REport Of Am College For The Advancement Of Medicine

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Annie Appleseed Project

 

 

Am College For Advancement In Medicne

 

 

Report of American College for Advancement of Medicine meeting, May 16-18, 2003

Washington, D.C. By Ann E. Fonfa

 

Dr. Jeffrey D. White, M.D., Director of Cancer Complementary and Alternative

Medicine, National Cancer Institute (NCI-OCCAM), discussed a small randomized

trial of vitamin E and cisplatin.

 

A human study of 47 patients randomized to vitamin E at 300 mg/d orally before

cisplatin therapy and continued for 3 months after suspension of treatment.

 

Results: 27 patients completed 6 cycles of cisplatin, there were 13 in the

vitamin E group and 14 in the control group. Neurotoxicity incidence was

“considerably lower with vitamin E - 30.7% vs 85.7%; P<.01.” Neurotoxicity

score: “significantly lower with vitamin E - (2 v 4.7, P<.01.”

 

Dr. White also indicated that they will continue to use PC-SPES with prostate

cancer as soon as they have a source for uncontaminated product.

 

 

 

Steve Austin, N.D. of Portland, OR addressed the question of the use of

antioxidants during chemotherapy treatments. He said that the current

controversy and ‘belief’ system of a conflict, was based on a hypothetical

article written by Livingston and Labriola. He indicated that Dr. David Lamson

(Tahoma Clinic, Renton, OR, Coordinator of Oncology, Bastyr University), had

written two articles from the opposite viewpoint, and that he himself had

written one. Austin suggested that there has been no data demonstrating a

conflict of usage.

 

Ann’s NOTE: In fact several Centers of the National Institute(s) of Health are

cosponsoring a meeting on Antioxidants and Cancer, June 26-27, 2003. For more

information, go to:http://www3.cancer.gov/prevention/frpca2003/ Also we offer

the articles referred to above on antioxidants on our site:

http://annieappleseedproject.org/anincanthero.html

 

 

 

An interesting talk by Todd Bezilla, D.O. discussed exercise as a way to improve

libido in women. He suggested learning to control one’s breath first was of key

importance. He stated that exercise in water will not improve bone density,

although it is very good for other aspects of health. He suggested using Tai

Chi, Yoga and other balance-oriented calisthenics 4-5 times a week (ten minutes

per session). For weight training exercises, he suggested 15-20 minutes 3 times

weekly. He did not believe going slowly (a current concept) would benefit and

suggested it might raise blood pressure.

 

For flexibility issues (major joints, body regions and trouble areas), he

suggested stretching after a workout, or after shower/sauna.

 

Ann’s NOTE: People with lymphedema or the potential to develop it (that’s all of

us who have had [probably more than one] lymph nodes removed), need to avoid the

heat of a sauna, though it has been suggested that infra-red saunas may be

different. In response to my question, he did agree that varying the type of

exercise done daily is most beneficial.

 

Dr. Bezilla mentioned the benefit of icing after a workout whether it hurts or

not. He suggested this was particularly beneficial if you had an area that

tended to be hurt.

 

 

 

Stanislaus Burzynski, M.D., Ph.D., Medical Director, Burzynski Research

Institute, Burzynski Clinic and Pharmaceutical Plan, spoke about the 78 Phase II

clinical trials on antineoplastons he is currently running under FDA

supervision/approval. He reports weekly, monthly and annually on progress.

 

He showed a slide from the University of Kurume Medical School in Japan. The

patients had colon cancer with liver metastases. All received chemo with 91%

survival in those also receiving antineoplastons A10 and AS2-1 versus 39% in

control group.

 

Studies at the above institution as well as the Medical College of Georgia and

the Buryznski Institute “revealed that animals can be protected from development

of breast, lung and liver cancers, by adding small amounts of Antineoplaston A10

to their food. Preventive effects against cancer was found in animals exposed to

common carcinogens, including benzo(a)pyrene, uretane and aflatoxin B1 " .

 

Dr. Burzynski stated that 1.4% of all patients show serious anemia, 1.5% have

hypercalcemia and less than 1%, toxicities of skin. Positive effects include

increased energy, improved healing, and reduction of cholesterol.

 

 

 

Kedar Prasad, Ph.D., Former president International Society for Nutrition and

Cancer, Director for the Center for vitamins and Cancer Research, U Colorado

Health Sciences Center.

 

The title of this talk was “Rationale for Using High Dose Multiple Antioxidants

as an Adjunct to Standard or Experimental Cancer”.

 

Dr. Prasad stated that most objections to multiple antioxidant use with cancer

therapies, hinge on the idea of free radicals and oxidation. If one believes

that antioxidants only function as scavengers of free radicals, then the theory

goes, they must also protect cancer cells.

 

He believes this is a wrong assumption. There is evidence that there is

enhancement of the cancer therapy using vitamin A, retinoic acid, vitamin E

succinate, vitamin C and beta-carotene. Dr. Prasad’s work indicates that

antioxidants can also induce anti-angiogenesis.

 

He suggests that delivery before, (15-30 minutes), and every day during the

entire treatment period would be appropriate. He pointed out that there have

been NO papers written that show damage in any way for such a protocol. Dr.

Prasad said that dietary antioxidants at low doses before treatment would be a

mistake. Before treatment antioxidants can even (beneficially) cause apoptosis

without going through P53 or P16. Once radiation therapy or a chemo like 5Fu are

given, antioxidants do work through the tumor suppressors. Since antioxidants

decrease the expression of c-myc and H-ras (oncogene), use before radiation

therapy or concurrently is best.

 

He stated that the use of alpha lipoic acid, n-acetyl cysteine (NAC) or

glutathione at any dose even just before treatment, would be a mistake.

Glutathione makes cells resistant to, and causes them to act as though they were

in s-phase. Glutathione by IV shows inhibition of cancer cells. But Dr. Prasad

stressed that this is NOT compatible with chemotherapy or radiation therapy.

 

He stated that super oxide disumutase protects from radiation damage.

 

Vitamin E succinate causes growth inhibition, differentiation and apoptosis.

Vitamin C at 200 ug/ml causes growth inhibition in some cells, as does

beta-carotene at 20 ug/ml. Together they offer much better efforts.

 

BIG news: Vitamin E succinate can convert hormone ‘insensitive’ (ER negative)

breast cancer to ER positive. It can also work in prostate cancer as it is

hormone sensitive too.

 

Ann’s NOTE: Apparently there is also evidence that Vitamin A can act similarly.

Ann had this effect occur as a result of treatment. See Ann’s Bio for more

information. Clinicians and researchers have confirmed that this is so. In a

SEARCH for studies, I found ‘throwaway’ type referrals to this phenomenon, as

though it were so obvious, nothing really needed to be said. How can this be?

 

It is known that vitamin C in small doses can induce cell growth, thus taking a

multi-vitamin (containing 60- 90 mg) such as some oncologists recommend, may be

harmful. Too little C or other antioxidant is not good according to Dr. Prasad’s

research.

 

Vitamin C taken at 100 ug/ml has a beneficial effect on its own, but combined

with E, A, beta-carotene, it can achieve a 90% ‘kill’ rate.

 

Dr. Prasad made it clear he is speaking about d-alpha tocopherol (not synthetic

dl). The antioxidant combination is okay with 5 FU and Adriamycin. A study by

Chinery et al, Nature Medicine actually tested vitamin E with 5 FU, but the

combination antioxidants are best. (Invest New Drugs 2001;19(1):21-7, A phase I

study of vitamin E, 5-fluorouracil and leucovorin for advanced malignancies)

 

Tamoxifen & C & beta-carotene & retinoic acid & E succinate are an excellent

combination.

 

Hyperthermia benefits from added vitamin E.

 

Dr. Prasad’s laboratory has been working on the best combination of vitamins in

the best doses.

 

 

 

Hugh Riordan, M.D., President and Director of the Center for the Improvement of

Human Functioning International, and the Bio-Communications Research Institute,

spoke on “The Use of High Dose Intravenous Vitamin C in Cancer and Other

Diseases - a 28 year Perspective”.

 

Dr. Riordan’s work is based on orthomolecular principles. In his many years of

practice he and his associates have administered as much as 24 hour continuous

IV vitamin C for one full month without damaging effects.

 

A normal dose for a person with cancer at their facility might be 200 grams

administered over 5 hours. Dr. Riordan has been receiving such doses himself for

years.

 

Dr. Riordan stated that in the United States about 39% of men and over 43% of

women do not even receive 60 mg of vitamin C daily. Normal young males need

about 200 mg as per the work of Mark Levine (NIH).

 

Achievable plasma levels of vitamin C are 100-fold greater with intravenous

infusions than oral intake.

 

Dr. Riordan said that his group has found that administering lipoic acid

increases the effectiveness of vitamin C. He stressed that this must be given

only if the patient is NOT receiving chemotherapy or radiation.

 

Ann’s NOTE:

 

AnnFonfa [AnnFonfa]

Sunday, June 01, 2003 6:41 PM Prasad Kedar I noticed

something interesting

 

Dear Kedar,

 

In looking over my notes from Dr. Hugh Riordan's presentation on the use of

vitamin C, I saw that he stated that they used lipoic acid to enhance the

tumor-killing effects of vitamin C. He also mentioned that this was in patients

who did not/are not receiving chemo or radiation.

 

Do you feel this would be compatible to the statement you made about avoiding

lipoic acid (and glutathione/ NAC) during treatment?

 

Thanks for a response.

 

Ann F.

 

The Appleseed

 

-Dear Ann: You are correct. Alpha-lipoic acid should be avoided only during

standard cancer therapy. Dr. Riordan’s strategy is to improve the degradation of

vitamin C so that the plasma level of vitamin C persists for a longer time.

Kedar

 

 

 

Isaac Eliza, M.D., M.S., Lac spoke about “Modified Citrus Pectin in the

Prevention and Treatment of Cancer”. He is a formulator of dietary supplements,

lectures on Traditional and integrative medical approaches and

holds patents for several of his unique herbal formulations.

 

Modified Citrus Pectin is a complex polysaccharide (long chain carbohydrate)

obtained from the peel and pulp of citrus fruits such as lemons, grapefruits,

oranges and tangerines. This long chain of sugars has numerous branches with

important binding capabilities that are related to pectin’s unique

antimetastatic attributes.

 

In vitro and in vivo research on modified citrus pectin (MCP) “demonstrated its

ability to interfere with cell-cell interactions preventing adhesion of prostate

cancer cells to endothelial cells, thereby reducing metastasis potential.

Interactions between the galacroside-binding molecules,(galectins) on the

surface of tumor cells and MCP were the purported mechanism of action.

Subsequently, the importance of galectin molecules over-expression on cancer

cells for primary tumor growth, angiogenesis, and metastasis has been

elucidated.

 

It is not surprising that more recent research has expanded the anti-cancer

properties of MCP to include anti-angiogenesis, inhibition of primary tumors, as

well as prevention of metastasis in human breast and colon cancer in a murine

(mouse) model. (Nangia-Makker, P et al, JNCI 2002;94(24):1854-62)

 

Clinical studies, a phase one pilot trial and subsequent phase two trial have

validated the effectiveness of MCP in the treatment of prostate cancer.”

 

In a phase II study, twelve patients were given 15 grams of MCP (PectaSol,

EcoNugenics, Inc. Santa Rosa, CA 95407) per day for one year. Six out of the

twelve subjects more than doubled their PSA doubling time. Two other human

subjects experienced a decrease in their absolute PSA values. (Guess B, et al,

The Prostate 2003;54(2):88-94 Dr. Eliaz notes that the MCP he is referring to

throughout this article has the following characteristics: molecular weight

between 10,000 and 20,000 daltons, DE <10% (degree of esterification), sugar

content matters too. For more information on this product see Clin Prac of Alt

Med, Volume 2, No. 3, Fall 2001:177-179.

 

MCP is well tolerated. Although, based on the human clinical trial and our

clinical experience, the optimal dosage for slowing of metastasis may be 15

grams per day, divided into three doses. “It is recommended to use MCP for one

year after your successful treatment” (referring to surgery or radiation for

prostate cancer”. Dr. Eliaz also suggests that taking 15 g per day for a few

weeks after a surgical biopsy or surgery, will “help prevent cancer cells from

spreading”. Dosages as low as 3 to 5 g per day can be beneficial as a preventive

measure. Take this product on an empty stomach, preferable 1-2 hours away from

other supplements. Two hours is considered enough time to have an empty stomach

in between meals.

 

Dr. Eliaz also suggested people with cancer take medicinal mushrooms which “have

been well researched for their anti-tumor and immune stimulating effects”. He

suggests a ‘priming’ dose for one to two months. This dose is two or three times

the maintenance level. Then drop to the normal maintenance dose which is

typically the suggested dose. He suggest doubling the maintenance dose during

the first two weeks of spring and autumn. Dr. Eliaz noted that it is important

to take medicinal mushrooms on a long term basis as some benefits “require and

extended time of consumption”. He also suggested using many different varieties

including (for serious health issues): Coriolus, Cordyceps, Reishi, Polyporus,

Maitake, and Agaricus. For prevention of common and serious illness: Shitake,

Hericum, Auricularis, Poria, Tremella, Coriolus, Cordyceps, Resishi, Polyporus

and Maitake.

 

He also suggested the use of Thymic Protein A as a high normal dose for three

days and low normal dose for one month. Then reduce to intermittent use (low

normal dose 2-3 days per week).

 

Ann’s NOTE: Back in 1995 when I experienced the first of many local recurrences,

I began using MCP. Unfortunately I have no way of knowing if this product made a

difference in my health. As of June, 2003 I have not developed metastatic

disease. There is no connection that I can show. Clearly it would be wonderful

to have randomized multicenter trials of high risk cancer patients. We need such

studies so that we can have more access (and insurance coverage) of ‘natural’

substances that may help us.

 

Here is the results of a query to Dr. Eliaz:

 

Dear Ann,

 

Thanks for the E-Mail. MCP can be taken on a long term basis. For prevention, I

recommend 5 grams per day. For patients with active disease, 15 grams per day.

Post treatment, I recommend the full dosage for 3-5 years, depending on the

condition and the type of cancer followed by a 5-10 grams per day thereafter.

 

We are seeing encouraging preliminary results with MCP as a chelating agent. For

chelation purposes, subjects are using 15 grams per day for one month (with no

heavy load of heavy metals) and for a longer period of time if there is a

documented heavy metal load. I think that at the end, MCP at 3-5 grams per day

should be a part of a daily regimen for all of us.

 

Best regards,

 

Isaac

 

 

 

Patrick Quillin, Ph.D., Director of Nutrition for Cancer Treatment Centers of

America for the past ten years, spoke on “Nutrition Therapies to Improve

Outcomes in Cancer Patients: Focus on Sugar and Fats”.

 

Dr. Quillin is the author of “Beating Cancer with Nutrition” and has a website

www.nutritioncancer.com where I found the following topics:

 

1) Nutrients make chemo and radiation more toxic to the cancer and less damaging

to the patient.

 

2) Starving the cancer by controlling blood glucose through diet and

supplements.

 

3) Common vegetables, herbs, and seasonings that have powerful anti-cancer

activity.

 

4) Malnutrition kills more than 40% of cancer patients.

 

5) Turbo-Charging your immune system to find and destroy cancer cells in your

body.

 

6) Sugar feeds cancer.

 

7) Nutrients can slow and reverse cancer growth. Learn about commonly available

and inexpensive vitamins, minerals, herbs, glandulars, fatty acids, food

extracts, and probiotics to fortify your body against cancer.

 

Quillin offered this look at a ‘healthy meal plate’ - 1/3 cooked plant food

(oatmeal, beans, bread, tortilla, pasta, yams, grains, nuts, legumes, cooked

vegetables)

 

1/3 lean protein source (fish, wild game, poultry, lean beef, eggs, brewers

yeast, beans, dairy, spirulina, kelp)

 

1/3 raw fruits and vegetables (tomato, spinach, carrots, peppers, fruit,

broccoli, cabbage, onion, etc.)

 

This conference had many other speakers and lots of terrific information. Tapes

are available by contacting acam.org

 

 

 

 

 

 

Paw Paw Fruit Against Cancer

 

ACAM talk, 6/03

 

 

Vitamin E Succinate

 

 

 

 

 

 

 

A few studies on Vitamin E succinate -this group breast cancer issues

 

D-Alpha Tocopheryl Succinate

Vitamin E Succinate-Prostate

Succinate Induces Bca Cells to Undergo Differentiation

Free Radical Fighter

Succinate & DNA Synthesis Arrest MDA-MB-4356 Cells

alpha-Tocopheroly Succinate:A Review

Vit E Succinate Promotes BCa Tumor Dormancy

Vit E Succinate Inhibits Colon Ca Liver Mets

alpha-Tocopherol Succinate Inhibits Gastric Ca Cells

 

Remember Ann is NOT A Doctor and has NO medical training.

 

 

Gettingwell- / Vitamins, Herbs, Aminos, etc.

 

To , e-mail to: Gettingwell-

Or, go to our group site: Gettingwell

 

 

 

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