Nutrasweet (Aspartame) and Breast and Prostate Cancer

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Nutrasweet (Aspartame) and Breast and Prostate

Cancer

 

 

http://www.dorway.com/schwart2.html

 

George R. Schwartz, M.D.

 

Nutrasweet and Breast and other Cancers

 

Summary

 

There is a startling epidemiologic connection between Nutrasweet

(aspartame) and breast cancer. The biochemical mechanism which can

explain the correlation offers additional weight to the epidemiologic

research finding. This extraordinary correlation points to millions of

breast cancer cases possibly induced by Nutrasweet (aspartame). This

alarming association mandates an emergency need for close scientific

scrutiny.

Mechanism of Action

 

Nutrasweet (aspartame) is composed of linkages of aspartic acid,

phenylalanine and methanol. The aspartic acid acts as a

neuroexcitatory agent.

 

(1) When Nutrasweet is digested, it yields 10% methanol (wood

alcohol).(2) The wood alcohol (methanol) is widely distributed

throughout the body including brain, muscle, fat and nervous tissue.

(3) It is then metabolized to formaldehyde which enters the cells and

binds to the proteins and DNA (the genetic material). 4) Cytogenetic

effects (changes in DNA) have been shown to result from formaldehyde

exposure(5) and DNA damage occurs from formaldehyde.(6) The nature of

the injury generally involves breaking and then creation of cross

linking within the genetic material which alters the cells.

 

This finding has been confirmed numerous times and the DNA-protein-

cross-links are believed to cause cancers in experimental animals.(7)

Changes in the genetic material is associated with cancer production

in humans.(8) The ability of Aspartame to cause cellular mutations has

been shown through studies by Shephard, et al.(9) There are increases

in malignant brain tumors suggested to be associated with aspartame

use.(10) Formaldehyde is a known stimulant for cancer and genetic

damage in the cell . .(11, 12)

 

Epidemiology Research

 

Our epidemiologic research demonstrates the following:

 

**Rising incidence of breast cancer in the United States (more than

180,000 new cases yearly and now the single leading cause of death in

woman age 35-54(13) ) over 25 years tracking increased aspartame use.

(In 1974 Nutrasweet was approved for limited use, in 1983 it was

approved for use in diet sodas.) Note chart.

 

**We are now studying the rising incidence of prostate cancer, with

more than 132,000 new cases yearly and the second most common cancer

in men.(14) This cancer also appears to epidemiologically be

associated with a rise in aspartame use.

 

**Rising incidence of brain cancers(15)

 

Cancer statistics also note that rates of breast and prostate

cancerare 5 to 6 times higher in North American and Europe than in

Asia and Africa—places where Nutrasweet market penetration has so far

been less.(16, 17)

 

Chart of Pivotal Dates The chart of breast cancer increases

demonstrates these pivotal times. Testing involving Nutrasweet

occurred in the l972-l973 period. Limited approval as a sweetener was

granted (in the USA) in l974 and full unlimited approval was granted

in l983. Arrows on the chart demonstrate the extraordinary concordance

with increasing breast cancer rates. The likelihood of this being a

rare coincidence is offset by the biochemical evidence supporting a

likely mechanism for cancer induction. Early animal experiments

involving mice did demonstrate mammary tumors and urogenital changes

in males which were found in initial testing prior to Nutrasweet

approval.

 

Hypothesis

 

The epidemiologic correlations are striking and raise the hypothesis

of cancer induction. While there are many potential pathways, we are

postulating the most direct. Nutrasweet converts to methanol, which

goes to intracellular formaldehyde. The latter affects DNA causing

cell toxicity and chromosome abnormalities which precipitate cancers

in susceptible people. Nutrasweet has already beenshown to induce

mammary tumors and testicular changes in experimental animals.(18)

Based on the epidemiologic associations, and biochemical effects at

the cellular-DNA level, Nutrasweet and aspartame should be carefully

studied as a potential environmental cause of well over one million

cases of cancer.

 

 

 

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