Adaptrin:

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Adaptrin is put out by Pacific BioLogic..NOTE: I am not the owner !! I

use this product in my clinics and believe it to be a good product....

 

Herbal Help For Cardiovascular and Circulatory Problems

 

Applications

 

Adaptrin is a botanical formula that was developed by five successive

generations of physicians of the Badmaev family. It is formulated

according to the principles of Tibetan medicine. The formula was

introduced to Switzerland (via Russia and Poland) in the 1960's. Since

then, the compound has been subjected to extensive clinical testing.

Over the past 25 years, about 30 scientific studies have been conducted,

making it the most extensively researched botanical combination formula.

Furthermore, the product has been registered in Switzerland for

treatment of poor circulation due to atherosclerosis, in particular for

peripheral vascular disease.

 

Peripheral Vascular Disease (PVD) Studies

 

When Adaptrin was introduced into Switzerland, it was its effects on the

circulatory system, in particular, peripheral vascular disease (PVD)

that first attracted attention, Several prominent Swiss doctors,

including the Vice President of the Swiss Medical Society, Dr. Werner

Bubb, conducted further research efforts regarding the formula's

circulatory effects. Dr. Franz Huerlimann, an angiologist, was the first

to conduct a clinical double-blind study. In order to ensure consistency

amongst the patients' conditions, he worked with 24 of his patients

classified as Stage 2 PVD i.e. with walking pain, and who had undergone

physiotherapeutical walking training. He divided them into two groups,

of which 13 received Adaptrin and 11 a matched placebo. Each patient

received three tablets twice daily. As an objective measure, Dr.

Huerlimann had the patients walk on an inclined treadmill ergometer

until they experienced leg pains.

 

After three months of taking Adaptrin daily, the average pain-free

walking distance increased by 54% compared to 6% in the placebo group.

This result surpassed the effectiveness of any of the pharmaceutical

drugs on the market.

 

An additional finding was that a common complaint of PVD suffers,

resting pain, usually experienced at night, was eliminated in 9 or the

13 patients (70%) receiving Adaptrin after an average of two weeks

treatment. This observation was confirmed by Dr. Huerlimann in an open

field study of ten patients with advanced PVD, stages 3 and 4. In 7 out

of 10 patients (70%), pain at rest was eliminated or significantly

reduced within two weeks. There were no side effects observed in the

individuals taking Adaptrin. The results of this research were published

in Praxis (Swiss Medical Review) in 1978.

 

Dr. Huerlimann followed up his double-blind study with careful

observation of 220 patients using Adaptrin during a five year period

from 1978-1983, continuing to use the treadmill ergometer. These

results, reported at the First International Congress on Tibetan

Medicine held in Venice Italy, 1983, were entirely consistent with his

previous double-blind study results, that is, they showed substantial

increase in pain-free walking distance and reduction of pain at night.

He also reported on a survey he had conducted amongst eight fellow

physicians using Adaptrin in treatment of PVD, which demonstrated

similar success rates. In the treatment of stages 3 and 4 PVD, which

often require vascular surgery, Dr. Huerlimann reported a large number

of successful treatments with Adaptrin but remarked that Adaptrin " is

not in every case an alternative to vascular surgery or catheter

dilation, "

 

An MD student at Berne University, Ruke Schrader. decided to test the

effectiveness of Adaptrin in PVD in a tightly controlled study. The

faculty advisors, angiologists skeptical of botanical medicine, required

that the experiment be set up, in their own words, as " one of the most

rigorous experimental protocols for PVD ever done, "

 

The study was conducted during a two year period, 1982-1984. A total of

43 patients underwent study, each for a four month period. Of these, 23

received Adaptrin while the remaining 20 received a placebo. Following a

14 day period of observation with no treatment, the four month treatment

and study program began. The inclined treadmill ergometer test was again

used, and in this case both pain-free walking distance and maximal

walking distance were measured i.e., walking is continued until the pain

became unbearable. Patients were carefully selected: all were over 50

years of age, had PVD for at least 8 months, and had a maximal walking

distance of not more than 250 meters on the treadmill. All participants

had been diagnosed as having stage 2 PVD, i.e., walking with pain.

 

The results were similar to those of Dr. Huerlimann. Average pain-free

walking distance increased by about 54% after 12 weeks. However, by the

16th week of treatment, pain-free walking distance had increased by

101%, and maximal walking distance had increased by 98%. Thus, with the

larger patient number, longer treatment, and with more rigorous

measurement and reporting than had been used by Dr. Huerlimann, his

results were confirmed.

 

Furthermore, a careful statistical comparison of Adaptrin's effects with

those of all pharmaceutical drugs that had been studied demonstrated

that Adaprrin surpassed every other drug in increasing pain-flee walking

distance in physiotherapeutically trained patients; e.g., the most

effective phannaceutical drug, administered for 24 weeks, increased

walking distance by an average of 46%.

 

The results of the study were published in the Swiss Weekly Medical

Review. Widespread acceptance of Adaptrin for the treatment of PVD in

Switzerland has since followed, and the Swiss FDA approves the compound

as a treatment for poor circulation.

 

The conclusive study of Adaptrin for PVD was a large double blind study

conducted in 1984 by Dr. Samochowiec and his colleagues at the

Pharmacological Institute in Szczecin, Poland. One hundred patients

completed the four month study, of which 55 took Adaptrin and 45 took a

placebo. The study design was essentially identical to that of the Berne

study, but additional blood tests were conducted.

 

The results of this study were in complete conformity with that of the

Berne study. Maximal walking distance increased by 98% (placebo group:

no significant change); no side effects were noted.

 

Additional findings in the Adaptrin group were:

 

a) slight reduction of average blood pressure

b) reduction of cholesterol and triglycerides

c) significantly decreased platelet aggregation

 

Safety

 

Since 1979, not a single case of adverse side effects have been

reported, as certified by the Swiss Drug Monitoring Center. Moreover,

the product as a whole was subjected to acute toxicity studies (in

vivo), demonstrating no toxic effects even at more than 100 times the

corresponding human dose. There are no reports of evidence that Adaptrin

has any harmful side effects or harmful interactions with other drugs or

supplements. Of course. as with any food product it is conceivable that

an individual may have an allergic reaction, such as a food allergy to

spices. In such a case, use of the product should be discontinued.

 

Recommended Dosage

 

1 to 3 tablets daily. For best results, tablets should be taken on an

empty stomach. Beneficial effects have been reported within about the

first two to three weeks of therapy, though changes in blood chemistry

such as triglyceride levels may require at least six weeks. A typical

course of therapy would be to take 2 to 3 tablets daily, for

approximately four months. After that a dosage of 1 to 2 tablets daily

is recommended. Dr. Badmaev recommends that the flaIl dosage of 2 to 3

tablets daily be gradually worked up i.e. 1 tablet daily for the first

week, 2 tablets daily for the second week and 3 tablets daily the third

week and thereafter.

 

Ingredients Latin Name

Cetraria islandica musci

Pterocarpus santalinus cortex

Aegis sepiar fructus

Vetiveria zizanoides rhizome

Melia azedarach fructus

Saussurea lappa radix

Santalum album radix

Eugenia caryophyllus flos

Aquilegia vulgaris herba

Lactuca sativa herba

Calendula officinalis flos

Polygonum aviculare herba

Glycyrrhiza uralensis radix

Valeriana officinalis rhizome

Camphora japonicun cortex

Calcium sulphuricum

Elettaria cardamomum fructus

Pimenta dioica fructus

Plantago lanceolata herba

Sida cordifolia radix

Terminalia chebulae fructus

Prunus spinosa flos

Potentilla aurea herba

Heydychium spicatum rhizome

Aconitum nepellus

English Name

Iceland Moss

Red Sandalwood

Hardy Orange

Vetiver

Margosa

Spiral Flag

White Sandalwood

Cloves

Columbine

Wild Lettuce

Marigold

Knotgrass

Licorice

Valerian

Camphor Bark

Gypsum

Cardamom

Jamaican Pepper

Ribwort (Plantain)

Hertleaved Sida

Myrobalan

Blackthorn

Golden Cinquefoil

Gingerlily

Homeopathic Monkshood

:

 

Ingredient Analysis

 

Cetraria islandica musci (ICELAND MOSS)

A demulcent and nutrient tonic; it is used in digestive troubles and

pulmonary problems.

 

Pterocarpus santallaus cortex (RED SANDALWOOD)

A very astringent herb that controls diarrhea and discharges, promotes

healing, and has antidiabetic effects.

 

Aegis sepiar fructus (HARDY ORANGE)

Aegis sepiar is Poncirus trifoliata (1). They are employed as stomachic,

anti-diarrheic, anti-emetic, laxative, anti-spasmodic, stimulant, and

anti-phelgmetic, and diuretic (I). The Chinese name is either Chih-shih

or Chih-ko (2), and in traditional medicine is said to be slightly cold,

bitter, and used to break up energy stagnation, loosen sputum, and aid

digestion. In the Adaptrin formula, this component is used to break up

energy stagnation. The fruits are employed in treating rheumatism.

 

Vetiveria zizanoides rhizome (VETIVER)

An aromatic, sedative, antiseptic herb that increases production of red

blood corpuscles. Used internally for nervous and circulatory problems.

 

Melia azedarach fructus (MARGOSA)

The fruit is sedative, anthelmentic, and diuretic. It treats fevers, and

various abdominal troubles. In China is known as Ku-lien. It is slightly

cold, bitter, and clears moisture-related fevers, has laxative

properties and alleviates abdominal pain due to parasites.

 

Saussurea lappa radix (SPIRAL FLAG)

There are species of costus used in S.E. Asia, but it seems likely that

Fluck is correct in assigning this to Saussures.

 

(Costus is a relative of ammomum mentioned above). Saussurea lappa is

warm, bitter, and acrid, and promotes energy circulation and relieves

pain (Chinese name is Mu-hsiang). It is also used generally for

promoting health and aiding digestion. In agreement with the above

identification of this herb, the active constituents are labeled costus

acid, costus lactone, etc. (2). In Adaptrin, this works with the above

herbs to improve circulation of energy, relieve pain, and improve

nutritional status.

 

Santalum album radix (WHITE

SANDALWOOD)

An aromatic, bittersweet, astringent herb that cools the body, calms the

mind, relieves spasms, and improves digestion. It has diuretic,

analgesic, and antiseptic effects.

 

Eugenia caryophyllus flos (CLOVES)

This is Syzygium aromaticum, or the common clove. It is used as

stomachic, carminative, circulatory stimulant, anodyne, anti-emetic (4).

" They are an aid to treating diseases of the arteries. " (1)

Aquilegia vulgaris herbs (COLUMBINE)

Reported to have effects similar to those of aconitum (3). Lust says

that it is diuretic, diaphoretic, and astringent; externally it is

applied to rheumatic aches and veins. It is an anodyne and detoxicant

Lactuca sativa herbs (WILD LETTUCE)

Sedative and mildly diuretic, possibly diaphoretic as well. It is an

anodyne.

 

Caleudula officinalis flos (MARIGOLD)

In the Orient, primarily prescribed for obstinate cases of bleeding (1).

Grieve states that it is used for varicose veins, chronic ulcer,

prevents suppuration, is diaphoretic and stimulant

 

Folygomum aviculare herbs (KNOTGRASS)

Named Pien-hsu in Chinese medicine. It is neutral and bitter, clears

fevers, is diuretic, astringent and used to treat bleeding and kidney

problems (including stones).

 

Glycyrrhlua nyaleusis radix (LICORICE)

Anti-inflammatory, anti-pyretic, an aid to digestion, and a frequent

ingredient in Chinese herb formulas where it is said to harmonize the

effects of the other herbs.

Valeriana officinalis rhizome (VALERIAN)

Valerian root is anodyne, sedative, anti-spasmodic, carminative, and

anti-tussive.

 

Camphora Japonicum cortex (CAMPHOR BARK)

Refers to th. extracted granules of Cinnamomum camphora. It is anodyne,

diaphoretic, carminative, sedative, and used to treat rheumatism,

diseases of the respiratory system, and weak heart conditions.

 

Calcium sulphuricum (GYPSUM)

This is a mineral drug commonly employed in Chinese medicine as an

anti-inflammatory and sedative.

 

Elettaria cardamomum fructus (CARDAMOM)

This is the fruit of Ammomum cardamumum, used in China as stomachic,

carminative, anti-toxic, anti-emetic, used in medicines for digestive

problems and gout. In Java they are used for rheumatism.

 

Pimenta dioica fructus (JAMAICAN PEPPER)

This is also called Cochin Chinese cardamom (2) or A. costatum (ribbed

cardamom), known in Chinese as Tou-kou. It has heating properties, is

acrid and stimulates energy circulation, warms the stomach, aids

digestion, etc. Together with Aegle sepair fructus, it acts to improve

the nutritional status of the individual and to improve circulation of

energy.

 

Plautago lanceolata herba (RIBWORT)

Used as a cooling and diuretic herb. It is also a vulnerary.

 

Sida cordifolia radix (HEARTLEAVED SIDA)

The roots are bitter, used as stomachic, to treat fevers, and

rheumatism. It may be anodyne and antiseptic. It is diuretic and

mucilaginous.

 

Terminalia chebulae fructus (MYROBALAN)

Warming, bitter, sour, and acrid; it strengthens the lungs, is

expectorant, and anti-tussive. It is quite astringent. It is used for

those of lowered resistance to disease and weakened energy.

Prunus spinosa flos (BLACKTHORN)

A bittersweet, soothing herb that stimulates the circulatory system.

 

Potentilla aurea herba (GOLDEN

CINQUEFOIL)

Known as She-han in Chinese medicine. It is slightly cold, bitter,

relieves fevers and detoxifies. It is commonly employed to treat colds

and flu.

Hedychium spicatum rhizome

 

(GINGERLILY)

Used in China as a remedy for stomachache and toothache, having

analgesic properties in the essential oils. It also improves digestion.

This is another relative of ammomum. It is used as a spice in Taiwan.

 

Aconitum nepellus (HOMEOPATHIC MONKSHOOD)

This is the Chinese herb Fu-tzu, used as an anodyne, circulatory

stimulant, warming agent, to clear the energy passages (meridians). It

is especially useful for peripheral circulation and is commonly employed

for rheumatic complaints.

Adaptrin Indications Based on Constituents

 

1. RELIEVES PAIN. The following constituents (and possibly others) have

pain relieving attributes:

Aquilegia vulgaris

Heydychium spicatum

Valeriana officinalis

Santalum album

Eugenia caryophyllus

Lactuca sativa

Aconitum nepellus

Sausswea lappa

Camphora japonicum

Sida cordifolia

 

2. IMPROVES CIRCULATION OF ENERGY. (Circulation of blood, nerve energy,

etc.)

Aegle sepiar

Pimenta dioica

Elettaria cardamomum

Aconitum nepellus

Saussurea lappa

Eugenia caryophyllus

Vetiveria zizanoides

Prunus spinosa

 

3. IMPROVES DIGESTION. (stomachic, digestive aid, carminative, etc.)

Aegle sepiar

Pimenta dioica

Elettaria cardamomum

Eugenia caryophyllus

Heydychium spicatum

Sida cordifolia

Santalum album

Glycyrrhiza uralensis

Cetraria islandica

 

4. DIURETIC AND DIAPHORETIC

Calendula officinalis

Aegle sepair

Aquilegia vulgaris

Santalum album

Lactuca sativa

Melia azedarach

Sida cordifolia

Pterocarpus santalinus

Polygonum aviculare

Plantago lanceolata

 

5. TREATS PULMONARY PROBLEMS (expectorant, anti-tussive, lung tonic,

etc.)

Aegle sepiar

Glycyrrhiza uralensis

Tenninalia chebulae

Potentilla aurea

Cetraria islandica

Calcium sulphuricum

Camphora japonicum

Valeriana officinalis

In addition, some of the herbs act as anti-inflammatorics and

antiseptics.

The Action of Adaptrin According

To These Properties

The combination of herbs that promote energy circulation with herbs that

are diaphoretic improves the circulation of blood to the periphery.

Diuretics and diaphoretics combined relieve excess pressure in the

system. The pain relievers allow the person with PAO to have more

pain-free rest and to tolerate pain more easily. The improvement of

digestion can lead to better overall health and also allows blood flow

to be diverted from the digestive organs to the periphery. Adaptrin

should also be suitable for treating various bronchial complaints.

* Good Manufacturing Practices (GMP) are used throughout our

manufacturing process. OMP's are comprehensive manufacturing standards

established by the United States Pharmacopoeia for the production of

pharmaceuticals.

Bibliography

The preceding synopsis summarizes data from the following original

research papers. Brand-name designations of Adaptrin have, wherever they

occur, been replaced by its formula name, Badmaev 28 for regulatory

reasons.

Circulation and Cardiovascular Disorders:

Huerlimann, F. " A Lamaistic Formula for the Treatment of Peripheral

Vascular Diseases. " Swiss Medical Review No. 34, 1978.

Huerlimann, F. " Report on Five Years of Therapy Experiments with Badmaev

28 with 220 Patients with PVD. " Proceedings, First International

Congress on Tibetan Medicine, Venice, Italy, 1984.

Schraeder, R. " Effectiveness of Badmaev 28 for Intermittent Claudication

in Chronic PVD: A Controlled Double-Blind Study. " Summarized in Swiss

Weekly Medical Review 115, 1985.

Samochowiec, L., et al. " Clinical Test of the Effectiveness of Badmaev

28 in the Treatment of Patients with Chronic Peripheral Vascular

Disease. " Unpublished Report, 1986.

Wailti, R. " Treatment of Peripheral Gangrenes with Badmaev 28. " Personal

Communication, 1983.

Mechanism of Action of Badmaev 28 as a Circulatory Agent:

Bubb, W. " Hypotheses on the Action Mechanism of Badmaev 28. " Unpublished

Report, 1981.

 

Please note: This flyer is for information purposes only because it has

not been evaluated by the Food and Drug Administration. It is not

intended to diagnose or prescribe and these products are not intended to

treat, cure prescribe or prevent any disease.