acids decrease the response of the red blood

cell to insulin, thus having a potentially undesirable effect in

diabetics.

 

The primate research ws initiated at Maryland in collaboration with the

U.S. Department of Agriculture and the National Institutes of Health,and

the human research is from the University of Pittsburgh and quite

recent.

 

One major concern is that trans-fatty acids adversely affect *immune*

response by *lowering* *efficiency* of B cell *response* and decreasing

proliferation of " T " cells.

 

Basically, trans fatty acids cause alterations to numerous physiological

*functions* of biological cell *membranes* that are known to be critical

for cell *homeostasis*,

 

e.g. appropriate membrane transport and membrane *fluidity*,

 

and these fatty acid isomers produce alterations in *adipose* cell

size, cell number, *lipid* class and fatty acid *composition*.

 

The various mechanisms through which the trans fatty acids disrupt

function are related in part to the ability of trans fatty acids to

inhibit the *function* of membrane related *enzymes*

such as the delta-6 desaturase--

 

resulting in decreased *conversion* of e.g. linoleic acid to

gamma-linolenic acid or arachidonic acid;

 

interference with the necessary *conversion* of omega-3 fatty acids to

their elongated tissue omega-3 fatty acids;

 

and *escalation* of the *adverse* effects of essential fatty acid

deficiency.

 

This latter effect was shown especially by the work of Dr. Holman and

his colleagues at the Hormel Institute at the University of Minnesota,

the other effects have been shown by researchers at the University of

Maryland.

 

Dr. Ancel Keys had originally claimed that hydrogenated vegetable oils

were the *culprits* in heart disease.

This was in 1958, and the edible *oils* industry was very swift in their

 

*squelching* of that information.

 

 

 

JoAnn Guest

mrs-

DietaryTi-

http://www.geocities.com/mrsjoguest/Fats.html

http://www.geocities.com/mrsjoguest/CholesterolFacts.html

 

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