Chemical Exposure The Crucial Role to Glomerulonephritis and Chronic Renal Failure

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Uffe Ravnskov, MD, PhD

Glomerulonephritis and Chronic Renal Failure - the Crucial Role of Chemical

Exposure

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Glomerulonephritis, the commonest cause of end-stage renal failure in most

countries, is worsened and may even be caused by exposure to chemicals present

on many work places, at home and in the public environment

The commonest nephrotoxic chemicals are hydrocarbons, present for instance

in organic solvents, glues, fuels, paints and motor exhausts. Exposure is common

among painters, printers, cabinet makers, fitters and mechanics, electricians,

in much manufacturing, and in many other occupations

 

Also nephrotoxic are silicates, the main components in rocks and sand.

Exposure is prevalent among miners, foundry and quarry workers, sandblasters,

glaziers, and workers in the production and handling of asbestos, mineral wool

and fiber glass

Other chemicals that may promote glomerulonephritis or other kidney

diseases include gold, lead, mercury and various drugs, for instance

non-steroidal antiinflammatory drugs and lithium

 

Recent studies have found that even diabetic kidney disease may be

worsened by exposure to toxic chemicals. Exposure should also be ruled out in

patients with kidney parenchymal diseases of unknown origin

As shown in the following more than 60% of patients with end-stage renal

failure caused by glomerulonephritis have been exposed to toxic chemicals. Most

important for patients with progressive renal failure is therefore to

discontinue any exposure to nephrotoxic chemicals and drugs

 

 

Introduction

 

© Uffe Ravnskov

 

 

 

 

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