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Flaxseed links

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* Health and Healing *

Sunday, April 21, 2002 10:35 PM

Flaxseed & Cancer

 

http://www.thensome.com/flaxseedlinks.htm

 

 

__________

 

 

-Herbal Medicine, Healing, and Cancer :..Herbal Medicine, Healing and Cancer is

for humans but the information within it is so awesome and it contains

preventative tips also. Donald Yance has reviewed the literature and has treated

human cancer victims for over twenty years..amazon sells it for less than $16

dollars! For instance, I almost bought Melatonin for Yuki who just had radical

surgery in case of mammary cancer(thank goodness it was a cyst) because of that

book. I wish I had known about two years ago when I started the search to keep

Morgan alive. He also explains why possibly flaxseed and cottage cheese may

work-He explains what butryic acid is..He mentions Spes as a great pain killer

for cancer..and on and on..

 

Here is his excerpt on flaxseed oil and sulphur rich protein

 

Herbal Medicine, Healing & Cancer " by Donald Yance

" Flaxseed oil is rich in essential fatty acids, particularly ALA, which, when

taken in combination with sulfur-rich proteins, actually works to create a new

food. This was first discovered and made famous by Johanna Budwig, a West German

physician who had done a great deal of research on the oil-protein combination.

She discovered that EFAs need to bind to sulfur-rich proteins (she used low-fat

cottage cheese) before the body can properly assimilate them. Budwig found that

by feeding people with terminal cancer this oil-protein combination, the

yellowish-green substance in their blood was replaced by the healthy red

pigment, hemaglobin. The phosphatides returned and the lipoproteins reappeared.

Of all the deficiencies that may exist in people with cancer, perhaps those that

are most important and totally ignored are EFAs, which, when taken with protein,

enhance our albumin levels. Albumin is a blood protein of immense importance to

good health. When flaxseed oil and sulfur-rich protein are combined, the ALA and

the EFAs in the flaxseed oil become water-soluble and electron-rich; this causes

the cell membrane to become more stable by making it more flexible and

fluidlike. The electron-rich fatty acids now allow for efficient transport of

materials and energy between the inner and outer cell membrane. This is

important to the health of all cells and to the entire immune system.

A simple recipe for achieving these cellular benefits is to add 1 to 2 teaspoons

of flaxseed oil or ground flaxseeds to 1 cup of organic yogurt (preferabley goat

or soy yogurt).

Omega-3 fatty acids are extremely important because they modulate

prostaglandins, which are very active biological substances important to nearly

every bodily function. They suppress tumor-promoting prostaglandin E2 by

increasing prostiglandin E3 and suppressing AA. They also inhibit cancer

wasting. EPA and ALA, as well as other related omega-3 fatty acids, plus GLA

from evening primrose oil, have been found to kill a number of tumor-cell lines

and cause a significant reduction in tumor growth in animal studies. "

(pp.219-220)

 

 

 

--

Biosynthetic pathway to the cancer chemopreventive secoisolariciresinol

diglucoside-hydroxymethyl glutaryl ester-linked lignan oligomers in flax (Linum

usitatissimum) seed.

Application of stable and radioisotope precursor/tracer experiments resulted in

the identification of various phenylpropanoid, monolignol, and lignan

metabolites involved in the biosynthesis of the cancer chemopreventive

secoisolariciresinol diglucoside (SDG; 1)-containing ester-linked " polymer(s) "

in flax (Linum usitatissimum) seed.

Results from this study will facilitate future isolation and characterization of

the proteins and enzymes involved in biosynthesis of the SDG-HMG ester-linked

oligomers in flax seed.

--

" 1: Carcinogenesis 1996 Jun;17(6):1373-6

Flaxseed and its lignan and oil components reduce mammary tumor growth at a late

stage of carcinogenesis.

Thompson LU, Rickard SE, Orcheson LJ, Seidl MM.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto,

Ontario, Canada.

Flaxseed, a rich source of mammalian lignan precursor

secoisolariciresinol-diglycoside (S.D.) and alpha-linolenic acid (ALA), has been

shown to be protective at the early promotion stage of carcinogenesis. The

objective of this study was to determine whether supplementation with flaxseed,

its lignan or oil fractions, beginning 13 weeks after carcinogen administration,

would reduce the size of established mammary tumors (present at the start of

treatment) and appearance of new tumors in rats. Dietary groups consisted of the

basal diet (BD, 20% corn oil) alone or supplemented with a gavage of 2200

nmol/day S.D. [s.D., equal to level in 5% flaxseed (F)], 1.82% flaxseed oil

(OIL, equal to level in 5% F) or 2.5% or 5% flaxseed (2.5% F and 5% F,

respectively). After 7 weeks of treatment, established tumor volume was over 50%

smaller in all treatment groups (OIL, 2.5% F, 5% F, P < 0.04; S.D., P < 0.08)

while there was no change in the BD group. New tumor number and volume were

lowest in the S.D. (P < 0.02) and 2.5% F (P < 0.07) groups. The combined

established and new tumor volumes were smaller for the S.D., 2.5% F and 5% F

groups (P < 0.02) compared to the OIL and BD groups. The high negative

correlation (r = -0.997, P < 0.001) between established tumor volume and urinary

mammalian lignan excretion in the BD, S.D., 2.5% F and 5% F groups indicates

that the reduction in tumor size is due in part to the lignans derived from the

S.D. in flaxseed. However, there was no relationship between new or total tumor

development and urinary lignan levels. The effect of flaxseed oil may be related

to its high ALA content. In conclusion, the S.D. in flaxseed appears to be

beneficial throughout the promotional phase of carcinogenesis whereas the oil

component is more effective at the stage when tumors have already been

established.

PMID: 8681458 [PubMed - indexed for MEDLINE] " medline

 

--

" 1: Cancer Lett 1999 Jul 19;142(1):91-6

Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces

experimental metastasis of melanoma cells in mice.

Li D, Yee JA, Thompson LU, Yan L.

Department of Biomedical Sciences, Creighton University School of Medicine,

Omaha, NE 68124-0405, USA.

We investigated the effect of dietary supplementation with secoisolariciresinol

diglycoside (SDG), a lignan precursor isolated from flaxseed, on experimental

metastasis of B16BL6 murine melanoma cells in C57BL/6 mice. Four diets were

compared: a basal diet (control group) and the basal diet supplemented with SDG

at 73, 147 or 293 micromol/kg (equivalent to SDG provided in the 2.5, 5 or 10%

flaxseed diet). Mice were fed the diet for 2 weeks before and after an

intravenous injection of 0.6 x 10(5) tumor cells. At necropsy, the number and

size of tumors that formed in the lungs were determined. The median number of

tumors in the control group was 62, and those in the SDG-supplemented groups

were 38, 36 and 29, respectively. The last was significantly different from the

control (P < 0.01). Dietary supplementation with SDG at 73, 147 and 293

micromol/kg also decreased tumor size (tumor cross-sectional area and volume) in

a dose-dependent manner compared with the control values. These results show

that SDG reduced pulmonary metastasis of melanoma cells and inhibited the growth

of metastatic tumors that formed in the lungs. It is concluded that dietary

supplementation with SDG reduces experimental metastasis of melanoma cells in

mice.

PMID: 10424786 [PubMed - indexed forflaxseed melanoma-medline MEDLINE] "

--

Protective effects of dietary phytoestrogens in chronic renal disease.1: J Ren

Nutr 2001 Oct;11(4):183-93

Protective effects of dietary phytoestrogens in chronic renal disease.

Ranich T, Bhathena SJ, Velasquez MT.

Division of Renal Diseases and Hypertension, Department of Medicine, George

Washington University Medical Center, Washington, DC 20037, USA.

Phytoestrogens are naturally occuring plant compounds that are present primarily

in soybeans as isoflavones and in flaxseed as lignans. Because of their

structural similarity to endogenous estrogens, phytoestrogens bind to both

estrogen receptors (ER)-alpha and beta (but more strongly to ER-beta) and exert

estrogen-like effects. There is increasing evidence that dietary phytoestrogens

have a beneficial role in chronic renal disease. Nutritional intervention

studies have shown that consumption of soy-based protein and flaxseed reduces

proteinuria and attenuates renal functional or structural damage in animals and

humans with various forms of chronic renal disease. It is not clear which

component(s) of the soybean or flaxseed is (are) responsible for the protective

effects observed in experimental animals and in limited studies in humans.

Vegetable protein has been shown to have a beneficial effect on renal disease in

animals and humans. Thus, the role of soy and flaxseed cannot be ruled out.

Isoflavones and lignans are readily absorbed from the gut and converted to

active metabolites, which may be partly responsible for the beneficial renal

effects of soy protein and flaxseed. In addition, an interaction between type of

protein and phytoestrogens is also possible. The biological actions of

isoflavones and lignans have been well defined in different cell types in vitro

and also in vivo, but how these compounds might reduce renal injury remains to

be elucidated. Possible mechanisms include inhibition of cell growth and

proliferation via ER-mediated mechanisms or non-ER-mediated pathways through

inhibition of tyrosine protein kinases, modulation of growth factors involved in

extracellular matrix synthesis and fibrogenesis, inhibition of cytokine-induced

activation of transcription factors, inhibition of angiogenesis, antioxidative

action, suppression of platelet activating factor and platelet aggregation, and

immunomodulatory activity. To date, clinical trials in humans are few, of

relatively short duration, and involve a small number of patients. Prospective

randomized trials are needed to evaluate the long-term safety and effectiveness

of dietary phytoestrogens on renal disease progression in patients with chronic

renal failure. Copyright 2001 by the National Kidney Foundation, Inc.

--

 

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g.. DESIGNING HEALTH-FLAX SEED

h.. more on flaxseed oil

i.. FLAXSEED OIL LABRADORS

j.. bht LIVER CANCER in hills

k.. herbal parasite cleanser

cancer-parasite theory

l.. diets for dogs-ie liver problems,kidney problems etc

m.. Holistic links

n.. cancer-diets etc and experienceMORE DIET INFORMATION

o.. IMMUNE ENHANCING STUDY

p.. DOG IMMUNE DISEASE

q.. Dodds on Immune system

r.. AIHA-AUTOIMMUNE

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t.. Hydrazine Sulfate

u.. Hydrazine sulfate

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x.. FLAXSEED LIGNANS & THE IMMUNE SYSTEM -a great review

" Flaxseed contains Secoisolariciresinol diglucoside (SDG), a potent

antioxidant and a known precursor of the mammalian lignans, enterolactone and

enterodiol. These compounds have other pharmacological properties including

phytoestrogen properties similar to isoflavones. Studies performed in the

Department of Physiology, College of Medicine, University of Saskatchewan, have

shown that SDG prevents the development of hypercholesterolemic atherosclerosis,

reduces total cholesterol and LDL-cholesterol, and has a tendency to raise

HDL-cholesterol in animal models. In addition, SDG has shown the ability to

lower blood pressure, and has demonstrated that it is effective in preventing

diabetes mellitus (Type I and Type II) and endotoxic shock. "

" The rapid rate of postmenopausal bone loss is mediated by the inflammatory

cytokines interleukin-1, interleukin-6, and tumor necrosis factor alpha. Dietary

supplementation with flaxseeds and flaxseed oil in animals and healthy humans

significantly reduces cytokine production while concomitantly increasing calcium

absorption, bone calcium, and bone density. Possibilities may exist for the

therapeutic use of the omega-3 fatty acids, as supplements or in the diet, to

blunt the increase of the inflammatory bone resorbing cytokines produced in the

early postmenopausal years, in order to slow the rapid rate of postmenopausal

bone loss. Evidence also points to the possible benefit of gamma-linolenic acid

in preserving bone density. (Kettler D, Altern Med Rev, 6(1): 61, 2001) "

" Results of many studies indicate that consumption of n-3 fatty acids can

benefit persons with cardiovascular disease and rheumatoid arthritis. However,

encapsulated fish oil is unlikely to be suited to lifetime daily use and

recommendations to increase fish intake have not been effective. Foods naturally

rich in n-3 fatty acids, such as flaxseed meal can be used to achieve desired

biochemical effects without the ingestion of supplements or a change in dietary

habits. A wide range of n-3-enriched foods could be developed on the basis of

the therapeutic and disease-preventive effects of n-3 fatty acids. (Mantzioris

E, et al, Am J Clin Nutr, 72(1): 42, 2000) " " TARGET= " _blank " >Fat soluable

vitamins A,D,E,K

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ad.. Colorado State nutrition

 

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af.. Altvetmed cancer diet

 

ag.. MORE DESCRIPTION ON HERBS ETC COMMERCIAL SITE

 

ah.. melatonin cancer treatment-some research

 

ai.. homepathy Christina Chambreau, DVM

 

aj.. WELLPET Cancer diets

ak.. lymphoma comparison protocols

Friday April 13 06:39 PM EDT Study: Common Seed Fights Cancer A recent Canadian

study shows that a common seed may be a promising new cancer fighter,

researchers say. Dr. Paul Gross of Princess Margaret Hospital and a team of

researchers from the University of Toronto asked a group of newly diagnosed

breast cancer patients to eat two tablespoons of ground flaxseed in a muffin

each day. Then, Gross' research team analyzed samples of their tumors. The study

found that flax actually slowed the growth of breast cancer. " The scientific

community is very interested in this study, " Gross said. " We've been bombarded

by other investigators from around the world. " Researchers found that in less

than a month, the women taking flaxseed slowed their rate of tumor growth by up

to 33 percent. There also was nearly a 60-percent drop in the spread of the most

aggressive cancer cells. " Flaxseed is the first nutritional product that has

been studied, and that has produced hard scientific evidence, " Gross said.

According to the study, researchers believe that a fiber in the seed helps to

sweep the hormone estrogen out of the body, which blocks its ability to make

tumors grow. Flax would be the first cancer treatment that isn't a chemical,

researchers said. However, since flax is a food, it doesn't have the backing of

a drug company. Researchers said that they don't know how much longer they would

be able to continue their work. Some cancer support groups believe that the data

shouldn't be ignored. " There is a community out there who are hungry for this

kind of information, and it won't bother them that it's not a pharmaceutical, "

Sue Wright of the Willow Breast Cancer Support Center. " In fact, it might even

encourage them. "

 

 

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