Get off the Drugs - An Eye Opener!

[Guest guest]

Get off the Drugs and Get Well

 

 

 

By Ronald Rosedale, M.D.

Presented at Designs for Health Institute's BoulderFest

 

 

Let's talk about a couple of case histories. These are actual patients that

I've seen; let's start with patient A. This patient who we will just call

patient A saw me one afternoon and said that he had literally just signed

himself out of the hospital " AMA, " or against medical advice. Like in the

movies, he had ripped out his IV's.

 

 

The next day he was scheduled to have his second by-pass surgery. He had

been told that if he did not follow through with this by-pass surgery, within

two weeks he would be dead. He couldn't walk from the car to the office without

severe chest pain.

 

 

He was on 102 units of insulin and his blood sugars were 300 plus. He was on

eight different medications for various things. But his first by-pass surgery

was such a miserable experience he said he would rather just die than have to go

through the second one and had heard that I might be able to prevent that.

 

 

To make a long story short, this gentleman right now is on no insulin. I

first saw him three and a half years ago. He plays golf four or five times a

week. He is on no medications whatsoever, he has no chest pain, and he has not

had any surgery. He started an organization called " Heart Support of America " to

educated people that there are alternatives to by-pass surgery that have nothing

to do with surgery or medication. That organization, he last told me had a

mailing list of over a million people, a large organization, " Heart Support of

America. "

Patient B is a patient who had a triglyceride level of 2200. Patient B was

referred by patient A. He had a triglyceride of 2200, cholesterol of 950 and was

on maximum doses of all of his medications. He was 42 years old, and he was told

that he had familial hyperlipidema and that he had better get his affairs in

order, that if that was what his lipids were despite the best medications with

the highest doses, he was in trouble. He was not fat at all, he was fairly thin

 

 

Whenever I see a patient on any of those medications, they're off the very

first visit. They have no place in medicine. He was taken off the medications

and in six weeks his lipid levels, both his Triglycerides and his cholesterol

were hovering around 220. Six more weeks they were both under 200, off of the

medications. They have no place in medicine.

 

 

I should mention that this patient had a CPK that was quite elevated. It was

circled on the lab report that he brought in initially with a question mark by

it because they didn't know why. The reason why was because he was eating off

his muscles, because if you take (gemfibrozole) and any of the HMG co-enzyme

reductase inhibitors together, that is a common side effect that is in the PDR,

and they shouldn't be given together.

 

 

So he was chewing up his muscles, including his heart which they were trying

to treat. So if indeed he was going to die, it was going to be that treatment

that was going to kill him.

 

 

Let's go to something totally different, a lady with severe osteoporosis.

She is almost three standard deviations below the norm in both the hip femeral

neck and the cervical vertebrae, and she is very worried about getting a

fracture. A fairly young woman and she was put on a high carbohydrate diet and

told that would be of benefit, and placed on estrogen, which is a fairly typical

treatment.

 

 

They wanted to put her on some other medicines and she didn't want to, she

wanted to know if there was an alternative. Although we didn't have as dramatic

a turn around, we got her to one standard deviation below the norm in a year,

taking her off the estrogen she was on, anyway.

Let's go to claudication

That is severe angina of the leg when you walk, same thing as angina of the

heart except of the leg. While walking, after walking a certain distance, there

is pain. There was a gentleman who had extremely severe claudication, who

happens to be my stepfather. It was a typical case, he would walk about fifty

yards and then he would get severe, crampy pain in his legs. He was quite well

off and was going to see the best doctors in Chicago, and they couldn't figure

out what was wrong with him initially.

 

 

He went to a neurologist, they thought it might be neurological pain or back

pain. He finally went to a vascular surgeon who said he thought it was vascular

disease, so they did an arthrogram and sure enough, he had severe vascular

disease. They wanted to do the typical by-pass surgery that they normally do on

this. He was thinking of going in for the surgery for one reason, they had a

trip planned to Europe in two weeks, and he wanted to be able to walk since they

normally do a lot of walking.

 

 

Ten years previously he'd had an angioplasty for heart disease. At the time

ten years ago, I told him he had to change his diet and he didn't of course. But

this time he listened. I said that if he was not going to have a by-pass, then

do exactly what I tell you to do and in two weeks you'll be walking just fine

because by modulating this one aspect of his disease, I have never seen it not

work, and it works very quickly to open up the artery.

 

 

We can talk about a patient with a very high cancer risk

 

 

She had a mother and a sister who both died of breast cancer and she didn't

want to, so she came in and I put her on the exact same treatment as the other

cases I just mentioned. They were all treated virtually identically because they

all had the same thing wrong with them.

 

 

What would be the typical treatment of cardiovascular disease? First they

check the cholesterol. High cholesterol over 200, they put you on cholesterol

lowering drugs and what does it do? It shuts off your CoQ10. What does CoQ10 do?

It is involved in the energy production and protection of little energy furnaces

in every cell, so energy production goes way down.

 

 

A common side effect of people who are on all these HMG co-enzyme reductase

inhibitors is that they tell you their arms feel heavy. Well, the heart is a

muscle too, and it's going to feel heavy too. One of the best treatments for a

weak heart is CoQ10 for congestive heart failure. But they have no trouble

shutting CoQ10 production off so that they can treat a number. And the common

therapies for osteoporosis are drugs, and the common therapy for calaudication

is surgery. For cancer reduction there is nothing. But all of these have a

common cause.

 

 

The same cause as three major avenues of research in aging. One is called

caloric restriction. There are thousands of studies done since the fifties on

caloric restriction. They restrict calories of laboratory animals.

 

 

They have known since the fifties that if you restrict calories but maintain

a high level of nutrition, called " C.R.O.N.'s: " Caloric restriction with optimal

nutrition, or adequate nutrition, which would be CRAN " S, these animals can live

anywhere between thirty and two-hundred percent longer depending on the species.

 

 

They've done it on several dozen species and the results are uniform

throughout. They are doing it on primates now and it is working with primates,

we won't know for sure for about another ten years, they are about half way

through the experiment, our nearest relatives are also living much longer.

Then there are Centenarian studies

There are three major centenarian studies going on around the world. They

are trying to find the variable that would confer longevity among these people.

Why do centenarians become centenarians? Why are they so lucky? Is it because

they have low cholesterol, exercise a lot, live a healthy, clean life?

 

 

Well the longest recorded known person who has ever lived, Jean Calumet of

France who died last year at 122 years, smoked all of her life and drank.

 

 

What they are finding on these major centenarian studies is that there is

hardly anything in common among them. They have high cholesterol and low

cholesterol, some exercise and some don't, some smoke, some don't. Some are

nasty as can be and some nice and calm and nice. Some are ornery, but they all

low sugar, relatively for their age. They all have low triglycerides for their

age.

 

 

And they all have relatively low insulin. Insulin is the common denominator

in everything I've just talked about. They way to treat cardiovascular disease

and the way I treated my stepfather, the way I treated the high risk cancer

patient, and osteoporosis, high blood pressure, the way to treat virtually all

the so-called chronic diseases of aging is to treat insulin itself.

 

 

The other major avenue of research in aging has to do with genetic studies

of so-called lower organisms. We know the genetics involved. We've got the

entire genes mapped out of several species now, of yeast and worms. We think of

life span as being fixed, sort of.

 

 

Humans kind of have an average life span of seventy-six, and the maximum

life-span was this French lady at one-hundred and twenty-two. In humans we feel

it is relatively fixed, but in lower forms of life it is very plastic. Life span

is strictly a variable depending on the environment. They can live two weeks,

two years, or sometimes twenty years depending on what they want themselves to

do, which depends very much on the environment.

 

 

If there is a lot of food around they are going to reproduce quickly and die

quickly, if not they will just bide their time until conditions are better. We

know now that the variability in life span is regulated by insulin.

 

 

One thinks of insulin as strictly to lower blood sugar. Today in the clinic

there was a patient listing off her drugs, she listed about eight drugs she was

on and didn't even mention insulin. Insulin is not treated as a drug. In fact,

in some places you don't even need a prescription, you can just get it over the

counter, it's treated like candy.

 

 

Insulin is found as in even single celled organisms. It has been around for

several billion years. And its purpose in some organisms is to regulate life

span. The way genetics works is that genes are not replaced, they are built

upon. We have the same genes as everything that came before us. We just have

more of them.

 

 

We have added books to our genetic library, but our base is the same. What

we are finding is that we can use insulin to regulate lifespan too.

 

 

If there is a single marker for lifespan, as they are finding in the

centenarian studies, it is insulin, specifically, insulin sensitivity.

 

 

How sensitive are your cells to insulin. When they are not sensitive, the

insulin levels go up. Who has heard of the term insulin resistance?

Insulin resistance is the basis of all of the chronic diseases of aging,

because the disease itself is actually aging.

 

 

We know now that aging is a disease. The other case studies that I

mentioned, cardiovascular disease, osteoporosis, obesity, diabetes, cancer, all

the so-called chronic diseases of aging, auto-immune diseases, those are

symptoms.

 

 

If you have a cold and you go to the doctor, you have a runny nose, I did

Ear, Nose and Throat for ten years, I know what the common treatment for that

is, they give you a decongestant. I can't tell you how many patients I saw who

had been given Sudafed by their family doctors for a cold and they came to see

me after because of a really bad sinus infection.

 

 

What happens when you treat the symptom of a runny nose from a cold and you

take a decongestant? It certainly decongests you by shutting off the mucus. Why

do you have the mucus, because you are trying to clean and wash out the

membranes, and what else? What else is in mucus? Secretory IgA, a very strong

antibody to kill the virus is in the mucus. If there is no mucus, there is no

secretory IgA.

 

 

Decongestants also constrict blood vessels, the little capillaries, or

arterioles that go to those capillaries, the cilia, the little hair-like

projections that beat to push mucus along to create a stream, they get paralyzed

because they don't have blood flow so there is no more ciliary movement. What

happens if you dam a stream and create a pond?

 

 

In days you've got larvae growing. If the stream is moving, you are fine.

You need a constant stream of mucus to get rid of and prevent an infection. I am

going in to this in some detail because in almost all cases if you treat a

symptom, you are going to make the disease worse because the symptom is there as

your body's attempt to heal itself.

 

 

Now, the medical profession is continuously segregating more and more

symptoms into diseases, they call the symptoms diseases. Using ENT for example,

that patient will walk out of there with a diagnosis of Rhinitis which is

inflammation of the nose. Is there a reason that patient has inflammation of the

nose? I think so. Wouldn't that underlying cause be the disease as opposed to

the descriptive term of Rhinitis or Pharyngitis?

Some one can have the same virus and have Rhinitis or Pharyngitis, or

Sinusitis, they can have all sorts of " itis's " which is a descriptive term for

inflammation. That is what the code will be and that is what the disease will

be. So they treat what they think is the disease which is just a symptom.

 

 

It is the same thing with cholesterol.

 

 

If you have high cholesterol it is called hypercholesterolemia.

Hypercholesterolemia has become the code for the disease when it is only the

symptom. So they treat that symptom and what are they doing to the heart?

Messing it up.

 

 

So what you have to do if you are going to treat any disease is you need to

get to the root of the disease. If you keep pulling a dandelion out by it's

leaves, you are not going to get very far. But the problem is that we don't know

what the root is, or we haven't.

 

 

They know what it is in many other areas of science, but the problem is that

medicine really isn't a science, it is a business, but I don't want to get in to

that, we can talk hours on that. But if you really look at the root of what is

causing it, we can use that cold as a further example.

 

 

Why does that person have a cold?

 

 

If he saw the doctor, the doctor might tell him to take an antibiotic along

with the decongestant. You see this all the time because the doctor wants to get

rid of the patient. Well we all know that in almost all cases of an upper

respiratory infection it is a virus, and the antibiotic is going to do worse

than nothing because it is going to kill the bacterial flora in the gut and

impair the immune system, making the immune system worse.

 

 

The patient might see someone else more knowledgeable who will say no, you

caught a virus, don't do anything, go home and sleep, let your body heal itself.

That's better. You might see someone else who would ask why you caught a virus

without being out there trying to hunt for viruses with a net. We are breathing

viruses every day; right now we are breathing viruses, cold viruses,

rhinoviruses.

 

 

Why doesn't everybody catch a cold tomorrow?

 

 

The Chinese will tell you that it is because the milieu has to be right, if

the Chinese were to quote the French. Your body has to be receptive to that

virus. Only if your immune system is depressed will it allow that virus to take

hold.

 

 

So maybe a depressed immune system is the disease. So you can be given a

bunch of vitamin C because your immune system is depressed and it is likely that

the person has a vitamin C deficiency. That's where most of us are at right now,

where we would give a bunch of vitamin C to try to pick up the immune system.

 

 

But why is the vitamin C not working. Vitamin C is make in almost all living

mammals except humans and a couple other species. Vitamin C is made directly

from glucose and actually has a similar structure and they compete for one

another.

 

 

We've known for many years that sugar depresses the immune system.

We have known that for decades. It was only in the 70's that they found out

that vitamin C was needed by white blood cells so that they could phagocytize

bacteria and viruses. White blood cells require a fifty times higher

concentration at least inside the cell as outside so they have to accumulate

vitamin C.

 

 

There is something called a phagocytic index which tells you how rapidly a

particular macrophage or lymphocyte can gobble up a virus, bacteria, or cancer

cell. It was in the 70's that Linus Pauling knew that white blood cells needed a

high dose of vitamin C and that is when he came up with his theory that you need

high doses of vitamin C to combat the common cold.

 

 

But if we know that vitamin C and glucose have similar chemical structure,

what happens when the sugar levels go up? They compete for one another upon

entering the cells. And the thing that mediates the entry of vitamin C into the

cells is the same thing that mediates the entry of glucose into the cells. If

there is more glucose around there is going to be less vitamin C allowed into

the cell and it doesn't take much. A blood sugar value of 120 reduces the

phagocytic index seventy-five percent.

 

 

Here we are getting a little bit further down into the roots of disease. It

doesn't matter what disease you are talking about, whether you are talking about

a common cold or about cardiovascular disease, or osteoporosis or cancer, the

root is always going to be at the molecular and cellular level, and I will tell

you that insulin is going to have its hand in it, if not totally controlling it.

What is the purpose of insulin?

 

 

 

As I mentioned, in some organisms it is to control their lifespan, which is

important. What is the purpose of insulin in humans? If you ask your doctor,

they will say that it's to lower blood sugar and I will tell you right now, that

is a trivial side effect. Insulin's evolutionary purpose, among others at least

known right now, we are looking at others, is to store excess nutrients.

 

 

We come from a time of feast and famine and if we couldn't store the excess

energy during times of feasting, we would all not be here, because we all have

had ancestors that encountered famine. So we are only here because our ancestors

were able to store nutrients, and they were able to store nutrients because they

were able to elevate their insulin in response to any elevation in energy that

the organism encountered.

 

 

When your body notices that the sugar is elevated, it is a sign that you've

got more than you need right now, you are not burning it so it is accumulating

in your blood. So insulin will be released to take that sugar and store it. How

does it store it? (Someone in the audience suggest the answer

glycogen).Glycogen?

How much glycogen do you store?

 

 

 

Do you know how much glycogen you have in your body at any one time? Very

little. All the glycogen stored in your liver and all the glycogen stored in

your muscle if you had an active day wouldn't last you the day.

 

 

Once you fill up your glycogen stores how is that sugar is stored, as what

particular kind of triglyceride, or fatty acid? Palmitic acid. Saturated fat,

ninety-eight percent of which is palmitic acid.

 

 

So the idea of the medical profession to go on a high complex carbohydrate,

low saturated-fat diet is an absolute oxymoron, because those high complex

carbohydrate diets are nothing but a high glucose diet, or a high sugar diet,

and your body is just going to store it as saturated fat. The body makes it into

saturated fat quite readily.

What else does insulin do?

It doesn't just store carbohydrates, by the way. Somebody mentioned that it

is an anabolic hormone, it absolutely is. Body builders are using insulin now

because it is legal, so they are injecting themselves with insulin because it

builds muscle, it stores protein too.

 

 

A lesser known fact is that insulin also stores magnesium. We mentioned it's

role in vitamin C, it stores all sorts of nutrients. But what happens if your

cells become resistant to insulin? First of all you can't store magnesium so you

lose it, that's one effect, you lose it out the urine.

What is one of magnesium's major roles?

 

 

 

To relax muscles. Intracellular magnesium relaxes muscles. What happens when

you can't store magnesium because the cell is resistant? You lose magnesium and

your blood vessels constrict, what does that do?

 

 

Increases blood pressure, and reduces energy since intracellular magnesium

is required for all energy producing reactions that take place in the cell. But

most importantly, magnesium is also necessary for the action of insulin. It is

also necessary for the manufacture of insulin.

 

 

So then you raise your insulin, you lose magnesium, and the cells become

even more insulin resistant. Blood vessels constrict, glucose and insulin can't

get to the tissues, which makes them more insulin resistant, so the insulin

levels go up and you lose more magnesium. This is the vicious cycle that goes on

from before you were born.

 

 

Insulin sensitivity is going to start being determined from the moment the

sperm combines with the egg. If your mother, while you were in the womb was

eating a high carbohydrate diet, which is turning into sugar, we have been able

to show that the fetus in animals becomes more insulin resistant.

 

 

Worse yet, they are able to use sophisticated measurements, and if that

fetus happens to be a female, they find that the eggs of that fetus are more

insulin resistant. Does that mean it is genetic? No, you can be born with

something and it doesn't mean that it is genetic. Diabetes is not a genetic

disease as such. You can have a genetic predisposition. But it should be an

extremely rare disease.

What else does insulin do?

 

 

 

We mentioned high blood pressure, if your magnesium levels go down you get

high blood pressure. We mentioned that the blood vessels constrict and you get

high blood pressure.

 

 

Insulin also causes the retention of sodium, which causes the retention of

fluid, which causes high blood pressure and fluid retention: congestive heart

failure.

 

 

One of the strongest stimulants of the sympathetic nervous system is high

levels of insulin.

What does all of this do to the heart? Not very good things.

 

 

 

There was a study done a couple of years ago, a good, down to earth nicely

conducted study that showed that heart attacks are two to three times more

likely to happen after a high carbohydrate meal. They said specifically NOT

after a high fat meal.

Why is that?

 

 

 

Because the immediate effects of raising your blood sugar from a high

carbohydrate meal is to raise insulin and that immediately triggers the

sympathetic nervous system which will cause arterial spasm, constriction of the

arteries. If you take anybody prone to a heart attack and that is when they are

going to get it.

What else does insulin do?

Insulin mediates blood lipids. That patient who had a triglyceride of 2200,

one of the easiest things we can do is lower triglyceride levels. It is so

simple. There was just an article in J.A.M.A. an article and they were saying

that the medical profession doesn't know how to reduce triglycerides dietarily,

that drugs still need to be used.

 

 

It is so ridiculous because you will find that it is the easiest thing to

do. They come tumbling down. There is almost a direct correlation between

triglyceride levels and insulin levels. In some people more than others. The

gentleman who had a triglyceride level of 2200 while on all the drugs only had

an insulin level of 14.7.

 

 

That is only slightly elevated, but it doesn't take much in some people, all

we had to do was get his insulin level down to 8 initially and then it went down

to six and that got his triglycerides down to under 200.

 

 

The way you control blood lipids is by controlling insulin.

 

 

We won't go into a lot of detail, but we now know that LDL cholesterol comes

in several fractions, and it is the small, dense LDL that plays the largest role

in initiating plaque. It's the most oxidizable. It is the most able to actually

fit through the small cracks in the endothelium. And that's the one that insulin

actually raises the most. When I say insulin, I should say insulin resistance.

It is insulin resistance that is causing this.

 

 

Cells become insulin resistant because they are trying to protect themselves

from the toxic effects of high insulin. They down regulate their receptor

activity and number of receptors so that they don't have to listen to that

noxious stimuli all the time. It is like having this loud, disgusting rap music

played and you want to turn the volume down.

 

 

You might think of insulin resistance as like sitting in a smelly room and

pretty soon you don't smell it anymore because you get desensitized.

 

 

You can think about it, its not that you are not thinking about it anymore.

But if you walk out of the room and come back, the smell is back. You can get

resensitized is what that is telling you. It would be like you are starting to

go deaf and your are telling others to speak up because you can't hear them, so

if I was your pancreas, I would just start talking louder, and what does that do

to your hearing?

 

 

You would become deafer. Most cases of deafness, especially in old age is

due to excessive noise exposure. All the noise exposure your ears have been

exposed to, well the hair cells that end up triggering your brain to allow you

to hear eventually get killed. Sometimes it just takes a single firecracker.

 

 

This is the same thing with insulin resistance. What happens is that if your

cells are exposed to insulin at all they get a little bit more resistant to it.

So the pancreas just puts out more insulin. I saw a patient today, her blood

sugar was 102 and her insulin was 90! She wasn't sure if she was fasting or not,

but I've seen other patients where their blood sugar was under 100 and their

fasting insulin has been over 90.

 

 

That is a fasting insulin. I'm not sure how many people are familiar with

seeing fasting insulins. But if I drank all the glucose I could possibly drink

my insulin would never go above probably 40. So she was extremely insulin

resistant.

What was happening was she was controlling her blood sugar. Statistically

she was not diabetic. She is not even impaired glucose tolerant. Her glucose is

totally normal supposedly. But her cells aren't listening to insulin, she just

has an exceptionally strong pancreas.

 

 

Her islet cells that produce insulin are extremely strong and are able to

compensate for that insulin resistance by producing thirty times more insulin

than what my fasting insulin is. And just by mass action her pancreas is yelling

so loud that her cells are able to listen, but they are not going to listen

forever. Her pancreas is not going to be able keep up that production forever.

 

 

Well the usual treatment once she becomes diabetic, which would be

inevitable, once her production of insulin starts slowing down or her resistance

goes up any more, than her blood sugar goes up and she becomes a diabetic. For

many years, decades before that her insulin levels have been elevated.

 

 

They have been elevated for thirty years probably and have never been

checked. That insulin resistance is associated with the hyperinsulinemia that

produces all of the co-called chronic diseases of aging or at least contributes

to them. As far as we know in many venues of science, it is the main cause of

aging in virtually all life.

 

 

Insulin is that important.

 

 

So controlling insulin sensitivity is extremely important.

 

 

How else does insulin affect cardiovascular disease?

 

 

We've only just touched upon it. Insulin is a so-called mytogenic hormone.

It stimulates cell proliferation. It stimulates cells to divide. If all of the

cells were to become resistant to insulin we wouldn't have that much of a

problem. The problem is that all of the cells don't become resistant.

 

 

Some cells are incapable of becoming very resistant. The liver becomes

resistant first, then the muscle tissue, then the fat. When the liver becomes

resistant, what is the effect of insulin on the liver, it is to suppress the

production of sugar.

The sugar floating around in your body at any one time is the result of two

things, the sugar that you have eaten and how much sugar your liver has made.

When you wake up in the morning it is more of a reflection of how much sugar

your liver has made. If your liver is listening to insulin properly it won't

make much sugar in the middle of the night. If your liver is resistant, those

brakes are lifted and your liver starts making a bunch of sugar so you wake up

with a bunch of sugar.

 

 

The next tissue to become resistant is the muscle tissue. What is the action

of insulin in muscles? It allows your muscles to burn sugar for one thing. So if

your muscles become resistant to insulin it can't burn that sugar that was just

manufactured by the liver. So the liver is producing too much, the muscles can't

burn it, and this raises your blood sugar.

 

 

Well the fat cells become resistant, but not for a while. It is only after a

while that they become resistant. It takes them longer.

 

 

Liver first, muscle second, and then your fat cells.

 

 

So for a while your fat cells retain their sensitivity. What is the action

of insulin on your fat cells? To store that fat. It takes sugar and it stores it

as fat. So until your fat cells become resistant you get fat, and that is what

you see. As people become more and more insulin resistant, they get fat and

their weight goes up.

 

 

But eventually they plateau. They might plateau at three hundred pounds, two

hundred and twenty pounds, one hundred and fifty pounds, but they will

eventually plateau as the fat cells protect themselves and become insulin

resistant.

 

 

As all these major tissues, this massive body becomes resistant, your liver,

muscles and fat, your pancreas is putting out more insulin to compensate, so you

are hyperinsulinemic and you've got insulin floating around all the time, 90

units, more.

 

 

But there are certain tissues that aren't becoming resistant such as your

endothelium, the lining of the arteries do not become resistant very readily. So

all that insulin is effecting the lining of your arteries.

 

 

If you drip insulin into the artery of a dog, there was a Dr. Cruz who did

this in the early 70's by accident, he was doing a diabetic experiment and found

out that the femoral artery that the insulin was being dripped into was almost

totally occluded with plaque after about three months.

 

 

The contra lateral side was totally clear, just contact of insulin in the

artery caused it to fill up with plaque. That has been known since the 70's, it

has been repeated in chickens, in dogs, it is really a well-known fact. Insulin

floating around in the blood causes a plaque build up. They didn't know why, but

we know that insulin causes endothelial proliferation, that's the first step, it

causes a tumor, an endothelial tumor.

Insulin causes the blood to clot too readily.

Insulin causes the conversion of macrophages into foam cells, which are the

cells that accumulate the fatty deposits. Every step of the way, insulin's got

its fingers in it and is causing cardiovascular disease. It fills it with

plaque, it constricts the arteries, it stimulates the sympathetic nervous

system, it increases platelet adhesiveness and coaguability of the blood.

 

 

Any known cause of cardiovascular disease insulin is a part of. It

influences nitric oxide synthase. You produce less nitric oxide in the

endothelium. We know that helps mediate vasodilatation and constriction, i.e.

angina.

 

 

I mentioned that insulin increases cellular proliferation, what does that do

to cancer? It increases it. And there are some pretty strong studies that show

that one of the strongest correlations to breast and colon cancer are with

levels of insulin.

 

 

Hyperinsulinemia causes the excretion of magnesium in the urine. What other

big mineral does it cause the excretion of? Calcium.

What is the cause of osteoporosis?

 

 

 

There are two major causes, one is a high carbohydrate diet which causes

hyperinsulinemia. People walking around with hyperinsulinemia can take all the

calcium they want by mouth and it's all going to go out in their urine.

 

 

Insulin is one of the first hormones that any organism ever developed, and

as I mentioned in genetics, things are built upon what was there before. So all

the other hormones we have in our body were actually built upon insulin. In

other words, insulin controls growth hormone.

How does growth hormone work?

The pituitary produces growth hormone, and then it goes to the liver and the

liver produces what are called IgF 1 thru 4, there are probably more. What does

IgF stand for? Insulin-like growth factor. They are the active ingredients.

Growth hormone has some small effects on its own, but the major growth factors

are the IgF's that then circulate throughout the body.

 

 

Why are they called IgF's or insulin like growth factors? Because they have

an almost identical molecular structure to insulin. When I said that insulin

promotes cellular proliferation, it is because it cross reacts with IgF

receptors. So somewhere in the evolutionary tree, IgF's diverged from insulin.

Insulin can work very well all by itself, it doesn't need growth hormone. Growth

hormone can't do anything without insulin.

Thyroid-how does thyroid work?

 

 

 

The thyroid produces mostly T4. T4 goes to the liver and is converted to T3,

mostly there, other tissues too, but mostly in the liver. We are getting the

idea that insulin controls a lot of what goes on in the liver, and the liver is

the primary organ that becomes insulin resistant.

 

 

When the liver can no longer listen to insulin, you can't convert T4 to T3

very well. Usually in people who are hyperinsulinemic with a thyroid hormone

that comes back totally normal, it is important to measure their T3. Their free

T3 will just as often as not be low. Get their insulin down and it comes back

up.

 

 

Sex hormones, estrogen, progesterone, and testosterone, does insulin help

control them? Absolutely, in various ways. Insulin helps control the manufacture

of cholesterol and where do all the sex hormones come from? All the stearic

hormones are originally derived from cholesterol, so that's one way. Dr Nestler

from the University of Virginia who has spent the last eight years doing

multiple studies to show that DHEA levels are directly correlated with insulin

levels, or I should say insulin resistance.

 

 

The more insulin resistant you are, the lower your DHEA levels. He firmly

believes this and has a lot of studies to back it up, that the decline in DHEA

is strictly due to the increase in insulin resistance with age. If you reduce

the insulin resistance, the DHEA rises.

 

 

And how are these sex hormones carried around the body? Something called sex

hormone binding globulins. The more that is bound, the less free, active hormone

you have. Sex hormone binding globulin is controlled by what? Insulin. There is

not a hormone in the body that insulin doesn't affect, if not directly control.

Let's talk about osteoporosis.

You take a bunch of calcium. The medical profession just assumes that it has

a homing device and it knows to go into your bone. What happens if you high

levels of insulin and you take a bunch of calcium. Number one, most of it is

just going to go out in your urine. You would be lucky if that were the case

because that part which doesn't does not have the instructions to go to your

bone because the anabolic hormones aren't working.

 

 

This is first of all because of insulin, then because of the IGF's from

growth hormone, also testosterone and progesterone, they are all controlled by

insulin and when they are insulin resistant they can't listen to any of the

anabolic hormones. So your body doesn't know how to build tissue anymore, so

some of the calcium may end up in your bone, but a good deal of it will end up

everywhere else.

 

 

Metastatic calcifications, including in your arteries.

 

 

Diseases are a result of a lack of communication. There are certain things

that your cells need to be healthy. If you learn nothing else today, you should

know that everything is at the cellular and molecular level and we are nothing

but a community of cells. We are a commune of cells. We are a metropolis of

cells that have been given instructions to cooperate.

 

 

When you have a large number of cells, like we are, ten trillion or so,

there must be proper communication so that there will be proper division of

labor. You can take most any cell in your body and under the right conditions

you can put it in a petrie dish and it can live all on it's own. They each have

a life of their own.

 

 

You can manipulate the genetics of a cell, and we've now made a blood cell

in to a nerve cell. Pretty soon we are going to be able to take any cell we want

and make it into any other cell, because every cell in your body has the

identical genetics, all derived from that egg and that sperm that came together.

Why is one cell different from another? Because they are reading different parts

of the same library.

You can influence which part of that genetic library that every cell reads

by the environment of that cell. The environment of that cell is going to be

very much dictated by, number one, hormones, and what you eat. Eating is just

internalizing the external environment. That is what you have circulation for,

to bring that external environment to each and every one of those cells that is

inside of you.

 

 

I hope that by now you have gotten the idea that high insulin resistance is

not very good for you. So now let's talk about what causes insulin resistance.

We have been talking about high carbohydrate diets, let's start talking about

that a little bit more.

 

 

This is what causes insulin resistance.

 

 

That is definitely what worsens it. Any time your cell is exposed to insulin

it is going to become more insulin resistant. That is inevitable, we cannot stop

that, but the rate we can control. An inevitable sign of aging is an increase in

insulin resistance.

 

 

That rate is variable, if you can slow down that rate you can become a

centenarian, and a healthy one. You can slow the rate of aging. Not just even

the rate of disease, but the actual rate of aging itself can be modulated by

insulin. We talked about some of the lower animals and there is some pretty good

evidence that even in humans we still retain the capacity to control lifespan at

least partially. We should be living to be 130, 140 years old routinely.

 

 

Let's talk about carbohydrates, what are they? We talk about simple and

complex carbohydrates, that is totally irrelevant, it means absolutely nothing.

Carbohydrates are fiber or non-fiber. Few things in life are as clear-cut as

this. Fiber is good for you, and a non-fiber carb is bad for you. You can bank

on that.

 

 

There is not a whole lot of middle ground. If you have a carbohydrate that

is not a fiber it is going to be turned into a sugar, whether it be glucose or

not. It may be fructose and won't necessarily raise your blood glucose, fructose

is worse for you then glucose, so if you just go by blood sugar, which is just

glucose, it doesn't mean that you are not raising your blood fructose, or your

blood galactose which is the other half of lactose.

 

 

All of those sugars are as bad or worse for you than glucose. You can't just

go by so-called blood sugar which is just blood glucose, because we just don't

measure blood fructose or blood galactose, but they are all bad for you. Why are

they bad, well number one we know that it provokes insulin and every time you

provoke insulin it exposes yourself to more insulin and just like walking in a

smelly room it is going to become more resistant to insulin.

 

 

So every time you have a surge of sugar and you have a surge of insulin, you

get more and more insulin resistant and all of the problems we've talked about.

What else is bad about sugar?

We know it increases insulin, but even by itself, sugar is bad for you. You

can divide aging into basically two major categories, there is genetic causes of

aging, we know that cells have a limited capacity to divide, normally we never

get there, but the more rapidly you make cells divide, the more rapidly they

age.

 

 

One of the effects of insulin is to stimulate cellular proliferation and

division. So we know that it increases the rate of aging of a cell population

just by that, that is another whole discussion. Let's go to the other half. Our

cells accumulate damage with age we cannot help that.

 

 

When I say aging, we really are talking about something called senescence,

or the damage associated with aging, but the common usage is the word aging. I

cannot prevent you from being a day older tomorrow, that is aging, tomorrow you

will be a day older than today, and that we cannot do anything about. When we

talk about aging we normally think about the damage that is associated with that

day.

 

 

We have accumulated more damage during that day, that is called senescence.

What causes that damage? There is often an example of test tubes in a

laboratory. You don't think of test tubes as aging, yet if you mark test tubes

with a little red dot and counted the number of test tubes there were at the end

of the year with a little red dot left, there would hardly be any, why, because

they have encountered damage. They've broken, so even though there is not aging

they do have immortality rates. Aging is an increase in the rate of mortality.

In humans, the rate of mortality doubles every eight years.

 

 

 

That is really how you gauge the rate of aging. We found in animal studies

that the rate of aging can be largely controlled by insulin. But the damage that

accumulates during that aging is caused by largely by sugar.

 

 

The two major causes of accumulated damage are oxygenation, and glycation.

I'm not going to spend my time talking about oxidation. Most of you know all

about that.

What is oxidation?

 

 

 

There are several definitions but we can use a very common one, whenever

oxygen combines with something, it oxidizes. Oxygen is a very poisonous

substance. Throughout most of the history of life on Earth there was no oxygen.

Organisms had to develop very specific mechanisms of dealing with high levels of

oxygen before there could ever be life with oxygen.

 

 

So we evolved very quickly, as plants arose and developed a very easy means

of acquiring energy, they could just lay back and catch rays, and they dealt

with that oxygen with the carbon dioxide by spitting it out, they didn't want it

around. So the oxygen in the atmosphere increased. All the other organisms then

had to cope with that toxic oxygen. Many perished if they didn't have ways of

dealing with it.

 

 

One of the earliest ways of dealing with all that oxygen was for the cells

to huddle together, so that at least the interior cells wouldn't be exposed to

as much. So, multi-celled organisms arose after oxygen did. Of course, with that

came the need for cellular communication.

So let's talk about glycation.

Everyone knows that oxygen causes damage, but unfortunately, the press has

not been as kind to publicize glycation. Glycation is the same as oxidation

except substitute the word glucose. When you glycate something you combine it

with glucose. Glucose combines with anything else really, it's a very sticky

molecule.

 

 

Just take sugar on your fingers. It's very sticky. It sticks specifically to

proteins. So the glycation of proteins is extremely important. If it sticks

around a while it produces what are called advanced glycated end products.

 

 

That acronym is not an accident; it stands for A.G.E.'s. If you can turn

over, or re-manufacture the protein that's good, and it increases the rate of

protein turnover if you are lucky. Glycation damages the protein to the extent

that white blood cells will come around and gobble it up and get rid of it, so

then you have to produce more, putting more of a strain on your ability to

repair and maintain your body.

 

 

That is the best alternative; the worst alternative is when those proteins

get glycated that can't turn over very rapidly, like collagen, or like a protein

that makes up nerve tissue. These proteins cannot be gotten rid of, so the

protein accumulates, and the A.G.E.'s accumulate and they continue to damage.

 

 

That includes the collagen that makes up the matrix of your arteries.

A.G.E.'s are so bad that we know that there are receptors for A.G.E.'s, hundreds

of receptors for every macrophage. They are designed to try to get rid of those

A.G.E.'s, but what happens when a macrophage combines with an A.G.E. product?

 

 

It sets up an inflammatory reaction. We know that cardiovascular is an

inflammatory process, any type of inflammation. You eat a diet that promotes

elevated glucose, and you produce increased glycated proteins and A.G.E.'s, you

are increasing your rate of inflammation of any kind. You get down to the roots,

including arthritis, headaches.

 

 

When you start putting people on a diet to remedy all of this, my practice

is largely diabetes, so my patients are more concerned with their blood sugar

and their heart, things like that, but it is so common to have them come back

and tell me they used to have horrible headaches and now don't have them

anymore, or that they had a horrible pain in their shoulder, or terrible

Achilles tendonitis that they don't have any more.

 

 

The glycated proteins are making the person very pro-inflammatory.

 

 

So we age and at least partially we accumulate damage by oxidation, and one

of the most important types of tissues that oxygenate is the fatty component,

the lipid, especially the poly-unsaturated fatty acids, they turn rancid. And

they glycate, and the term for glycation in the food industry is carmelization.

 

 

They use it all the time, that is how you make caramel. So the way we age is

that we turn rancid and we carmelize. It's very true. And that is what gets most

of us. If that doesn't get us, then the genetic causes of aging will, because

every cell in your body has genetic programs to commit suicide. There are

various theories for this, one is that if they didn't, virtually every cell in

your body would eventually turn cancerous.

 

 

Whether those so-called applopatic genes developed as a means to prevent

cancer or not is open to speculation but it is a good theory. We know that all

cancer cells have turned off the mechanisms for applotosis, which is the medical

term for chemical suicide. So we know that it plays a role.

Let's get to diet.

Diet really becomes pretty simple. Carbohydrates we started talking about.

You've got fiber and non-fiber and that's real clear-cut. Fiber is good,

non-fiber is bad. Fibrous carbs, like vegetables and broccoli, those are great.

What is a potato? A potato is a big lump of sugar. That's all it is. You chew a

potato, what are you swallowing? Glucose. You may not remember, but you learned

that in eighth grade, but the medical profession still hasn't learned that.

 

 

What is the major salivary enzyme?

 

 

Amylase. What is amylase used for? To break down amylose which is just a

tree of glucose molecules. What is a slice of bread? A slice of sugar. Does it

have anything else good about it? Virtually no. Somebody emailed me who had

decided to do a little research. And there are fifty-some essential nutrients to

the human body.

 

 

You know you need to breathe oxygen. It gives us life and it kills us. Same

with glucose. Certain tissues require some glucose. We wouldn't be here if there

were no glucose, it gives us life and it kills us. We know that we have

essential amino acids and we have essential fatty acids. They are essential for

life, we better take them in as building blocks or we die. So what he did is he

took all the essential nutrients that are known to man and plugged it in to this

computer data bank and he asked the computer what are the top ten foods that

contain each nutrient that is required by the human body. Each of the

fifty-three or fifty-four, depending on who you talk to, essential nutrients

that there are were plugged in, and did you know that grains did not come up in

the top ten on any one.

What is the minimum daily requirement for carbohydrates? ZERO!!

 

 

 

What is the food pyramid based on? A totally irrelevant nutrient.

Let's go beyond Carbohydrates.

 

 

Let's back up even further? Why do we eat? One reason is energy. That's half

of the reason. It is very simple, there are two reasons why we eat, one is to

gather energy. We need to obtain energy. The other essential reason (Not just

for fun! Fun is a good one, but you won't have much fun if you eat too much) is

to replace tissue, to gather up building blocks for maintenance and repair.

 

 

Those are the two essential reasons that we need to eat. We need the

building blocks and we need fuel, not the least of which is to have energy to

obtain those building blocks and then to have energy to fuel those chemical

reactions to use those building blocks.

 

 

So what are the building blocks that are needed, proteins and fatty acids.

Not much in the way if carbohydrates. You can get all the carbohydrates you need

from proteins and fats. So the building blocks are covered by proteins and fats.

 

 

What about fuel?

 

 

That's the other reason we eat. There are two kinds of fuel that your body

can use with minor exceptions, sugar and fat. We mentioned earlier that the body

is going to store excess energy as fat. Why does the body store it as fat?

Because that is the body's desired fuel. That is the fuel the body wants to burn

and that will sustain you and allow you to live. The body can store only a

little bit of sugar.

 

 

In an active day you would die if you had to rely one-hundred percent on

sugar.

 

 

Why doesn't your body store more sugar if it is so needed? Sugar was never

meant to be your primary energy source.

 

 

Sugar is meant to be your body's turbo charger.

 

 

Everybody right here, right now should be burning mostly, almost all fat

with minor exceptions. Your brain will burn sugar, it doesn't have to, it can do

very well, even better by burning by-products of fat metabolism called ketones.

That is what it has to burn when you fast for any length of time. They have

shown that if your brain was really good at burning ketones from fat that you

can get enough sugar that your brain needs actually from fat; just eating

one-hundred percent fat.

 

 

You can make a little bit of sugar out of the glycerol molecule of fat. Take

two glycerol molecules and you have a molecule of glucose. Two triglycerides

will give you a molecule of glucose. The brain can actually exist without a

whole lot of sugar, contrary to popular belief. Glucose was meant to be fuel

used if you had to, in an emergency situation, expend and extreme amount of

energy, such as running from a saber tooth tiger.

 

 

It is a turbo charger, a very hot burning fuel, if you need fuel over and

above what fat can provide you will dig into your glycogen and burn sugar. But

your primary energy source as we are here right now should be almost all fat.

But what happens if you eat sugar.

Your body's main way of getting rid of it, because it is toxic, is to burn

it. That which your body can't burn your body will get rid of by storing it as

glycogen and when that gets filled up your body stores it as fat. If you eat

sugar your body will burn it and you stop burning fat.

 

 

We talked about a lot of the effects of high insulin. We talked about

insulin causing the formation of saturated fat from sugar. Another major effect

of insulin on fat is it prevents you from burning it. What happens when you are

insulin resistant and you have a bunch of insulin floating around all the time,

you wake up in the morning with an insulin of 90.

 

 

How much fat are you going to be burning? Virtually none. What are you going

to burn if not fat? Sugar coming from your muscle. So you have all this fat that

you've accumulated over the years that your body is very adept at adding to.

Every time you have any excess energy you are going to store it as fat, but if

you don't eat, where you would otherwise be able to burn it, you cannot and you

will still burn sugar because that is all your body is capable of burning

anymore.

 

 

Where is it going to get the sugar?

 

 

Well you don't store much of it in the form of sugar so it will take it from

your muscle. That's your body's major depot of sugar. You just eat up your

muscle tissue. Any time you have excess you store it as fat and any time you are

deficient you burn up your muscle.

 

 

Getting back to the macronutrients, fuel, fat is your best fuel by far and

the fuel that your body wants to use. So there are two reasons to eat, you need

to gather the building blocks for maintenance and repair, that's protein and

fat, no carbohydrate needed, and you eat for fuel, without question, fat is your

most efficient fuel and the fuel that your body desires the most.

 

 

So where do carbohydrates come in?

 

 

They don't. There is no essential need for carbohydrates. SO why are we all

eating carbohydrates? To keep the rate of aging up, we don't want to pay social

security to everyone.

 

 

I didn't say you can't have any carbs, I said fiber is good. Vegetables are

great, I want you to eat vegetables. The practical aspect of it is that you are

going to get carbs, but there is no essential need. The traditional Eskimo diet

for most of the year subsists on almost no vegetables at all, but they get their

vitamins from organ meats and things like eyeball which are a delicacy, or were.

 

 

So, you don't really need it, but sure, vegetables are good for you and you

should eat them. They are part of the diet that I would recommend, and that is

where you'll get your vitamin C. I recommend Vitamin C supplements, I don't have

anything against taking supplements, I use a lot of them.

Fruit is a mixed blessing. You can divide food on a continuum. There are

some foods that I really can't say anything good about since there is no reason

really to recommend them. And the other end of the spectrum are foods that are

totally essential, like omega 3 fatty acids for instance which most people are

very deficient in, and even those have a detriment because they are highly

oxidizable, so you had better have the antioxidant capacity. So if you are going

to supplement with cod liver oil you should supplement with Vitamin E too or it

will actually do you more harm than good.

 

 

But most foods fall in the middle somewhere. Things like strawberries, you

are going to get something bad with strawberries, you are going to get a lot of

sugar with strawberries, but you are also going to get a food that is also the

second or third highest in antioxidant potential of any food known, the first

being garlic the second either being strawberries or blueberries. So, there is

something good to be had from it. So I will let some patients put some

strawberries in let's say a protein smoothie in the morning. But if they are a

hard core diabetic, strawberries are out.

 

 

It doesn't take much, if you have a type I diabetic who is not producing any

insulin they can tell you what foods do to their blood sugar. It doesn't take

much. What is very surprising to these people once they really measure is what

little carbohydrate it takes to cause your blood sugar to skyrocket.

 

 

One saltine cracker will take the blood sugar to go over 100 and in many

people it will cause the blood sugar to go to 150 for a variety of reasons, not

just the sugar in it.

 

 

When you are eating a high carbohydrate diet, when you are born, your

mother, everbody is telling you to eat a bowl of Cheerios for breakfast. You eat

that bowl of cheerios and that turns to sugar, and your sugar goes up very

rapidly and that causes a big rush of insulin and your body all of a sudden

senses a huge amount of sugar being delivered to it at once, of which it was

never used to, in an evolutionary sense.

 

 

We only have one hormone that lowers sugar, and that's insulin. Its primary

use was never to lower sugar. We've got a bunch of hormones that raise sugar,

cortisone being one and growth hormone another, and epinephrine, and glucagon.

 

 

Our primary evolutionary problem was to raise blood sugar to give your brain

enough and your nerves enough and primarily red blood cells, which require

glucose. So from an evolutionary sense if something is important we have

redundant mechanisms. The fact that we only have one hormone that lowers sugar

tells us that it was never something important in the past.

 

 

So you get this rush of sugar and your body panics, your pancreas panics and

it stores, when it is healthy, insulin in these granules, ready to be released.

It lets these granules out and it pours out a bunch of insulin to deal with this

onslaught of sugar and what does that do?

 

 

Well the pancreas generally overcompensates, and it causes your sugar to go

down, and just as I mentioned, you have got a bunch of hormones then to raise

your blood sugar, they are then released, including cortisone. The biggest

stress on your body is eating a big glucose load.

 

 

Then Epinephrine is released too, so it makes your nervous and it also

stimulates your brain to crave carbohydrates, to seek out some sugar, my sugar

is low. So you are craving carbohydrates, so you eat another bowl of cheerios,

or a big piece of fruit, you eat something else so that after your sugar goes

low, and with the hormone release, and with the sugar cravings and carbohydrate

craving your sugars go way up again which causes your pancreas to release more

insulin and then it goes way down.

 

 

Now you are in to this sinusoidal wave of blood sugar, which causes insulin

resistance. Your body can't stand that for very long. So you are constantly

putting out cortisone.

We can talk about insulin resistance.

We hear a lot about insulin resistance, but stop and think a little bit, do

you think our cells only become resistant to insulin? The more hormones your

cells are exposed to, the more resistant they will become to almost any hormone.

Certain cells more than others, so there is a discrepancy. The problem with

hormone resistance is that there is a dichotomy of resistance, that all the

cells don't become resistant at the same time.

 

 

And different hormones affect different cells, and the rate of hormone is

different among different cells and this causes lots of problems with the

feedback mechanisms. We know that one of the major areas of the body that

becomes resistant to many feedback loops is the hypothalamus. The various

interrelationships there I really don't have time to go in to here.

 

 

But hypothalamic resistance to feedback signals plays a very important role

in aging and insulin resistance because the hypothalamus has receptors for

insulin too. I mentioned that insulin stimulates sympathetic nervous system, it

does so through the hypothalamus, which is the center of it all.

 

 

The receptors self-regulate.

 

 

If you want to know if insulin sensitivity can be restored to its original

state, well, perhaps not to its original state, but you can restore it to the

state of about a ten year old.

 

 

One of my first experiences with this, I had a patient who literally had

sugars over 300. He was taking 200+ units of insulin, he was a bad

cardiovascular patient, and it only made sense to me that you don't want to feed

these people carbohydrates, so I put him on a low carbohydrate diet.

 

 

He was an exceptional case, after a month to six weeks he was totally off of

insulin. He had been on 200 some units of insulin for twenty-five years. He was

so insulin resistant, one thing good about it is that when you lower that

insulin, that insulin is having such little effect on him that you can massively

lower the insulin and its not going to have much of an effect on his blood sugar

either. 200 units of insulin is not going to lower your sugar any more that 300

mg/deciliter.

You know that the insulin is not doing much. So we could rapidly take him

off the insulin and he was actually cured of his diabetes in a matter of weeks.

So he became sensitive enough, he was still producing a lot of insulin on his

own, then we were able to measure his own insulin and it was still elevated, and

then it took a long time, maybe six months or longer to bring that insulin down.

 

 

It will probably never get to the point of the sensitivity of a ten year

old, but yes, your number of insulin receptors increases, and the activity of

the receptors, the chemical reactions that occur beyond the receptor occur more

efficiently.

 

 

You can increase sensitivity by diet, that is one of the major reasons you

want to take Omega 3 oils. We think of circulation as that which flows through

arteries and veins, and that is not a minor part of our circulation, but it

might not even be the major part. The major part of circulation is what goes in

and out of the cell.

 

 

The cell membrane is a fluid mosaic. The major part of our circulation is

determined by what goes in and out. It doesn't make any difference what gets to

that cell if it can't get into the cell. We know that one of the major ways that

you can affect cellular circulation is by modulating the kinds of fatty acids

that you eat. So you can increase receptor sensitivity by increasing the

fluidity of the cell membrane, which means increasing the omega 3 content,

because most people are very deficient.

 

 

They say that you are what you eat and that mostly pertains to fat because

the fatty acids that you eat are the ones that will generally get incorporated

into the cell membrane. The cell membranes are going to be a reflection of your

dietary fat and that will determine the fluidity of your cell membrane. You can

actually make them over fluid.

 

 

If you eat too much and you incorporate too many omega 3 oils then they will

become highly oxidizable (so you have to eat Vitamin E as well and

monounsaturates as well) There was an interesting article pertaining to this

where they had a breed of rat that was genetically susceptible to cancer.

 

 

What they did was they fed them a high omega 3 diet, plus iron, without any

extra Vitamin E and they were able to almost shrink down the tumors to nothing,

because tumors are rapidly dividing. This is like a form of chemotherapy, and

the membranes that were being formed in these tumor cells were very high in

omega three oils, the iron acted as a catalyst for that oxidation, and the cells

were exploding from getting oxidized so rapidly. So omega 3 oils can be a double

edged sword.

Most food is a double edged sword.

Like oxygen and glucose, they keep us alive and they kill us, eating is the

biggest stress we put on our body and that is why in caloric restriction

experiments you can extend life as long as you maintain nutrition. This is the

only proven way of actually reducing the rate of aging, not just the mortality

rate, but the actual rate of aging, because eating is a big stress.

 

 

It has actually been shown by quite a number of papers that resistance

training for insulin resistance is better than aerobic training. There are a

variety of other reasons too. Resistance training is referring to muscular

exercises. If you just do a bicep curl, you immediately increase the insulin

sensitivity of your bicep. Just by exercising, and what you are doing is you are

increasing the blood flow to that muscle. That is one of the factors that

determines insulin sensitivity is how much can get there. It has been shown

conclusively that resistance training will increase insulin sensitivity.

 

 

Back to the macronutrients because that is real simple, you don't want very

much in the way of non-fiber carbs, fiber carbs are great, you are going to get

some non-fiber carbs. Even if you just eat broccoli you are going to get some

non-fiber carbs. That is OK since at least for the most part you are getting

something that is really pretty good for you. Protein is an essential nutrient.

 

 

You want to use it as a building block because your body requires protein to

repair damage and replenish enzymes. All of the encoded instructions from your

DNA are to encode for proteins. That is all the DNA encodes for. You need

protein, but you want to use it as a building block, but I don't believe in

going over and above the protein that you need to use for maintenance, repair

and building blocks.

 

 

I don't think you should be using protein as a primary fuel source. Your

body can use protein very well as a fuel source. It is good to lose weight while

using it a s a fuel source because it is an inefficient fuel source. Protein is

very thermogenic, it produces a lot of heat, which means that less of it is

going into stored energy, more is being dissipated. Just like throwing a log

into a fireplace.

Your primary fuel should be coming from fat.

So you can calculate the amount of protein a person requires, or at least

estimate it by their activity level. The book Protein Power actually went very

well in to this. You have to calculate how much protein is required by their

activity level and their lean body mass. There is still some gray area as to how

many grams per kilogram of lean body mass, depending on the activity that person

requires.

 

 

Anywhere perhaps one to two grams of protein per kilogram of lean body mass,

maybe even a little bit higher if someone is really active.

 

 

You don't want to go under that for very long. I'd say that it is better to

go over than to go under that amount for very long. But I especially don't want

my diabetic patients, which means all of us, because in a very real sense we

really all have diabetes, it is just a matter of degree, we all have a certain

degree of insulin resistance.

 

 

If you can cure a diabetic of diabetes, you can do the same thing to a

so-called non-diabetic person and still improve that person. I want to improve

my insulin sensitivity just as much as I do my diabetics because insulin

sensitivity is going to determine for the most part how long you are going to

live and how healthy you are going to be. It determines the rate of aging more

so than anything else we know right now.

What about supplements such as Chromium for example?

Chromium, it depends on whom you are dealing with, but are we talking about

a diabetic patient, who is supposed to be the topic of this talk, yes, all my

diabetics go on 1,000 mcg. of chromium, some a little bit more if they are

really big people. Usually 500 mcg for a non-diabetic. It depends on their

insulin levels.

 

 

I don't care so much what their sugar levels are, I care what their insulin

levels are, which is a reflection of their insulin sensitivity. We are talking

about hyperinsulinemia or non-hyper-insulinemia. Its insulin we should be

concerned about.

 

 

I use a lot of supplements. What you really want to do, and my purpose

mostly is to try to convert that person back into being an efficient burner of

fat. We talked about when you are very insulin resistant and you are waking up

in the morning with an insulin that is elevated, you cannot burn fat, you are

burning sugar.

 

 

They don't know how to burn fat anymore and that is your best fuel.

 

 

One of the reasons that sugar goes up so high is because that is what your

cell is needing to burn, but if it is so insulin resistant it requires a blood

sugar of 300 so that just by mass action some can get in to the cell and be used

as fuel. If you eliminate that need to burn sugar, you don't need such high

levels of sugar even if you are insulin resistant.

 

 

So you want to increase the ability of the cells in the body to burn fat.

 

 

You want to make that glucose burner into a fat burner. You want to make a

gasoline burning car into a diesel burning car. Did anyone ever look at the

molecular structure of diesel fuel in your spare time? It looks almost identical

to a fatty acid. There is a company right now that can tell you how to alter

vegetable oil to use in your Mercedes. It's just a matter of thinning it out a

little bit. It is a very efficient fuel.

 

 

You can look at other variables that will give you some idea too such as

triglycerides. If they are very sensitive to high levels of insulin, they come

in with insulin levels of 14 and they have triglycerides of 1000, then you would

treat them just as you would if they had an insulin level of 50. It gives you

some idea of the effect of the hyperinsulinemia on the body.

 

 

You can use triglycerides as a gauge, which I often do. The objective is to

try to get the insulin level just as low as you possibly can. There is no limit.

They classify diabetes now as a fasting blood sugar of 126 or higher. A few

months ago it might have been 140. It is just an arbitrary number, does that

mean that someone with a blood sugar of 125 is non-diabetic and fine? If you

have a blood sugar of 125 you are worse than if you had a blood sugar of 124.

Same with insulin. If you have a fasting insulin of 10 you are worse off than if

you had an insulin of 9. You want to get it just as low as you can.

 

 

With athletes, let's think about that. What is the effect of carbohydrate

loading before an event. What happens if you eat a bowl of pasta before you have

to run a marathon. What does that bowl of pasta do? It raises your insulin. What

is the instruction of insulin to your body?

 

 

To store energy and not burn it. I see a fair amount of athletes and this is

what I tell them, you want everybody, athletes especially, to be able to burn

fat efficiently. So when they train, they are on a very low carbohydrate diet.

The night before their event, they can stock up on sugar and load their glycogen

if they would like.

 

 

They are not going to become insulin resistant in one day. Just enough to

make sure, it has been shown that if you eat a big carbohydrate meal that you

will increase your glycogen stores, that is true and that is what you want. But

you don't want to train that way because if you do you won't be able to burn

fat, you can only burn sugar, and if you are an athlete you want to be able to

burn both.

Few people have problems burning sugar if they are an athlete, but they have

lots of problems burning fat, so they hit the wall. And for a certain event like

sprinting it is less important, truthfully, for their health it is very

important to be able to burn fat, but a sprinter will go right into burning

sugar. If you are a 50 yard dash man, whether you can burn fat or not is not

going to make a huge difference in your final performance.

 

 

Beyond your athletic years if you don't want to become a diabetic, and if

you don't want to die of heart disease and if you don't want to age quickly.It

is certainly not going to do you any harm to be able to burn fat efficiently in

addition to sugar.

 

 

Vanadyl Sulfate is an insulin mimic, so that it can basically do what

insulin does by a different mechanism. If it went through the same insulin

receptors, then it wouldn't offer any benefit, but it doesn't, it actually has

been shown to go through a different mechanism to lower blood sugar, so it

spares insulin and then it can help improve insulin sensitivity. On someone who

I am trying to really get their insulin down I go 25mg 3X/day temporarily.

 

 

I put people on glutamine powder. Glutamine can act really as a brain fuel,

so it helps eliminate carbohydrate cravings while they are in that transition

period. I like to give it to them at night and I tell them to use it whenever

they feel they are craving carbohydrates. They can put several grams into a

little water and drink it and it helps eliminate carbohydrate cravings between

meals.

 

 

It is a high protein diet that will increase an acid load in the body, but

not necessarily a high fat diet. Vegetables and greens are alkalinizing, so if

you are eating a lot of vegetables along with your protein it equalizes the

acidifying effect of the protein. I don't recommend a high protein diet. I

recommend an adequate protein diet.

 

 

I think you should be using fat as your primary energy source, and fat is

kind of neutral when it comes to acidifying or alkalinizing. In general, over

50% of the calories should come from fat, but not from saturated fat. When we

get to fat, the carbohydrates are clear cut, no scientist out there is really

going to dispute what I've said about carbohydrates.

There is the science behind it. You can't dispute it. There is a little bit

of a dispute as to how much protein a person requires. When you get to fat,

there is a big grey area within science as to which fat a person requires. We

just have one name for fat, we call it fat or oil. Eskimos have dozens of names

for snow and east Indians have dozens of names for curry. We should have dozens

of names for fat because they do many different things. And how much of which

fat to take is still open to a lot of investigation and controversy.

 

 

My take on fat is that if I am treating a patient who is generally

hyperinsulinemic or overweight, I want them on a low saturated fat diet. Because

most of the fat they are storing is saturated fat. When their insulin goes down

and they are able to start releasing triglycerides to burn as fat, what they are

going to be releasing mostly is saturated fat. So you don't want to take anymore

orally. There is a ration of fatty acids that is desirable, if you took them

from the moment you were born, but we don't, we are dealing with an imbalance

here that we are trying to correct as rapidly as we can.

 

 

You have plenty of saturated fat. Most of us here have enough saturated fat

to last the rest of our life. Truthfully. Your cell membranes require a balance

of saturated and poly-unsaturated fat, and it is that balance that determines

the fluidity. As I mentioned, your cells can become over-fluid if they don't

have any saturated fat.

 

 

Saturated fat is a hard fat. We can get the fats from foods to come mostly

from nuts. Nuts are a great food because it is mostly mono-unsaturated. Your

primary energy source ideally would come mostly from mono-unsaturated fat. It's

a good compromise. It is not an essential fat, but it is a more fluid fat. Your

body can utilize it very well as an energy source.

 

 

Animal proteins are fine and are good for you, but not the ones that are fed

grains.

 

 

Grainfed animals are going to make saturated fat out of the grains.

Saturated fat in nature occurs to a very tiny degree. Not in the wild there is

very little saturated fat out there. If you talk about the Paleolithic diet, we

didn't eat a saturated fat diet. Saturated fat diets are new to mankind. We

manufactured a saturated fat diet by feeding animals grains. You can consider

saturated fat to be second generation carbohydrates. We eat the saturated fats

that other animals produce from carbohydrates.

 

 

Zone was a good diet compared to the American diet it was unusual. Is it an

optimal diet? No. Is it optimal for what is known today about nutrition, it is

not. He is stuck in this mold he can't get out of but now he is trying to get

out of it through the back door. Initially the author spoke about how it made no

difference if you got your carbohydrate from candy or vegetables.

 

 

The Volkswagen was a good car, but eventually they had to change it to keep

up with modern technology. What he is doing now is changing his recipes so that

the 40% carbohydrates are coming primarily from vegetables, and the

carbohydrates are going way down because he knows that if he doesn't it's not as

good a diet.

 

 

I would go 20% of calories from carbs. Depending on the size of the person,

25 to 30% of calories from protein, and 60-65% from fat. You can get non-grain

fed beef.

Insulin is not the only cause of disease.

There are other considerations such as iron. We know that high iron levels

are bad for you. If a person's ferritin is high, red meat is out for a while,

till we get their iron down. SO there are other things involved about if we are

going to allow a person to eat red meat or not.

 

 

There is a great deal of difference between a non-grain fed cow and a grain

fed cow.

 

 

Non-grain fed will have only 10% or less saturated fat. Grain fed can have

over 50%.

 

 

There is a big difference. A non-grain fed cow will actually be high in

Omega 3 oils. Plants have a pretty high percentage of Omega 3, and if you

accumulate it by eating it all day, every day for most of your life, your fat

gets a pretty high proportion of Omega 3. I would try for 50% oleic fat, and the

others would depend on the individual, but about 25% of the other two.

 

 

In a fat diabetic I would probably go down on the saturated fat and go 60%

oleic. I would go 1 to 1 on the omega 6 to 3, that would be therapeutic. The

maintenance ratio would be about 2.5 to 1 omega 6 to 3. Arachadonic acid, DHA,

to EFA. Therapeutic, I would go lesser on the saturated fats. I would try to do

most of this through diet. There are some practicalities involved. I would ask

the person if they like fish and if they practically puke in front of me they

are going on a tablespoon of cod liver oil, the best brand is made by Carlson

which doesn't taste fishy at all.

 

 

There are probably some others too that are okay. Most people end up going

on a supplement of Omega 3 oils because most of them are not going to eat enough

fish to get it, which would be about four days a week, and it can't be

overcooked etc., it is a little hard to get that much entirely from diet.

 

 

I like sardines if they will eat them. Sardines are a very good therapeutic

food. They are baby fish so they haven't had time to accumulate a bunch of

metal. They are smoked so they are not cooked and the oil is not spoiled in

them. You have to eat the whole thing. Not the boneless and skinless. You need

to eat all the organs and they are high in vitamins and magnesium.

 

 

DNA glycates.

 

 

So if people are worried about chromosomal damage from chromium, what they

should really be worried about instead is high blood sugar. DNA repair enzymes

glycate as well. Insulin is by far your biggest poison. They disproved that

study that was against chromium many times. They showed that it only happens if

you put cells in a petrie dish with chromium but in vivo studies prove

otherwise. The lowering of insulin is going to be better than any possible

detriment of any of the therapies you are using. Insulin is associated with

cancer, everything.

 

 

Insulin should be tested on everybody repeatedly, and why it is not is only

strictly because there hasn't been drugs till recently that could effect

insulin, so there is no way to make money off of it. Fasting insulin is one way

to look at it, not necessarily the best way. But it is the way that everybody

could do it. Any family doctor can measure a fasting insulin. There are other

ways to measure insulin sensitivity that are more complex that we do sometimes.

 

 

We use intravenous insulin and watch how rapidly their blood sugar crashes

in a fasting state in 15 minutes and that assesses insulin sensitivity, then you

give them dextrose to make sure they don't crash any further. There are other

ways that are utilized to directly assess insulin sensitivity, but you can get a

pretty good idea just by doing a fasting insulin.

 

 

 

 

 

 

 

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