Scientific Research on Fucoidan

[Guest guest]

BEAUTY SECRET THAT YOU DON'T KNOW ABOUT. " Actually makes the skin

younger! "

 

Here are two of the clinical trials that prove it.

 

 

 

 

J Cosmet Sci 2002 Jan-Feb;53(1):1-9 Related Articles, Books, LinkOut

 

 

Treatment of human skin with an extract of Fucus vesiculosus changes

its thickness and mechanical properties.

 

Fujimura T, Tsukahara K, Moriwaki S, Kitahara T, Sano T, Takema Y.

 

Biological Science Laboratories, Kao Corporation, 2606 Akabane,

Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan.

 

Recently the researchers found that an extract of Fucus vesiculosus,

which is a type of seaweed, promotes the contraction of fibroblast-

populated collagen gels through increased expression of integrin

molecules. In this study, they investigated the effects of topical

application of an aqueous extract of this alga on the thickness and

the mechanical properties of human skin. A gel formulation that

included 1% of the extract was applied topically to human cheek skin

twice daily for five weeks. A significant decrease in skin thickness

measured by B-mode ultrasound was elicited, as was a significant

improvement in elasticity measured with a Cutometer as compared with

controls. In cheek skin, the thickness normally increases and the

elasticity usually decreases with age. These results suggest that the

Fucus vesiculosus extract possesses anti-aging activities and should

be useful for a variety of cosmetics.

 

Publication Types:

Clinical Trial

Controlled Clinical Trial

 

PMID: 11917251 [PubMed - indexed for MEDLINE]

 

 

 

1: Biol Pharm Bull 2000 Oct;23(10):1180-4 Related Articles, Books,

LinkOut

 

 

Fucoidan is the active component of fucus vesiculosus that promotes

contraction of fibroblast-populated collagen gels.

 

Fujimura T, Shibuya Y, Moriwaki S, Tsukahara K, Kitahara T, Sano T,

Nishizawa Y, Takema Y.

 

Biological Science Laboratories, Kao Corporation, Haga, Tochigi,

Japan. 301620

 

The fibroblast-populated collagen gel culture method has been

evaluated as a dermal model of wound contraction and granulation in

tissues during the wound healing process and as an in vitro model of

dermal tissue. We previously reported that an extract of Fucus

vesiculosus promoted fibroblast-populated collagen gel contraction

and that the promotion of the gel contraction was due to the

increased expression of integrin alpha2beta1 on the surface of the

fibroblasts. In this study, we investigated the active component of

the extract of this alga using extraction and fractionation

techniques. Water extraction of the alga was followed by

precipitation with excess ethanol and then gel filtration with the

boundary molecular weight of 30,000. The high molecular weight

fraction obtained from gel filtration was fractionated by ion

exchange chromatography on diethylaminoethyl cellulose column to give

active fractions that have more polar properties. These polar, high

molecular weight fractions which contained molecules with fucose and

sulfate groups showed significant gel contraction-promoting activity

and integrin expression-enhancing activity, and were estimated to be

the sulfated-polysaccharide fucoidan. Commercially available fucoidan

showed similar activities to the above-described fraction of this

alga. Although it remains necessary to precisely identify the

specific active component, the above results indicate that fucoidan

is the active component which promotes collagen gel contraction, and

also indicate the possibility that it dose so by enhancing the

integrin alpha2beta1 expression.

 

PMID: 11041247 [PubMed - indexed for MEDLINE]

 

or scientific studies and testimonials go to:

 

http://www.angelfire.com/ar/maybe4u2/limu.html

gina1906