Inflammation and Aging: Conclusion and References

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Good Morning!

 

Inflammation and Aging: Conclusion and References

 

Aging is a process. It involves changes in the body and mind that

vary enormously across individuals. There can be no doubt that

genetics plays a role. Scientists agree that one of the most

significant factors contributing to aging is chronic inflammation.

As we age, we tend towards a number of identifiable inflammatory

diseases.

 

Chronic inflammation damages the cells of our brains, heart, arterial

walls, and other body structures. Heart disease, Alzheimer's,

Parkinson's, rheumatoid arthritis, psoriasis, prostatitis and stroke

are just a few of the " diseases of aging " attributed to chronic

inflammation. Inflammation tends to increase with age, making us more

susceptible to disease. However, it is possible to significantly slow

this process.

 

Research has shown that the key to good health, maintaining wieght

and balancing blood sugar levels include cutting back on inflammation

promoting foods, such as simple carbohydrates and omega-6 fats, and

emphasizing anti-inflammatory fats and antioxidants.

 

The first line of defense seems to be dietary antioxidants from rich

clean food sources, followed by therapeutic quality antioxdants over

the counter, moderate exercise and healthy lifestyle changes.

Turning the clock back on aging may or may not be up to genetics but

living and eating well is definitively a choice we can make ourselves.

 

 

Andrew Pacholyk LMT, MT-BC, CA

Peacefulmind.com

Alternative medicine and therapies

for healing mind, body & spirit!

 

 

 

References used in articles:

 

1.Lindahl, B. et al. Markers of myocardial damage and inflammation in

relation to long-term mortality in unstable coronary artery disease.

FRISC Study Group. Fragmin during Instability in Coronary Artery

Disease. New. England Journal of Medicine. 2000 Oct 19; 343(16): 1139

47.

2 Brod, S.A. Unregulated inflammation shortens human functional

longevity. Inflamm. Res. 2000 Nov; 49(11): 561-70.

3. Lindahl et al. 2000 Oct 19; 343(16): 1139 47. Packard et al. 2000;

287:3223-3237 Rader 2000 3261-3263, The New England Journal of

Medicine 2000

4. Licinio, J., Wong, M.L. The role of inflammatory mediators in the

biology of major depression: central nervous system cytokines

modulate the biological substrate of depressive symptoms, regulate

stress-responsive systems, and contribute to neurotoxicity and

neuroprotection. Mol. Psychiatry 1999 Jul; 4(4): 317 27.

5. Sitzer, M., Markus, H.S., Mendall, M.A., Liehr, R., Knorr,

U., Steinmetz, H. C-reactive protein and carotid intimal medial

thickness in a community population. J. Cardiovasc. Risk 2002 Apr; 9

(2): 97-103.

6. Mantovani G, Maccio A, Madeddu C, Mura L, Gramignano G, Lusso MR,

Murgia V, Camboni P, Ferreli L, Mocci M, Massa E. " The impact of

different antioxidant agents alone or in combination on reactive

oxygen species, antioxidant enzymes and cytokines in a series of

advanced cancer patients at different sites: correlation with disease

progression " . Free Radic Res. 2003 Feb;37(2):213-23. Department of

Medical Oncology, University of Cagliari, Cagliari, Italy.

 

7. Gokce N, Keaney JF, Jr., Frei B, et al. Long-term ascorbic acid

administration reverses endothelial vasomotor dysfunction in patients

with coronary artery disease. Circulation. 1999;99(25):3234-3240.

 

8. Jacques PF: The potential preventive effects of vitamins for

cataract and age-related macular degeneration. Int J Vit Nutr Res

1999; 69:198-205.

 

9. Erlinger TP, Arch INtern Med 2001 Aug 13-27; 161(15):1903-8

 

10. Gokce N, Keaney JF Jr, Frei B, Holbrook M, Olesiak M, Zachariah

BJ, Leeuwenburgh C, Heinecke JW, Vita JA. Long-term ascorbic acid

administration reverses endothelial vasomotor dysfunction in patients

with coronary artery disease. Circulation, Jun 29;99 (25):3234-40

 

11. Childs A, Jacobs C, Kaminski T, Halliwell, B and C, Leeuwenburgh.

Supplementation with vitamin C and N-acetyl-cysteine increases

oxidative stress in humans after an acute muscle injury induced by

eccentric exercise. Free Radical Biology Med, 2001;13(6):745-753.

 

12. Devaraj, S., Jialal, I. Alpha tocopherol supplementation

decreases serum C-reactive protein and monocyte interleukin-6 levels

in normal volunteers and type 2 diabetic patients. Free Radical

Biology Med. 2000 Oct 15; 29(8): 790 2.

13. Devaraj, S., Jialal, I. Alpha tocopherol supplementation

decreases serum C-reactive protein and monocyte interleukin-6 levels

in normal volunteers and type 2 diabetic patients. Free Radical

Biology Med. 2000 Oct 15; 29(8): 790 2.

14. Dr. Marianne J. Engelhart of the Erasmus Medical Center in

Rotterdam, the Netherlands: Those with the highest intake of vitamin

C and vitamin E from food appeared to be the least likely to develop

Alzheimer's disease. The Journal of the American Medical Association.

6/26/03

15. Meydani M. Vitamin E and prevention of heart disease in high-risk

patients. Nutr Rev 2000;58:278-81.

16. 1993, The New England Journal of Medicine published two

epidemiologic studies which found that people who took vitamin E

supplements had fewer deaths from heart disease.

17. Heinonen OP, Albanes D, Virtamo J, Taylor PR, Huttunen JK,

Hartman AM, Haapakoski J, Malila N, Rautalahti M, Ripatti S, Maenpaa

H, Teerenhovi L, Koss L, Virolainen M, Edwards BK. Prostate cancer

and supplementation with alpha-tocopherol and beta-carotene:

incidence and mortality in a controlled trial. Department of Public

Health, University of Helsinki, Finland. Journal National Cancer

Institute. 1998 Mar 18;90(6):440-6, 441-7.

18. Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA,

Willerr WC. Intake of carotenoids and retinol in relation to risk of

prostate cancer. J Natl Cancer Inst 87:1767-1776, 1995

19. Dorgan JF, Sowell A, Swanson CA, Potischman N, Miller R.

Schussler N, Stephenson HEJr. Relationships of serum carotenoids,

retinol, a-tocopherol and selenium with breast cancer risk: results

from a prospective study in Columbia, Missouri (United States).

Cancer Causes Control 9:89-97, 1998

20. Antioxidants and age-related macular degeneration. Age-Related

Macular Degeneration Study Group. Journal of the American Optometric

Association. January 1996--Vol 67, No. 1.

21. Farr SA, Poon HF, Dogrukol-Ak D, Drake J, Banks WA, Eyerman E,

Butterfield DA, Morley JE. " The antioxidants alpha-lipoic acid and N-

acetylcysteine reverse memory impairment and brain oxidative stress

in aged SAMP8 mice. " Geriatric Research Education and Clinical Center

(GRECC), VA Medical Center (151/JC), 915 N. Grand Boulevard, St.

Louis, MO 63109, USA.

 

22. Moini H, Packer L, Saris NE. Antioxidant and pro-oxidant

activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl

Pharmacol 2002 Jul 182:84-90

 

 

23. Lopez-Burillo S, Tan DX, Mayo JC, Sainz RM, Manchester LC, Reiter

RJ.

Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-

lipoic acid differentially reduce oxidative DNA damage induced by

Fenton reagents: a study of their individual and synergistic

actions. Department of Biochemistry, Molecular Biology and

Physiology, School of Medicine, University of Valladolid, Valladolid,

Spain. 2001

 

24. Gregory JF, 3rd. Ascorbic acid bioavailability in foods and

supplements. Nutr Rev. 1993;51(10):301-303.

 

25. DeRitter E. Physiologic availability of dehydro-L-ascorbic acid

and palmitoyl-L-ascorbic acid. Science. 1951;113:628-631.

 

26. Johnston CS, Luo B. Comparison of the absorption and excretion of

three commercially available sources of vitamin C. J Am Diet Assoc.

1994;94(7):779-781.

 

27. Padayatty SJ, Levine M. Reevaluation of ascorbate in cancer

treatment: emerging evidence, open minds and serendipity. Journal

American College Nutrition. 2000;19(4):423-425.

 

28. Boylan MT, Crockard AD, Duddy ME, Armstrong MA, McMillan SA,

Hawkins SA. Interferon-beta 1a administration results in a transient

increase of serum amyloid A protein and C-reactive protein:

comparison with other markers of inflammation. Immunology Letters

2001; 75: 191-197.

29. Kamal-Eldin A, Appelqvist LA. The chemistry and antioxidant

properties of tocopherols and tocotrienols. Lipids 1996;31:671–701

[review].

 

30. Kamat JP, Devasagayam TPA. Tocotrienols from palm oil as potent

inhibitors of lipid peroxidation and protein oxidation in rat brain

mitochondria. Neurosci Lett 1995;195:179–82.

 

31. Theriault A, Chao JT, Wang Q, et al. Tocotrienol: a review of its

therapeutic potential. Clin Biochem 1999;32:309–19 [review].

 

32. Suarna C, Hood RL, Dean RT, Stocker R. Comparative antioxidant

activity of tocotrienols and other natural lipid-soluble antioxidants

in a homogeneous system, and in rat and human lipoproteins. Biochim

Biophys Acta 1993;1166:163–70.

 

33. Albanes D, Heinonen OP, Taylor PR, Virtamo J, Edwards BK,

Rautalahti M, Hartman AM, Palmgren J, Freedman LS, Haapakoski J,

Barrett MJ, Pietinen P, Malila N, Tala E, Liippo K, Salomaa ER,

Tangrea JA, Teppo L, Askin FB, Taskinen E, Erozan Y, Greenwald P,

Huttunen JK. Beta Carotene and Lung Cancer., J Natl Cancer Inst.

1996 Nov 6;88(21):1560-70.

 

34. Serum retinol levels and the risk of fracture. K. Michaëlsson, H.

Lithell, B. Vessby, et al., New Engl J Med, 2003, vol. 348, pp. 287—

294

 

35. Burke BE, et al. Randomized, double-blind, placebo-controlled

trial of coenzyme Q10 in isolated systolic hypertension. South Med J

2001 Nov;94(11):1112-7.

 

36. Watts GF, et al. Coenzyme Q(10) improves endothelial dysfunction

of the brachial artery in Type II diabetes mellitus. Diabetologia

2002 Mar;45(3):420-6.

37. Ebadi M, Govitrapong P, Sharma S, Muralikrishnan D, Shavali S,

Pellett L, Schafer R, Albano C, Eken J. Ubiquinone (coenzyme q10)

and mitochondria in oxidative stress of parkinson's disease. Biol

Signals Recept 2001 May-Aug;10(3-4):224-53

38. Tran MT, Mitchell TM, Kennedy DT, Giles JT. Role of coenzyme Q10

in chronic heart failure, angina, and hypertension. Pharmacotherapy

2001 Jul;21(7):797-806

39. Singh RB, Niaz MA Genetic variation and nutrition in relation to

coronary artery disease. J Assoc Physicians India 1999 Dec;47

(12):1185-90

40. Langsjoen H, Langsjoen P, Langsjoen P, Willis R, Folkers K.

Usefulness of coenzyme Q10 in clinical cardiology: a long-term study.

Mol Aspects Med 1994;15 Suppl:s165-75

41. Langsjoen PH, Langsjoen PH, Folkers K. Isolated diastolic

dysfunction of the myocardium and its response to CoQ10 treatment.

Clin Investig 1993;71(8 Suppl):S140-4

42. Overvad K, Diamant B, Holm L, Holmer G, Mortensen SA, Stender S.

Coenzyme Q10 in health and disease.Eur J Clin Nutr 1999 Oct;53

(10):764-70

43. Beck J, et al: Periodontal disease and cardiovascular disease. J

Periodontal 67 (suppl): 1123-1137,1996.

44. Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos

JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich

S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M; Parkinson

Study Group. Effects of coenzyme Q10 in early Parkinson disease:

evidence of slowing of the functional decline. Arch Neurol 2002 Oct;59

(10):1541-50

45. Birkmayer, J.G.D., Coenzyme Nicotinamide Adenine Dinucleotide –

New Therapeutic Approach for Improving Dementia of the Alzheimer

Type. Ann Clin and Lab Science 26(1):1-9, 1996

46. White KP, Speechley M, Harth M, Ostbye T. The London fibromyalgia

epidemiology study: the prevalence of fibromyalgia syndrome in

London, Ontario. J Rheumatol, 1999;26:1570-1576.

47. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia.

Treatment with Deanol. J Am Ger Soc 1977;25:241–44.

 

48. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-

dimethylaminoethanol in Alzheimer's disease. Am J Psych 1981;138:970–

72.

49. Pfeiffer, C., et al. Stimulant effect of 2-Dimethyl-l-

aminoethanol (DMAE): Possible precursor of brain acetylcholine.

Science. 126:610-611, 1957.

..50. Murphree, H. B., et al. The stimulant effect of 2-

diethylaminoethanol (DMAE) in human volunteer subjects. Clinical

Pharmacology and Therapeutics. 1:303-310, 1960.

 

51. Ceder, G., et al. Effects of 2-Dimethylaminoethanol (DMAE) on the

metabolism of choline in plasma. Journal of Neurochemistry. 30:1293-

1296, 1978.

 

52. Zs-Nagy, I., et al. On the role of cross-linking of cellular

proteins in aging. Mech Aging Dev. 14:245-251, 1980.

53. Passeri, M., et al. Acetyl-L-carnitine in the treatment of mildly

demented elderly patients. International Journal of Clinical

Pharmacology Research. 10(1-2):75-79, 1990.

 

54. Pettegrew, J. W., et al. Clinical and neurochemical effects of

acetyl-L-carnitine in Alzheimer's disease. Neurobiol Aging. 16:1-4,

1995.

 

55. Rai, G., et al. Double-blind, placebo controlled study of acetyl-

L-carnitine in patients with Alzheimer's dementia. Current Medical

Research and Opinion. 11(10):638-647, 1989.

 

56. Sano, M., et al. Double-blind parallel design pilot study of

acetyl levocarnitine in patients with Alzheimer's disease. Arch

Neurol. 49:1137-1141, 1992.

 

57. De Falco, F. A., et al. Effect of the chronic treatment with L-

acetylcarnitine in Down's syndrome. Clin Ther. 144:123-127, 1994.

 

58. Ridker PM, Hennekens CH, Buring JE, et al. C-reactive protein and

other markers of inflammation in the prediction of cardiovascular

disease in women. New England Journal of Medicine, 2000;342:836-843.

 

59. Pradhan AD, Manson JE, Rifai N, et al. C-reactive protein,

interleukin-6, and risk of developing type 2 diabetes mellitus. JAMA,

2001;286:327-334.

 

60. Festa A, D'Agostino R, Howard G, et al. Chronic subclinical

inflammation as part of the insulin resistance syndrome. The insulin

resistance atherosclerosis study (IRAS). Circulation, 2000;102:42-47.

 

 

61. Manson JE, Buring HE, et al. Relation between a diet with a high

glycemic load and plasma concentrations of high-sensitivity C-

reactive protein in middle-aged women. American Journal of Clinical

Nutrition, 2002;75:492-498.

 

62. Simin Liu, M.D., Ph.D., found that women who ate large amounts of

high-glycemic (or diabetes promoting) carbohydrates, including

potatoes, breakfast cereals, white bread, muffins, and white rice,

had very high CRP levels. Harvard Medical Journal 2000 Oct 19; 343

(16): 1139 47.

63. Lau CS, Morley KD, Belch JJF. Effects of fish oil supplementation

on non-steroidal anti inflammatory drug requirement in patients with

mild rheumatoid arthritis - a double-blind placebo controlled study.

British Journal of Rheumatology, 1993;32:982-989.

64. Curtis CL, Hughes CE, Flannery CR, et al. n-3 fatty acids

specifically modulate catabolic factors involved in articular

cartilage degradation. Journal of Biological Chemistry, 2000;275:721

724.

65. Zurier RB, Rossetti RG, Jacobson EW, et al. Gamma-linolenic acid

treatment of rheumatoid arthritis. A randomized, placebo-controlled

study. Arthritis & Rheumatism, 1996;11:1808 1817.