D-Mannose : Urinary Tract

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Urinary tract or bladder infection is both a painful condition and a major cause

of doctor visits. Every year 6 million Americans suffer at least one occurrence

of this common problem and 20% of this group experience more than one episode.

Antibiotics are routinely used for 10 days or longer to combat the infection and

provide relief.

 

Unfortunately, there is growing evidence that the sought after relief is getting

harder and harder to achieve for three very important reasons:

 

1. Only a few of the commonly used antibiotics achieve adequate levels in the

urinary tract to be fully effective;

2. The infection causing bacteria attach to the mucosal wall of the bladder

making removal difficult; and

3. Infection causing bacteria are becoming increasingly resistant to

antibiotics.

The third reason points out the growing concern that comes with the use of

antibiotics. Pathogenic bacteria are becoming resistant. Recent data indicates

that 20% of the patients admitted to a New York hospital are resistant to

standard antibiotic therapy. The problem is even greater in the rest of the

world, especially third world countries.

 

With respect to the first reason, there is little we can do to increase the

level of antibiotics in the urinary tract. The second reason, however, offers

the potential means to maintain urinary tract health and reduce the ultimate use

of antibiotics. It stands to reason that, if the bacteria cannot attach to the

mucosal wall of the bladder, they will pass from the body in the urine and no

infection will occur .We know that the most common bacteria involved in urinary

tract infections is E. coli. We also know that E. coli is mannose sensitive.

 

How does this relate to maintaining urinary tract health? E. coli tend to bind

to the epithelial tissues on the interior surface of the bladder. This ability

of E. coli to bind to bladder tissue provides a home for subsequent growth and

infection. In the presence of Mannose, E. coli exhibits a greater affinity for

the Man- nose than the epithelial surface of the bladder. The net result is that

the E. coli either rapidly detaches from the bladder wall and attaches to the

Mannose or attaches to the Mannose before it can attach to the bladder. The

freely floating E. coli (attached to the Mannose) is now readily eliminated on

urination.

 

If the preceding is true, why hasn't Mannose been used routinely for maintaining

urinary tract health? Apparently, the reason for this can be found in a single

paper published on the use of Mannose in one patient. The authors of this case

report erroneously reported that Mannose was not orally absorbed.

 

It was not until 1997 that Dr. Hudson Freeze published a clarifying paper

showing that Mannose is orally absorbed in both normal individuals and patients

with Carbohydrate Deficient Glycoprotein Syndrome. His work showed that

supplementation with Mannose increases blood levels in a dose dependent manner.

Peak blood levels are observed after 1-2 hours with a clearance halftime of 4

hours. Clearance speed is critical to how quickly Mannose will reach the

bladder. No side effects were observed. Dr. Hudson concludes, " These results

establish the feasibility of using Mannose as a potential therapeutic dietary

supplement. "

 

What is Mannose/D-Mannose? It is a carbohydrate sugar with a molecular weight of

180.16. Its low molecular weight and water solubility are keys to its rapid

absorption and excretion. Man- nose is naturally produced in the body.

 

Supporting Evidence for the use of Mannose as a supplement to maintain and

support urinary tract health follows:

 

A. Adherence of E. coli was inhibited by Mannose [1. Med Microbiol1982 Aug 15

(3):303-16]

B. A 10 % solution of Mannose injected directly into the bladder significantly

Reduced bacteriuria within I day ( efficacy is dependent on concentration of

Mannose & bacteria) [urol Res 198311(2):97-102]

C. Irrigation of the bladder with 6% Mannose inhibited bacterial adherence: " As

6% Mannose effectively inhibited type 1 pili and also had some antibacterial

activity, it may reduce urinary tract infection if used as irrigation solution. "

[urol Res 1993 21 (6):401-5 U. of Basel Switzerland- Urology Clinics, Gasser

T.C.]

D. P-fimbriated E. coli is the most prevalent microorganism in acute un. ...

P-fimbriated E. coli is Mannose sensitive (readily attaches to Mannose). [J.

Chemo- therapy 1999 Oct; (5):357-62]

E. Mannose inhibition of the adherence of E. coli is dose dependent. ...With the

maximal inhibitory dose, adherence was reduced by approximately 80%. (Invest.

Urol. 1981 Mar: 18(5):364-70F]

F. Mannose inhibits E. coli adherence to urinary bladder epithelium. [urol. Res.

1985 13(2):79-8 ]

G. Mannose for Bladder and Kidney infections -Jonathan Wright M.D., Townsend

Letter for Doctors & Patients, 1999 July p.96-98

 

 

Summary: Mannose, taken as directed, can help maintain a healthy urinary tract

by binding with infectious bacteria like E. coli before it can attach to the

bladder wall and cause infection. The Man- nose-bound bacteria is readily

excreted in the urine. Mannose is orally absorbed and can be given as a drink,

capsule or tablet.

 

Dosage: For maximum effect, take 1.5-2.5 gInS (one level teaspoon of WRI

D-Mannose is approximately 2 grams) every 3-4 hours during waking hours for 48

hours. Repeat as necessary.

 

 

 

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