'Pharmageddon' / Risks of Edible Transgenic Vaccines

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SocietyScience Society Sustainability http://www.i-sis.org.uk General Enquiries

sam Website/Mailing List press-release ISIS Director

m.w.ho

UNSUBSCRIPTION INSTRUCTIONS ARE AT THE FOOT OF THIS MESSAGE

‘Pharmageddon’

Our fields are being turned into pharmaceutical and industrial factories that

poison our food supply and entire life support system. Our governments have been

warned and should be held liable for all damages along with the companies

involved. Dr. Mae-Wan Ho reports.

 

The complete document with references, is available in the ISIS members site.

Full details here

 

We have repeatedly warned against using food crops to produce gene drugs and

industrial chemicals since 1998 [1-3]. The inevitable contamination of our food

supply has now come to light. But the more insidious pollution of our soil,

water and air has yet to be assessed [3]. Poisons can seep through the plant

roots and dissolve in ground water. Pollen carrying the offending drugs and

chemicals could be inhaled. Wild and domestic animals of all kinds are likely to

feed on the crops.

 

On November 11, the US government ordered the biotech company, ProdiGene, to

destroy 500,000 bushels of soybeans contaminated with GM maize, engineered to

produce a drug not approved for human consumption [4]. The US Department of

Agriculture (USDA) refused to give details on the protein involved because it is

deemed ‘confidentual business information’.

 

It could be one of the following [5]: the HIV glycoprotein gp120, a

blood-clotting agent (aprotinin), a digestive enzyme (trypsin), an industrial

adhesive (a fungal enzyme, laccase), vaccines for hepatitis B, vaccine for a pig

disease, transmissible gastroenteritis.

 

USDA records show that ProdiGene has received 85 test permits for experimental

open-air trials of pharm crops and chemical crops in at least 96 locations.

 

The ‘edible’ AIDS vaccine with the HIV glycoprotein gp120 gene [6] has been

condemned as dangerous by a number of AIDS virologists [7-9] because the gp120

gene and gene product can undermine our immune system and generate new viruses

and bacteria that cause diseases.

 

A day later, the US government disclosed that ProdiGene did the same thing in

Iowa back in September. The USDA ordered 155 acres of nearby corn to be

incinerated for fear of contamination [10,11].

 

This is just the tip of the iceberg. The true extent of the contamination

remains unknown owing to the secrecy surrounding more than 300 field trials of

such crops across the country since 1991. Still others sites are in Canada [3].

The chemicals these plants produce include vaccines, growth hormones, clotting

agents, industrial enzymes, human antibodies, contraceptives, immune suppressive

cytokines and abortion-inducing drugs.

 

The majority of engineered biopharmaceuticals are being incorporated into maize.

ProdiGene, the company at the centre of the current scandal has the greatest

number of pharm crops and projects that 10 percent of the US maize will be

devoted to biopharm products by 2010.

 

Far from supporting even weak containment strategies such as buffer zones,

ProdiGene has told its shareholders it is hoping to " gain regulatory approval to

lessen or abandon these requirements altogether " .

 

Trials in other countries have also come to light. According to a recent report

by Genetically Engineered Food Alert, a US-based coalition of environmental and

consumer advocacy groups, Puerto Rico is one of four main centres in the US for

these tests. The other three are the states of Nebraska, Wisconsin and Hawaii.

 

Another report by the same group reveals that these plants are by no means the

only experimental GM crops grown in Puerto Rico. This Caribbean island has been

host to 2,296 USDA-approved GM open-air field tests as of January 2001, making

Puerto Rico host to more GM food experiments per square mile than any US state,

except Hawaii.

 

Puerto Rico is not a state. Its residents are US citizens but have no voice or

vote in the US Congress or in the UN.

 

Puerto Rico Farmers Association president Ramon Gonzalez revealed that he plants

GM crops in his farm in the town of Salinas. He said that genetically modified

crops in Puerto Rico are commercial and include a herbicide-resistant soya made

by Monsanto (Roundup-ready) and a variety of corn that produces its own

bio-pesticide, or Bt corn.

 

According to Gonzalez, the harvested GM crops planted there are sold as seed to

be planted elsewhere. " Puerto Rico is the preferred place to make seed because

our weather permits us to have up to four harvests a year. "

 

Local regulatory agencies seem to be unaware of the issue. A spokeswoman for the

Puerto Rico Environmental Quality Board said that as Puerto Rico has no laws or

regulations for GM crops, it has no mandate to intervene or investigate.

 

USDA spokesman Jim Rogers is reported to have said, " Nobody’s going to know all

the possible risks " , and " We mitigate these risks to what we feel is

appropriate " [12].

 

On the contrary, we do know enough of the risks for such crops to be banned

immediately. The USDA and other government regulators have been warned, and they

should be held liable for all damages along with the companies involved.

 

 

Risks of Edible Transgenic Vaccines

Prof. Joe Cummins reviews recent developments in plant edible vaccines and

points out some additional risks that have not been considered.

 

The complete document with references, is available in the ISIS members site.

Full details here

 

Using transgenic plants to produce vaccine cheaply has been the main area of

molecular farming. A large number of transgenic plant vaccines are being

developed and field tested [1,2].

 

Early tests of a hepatitis B vaccine in potato were hampered by the low levels

of antigen produced in the plant, and by the safety requirement that only

individuals previously immunized with injected vaccine should be exposed to the

plant vaccine [3]. The main safety concern is that the oral vaccine preparations

will induce " immune tolerance " , thereby making the individual susceptible to the

hepatitis B virus.

 

Oral tolerance is a fundamental biological response to ingested antigens, so

that it is possible to eat proteins that would produce an immune response if

injected. These difficulties appear to have cooled the fervour of clinical

investigators and pharmaceutical companies. Though earlier, a vaccine for pig

gastroenteritis produced in transgenic corn was claimed to be effective and

ready for commercial release by 2003 [4].

 

Most transgenic plants have been produced using fertile plants, with crop

isolation to limit pollen escape. Researchers have employed chloroplast

transgene insertions to boost production levels and to limit the escape of

modified genes in pollen. But chloroplast transgene containment is known not to

be completely effective [5,6].

 

The two main concerns over transgenic vaccines are the contamination of food

crops through cross pollination and of the vaccine itself in plant debris

spreading as dust and as pollutants in surface and groundwater. The vaccine

antigen may affect browsing animals and humans living in the area drinking

vaccine-polluted water or breathing vaccine-polluted dust. The problem of

inducing oral tolerance has already been pointed out above.

 

There is another kind of immune tolerance that could be acquired during

embryogenesis. Burnet and Medawar found that the immune system established the

difference between ‘self’ and ‘non-self’ molecules in the developing embryo

(reviewed in reference [7]). Exposing the embryo to vaccine will cause the

newborn to be tolerant to the vaccine and thus to regard both the vaccine and

the infecting pathogen as ‘self’. Individuals born in the vaccine-polluted area

may well not be able to produce antibodies to the vaccine antigen, and thus to

lack protection against infection by the pathogen.

 

A number of transgenic plant vaccines currently being developed will be

discussed. Cholera toxin gene was introduced into the chloroplast genome of the

tobacco, the construction was geared towards high levels of vaccine-antigen

production The chloroplast construction allowed 410 times higher antigen

production than nuclear gene inserts [8].

 

Edible cholera B vaccines were produced in transgenic tomato [9,10]. And an

antigen gene from the malaria parasite in transgenic tobacco has been proposed

as a malaria vaccine [11].

 

Mice fed transgenic alfalfa with a gene for an antigen to foot and mouse virus

were found to produce antibodies against the foot and mouth virus [12]. That

study bears careful scrutiny because alfalfa pollen is known to spread to

adjacent crops, and pregnant cows and sheep fed on the vaccine crop may give

birth to offspring tolerant to the virus.

 

Transgenic tobacco was modified to produce vaccines against hepatitis B virus

and cytomegalovirus. Virus-like particles were produced and concentrated in the

tobacco seeds. However, the modified seeds did not provoke an immune response to

hepatitis B and cytomegalovirus in mouse. Instead, a strong response to tobacco

seed proteins was observed [13]. This unexpected result ought to serve as

warning of the unpredictable risks inherent to the transgenic process.

 

A transgenic potato was loaded with genes for cholera, E.coli antigens and

rotavirus enterotoxin, and adult mice were found to produce antibodies to the

toxins after feeding on the transgenic potatoes. Neonate mice passively

immunized by suckling from mice fed transgenic potatoes had less diarrhea than

neonates unexposed to the vaccine [14].

 

The alfalfa mosaic virus was used to produce rabies vaccine in spinach and

tobacco [15]. The experiments progressed to having people eat spinach leaves

(salad) containing the vaccine. Such vaccines with recombinant viral vectors

should have been handled with very great care to prevent the viral vector from

recombining and spreading to infect crops in the field. The rabies vaccination

may be important for wild animals and humans, but problems associated with oral

tolerance or exposure of children in the womb should be addressed before these

vaccines are released to the environment, as the release could actually increase

the spread of rabies.

 

Transgenic crop vaccines may be useful, but the risks to human health and the

environment are real.

 

It is imperative that the cultivation and production of pharm crops should be

limited to controlled production facilities such as greenhouses, or better yet,

in plant tissue culture, that prevent environmental release of the

biopharmaceuticals.

 

 

 

This article can be found on the I-SIS website at

http://www.i-sis.org.uk/Pharmageddon.php

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