Guest guest Posted July 4, 2002 Report Share Posted July 4, 2002 http://www.glycoscience.com/glycoscience/start_frames.wm?FILENAME=R003 DIETARY SUPPLEMENTS THAT SUPPORT CARDIOVASCULAR HEALTH: A REVIEW OF POTENTIAL BENEFITS By Jane Ramberg, MS and Tom Gardiner, PhD INTRODUCTION Heart disease should be a concern for virtually everyone. Why? Because it is the number one killer throughout the entire developed world.1 It is also the number one killer of American adults, accounting for more than 40% of all deaths and costing over $286 billion in health care costs and lost productivity.2 Today, about 61 million Americans (about 25% of the total adult population) are living with cardiovascular disease.3 If it were eliminated, life expectancy would increase by almost 10 years.4 Let's take a look at heart-health risk data that has been collected for Americans with the assumption that generally similar statistics exist in other developed countries. Who is at risk? The elderly, people who eat a poor diet, the obese, alcoholics, diabetics, sedentary individuals, smokers, and illicit drug users are at particular risk; after menopause, the risk for women increases dramatically.3 ,5 ,6 People with diabetes are 2-4 times more likely to have heart disease or stroke.4 In fact, two-thirds of diabetics die of some form of heart or blood vessel disease. People who are overweight have a higher risk of cardiovascular disease and almost 60% of adults are overweight or obese.3 Smokers have twice the risk for heart attacks; every day, more than 3,000 young people become habitual smokers.3 Stress is also believed to play a role in heart disease risk, in part because it contributes to the development of behaviors, such as smoking and overeating, that contribute to increased risk.6 What are the warning signs indicating that a person may be at a higher risk for heart disease or stroke? High blood pressure and high blood levels of total cholesterol (e.g., above 200 mg/dL) and LDL cholesterol (above 130 mg/dL), and low levels of HDL cholesterol (below 40 mg/dL for men and 50 mg/dL for women) are risk factors.1 More than 50% of adults have total cholesterol levels above 200 mg/dL.2 When high blood pressure is accompanied by obesity, smoking, high blood cholesterol levels or diabetes, the risk of heart attack or stroke increases several times.6 Although blood level homocysteine was proposed as a risk factor more than 30 years ago and has now been unequivocally validated,5 ,7 ,8 ,9 ,10 ,11 ,12 it remains largely unrecognized. In fact, homocysteine ranks of equal importance to hyperlipidemia and smoking and may account for 10% of the attributable risk of heart disease.1 What is homocysteine? It's an amino acid that can be converted in the body into glutathione, an important cellular antioxidant. If blood levels of folic acid, or vitamin B6 or vitamin B12 are depleted, this conversion cannot occur. Consequently, rising homocysteine levels promote blood clotting, narrowing of arteries, and toxicity to blood vessel lining cells.1 Individuals with blood levels of homocysteine over about 15.8 nmol/ml are at significantly higher risk of developing heart disease. 1 What can be done? While some risk factors, such as genetic predisposition, gender, and age cannot be altered, most can. Even modest changes in one or more of these factors could have a large public health impact.2 ,3 By quitting smoking and getting more exercise, individuals can lose weight, reduce their blood pressure and, probably, their blood cholesterol levels. The American Heart Association (AHA) also emphasizes that a healthy diet can have a major role in reducing the risk of heart disease. Diet is known to affect many health parameters, including body weight, blood pressure, and blood cholesterol and homocysteine levels. What can people do to improve their diets? First, they should reduce their caloric intake. Second, they should eat a higher quality diet, avoiding fatty foods and eating more fruits and vegetables and whole grains. Today, only 18% of women and 20% of men report eating the recommended 5 servings of fruits and vegetables each day.3 A heart-healthy diet is also a low-glycemic diet; a low-glycemic diet has been shown to increase the " good " HDL cholesterol13 and reduce the risk of heart disease.14 The AHA also recommends limiting salt intake to less than 6 grams per day and alcohol consumption to one drink per day for women and two drinks per day for men.15 More information about heart health can be found at: http://www.americanheart.org. What specific dietary components, taken in conjunction with a healthy diet, can support heart health? This is a topic of particular interest for those health-conscious individuals who understand that the best available diets can often benefit from supplementation. Indeed, a growing body of evidence is documenting the cardiovascular benefit of micronutrient supplementation.16 It should come as no surprise that many of the most beneficial nutrients are those found in foods most commonly lacking in the typical diet: whole grains and fresh fruits and vegetables. Antioxidant nutrients can be beneficial because they reduce the risk of atherosclerosis (the formation of fatty deposits in blood vessels). Other dietary nutrients can help maintain or lower blood pressure, total blood cholesterol and LDL cholesterol, lipid, and homocysteine levels and elevate blood HDL cholesterol levels. The benefits of a selection of nutrients known to have heart health benefits are briefly summarized in the table below. A consolidated benefits review for each individual nutrient follows for those desiring additional information. This is not intended to be a complete summary of all heart healthy nutrients. For example, supplementation with niacin, copper and zinc has been associated with decreased heart disease risk,1 but these nutrients are beyond the scope of this review. In addition, to keep this review a reasonable length, the numerous additional health benefits provided by the nutrients included in this review are not discussed. When considering the information contained herein regarding the recommended amounts of specific nutrients, it's important to remember that, by definition, a dietary supplement is intended to supplement an already healthy diet. Thus, the amount of supplements taken may be adjusted if foods containing these nutrients are also consumed. Finally, anyone under the care of a physician for heart-related issues should share their dietary habits, including their supplement use, with their physician. VITAMIN C Synonyms a.. Commonly known as ascorbate, ascorbic acid, dehydroascorbic acid, hexuronic acid Food Sources a.. Citrus fruits and juices, broccoli, cabbage, potatoes, cauliflower, peppers, green leafy vegetables, cantaloupe, strawberries, tomatoes, rose hips, acerola, camu-camu, carambola fruit.17 ,18 Cardiovascular Benefits Summary a.. May reduce the risk of cardiovascular disease,19 ,20 ,21 ,22 ,23 ,24 ,25 ,26 ,27 but not proven to reduce the risk of stroke.28 b.. May reduce risk of death from stroke in elderly persons.29 c.. May reduce blood pressure.30 ,31 ,32 ,33 d.. Supports the normal metabolism of fats.17 ,34 e.. Necessary for the control of blood cholesterol and lipids.17 ,35 f.. An antioxidant vitamin36 ,37 that prolongs the useful life of vitamins A and E and protects the polyunsaturated fatty acids17 ,38 and LDL cholesterol35 from oxidation. g.. Necessary for normal red blood cell formation.18 h.. Necessary for the formation and maintenance of collagen, a component of heart tissue.39 i.. Necessary for normal healing.40 j.. May decrease mortality from health-related causes of death (e.g., not trauma or accidents).41 ,42 ,43 ,44 Safety a.. The current RDA is 60 mg for adult nonsmoking men and women.17 b.. The current RDI is 60 mg.45 c.. The minimum amount actually believed to be necessary to reduce the risk of chronic disease is 80-120 mg/day.46 ,47 d.. Large intakes of about 1,000 mg are safe.48 e.. Very large doses may interfere with anticoagulant therapy.18 VITAMIN E Synonyms a.. Natural vitamin E is composed of 8 tocopherols and 8 tocotrienols.17 Food Sources a.. Vegetable oils, legumes, some whole grains, nuts, dark green leafy vegetables, avocado.18 ,49 b.. Palm oil, rice bran, and barley are rich sources of tocotrienols.50 ,51 ,52 Cardiovascular Benefits Summary a.. An antioxidant vitamin.17 ,25 ,53 ,54 ,55 ,56 ,57 b.. Supplementation may reduce the risk of coronary heart disease.22 ,58 ,59 ,60 ,61 ,62 ,63 ,64 c.. Supplementation may reduce the risk of atherosclerosis.18 d.. Supplementation reduces blood pressure when combined with other antioxidant vitamins.65 e.. Inhibits cholesterol synthesis.51 ,52 ,66 ,67 ,68 ,69 ,70 ,71 ,72 ,73 ,74 f.. Inhibits atherosclerosis in animals50 ,75 and humans.76 g.. May reduce the risk of cardiovascular disease.66 ,70 ,76 ,77 h.. Necessary for normal red blood cell function.17 i.. Necessary for normal muscle function.17 j.. Supports the synthesis of the antioxidants vitamin C, and coenzyme Q-10.17 k.. Protects against symptoms caused by a selenium deficiency.78 ,79 l.. Protects against premature aging.18 m.. May reduce the risk of mortality from health-related causes.42 Safety a.. The current RDA is 14.90 IU for adult males and 11.92 IU for adult females.17 b.. The current RDI is 30 IU.45 c.. Daily intakes of about 1,000 mg (i.e., approximately 1,490 IU) are safe.48 d.. No toxicity was reported with 500 mg (approximately 745 IU)/day for 3 years.18 e.. Occasionally, muscle weakness, fatigue, nausea and diarrhea have been reported in individuals taking 800 to 3,200 mg/day.80 f.. Excess intake is excreted.17 g.. While regarded as largely nontoxic, vitamin E can antagonize the action of vitamin K and enhance the anticoagulant effect of warfarin.18 ,80 FOLIC ACID Synonyms a.. Folate, folacin Food Sources a.. Liver, kidney, green leafy vegetables, nuts, citrus fruits, legumes, soybeans, whole grains, beets, peas, tomatoes, fish, eggs, celery.17 ,18 Cardiovascular Benefits Summary a.. May help normalize blood levels of homocysteine.81 b.. May help prevent cardiovascular disease.5 ,7 ,8 ,9 ,11 ,58 ,82 ,83 ,84 ,85 ,86 ,87 ,88 ,89 ,90 ,91 ,92 ,93 ,94 c.. May protect against coronary artery disease.95 d.. May improve function of blood vessels in patients with high blood homocysteine and/or cholesterol who are at increased risk of atherosclerosis.10 ,87 ,96 ,97 ,98 e.. Used to treat certain types of anemia.17 f.. Necessary for normal carbohydrate and fat metabolism.18 Safety a.. Supplement forms may be preferable for heart health: folate bioavailability is 50% from food and 85% from synthetic supplements.1 b.. The current RDA is 200 mcg for adult males and 180 mcg for adult females (400 mcg if pregnant or 280 mcg if breastfeeding).17 c.. Current RDAs may not provide adequate protection against cardiovascular disease.99 d.. The current RDI is 400 mcg.45 e.. Normally has no adverse effects.17 f.. Daily intakes of about 10,000 mcg are safe.48 g.. Symptoms of epileptics taking anti-seizure medications may be aggravated by taking folic acid to treat megaloblastic anemia.17 VITAMIN B6 Synonyms a.. Pyridoxine Food Sources a.. Many foods, including fish, meats, kidney, liver, whole grain breads and cereals, carrots, cabbage, peas, potatoes, milk, eggs, bananas, green beans, fortified cereals.58 Cardiovascular Benefits Summary a.. Lowers blood homocysteine.86 ,90 ,100 b.. Lowers blood pressure in hypertensive individuals.101 ,102 c.. Dietary supplementation may help prevent or treat cardiovascular disease.58 ,91 ,92 ,95 ,103 ,104 ,95 ,92 d.. Important for normal carbohydrate and fat metabolism.105 e.. Necessary for normal protein synthesis.17 f.. May be useful for individuals under stress.34 Safety a.. The current RDA is 2.0 mg for adult males and 1.6 mg for adult females.17 b.. The current RDI is 2.0 mg.45 c.. Levels above current RDA may be necessary to reduce risk of heart disease.58 d.. Consumption of 100 mg or more is associated with toxicity.18 e.. Consumption of megadoses (2-6 grams/day for 2-40 months) may cause nervous system impairment.80 VITAMIN B12 Synonym a.. Cyanocobalamin Food Sources a.. Fish, meat, liver, dairy products.17 Cardiovascular Benefits Summary a.. May reduce blood levels of homocysteine.86 ,106 ,11 ,107 , b.. Important for healthy blood cell formation.17 c.. May support adaptation to stress.108 Safety a.. Generally Recognized as Safe (GRAS) (21CFR184.1945) for use as a nutritional supplement.109 b.. The current RDA is 2.0 mcg for adult males and females.17 c.. The current RDI is 6.0 mcg.45 d.. Daily intakes of about 1,000 mcg are safe.48 e.. Has no known toxic effects.17 MAGNESIUM Food Sources a.. Soy flour, nuts, whole grains, molasses, green leafy vegetables, meats, seafoods, dried fruit, coffee, chocolate.17 Cardiovascular Benefits Summary a.. May help prevent and treat cardiovascular disease.103 ,110 b.. May lower the risk of developing atherosclerosis.111 c.. May help control high blood pressure.34 ,112 ,113 ,114 ,115 d.. May help treat congestive heart failure.116 e.. Necessary for normal nerve and muscle function.17 f.. May increase muscle strength.117 g.. Necessary for normal protein synthesis.17 Safety a.. The current RDA is 350 mg for adult males and 280 mg for adult females.17 b.. The current RDI is 400 mg.45 c.. No significant adverse effects were reported when patients were given oral daily doses of 600 mg for 6 weeks.112 d.. Some magnesium salts may cause diarrhea.118 e.. Patients with kidney failure may experience toxicity.49 L-ARGININE Food Sources a.. Meats, wheat germ, cottage cheese, ricotta, nuts, eggs, milk, granola.49 ,119 Cardiovascular Benefits Summary a.. Important in maintaining cardiovascular health.120 b.. May help lower blood pressure.121 c.. Improves dilation of blood vessels and increases blood flow.122 ,123 d.. Improves heart blood vessel function in patients with angina.124 e.. Provides symptomatic benefit in peripheral artery disease.125 ,126 f.. Inhibits development of atherosclerosis (in animals).127 ,128 ,129 g.. May facilitate removal of existing blood vessel cholesterol deposits (in animals).130 h.. May help prevent platelet aggregation in people with high blood cholesterol.131 i.. Important for normal muscle metabolism and disposal of protein metabolic waste.132 j.. Important for transmission of nerve impulses.132 k.. Dietary supply is essential following injury or other trauma to improve healing.133 Safety a.. Up to 30 grams/day have been well-tolerated, with nausea and diarrhea reported infrequently.134 b.. No significant adverse effects reported for patients with angina given 9 grams/day for 6 months.124 c.. No significant adverse effects in hypercholesterolemic patients given 14 grams/day for 3 months.135 GARLIC Food Source a.. Root of Allium sativum Cardiovascular Benefits Summary a.. Dietary supplementation prevents and reduces atherosclerosis in animals with high blood cholesterol136 ,137 ,138 ,139 ,140 and in humans.141 ,142 b.. Inhibits platelet aggregation (a prelude to blood clot formation).143 ,144 ,145 ,146 ,147 ,148 ,149 ,150 ,151 ,152 ,153 ,154 ,155 ,156 ,157 ,158 ,159 ,160 c.. May prevent oxidative damage to blood vessel lining cells.161 ,162 ,163 ,164 ,165 d.. May support aortic blood flow in aging individuals.166 e.. May prevent some forms of heart disease and stroke.167 ,168 ,169 ,170 ,171 ,172 ,173 ,174 ,175 Safety a.. Individuals taking anti-coagulant medications (e.g., warfarin or coumadin) should consult their physician before consuming large quantities, since it can inhibit blood clotting.167 ,176 GRAPE EXTRACT Food Source a.. Fruit of the common grape (Vitis vinifera) Cardiovascular Benefits Summary a.. Grape seeds are a preferential source of oligomeric proanthocyanidin (pycnogenol) complexes (OPCs),177 ,178 which are naturally occurring antioxidants.17 ,179 ,180 b.. Grape seed extract (GSE) is a potent antioxidant.181 ,182 c.. Dietary supplementation with GSE increased antioxidant activity in blood.179 d.. OPCs have anti-inflammatory and immune system modulation effects.183 ,184 e.. OPCs protect collagen and elastin, proteins found in blood vessels and muscle.185 ,186 f.. OPCs increase venous tone187 and reduce the pain and swelling associated with varicose veins and other vascular diseases.188 ,189 g.. Grape seed OPCs lower blood cholesterol and inhibit the development of atherosclerosis in animals with high blood cholesterol levels.190 ,191 h.. OPCs protect heart muscle from oxidative injury following heart attack (in animals).192 ,193 Safety a.. There have been no known adverse reactions to grape seed extracts and there are no contraindications for its use.194 b.. OPCs have been given orally in doses as high as 300 mg/day for up to 6 months in patient studies, with no adverse effects noted.188 ,189 HAWTHORN BERRY EXTRACT Food Sources a.. Ripe berries of the hawthorn plant (Crataegus sp) Cardiovascular Benefits Summary a.. May improve coronary artery blood flow.195 b.. Extracts are antioxidants196 ,197 and may protect heart muscle from damage caused by heart attack.198 ,199 c.. Improves performance of the heart in patients with mild congestive heart failure.200 ,201 ,202 ,203 ,204 d.. Flavonoid compounds extracted from the hawthorn plant increase the performance of animal heart tissue (in vitro).205 ,206 e.. Extracts cause dilation of arterial blood vessels,207 which may contribute to their cardioprotective effect. f.. Lowers blood cholesterol and other lipids and increases excretion of bile acids and decreases synthesis of cholesterol in the liver.208 Safety a.. A dose of 160 to 900 mg of a standardized Hawthorn berry extract containing 2.2% flavonoids or 18.75% oligomeric procyanidines, given 2-3X per day has been recommended.194 b.. No toxic effects have been reported.209 However, people taking prescription heart medications or CNS depressants should consult with their doctor before using hawthorn-containing products.194 TAURINE Synonyms a.. 2-aminoethanesulfonic acid Food Sources a.. Red meats, fish, beets, human milk.210 Cardiovascular Benefits Summary a.. Improves the symptoms of congestive heart failure.211 ,212 ,213 ,214 ,215 ,216 ,217 ,218 ,219 b.. Protects heart muscle from damage due to calcium imbalances.220 c.. Prevents against irregular heartbeat resulting from potassium imbalances.221 d.. Increases the strength of heart muscle contractions.222 e.. Lowers blood pressure in animals,223 ,224 ,225 ,226 and patients227 ,228 with high blood pressure. f.. Supplementation may reduce blood cholesterol levels.229 g.. Supplementation may reduce the risk of atherosclerosis (animal studies).230 ,231 h.. May help control blood clot formation.232 ,233 i.. May protect the heart from oxidative injury following heart attack or angina.234 j.. Individuals with high blood pressure, seizure disorders, or heart disease are at risk for deficiencies.119 Safety a.. No significant adverse health effects reported in patients given daily oral doses of 3-6 grams given for 3-6 weeks.214 ,229 ,219 ,211 TRIMETHYLGLYCINE Synonyms a.. Betaine, glycine betaine Food Sources a.. Plant foods, particularly beets.17 Cardiovascular Benefits Summary a.. Lowers blood levels of homocysteine.12 ,90 ,235 ,236 ,237 ,238 ,239 b.. May help prevent heart attack, stroke, and thromboembolism.12 ,235 ,236 c.. May protect liver from diets high in fat and cholesterol (animal studies).17 ,49 Safety a.. Considered safe when 6-9 grams was given daily for up to 16 years.235 ALPHA-LIPOIC ACID Synonyms a.. Thioctic acid b.. A B-complex vitamin.17 Food Sources a.. Yeast, liver.17 Cardiovascular Benefits Summary a.. May improve heart function in diabetics.240 b.. May protect heart muscle from oxidative stress following angina or heart attacks.241 c.. Provides effective antioxidant support.49 ,242 ,243 ,244 ,245 ,246 d.. A treatment for individuals in whom the liver is affected by oxidative stress. 247 e.. May protect brain cells following stroke.248 ,249 ,250 ,251 ,252 ,253 f.. May help individuals adapt to and have fewer adverse health effects from stress.108 Safety a.. No significant adverse effects when given orally at a daily dose of 800 mg for 4 months.240 N-ACETYL-L-CYSTEINE Food Sources a.. Duck, wheat germ, yogurt, pork, turkey, chicken.119 Cardiovascular Benefits Summary a.. May help prevent damage caused by blood oxidants following ischemic (restricted blood flow) injury (in animals).254 ,255 b.. May inhibit muscle fatigue.256 Safety a.. Well tolerated by patients at oral doses of 4-6 grams/day for 30 months.257 b.. Should be used with caution by individuals with asthma.118 COENZYME Q-10 Synonyms a.. Ubiquinone, ubidecarenone Food Sources a.. Heart, sardines, peanuts, spinach.17 Cardiovascular Benefits Summary a.. Patients with coenzyme Q-10 deficiency and heart disease may show symptomatic improvement following supplementation.103 ,258 b.. May help treat congestive heart failure when used in conjunction with conventional medications.116 ,258 ,259 ,260 ,261 ,262 c.. May protect against symptoms following heart attack.260 d.. May protect against symptoms following heart surgery.263 ,264 e.. May protect the heart, kidney, lung and spleen against oxidative damage.265 ,266 f.. May be useful for cardiomyopathy (heart muscle disease).103 ,258 ,267 ,268 ,269 g.. Lowers blood pressure in hypertensive individuals.267 ,270 ,271 h.. Lowers blood lipoprotein(a) and glucose and increases HDL cholesterol.272 i.. Patients with congestive heart failure are at risk for deficiencies.261 j.. Individuals taking statin drugs to treat high blood cholesterol are at risk for deficiencies.273 ,274 ,275 Safety a.. No serious side effects or drug interactions were noted when oral doses up to 600 mg/day were given for as long as 6 years.259 ,260 ,267 ,268 ,276 b.. Beneficial dosage is typically about 120 mg/day.259 ,261 ,263 ,264 ,269 ,270 ,271 ,272 ,276 ,277 *§ _Newsletter §* " Health & Medical Conspiracies " HH_Newsletter Subscribe:......... HH_Newsletter- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 2002 Report Share Posted July 4, 2002 Hi Wayne, thanks, I will read the article more closely. I think a stint is a 'balloon' inserted into the artery to keep it 'open', known as angioplasty. I did not read all of the article I must confess, but I will not bother now that you have advised it is filled with flaws. Marianne > He allows them to install a stint, ( a tube I think ). Now he can't run > for a time. Maybe this will allow him to get over the hill without chest > pains. > > I have been knowing this guy about 35 years. He has always exercised and > > been health conscious? > > What when wrong? Only one thing. He believed the misinformation that > was provided to him by all the sources that dump out false > information. Time will tell. I will keep you posted. > > Back to the article, I don't have the time to elaborate on all the > flaws. Maybe someone else will. If not, I will do it later. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 2002 Report Share Posted July 4, 2002 Evening Marianne, > http://www.glycoscience.com/glycoscience/start_frames.wm?FILENAME==R003 >DIETARY SUPPLEMENTS THAT SUPPORT CARDIOVASCULAR HEALTH: A REVIEW OF >POTENTIAL BENEFITS >By Jane Ramberg, MS and Tom Gardiner, PhD That is an interesting article. However, I think it is a " mainstream and conventional " article as I see numerous flaws in the article, which indicates that the people who wrote it are married to big medicine. One of the biggest misconceptions is that exercise prevents heart disease. Some of the most physically fit and strongest persons that every lived died with heart attacks before 60 years old. Here is a second person story about a friend of mine. This happened within the last two weeks. First, he went to the foot doctor because his foot was hurting. The doc said, " What have you been doing to make the foot hurt " ? My friend replied, I do 24 miles on the bicycle, then 7 miles on the treadmill. The doc said, that is why your foot hurts. My friend replied, " NO, I have been doing that a long time " . So the doc examined his foot and found the tendons too tight. He had to roll his feet of bottles for 5 weeks to solve the problem. Next.... he runs a number of miles per day. When he gets to a certain hill, while going up the hill, he has slight chest pains. He goes to the mainstream docs who do all their test and determine that he needs his heart patched. He allows them to install a stint, ( a tube I think ). Now he can't run for a time. Maybe this will allow him to get over the hill without chest pains. I have been knowing this guy about 35 years. He has always exercised and been health conscious? What when wrong? Only one thing. He believed the misinformation that was provided to him by all the sources that dump out false information. Time will tell. I will keep you posted. Back to the article, I don't have the time to elaborate on all the flaws. Maybe someone else will. If not, I will do it later. Wayne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 7, 2002 Report Share Posted July 7, 2002 It is called a STENT. A tube inserted into the artery In a message dated 07/04/2002 3:16:38 PM Pacific Daylight Time, marianne2406 writes: > Hi Wayne, thanks, I will read the article more closely. > > I think a stint is a 'balloon' inserted into the artery to keep it 'open', > known as angioplasty. Quote Link to comment Share on other sites More sharing options...
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