Gut response

[Guest guest]

Just On the surface, I could envision many problems with this approach.

 

If the bacteria gets first call on any thiamine engested to the stomach, it

could malnourish the body of thiamine which could lead to many other health

problems problems.

 

Instaed of correcting the ecology of the stomach to a natural state which could

enable the stomach as well as the body to heal, they are going to attack the

" problem " like always with an attack agent. This time with a genetically

modified organism. There are usuallly repurcussions from these in the body

because the body has had millions of years to adapt to the natural ones but the

brand new laboratory made ones are usually toxic to the body, if not immediately

then over time.

 

Liken it to a lake. If the lakes ecology were out of balance and became toxic

because of an overgrowth of one organism, instead of helping it regain a

balanced ecology, we dumped genetically modified organisms into it hoping to

correct it. The chances of that happening would be slim as it will not just

affect the organism that you are targeting be change the total ecology of the

lake again and then you now have an unatural enviourment with unnatual organisms

to deal with in addition to the original problem. Now try correcting that.

 

What we should have done to the lake was make the lake enviourment " normal " and

let it rebalance itself. Same with a lake, an ocean, a person, animal, fish,

the air etc.

 

Frank

 

http://www.biomedcentral.com/news/20030616/02

 

Gut response

 

A bio-containable genetically modified organism promises hope for sufferers of

inflammatory bowel disease | By Cathy Holding

 

 

The intestinal mucosa has to discriminate between beneficial and pathogenic

organisms within the gut, a process regulated in part by specific T cells that

secrete immunosuppressive cytokines. Interleukin-10 (IL-10) mediates

immunoregulatory mechanisms that control inflammatory responses in the gut, and

evidence is accumulating that it may have a role in the pathology of Crohn

disease and ulcerative colitis, conditions collectively encompassed by the term

" inflammatory bowel disease. " Long-term administration of IL-10 to treat the

disease is problematic because no effective delivery method has been available.

In the June 16 Nature Biotechnology, Lothar Steidler and colleagues at Ghent

University report a recombinant bacteria developed to produce IL-10 that also

addresses the issue of containment of a live genetically modified organism

following its release into the gut environment for therapeutic use (Nature

Biotechnology, DOI:10.1038/nbt840, June 15, 2003).

 

Steidler et al. replaced the thymidylate synthase gene thyA in Lactococcus

lactis with an expression cassette for the IL-10 gene, simultaneously enabling

the microorganism to produce the cytokine and to render it dependent on

thymidine or thymine for survival. They reasoned that a recombination event to

restore the thyA gene, if it should occur at all, would simply replace the

expression cassette and return the bacterial genome to its premodification

state. They demonstrated survival dependence of the organism on thymidine and

thymine, its viability, and the secretion of functional IL-10 both in vitro and

in vivo in pig intestine, which closely resembles the human gut. One of their

strains is currently undergoing clinical trials in Holland.

 

" The thyA-deficient bacteria cannot accumulate in the environment. Our approach

thus provides a simple and robust system for biological containment, " conclude

the authors.

Links for this article

H. Groux, F. Powrie, " Regulatory T cells and inflammatory bowel disease, "

Immunology Today, 20:442-445, October 1999.

[PubMed Abstract]

 

L. Steidler et al., " Biological containment of genetically modified Lactococcus

lactis for intestinal delivery of human interleukin 10, " Nature Biotechnology,

DOI:10.1038/nbt840, June 15, 2003.

http://www.nature.com/nbt/

 

Ghent University

http://www.ugent.be/portal/en

 

 

 

 

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