Details on Detox Terms

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* Health and Healing *

Thursday, April 18, 2002 7:42 PM

Details on Detox Terms

 

 

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More on Detox Terms

From the Amalgam discussion list

Detailed Comments by Ray Saarela

 

Neutrophils ingest fungi as well as bacteria

 

Neutrophils are also called granulocytes, as they contain multiple " granules "

that they use to ingest pathogenic bacteria, fungi etc. Within the granules they

used H2O2 to kill the pathogens safely without releasing H2O2 to extracellular

space to cause free radical reactions.

 

Mercury causes impairment in intracellular oxidative burst due to electron

transport chain blockage due to inhibiting sulfur ( thiol ) reactive-group

containing enzymes needed along the chain, as well as inhibiting similarly

oxidase enzymes. This results in inability to kill catalase positive

micro-organism like candida, staph, serratia, aspergillus etc. that can tolerate

their own metabolic wastes when confined within dysfunctional granulocytes.

Catalase-negative microbes are still killed, but just to their own metabolic

wastes instead of the impaired neutrophil killing them

There are marvelous abstracts about how even very small levels ( smaller than

what comes from amalgams) impair granulocyte functions up to 50 %, and levels

possible from amalgams can inhibit granylocyte function ( neutrophils ) up to 90

% against fungi. So do not wonder WHY you have Candidiasis/ Aspergillosis/Staphs

etc. due to amalgam-mercury poisoning.

 

Neutrophils are the main defense against Candida

 

If neutrophils are low in counts and function due to mercury, Candidiasis

results, in addition to other infections like Staphs, Aspergillus etc. E-vitamin

and Glutathione can help Neutrophil function, as well as Myrrh. That is why

myrrh is added to tooth-paste.

 

Glutathione - Gamma-GlutamylCysteinelGlycine is glutathione, or GSH.

 

Glutathione is major eye antioxidant, major liver detoxificant, also important

for pancreas, kidneys, lungs, is found in high levels in Substantia Nigra, and

those with Alzheimer have depleted glutathione levels on their S.N (perhaps due

to mercury binding there?) Glutathione is responsible for Gamma-Glutamyl cycle

that takes proteins into cells. Additionally glutathione participates

neurotransmitter metabolism and prevents them turning to melanoma ( keeps

melanins from further oxidation) as well as is important in tyrosine metabolism.

 

There is a marvelous book-set about glutathione Coenzymes and Cofactors vol III,

1989. Available at least from Santa Cruz University of California througn

Interlibrary loan. Largest/biggest material of Glutathione ever made. Over

10,000 references referred in the text. Somehow, the taking up and giving of

oxygen issue was totally missed in that 1700-page book-set. And have never read

either that glutathione would directly participate in respiration. Perhaps the

dictionary you have has a typo? Glutathione is primarily a sulfur-antioxidant

that contains an SH-group, a thiol, that for example detoxifies mercury,

acetaminophen etc. by conjugating to them in the liver. N-acetylcysteine,

Glycine and Glutamate ( with those without ALS ) mix can help to up GSH levels.

Arginine increases glutamate intake so that could help also additionally. ALSers

must be careful with glutamate.

 

Mercury depletes glutathione and impairs glutathione synthesis, and that

results in the toxic effects of mercury. Glutathione is considered the most

important intracellular protection against mercury. People with low

intracellular glutathione levels suffer more from same amount of mercury than

those who have high glutathione levels to protect the cells from mercury binding

to the DNA cysteines and enzymes etc. The idea behind taking NAC

[N-acetyl-cysteine] is to elevate GSH, and the idea behind GSH is to provide

protection for the cells by giving " surrogate " target for mercury to bind

instead of more important DNA/Enzyme/ Hormone/antibody cysteines/disulfides ...

This was a very shortened version of the deal.

GSH does not enter cells itself, and that is why

one has to take the constituents NAC, Glycine and Glutamate.

 

IF one has enough glutamate floating around already ( i.e, ALS) one could take

only NAC and Glycine, if one does not get side-effects from NAC ... Also,

arginine might help additionally some ... NAC is taken as it is safer than

cysteine, and enters cells much easier.

 

Glutamic acid - Glutamate is also synthetized by various cells for sure in

various organisms. Glutamate is often dumped out of the cells due to mercury,

that seems to be the problem with ALS patients. They take Glutamate blockers

that reduce the dumping out of the cells, and that helps to keep more glutamate

within cells that is needed also for the Glutathione production along with

cysteine and Glycine.

 

Glycine detoxifies aspirin, for example, in the phase-II liver detoxification,

and is part of the glutathione mentioned above. Glycine is also involved in

bile-metabolism and other metabolic pathways. Biochemistry books provide more

enlightenment and entertainment for sure.

 

Cysteine, found very high in human hair, contains important reactive SH-group,

and is found in DNA-proteins, enzymes, Albumin, almost everywhere. Cysteine is

very important amino-acid, in addition to being part of glutathione. Those with

hair loss due to mercury may suffer from cysteine metabolism problems due to

mercury.

 

 

 

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The Amalgam listserv is dedicated to exploring the hazard of mercury found in

silver fillings. To browse the Archives of the Amalgam list, see

http://www.listserv.gmd.de/archives/amalgam.html.

 

Return to Say What? Glossary of Detox Terms

 

See also: Ray's comments on GSH nutrition posted in response to my posting on a

book, The GSH Phenomenon. Ray Saarela is a member of the Amalgam discussion

group who has done extensive reading on mercury detoxification.

 

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