Cretan Mediterranean Diet for prevention of Coronary Heart Disease

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American Journal of Clinical Nutrition, Vol 61, 1360S-1367S, 1995 by

The American Society for Clinical Nutrition, Inc

 

 

ORIGINAL RESEARCH COMMUNICATIONSCretan Mediterranean diet for prevention of

coronary heart disease

S Renaud, M de Lorgeril, J Delaye, J Guidollet, F Jacquard, N Mamelle, JL

Martin, I Monjaud, P Salen and P Toubol

INSERM Unit 63, Lyon-Bron, France.

As a result of the Seven Countries Study, the Mediterranean diet has been

popularized as a healthy diet. Nevertheless, it has not replaced the prudent

diet commonly prescribed to coronary patients. Recently, we completed a

secondary, randomized, prospective prevention trial in 605 patients recovering

from myocardial infarction in which we compared an adaptation of the Cretan

Mediterranean diet with the usual prescribed diet. After a mean follow-up period

of 27 mo, recurrent myocardial infarction, all cardiovascular events, and

cardiac and total death were significantly decreased by > 70% in the group

consuming the Mediterranean diet. These protective effects were not related to

serum concentrations of total, low-density-lipoprotein (LDL), or high-density-

lipoprotein (HDL) cholesterol. In contrast, protective effects were related to

changes observed in plasma fatty acids: an increase in n-3 fatty acids and oleic

acid and a decrease in linoleic acid that resulted from higher intakes of

linolenic and oleic acids, but lower intakes of saturated fatty acids and

linoleic acid. In addition, higher plasma concentrations of antioxidant vitamins

C and E were observed. We conclude that a Cretan Mediterranean diet adapted to a

Western population protected against coronary heart disease much more

efficiently than did the prudent diet. Thus, it appears that the favorable life

expectancy of the Cretans could be largely due to their diet.

 

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http://www.ajcn.org/cgi/content/abstract/61/6/1360S

 

 

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