FDA Attacks Alternative Clinics Part 4

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http://www.lef.org/magazine/mag2002/apr2002_report_clinic_04.html

 

 

 

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Abstracts of Published Studies Indicating Aloe's Potential Efficacy Against

Cancer

Aloe-emodin is a new type of anticancer agent with selective activity against

neuroectodermal tumors.Pecere T, Gazzola MV, Mucignat C, Parolin C, Vecchia FD,

Cavaggioni A, Basso G, Diaspro A, Salvato B, Carli M, Palu G.Department of

Histology, Microbiology, and Medical Biotechnologies, Medical School, University

of Padova, Italy.

Here we report that aloe-emodin (AE), a hydroxyanthraquinone present in Aloe

vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor

activity. The growth of human neuroectodermal tumors is inhibited in mice with

severe combined immunodeficiency without any appreciable toxic effects on the

animals. The compound does not inhibit the proliferation of normal fibroblasts

nor that of hemopoietic progenitor cells. The cytotoxicity mechanism consists of

the induction of apoptosis, whereas the selectivity against neuroectodermal

tumor cells is founded on a specific energy-dependent pathway of drug

incorporation. Taking into account its unique cytotoxicity profile and mode of

action, AE might represent a conceptually new lead antitumor drug. Cancer Res

2000 Jun 1;60(11):2800-4 Aloe Vera has been claimed to contain several important

therapeutic properties, including anticancer effects. The effect of Aloe Vera

administration was studied on a pleural tumor in rat. Growth of Yoshida AH-130

ascite hepatoma cells injected (2 x 10(5) in 0.1 ml) into pleura of male inbred

Fisher rats was evaluated at different times (7th and 14th days). Data show that

the use of Aloe Vera proved a therapeutic method, and that the present

experimental model could be useful in the study of other therapeutics treatments

in vivo.

 

Int J Tissue React 1998;20(4):115-8

 

 

 

The therapeutic potential of Aloe Vera in tumor-bearing rats.Corsi MM, Bertelli

AA, Gaja G, Fulgenzi A, Ferrero ME.Institute of General Pathology, Medical

Faculty, University of Milan, Italy.

Aloe Vera has been claimed to contain several important therapeutic properties,

including anticancer effects. The effect of Aloe Vera administration was studied

on a pleural tumor in rat. Growth of Yoshida AH-130 ascite hepatoma cells

injected (2 x 10(5) in 0.1 ml) into pleura of male inbred Fisher rats was

evaluated at different times (7th and 14th days). Data show that the use of Aloe

Vera proved a therapeutic method, and that the present experimental model could

be useful in the study of other therapeutics treatments in vivo.

 

Int J Tissue React 1998;20(4):115-8

 

 

 

Activation of a mouse macrophage cell line by acemannan:

the major carbohydrate fraction from Aloe vera gel.Zhang L, Tizard IR.Department

of Veterinary Pathobiology, Texas A & M University College Station 77843, USA.

Acemannan is the name given to the major carbohydrate fraction obtained from the

gel of the Aloe vera leaf. It has been claimed to have several important

therapeutic properties including acceleration of wound healing, immune

stimulation, anti-cancer and anti-viral effects. However, the biological

mechanisms of these activities are unclear. Because of this wide diversity of

effects, it is believed that they may be exerted through pluripotent effector

cells such as macrophages. The effects of acemannan on the mouse macrophage cell

line, RAW 264.7 cells were therefore investigated. It was found that acemannan

could stimulate macrophage cytokine production, nitric oxide release, surface

molecule expression, and cell morphologic changes. The production of the

cytokines IL-6 and TNF-alpha were dependent on the dose of acemannan provided.

Nitric oxide production, cell morphologic changes and surface antigen expression

were increased in response to stimulation by a mixture of acemannan and

IFN-gamma. These results suggest that acemannan may function, at least in part,

through macrophage activation.

 

Immunopharmacology 1996 Nov;35(2):119-28

 

 

 

Tumor inhibitors. 114. Aloe emodin:

antileukemic principle isolated from Rhamnus frangula L.Kupchan SM, Karim A.

A systematic fractionation of an ethanol-water (1:1) extract of the seeds of

Rhamnus frangula L., guided by assays for tumore-inhibitory activity, led to the

isolation of aloe emodin (1). This compound was found to show significant

antileukemic activity against the P-388 lymphocytic leukemia in mice. A

note-worthy vehicle-dependence of the testing results is reported. In the light

of this vehicle-dependence, the re-examination of other anthraquinone

derivatives is recommended.

 

Lloydia 1976 Jul-Aug;39(4):223-4

 

 

 

 

 

 

 

 

 

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