[FWD: The Transfats; Diabetes, Cancer and Heart Disease]

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JoAnn Guest <joguest

Mon, 18 Mar 2002 15:12:45 +0000

Melanoma

The Transfats; Diabetes, Cancer and Heart Disease

 

Transfats (Hydrogenated)

Play a Role in Cancer

Diabetes, & Heart Disease

 

Hydrogenation ruins the nutritional value of vegetable

oils.

Fatty Acids are the building blocks of fats. Amino Acids are the

building blocks of proteins.

More than a decade of research at the University of Maryland has shown

that consumption of trans fatty acids commonly called hydrogenated

vegetable oil has adverse effects in health areas such as heart disease,

 

cancer, diabetes, immunity, reproduction,lactation and obesity!

 

These and earlier reports had shown that consumption of transfatty acids

 

lower the " good " HDL cholesterol in a dose response manner and raise the

 

atherogenic lipoprotein (a) in humans as well as raising the " bad " LDL

cholesterol and total blood cholesterol levels by 20-30 milligram-

percent.

 

Perhaps the most significant event was the report from researchers at

Harvard University, who evaluated more than 85,000 women in a long-term

prospective study and found that there was a significantly higher intake

 

of trans fatty acids in those individuals who developed heart disease!

 

As regards to the question of cancer, trans fatty acids induce adverse

alterations in the activities of the important enzyme system that

metabolizes chemical carcinogens and drugs (medications), i.e. the

mixed-function oxidase cytochromes P-448/450.

 

The initial research in this area was done by the Maryland group in

collaboration with the U.S. Food and Drug Administration. Several groups

 

around the world reported a higher intake of partially hydrogenated fats

 

in those individuals who have developed cancer.

 

Both primate and human studies have shown inappropriate handling of

blood sugar; trans fatty acids decrease the response of the red blood

cell to insulin, thus having a potentially undesirable effect in

diabetics.

The primate research ws initiated at Maryland in collaboration with the

 

U.S. Department of Agriculture and the National Institutes of Health,

and the human research is from the University of Pittsburgh and quite

recent.

 

One major concern is that trans fatty acids adversely affect immune

response by lowering efficiency of B cell response and increasing

proliferation of T cells.

 

Basically, trans fatty acids cause alterations to numerous physiological

 

functions of biological membranes that are known to be critical for cell

 

homeostasis, e.g. appropriate membrane transport and membrane fluidity,

and these fatty acid isomers produce alterations in adipose cell size,

cell number, lipid class and fatty acid composition.

 

The various mechanisms through which the trans fatty acids disrupt

function are related in part to the ability of trans fatty acids to

inhibit the function of membrane related enzymes such as the delta-6

desaturase resulting in decreased conversion of e.g. linoleic acid to

gamma-linolenic acid or arachidonic acid; interference with the

necessary conversion of omega-3 fatty acids to their elongated tissue

omega-3 fatty acids; and escalation of the adverse effects of essential

fatty acid deficiency.

 

This latter effect was shown especially by the work of Dr. Holman and

his colleagues at the Hormel Institute at the University of Minnesota,

the other effects have been shown by researchers at the University of

Maryland.

 

Dr. Ancel Keys had originally claimed that hydrogenated vegetable oils

were the culprits in heart disease. This was in 1958, and the edible

oils industry was very swift in their squelching of that information;

they shifted the emphasis to " saturated " fat and started the phoney

attck on meat, eggs and dairy fats!

 

 

 

 

 

JoAnn Guest

joguest

Friendsforhealthnaturally

http://canceranswer.homestead.com/AIM.html

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" Health is not a Medical Issue "

 

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