Low-fat, high-carbohydrate diet, causes triacylglycerols to be increased significantly

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2499321 & dopt=Abstract

 

1: Am J Clin Nutr 2003 Jan;77(1):43-50Related Articles, Links

 

 

Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects

consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic

diets.

 

Schwarz JM, Linfoot P, Dare D, Aghajanian K.

 

Department of Nutritional Sciences and Toxicology, University of California,

Berkeley 94720-3104, USA. jschwarz

 

BACKGROUND: Hypertriglyceridemia is associated with increased risk of

cardiovascular disease. Until recently, the importance of hepatic de novo

lipogenesis (DNL) in contributing to hypertriglyceridemia was difficult to

assess because of methodologic limitations. OBJECTIVE: We evaluated the extent

of the contribution by DNL to different conditions associated with

hypertriglyceridemia. DESIGN: After 5 d of an isoenergetic high-fat,

low-carbohydrate diet, fasting DNL was measured in normoinsulinemic (<or= 85

pmol/L) lean (n = 9) and obese (n = 6) and hyperinsulinemic (>or= 115 pmol/L)

obese (n = 8) subjects. Fasting DNL was measured after a low-fat,

high-carbohydrate diet in normoinsulinemic lean (n = 5) and hyperinsulinemic

obese (n = 5) subjects. Mass isotopomer distribution analysis was used to

measure the fraction of newly synthesized fatty acids in VLDL-triacylglycerol.

RESULTS: With the high-fat, low-carbohydrate diet, hyperinsulinemic obese

subjects had a 3.7-5.3-fold higher fractional DNL (8.5 +/- 0.7%) than did

normoinsulinemic lean (1.6 +/- 0.5%) or obese (2.3 +/- 0.3%) subjects. With the

low-fat, high-carbohydrate diet, normoinsulinemic lean and hyperinsulinemic

obese subjects had similarly high fractional DNL (13 +/- 5.1% and 12.8 +/- 1.4%,

respectively). Compared with baseline, consumption of the high-fat,

low-carbohydrate diet did not affect triacylglycerol concentrations. However,

after the low-fat, high-carbohydrate diet, triacylglycerols increased

significantly and DNL was 5-6-fold higher than in normoinsulinemic subjects

consuming a high-fat diet. The increase in triacylglycerol after the low-fat,

high-carbohydrate diet was correlated with fractional DNL (P < 0.01), indicating

that subjects with high DNL had the greatest increase in triacylglycerols.

CONCLUSIONS: These results support the concept that both hyperinsulinemia and a

low-fat diet increase DNL, and that DNL contributes to hypertriglyceridemia.

 

Publication Types:

Clinical Trial

 

PMID: 12499321 [PubMed - indexed for MEDLINE]

 

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